公开(公告)号：US20100286531A1

公开(公告)日：2010-11-11

申请号：US12784482

申请日：2010-05-20

申请人： S. Eric Ryan ,  Jing Tang ,  Richard Gambale

发明人： S. Eric Ryan ,  Jing Tang ,  Richard Gambale

IPC分类号： A61B6/00

CPC分类号： A61B5/0086 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/02007 ,  A61B5/6852 ,  A61B5/6853 ,  A61B2017/22001 ,  A61N5/0601

摘要： A system for analyzing a body lumen including a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end; at least one delivery waveguide and at least one collection waveguide extending along the flexible conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located along a distal portion of the conduit; a spectrometer connected to the at least one delivery waveguide and the at least one collection waveguide, the spectrometer configured to perform diffuse reflectance spectroscopy, wherein the spectrometer emits at least one primary radiation signal of a wavelength having an absorption coefficient of between about 8 cm−1 and about 10 cm−1 when transmitted through a highly aqueous media; a controller system configured to calculate at least one of an extent, area, and volume of highly aqueous media based on the amount of absorption of the at least one primary radiation signal measured through the highly aqueous media by the spectrometer.

摘要翻译： 一种用于分析体腔的系统，包括沿着纵向轴线细长的柔性导管，所述柔性导管具有近端和远端; 至少一个输送波导和沿着柔性导管延伸的至少一个收集波导，所述至少一个输送波导的透射输出和沿着导管的远端部分定位的至少一个收集波导的透射输入; 光谱仪，其连接到所述至少一个传送波导和所述至少一个收集波导，所述光谱仪被配置为执行漫反射光谱，其中所述光谱仪发射具有约8cm -3的吸收系数的波长的至少一个初级辐射信号， 1和约10cm -1，当透过高含量介质时; 控制器系统，其被配置为基于由所述光谱仪通过所述高度水介质测量的所述至少一个主要辐射信号的吸收量来计算高度水介质的程度，面积和体积中的至少一个。

公开(公告)号：US20120078121A1

公开(公告)日：2012-03-29

申请号：US13321402

申请日：2010-05-20

申请人： S. Eric Ryan ,  Jing Tang ,  Richard Gambale

发明人： S. Eric Ryan ,  Jing Tang ,  Richard Gambale

IPC分类号： A61B5/02

CPC分类号： A61B5/0086 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/02007 ,  A61B5/6852 ,  A61B5/6853 ,  A61B2017/22001 ,  A61N5/0601

摘要： A catheter for placement within a body lumen, the catheter including a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end, at least one delivery waveguide and at least one collection waveguide extending along the flexible conduit, a lumen-expanding inflatable balloon disposed about a portion of the conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located within the balloon; and, at least one elongate arm connected to the conduit and positioned within the balloon, the at least one elongate arm radially translatable with respect to the conduit, and wherein at least one of the transmission output and transmission input is coupled to the elongate arm.

摘要翻译： 一种用于放置在体腔内的导管，所述导管包括沿着纵向轴线细长的柔性导管，所述柔性导管具有近端和远端，至少一个输送波导和沿着所述柔性导管延伸的至少一个收集波导 导管，围绕导管的一部分设置的管腔膨胀的可膨胀气囊，所述至少一个输送波导的透射输出和位于气囊内的至少一个收集波导的透射输入; 以及连接到所述导管并且定位在所述气囊内的所述至少一个细长臂，所述至少一个细长臂相对于所述导管可径向平移，并且其中所述变速器输出和变速器输入中的至少一个联接到所述细长臂。

公开(公告)号：US20140005553A1

公开(公告)日：2014-01-02

申请号：US13824631

申请日：2011-09-21

申请人： S. Eric Ryan ,  Jing Tang ,  Richard Gambale

发明人： S. Eric Ryan ,  Jing Tang ,  Richard Gambale

IPC分类号： A61B5/00 ,  A61B5/02 ,  A61B5/107

CPC分类号： A61B5/0086 ,  A61B5/0062 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/02007 ,  A61B5/1076 ,  A61B5/4836 ,  A61B5/6853 ,  A61M25/104 ,  G01J3/0218 ,  G01J3/0264 ,  G01J3/42

摘要： A system is provided for probing a body lumen that includes a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end, at least one delivery waveguide and at least one collection waveguide extending along the flexible conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located along a distal portion of the conduit. A spectrometer is connected to the at least one delivery waveguide and the at least one collection waveguide, the spectrometer configured to perform spectroscopy. A controller system is configured to calculate a distance between the flexible conduit and the wall of the body lumen based on a spectroscopic measurement of the at least one primary radiation signal that traveled between the flexible conduit and body lumen.

