公开(公告)号：US09347041B2

公开(公告)日：2016-05-24

申请号：US14233056

申请日：2012-07-13

申请人： Ryuhei Hayashi ,  Susumu Hara ,  Tomofumi Kageyama ,  Kohji Nishida

发明人： Ryuhei Hayashi ,  Susumu Hara ,  Tomofumi Kageyama ,  Kohji Nishida

IPC分类号： C12N5/02 ,  C12N5/079 ,  A61K35/30

CPC分类号： C12N5/0621 ,  A61K35/30 ,  C12N2501/115 ,  C12N2501/48 ,  C12N2533/52 ,  C12N2533/54 ,  C12N2533/90

摘要： The present invention relates to a method for preparing corneal endothelial progenitor cells by adherent culturing a cell population isolated from corneal endothelial cell tissue at a low density by using a serum-free medium. The present invention also relates to a method for preparing corneal endothelial cells by differentiation-inducing the corneal endothelial progenitor cells obtained by the aforementioned method. According to the present invention, corneal endothelial progenitor cells can be selectively grown from a corneal tissue-derived cell population, and corneal endothelial cells obtained by inducing the corneal endothelial progenitor cells can be applied to treatment of corneal endothelial diseases. As a result, problems of corneal transplantation such as shortage of donors and occurrence of rejection can be solved.

摘要翻译： 本发明涉及通过使用无血清培养基以低密度粘附培养从角膜内皮细胞组织分离的细胞群来制备角膜内皮祖细胞的方法。 本发明还涉及通过分化诱导通过上述方法获得的角膜内皮祖细胞来制备角膜内皮细胞的方法。 根据本发明，可以从角膜组织衍生的细胞群中选择性地生长角膜内皮祖细胞，并且通过诱导角膜内皮祖细胞获得的角膜内皮细胞可用于治疗角膜内皮细胞疾病。 结果，可以解决诸如供体不足和排斥发生等角膜移植的问题。

公开(公告)号：US20140170751A1

公开(公告)日：2014-06-19

申请号：US14233056

申请日：2012-07-13

申请人： Ryuhei Hayashi ,  Susumu Hara ,  Tomofumi Kageyama ,  Kohji Nishida

发明人： Ryuhei Hayashi ,  Susumu Hara ,  Tomofumi Kageyama ,  Kohji Nishida

IPC分类号： C12N5/079

CPC分类号： C12N5/0621 ,  A61K35/30 ,  C12N2501/115 ,  C12N2501/48 ,  C12N2533/52 ,  C12N2533/54 ,  C12N2533/90

摘要： The present invention relates to a method for preparing corneal endothelial progenitor cells by adherent culturing a cell population isolated from corneal endothelial cell tissue at a low density by using a serum-free medium. The present invention also relates to a method for preparing corneal endothelial cells by differentiation-inducing the corneal endothelial progenitor cells obtained by the aforementioned method. According to the present invention, corneal endothelial progenitor cells can be selectively grown from a corneal tissue-derived cell population, and corneal endothelial cells obtained by inducing the corneal endothelial progenitor cells can be applied to treatment of corneal endothelial diseases. As a result, problems of corneal transplantation such as shortage of donors and occurrence of rejection can be solved.

摘要翻译： 本发明涉及通过使用无血清培养基以低密度粘附培养从角膜内皮细胞组织分离的细胞群来制备角膜内皮祖细胞的方法。 本发明还涉及通过分化诱导通过上述方法获得的角膜内皮祖细胞来制备角膜内皮细胞的方法。 根据本发明，可以从角膜组织衍生的细胞群中选择性地生长角膜内皮祖细胞，并且通过诱导角膜内皮祖细胞获得的角膜内皮细胞可用于治疗角膜内皮细胞疾病。 结果，可以解决诸如供体不足和排斥发生等角膜移植的问题。

公开(公告)号：US08872070B2

公开(公告)日：2014-10-28

申请号：US13185823

申请日：2011-07-19

申请人： Susumu Hara ,  Toshiyuki Izumi ,  Masatoshi Hida

发明人： Susumu Hara ,  Toshiyuki Izumi ,  Masatoshi Hida

IPC分类号： B23K23/00 ,  B23K9/095 ,  G05B19/425 ,  B23K9/10 ,  G05B19/408 ,  B23K9/12 ,  B23K37/04

CPC分类号： B23K9/124 ,  B23K9/095 ,  B23K9/1062 ,  B23K9/1087 ,  B23K37/0452 ,  G05B19/4086 ,  G05B19/425 ,  G05B2219/35091 ,  G05B2219/36432 ,  G05B2219/36494

摘要： A three-dimensional rectangular coordinate system is set in which the direction of a weld line is the Y direction, a direction perpendicular to a surface of a material to be welded is the Z direction, and a direction perpendicular to the Y direction and the Z direction is the X direction. A coordinate system A of XAYAZA is set as a previous stage coordinate system, which ranges from a previous step to a current step, and a coordinate system B of XBYBZB is set as a next stage coordinate system, which ranges from the current step to a next step. The weld line is defined by these coordinate systems that use a workpiece as a reference, and an operator specifies the amount of travel of a torch in these workpiece coordinate systems. By this method, offline teaching can be accurately performed in a welding system without requiring skill in operation.

摘要翻译： 设置三维直角坐标系，其中焊接线的方向为Y方向，垂直于待焊接材料表面的方向为Z方向，垂直于Y方向的方向和Z 方向是X方向。 将XAYAZA的坐标系A设置为前一级坐标系，其范围从前一步到当前步，并且将XBYBZB的坐标系B设置为下一级坐标系，其范围从当前步到 下一步。 焊接线由使用工件作为参考的这些坐标系定义，操作员指定这些工件坐标系中割炬的行程量。 通过这种方法，可以在焊接系统中准确地执行离线教学，而不需要操作技能。

公开(公告)号：US08193867B2

公开(公告)日：2012-06-05

申请号：US12916194

申请日：2010-10-29

申请人： Zhuo Fu ,  Susumu Hara

发明人： Zhuo Fu ,  Susumu Hara

IPC分类号： H03L7/08 ,  H03M3/02

CPC分类号： H03L7/1974

摘要： A voltage control signal at a voltage control signal input terminal is used to adjust an output frequency of an oscillator circuit. The voltage level of the voltage control signal is converted in a one-bit analog-to-digital converter (ADC) to a digital output indicative of the voltage level. Successive digital representations of the voltage level of the voltage control signal are upsampled to generate upsampled blocks of data. A dither circuit inserts a digital dither in the upsampled blocks of data to generate dithered upsampled data, which is used to generate a control signal for a feedback divider of a phase-locked loop circuit and thereby adjust the output frequency.

摘要翻译： 电压控制信号输入端的电压控制信号用于调整振荡电路的输出频率。 电压控制信号的电压电平在一位模数转换器（ADC）中转换为指示电压电平的数字输出。 电压控制信号的电压电平的连续数字表示被上采样以产生上采样的数据块。 抖动电路在上采样数据块中插入数字抖动以产生抖动上采样数据，用于产生用于锁相环电路的反馈分频器的控制信号，从而调节输出频率。

公开(公告)号：US07999449B2

公开(公告)日：2011-08-16

申请号：US11571349

申请日：2005-03-24

申请人： Susumu Hara ,  Tetsuji Zama

发明人： Susumu Hara ,  Tetsuji Zama

IPC分类号： H01M4/02

CPC分类号： H01M14/00 ,  F03G7/005 ,  H01M4/0466 ,  H01M4/137 ,  H01M4/1399 ,  H01M4/608 ,  H01M4/663 ,  H02N11/006

摘要： The present invention relates to an electrode, wherein a substrate comprises a porous carbon material and an electroconductive polymer layer formed by an electrolytic polymerization method is provided substantially on the substrate; the electrode, wherein the porous carbon material comprises at least one porous carbon material selected from the group consisting of a carbon paper, a carbon fiber, a porous carbon sheet and an activated carbon sheet; and an actuator having the above electrode as a counter electrode.