摘要翻译： 提供了一种用于探测体腔的系统，其包括沿着纵向轴线细长的柔性导管，所述柔性导管具有近端和远端，至少一个输送波导和沿柔性导管延伸的至少一个收集波导 ，所述至少一个传送波导的传输输出和沿着所述导管的远端部分定位的所述至少一个收集波导的传输输入。 光谱仪连接到至少一个传送波导和至少一个收集波导，该光谱仪被配置为执行光谱。 控制器系统被配置为基于在柔性导管和体腔之间行进的至少一个主要辐射信号的光谱测量来计算柔性导管和体腔壁之间的距离。

公开(公告)号：US09113785B2

公开(公告)日：2015-08-25

申请号：US12520022

申请日：2007-12-21

申请人： S. Eric Ryan ,  Jing Tang ,  Matthew Flinders

发明人： S. Eric Ryan ,  Jing Tang ,  Matthew Flinders

IPC分类号： A61B6/00 ,  A61B5/00 ,  A61B18/24 ,  A61B17/00 ,  A61B17/22 ,  A61B18/00

CPC分类号： A61B5/0075 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/6853 ,  A61B18/24 ,  A61B2017/00274 ,  A61B2017/22051 ,  A61B2018/00547 ,  A61B2562/146

摘要： Systems, methods, and apparatus for providing a fluid and reduced-toxicity optical media with optical analysis and therapeutic energy delivery. An aspect of the invention provides an aqueous solution of increased-salinity of between about 1% and 35%. An increasing salinity in accordance with the invention provides improved transmissive efficiency at many wavelengths and less toxicity than many existing systems and methods. A catheter having integrated fibers for probing or treating internal lumens or other tissues can include a liquid-inflatable balloon or flushing mechanism using the solution for displacing blood or other obstructions in an optical path between the fiber and targeted tissue. Methods including spectroscopy can be employed with the solution for diagnosing medical conditions associated with diseased vessels or other tissues while reducing the risk of permanent damage resulting from the diagnosis. Additional applications include the deliver of therapeutic radiation externally and internally to tissues through h the solution media.

摘要翻译： 用于提供具有光学分析和治疗能量递送的流体和减毒光学介质的系统，方法和装置。 本发明的一个方面提供了约1％至35％之间的增加盐度的水溶液。 根据本发明的增加的盐度提供了许多波长的改进的透射效率和比许多现有的系统和方法更少的毒性。 具有用于探测或治疗内部腔或其他组织的集成纤维的导管可以包括使用溶液替代在纤维和靶组织之间的光路中的血液或其它障碍物的液体可充气球囊或冲洗机构。 可以使用包括光谱学的方法用于诊断与患病血管或其他组织相关的医学病症的解决方案，同时降低由诊断引起的永久性损伤的风险。 其他应用包括通过溶液介质在组织外部和内部传递治疗辐射。

公开(公告)号：US06654630B2

公开(公告)日：2003-11-25

申请号：US09871578

申请日：2001-05-31

申请人： Andres F. Zuluaga ,  Brett Bouma ,  Simon M. Furnish ,  Guillermo J. Tearney ,  S. Eric Ryan ,  Jing Tang ,  Mark A. Griffin

发明人： Andres F. Zuluaga ,  Brett Bouma ,  Simon M. Furnish ,  Guillermo J. Tearney ,  S. Eric Ryan ,  Jing Tang ,  Mark A. Griffin

IPC分类号： A61B600

CPC分类号： A61B5/0084

摘要： A catheter based optical system for generating data as to the condition of a tissue sample of a mammalian vessel. The system includes an elongated catheter shaft having a tissue engaging distal end and a coupled proximal end and an elongated optical delivery fiber arrangement disposed through a lumen of said catheter, said optical delivery fiber arrangement having a distal end and a proximal end. The distal end of the delivery fiber arrangement has a re-director light emitter thereon for directing light against mammalian tissues. An elongated optical collection fiber arrangement is disposed through a lumen of the catheter, the optical collection fiber arrangement having a distal end and a proximal most end. The distal end of the collection fiber arrangement has a re-director light receiver thereon for receiving light reflected from the mammalian tissue by the light emitter. The light emitter and the light receiver are longitudinally spaced apart from one another in the distal end of the catheter. The catheter apparatus includes a light source in communication with the delivery fiber and a signal detector in communication with the receiving fiber for receiving and presenting data collected.