摘要翻译： 本发明涉及一种电极，其中基底包括多孔碳材料和通过电解聚合方法形成的导电聚合物层，其基本上设置在基底上; 所述电极，其中所述多孔碳材料包括选自由碳纸，碳纤维，多孔碳片和活性炭片组成的组中的至少一种多孔碳材料; 以及具有上述电极作为对电极的致动器。

公开(公告)号：US07742352B1

公开(公告)日：2010-06-22

申请号：US11927845

申请日：2007-10-30

申请人： Susumu Hara ,  Jeffrey S. Batchelor ,  Jeffrey L. Sonntag

发明人： Susumu Hara ,  Jeffrey S. Batchelor ,  Jeffrey L. Sonntag

IPC分类号： G11C7/02

CPC分类号： G11C17/18 ,  G11C29/02 ,  G11C29/021 ,  G11C29/026 ,  G11C29/027 ,  G11C29/12005 ,  G11C29/48 ,  G11C29/50008

摘要： Techniques for use with a fuse-based non-volatile memory circuit include digitally controlling a resistance threshold of the circuit. The circuit includes a fuse circuit and a comparator circuit. The comparator circuit is configured to compare a first signal indicative of the fuse resistance to a second signal indicative of a reference level. At least one of the first and second signals is digitally controllable. The comparator circuit is configured to generate a digital output signal indicative of the comparison. The circuit may include a first digital-to-analog converter circuit configured to generate a first analog signal based on at least a first plurality of digital signals. The first signal is at least partially based on the first analog signal. The circuit may include a control circuit configured to digitally control the digitally controllable ones of the first and second signals at least partially based on the digital output signal.

摘要翻译： 与基于熔丝的非易失性存储器电路一起使用的技术包括数字地控制电路的电阻阈值。 电路包括熔丝电路和比较器电路。 比较器电路被配置为将指示熔丝电阻的第一信号与指示参考电平的第二信号进行比较。 第一和第二信号中的至少一个是数字可控的。 比较器电路被配置为产生指示比较的数字输出信号。 电路可以包括被配置为基于至少第一多个数字信号产生第一模拟信号的第一数模转换器电路。 第一信号至少部分地基于第一模拟信号。 电路可以包括控制电路，其被配置为至少部分地基于数字输出信号数字地控制第一和第二信号中的数字可控的信号。

公开(公告)号：US07598309B2

公开(公告)日：2009-10-06

申请号：US11364556

申请日：2006-03-01

申请人： Yasuhisa Sugita ,  Masato Koike ,  Susumu Hara ,  Atsushi Sugiyama

发明人： Yasuhisa Sugita ,  Masato Koike ,  Susumu Hara ,  Atsushi Sugiyama

IPC分类号： C08J3/22

CPC分类号： C08L23/10 ,  C08L23/12 ,  C08L23/14 ,  C08L23/142 ,  C08L2205/02 ,  C08L2205/03 ,  C08L2666/02

摘要： A polypropylene-based resin composition including (A) 70 to 96 mass % of a polypropylene-based soft resin having an ISO D hardness of 35 or less and containing 25 to 55 mass % of xylene-insoluble part at room temperature and 75 to 45 mass % of xylene-soluble part at room temperature, (B) 2 to 10 mass % of homopolypropylene having a melt mass flow rate (MFR) at 230° C. under a load of 2.16 kg measured in accordance with JIS K 7210 of 1 to 30 g/10 min. and stereoregularity (meso pentad fraction) of 90% or more, (C) 2 to 20 mass % of a propylene-ethylene random copolymer having an ethylene content of 1 to 10 mass %, and (D) 0 to 15 mass % of a platy inorganic filler.

摘要翻译： 聚丙烯类树脂组合物，其包含（A）70〜96质量％的ISO D硬度为35以下的聚丙烯类软质树脂，在室温下含有25〜55质量％的二甲苯不溶部分，75〜45 室温下二甲苯可溶部分质量％，（B）按照JIS K 7210测定的2.16kg载荷下熔融质量流量（MFR）为230℃时的均聚丙烯2〜10质量％ 至30g / 10min。 和（C）20〜20质量％的乙烯含量为1〜10质量％的丙烯 - 乙烯无规共聚物，（D）为0〜15质量％ 板状无机填料。

公开(公告)号：US20050165150A1

公开(公告)日：2005-07-28

申请号：US10505687

申请日：2003-02-25

申请人： Masato Koike ,  Susumu Hara ,  Hiroshi Ichikawa

发明人： Masato Koike ,  Susumu Hara ,  Hiroshi Ichikawa

IPC分类号： C08K3/20 ,  C09J7/02 ,  C09J123/14 ,  C08K3/10

CPC分类号： C09J123/142 ,  C08K3/20 ,  C09J7/243 ,  C09J2203/302

摘要： A nonhalogenic flame-retardant adhesive tape comprising a tape substrate having provided thereon an adhesive layer, wherein the tape substrate is a resin composition having an oxygen index of 22 or more, said resin composition comprising a base resin with which a metal hydroxide is mixed, and said base resin comprising a reactive propylene soft resin, and wherein the tape substrate has a 100% modulus of less than 1.4 kgf/mm2 at a tensile speed of 300 mm/minute, and a 100% elongation load of less than 0.2 kgf/mm per mm of width.

摘要翻译： 一种非卤素阻燃性粘合带，其特征在于，具备在其上设置有粘合剂层的带基材，其中所述带基材为氧指数为22以上的树脂组合物，所述树脂组合物包含与其混合金属氢氧化物的基础树脂， 并且所述基础树脂包含反应性丙烯软树脂，并且其中带基材以300mm /分钟的拉伸速度具有小于1.4kgf / mm 2的100％模量和100％ 伸长载荷小于0.2 kgf / mm / mm宽。

公开(公告)号：US20130082793A1

公开(公告)日：2013-04-04

申请号：US13250455

申请日：2011-09-30

申请人： Adam B. Eldredge ,  Susumu Hara

发明人： Adam B. Eldredge ,  Susumu Hara

IPC分类号： H03B1/00 ,  H01F27/29 ,  H01F27/28

CPC分类号： H01F27/2804 ,  H03B5/08

摘要： An apparatus includes a first conductive loop coupled to conduct a first current and a second conductive loop coupled in parallel with the first conductive loop and further coupled to conduct a second current. A first conductive portion forms a part of the first conductive loop and the second conductive loop. The first conductive portion is coupled to conduct the first current and the second current. In at least one embodiment of the apparatus, the first conductive loop and the second conductive loop are planar inductors formed in a conductive layer on a substrate of an integrated circuit.

摘要翻译： 一种装置包括：第一导电回路，其耦合以传导与第一导电回路并联耦合的第一电流和第二导电回路，并进一步耦合以传导第二电流。 第一导电部分形成第一导电环路和第二导电环路的一部分。 第一导电部分被耦合以传导第一电流和第二电流。 在装置的至少一个实施例中，第一导电环路和第二导电环路是形成在集成电路的衬底上的导电层中的平面电感器。

公开(公告)号：US20120043999A1

公开(公告)日：2012-02-23

申请号：US13285608

申请日：2011-10-31

申请人： Emmanuel P. Quevy ,  Susumu Hara ,  Jeffrey L. Sonntag

发明人： Emmanuel P. Quevy ,  Susumu Hara ,  Jeffrey L. Sonntag

IPC分类号： H03L7/06

CPC分类号： H03L7/18 ,  H03L1/022

摘要： A voltage controlled crystal oscillator (VCXO) is locked to a MEMS oscillator with a variable frequency ratio that is a function of a sensed temperature. That allows the long-term stability of the MEMS oscillator and temperature compensation to be reflected in a VCXO output signal having good short-term stability.

摘要翻译： 压控晶体振荡器（VCXO）被锁定到具有可变频率比的MEMS振荡器，该频率比是感测温度的函数。 这允许MEMS振荡器的长期稳定性和温度补偿反映在具有良好短期稳定性的VCXO输出信号中。