公开(公告)号：US06615062B2

公开(公告)日：2003-09-02

申请号：US09871759

申请日：2001-05-31

申请人： S. Eric Ryan ,  Brett Bouma ,  Guillermo J. Tearney ,  Simon Furnish ,  Jing Tang ,  Andres Zuluaga

发明人： S. Eric Ryan ,  Brett Bouma ,  Guillermo J. Tearney ,  Simon Furnish ,  Jing Tang ,  Andres Zuluaga

IPC分类号： A61B500

CPC分类号： A61B5/0084 ,  A61B5/14535 ,  A61B2560/0233 ,  G01N21/4785

摘要： The invention provides methods and apparatus to reference or normalize optical measurements, by removing or accounting for background factors and artifacts, such as motion artifacts, that arise during use of optical catheters.

摘要翻译： 本发明提供了通过去除或计算在使用光学导管时出现的背景因素和伪像（诸如运动伪像）来参考或归一化光学测量的方法和装置。

公开(公告)号：US20100049182A1

公开(公告)日：2010-02-25

申请号：US12520022

申请日：2007-12-21

申请人： S. Eric Ryan ,  Jing Tang ,  Matthew Flinders

发明人： S. Eric Ryan ,  Jing Tang ,  Matthew Flinders

IPC分类号： A61B18/18

CPC分类号： A61B5/0075 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/6853 ,  A61B18/24 ,  A61B2017/00274 ,  A61B2017/22051 ,  A61B2018/00547 ,  A61B2562/146

摘要： Systems, methods, and apparatus for providing a fluid and reduced-toxicity optical media with optical analysis and therapeutic energy delivery. An aspect of the invention provides an aqueous solution of increased-salinity of between about 1% and 35%. An increasing salinity in accordance with the invention provides improved transmissive efficiency at many wavelengths and less toxicity than many existing systems and methods. A catheter having integrated fibers for probing or treating internal lumens or other tissues can include a liquid-inflatable balloon or flushing mechanism using the solution for displacing blood or other obstructions in an optical path between the fiber and targeted tissue. Methods including spectroscopy can be employed with the solution for diagnosing medical conditions associated with diseased vessels or other tissues while reducing the risk of permanent damage resulting from the diagnosis. Additional applications include the deliver of therapeutic radiation externally and internally to tissues through h the solution media.

摘要翻译： 用于提供具有光学分析和治疗能量递送的流体和减毒光学介质的系统，方法和装置。 本发明的一个方面提供了约1％至35％之间的增加盐度的水溶液。 根据本发明的增加的盐度提供了许多波长的改进的透射效率和比许多现有的系统和方法更少的毒性。 具有用于探测或治疗内部腔或其他组织的集成纤维的导管可以包括使用溶液替代在纤维和靶组织之间的光路中的血液或其它障碍物的液体充气球囊或冲洗机构。 可以使用包括光谱学的方法用于诊断与患病血管或其他组织相关的医学病症的解决方案，同时降低由诊断引起的永久性损伤的风险。 其他应用包括通过溶液介质在组织外部和内部传递治疗辐射。

公开(公告)号：US20090187108A1

公开(公告)日：2009-07-23

申请号：US12350870

申请日：2009-01-08

申请人： Jing Tang ,  S. Eric Ryan

发明人： Jing Tang ,  S. Eric Ryan

IPC分类号： A61B6/08 ,  A61N5/06

CPC分类号： A61B5/6852 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/02007 ,  A61B5/14539 ,  A61B5/6853 ,  A61B6/12 ,  A61B2017/22001 ,  A61B2018/00345 ,  A61B2018/00386 ,  A61B2018/00404 ,  A61B2018/00577 ,  A61B2018/00982 ,  A61B2562/0242 ,  A61F2/958 ,  A61M25/1011 ,  A61M25/1027 ,  A61M25/104 ,  A61M29/02 ,  A61M2025/1079 ,  A61M2025/1088

摘要： A catheter is provided for placement within a body lumen, the catheter including a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end. The catheter further includes at least one delivery waveguide and at least one collection waveguide positioned along the flexible conduit, the at least one delivery waveguide and the at least one collection waveguide constructed and arranged to transmit radiation at a wavelength in a range of about 250 to 2500 nanometers. The catheter further includes a flexible, expandable first surface encircling surrounding a segment of the conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located within the flexible, expandable first surface, and the distal end of at least one of the at least one delivery waveguide and the at least one collection waveguide tethered to the flexible, expandable first surface radially translatable with respect to the flexible, expandable first surface, the at least one transmission input located between a portion of the flexible, expandable first surface and a portion of the second surface.

摘要翻译： 提供用于放置在体腔内的导管，所述导管包括沿着纵向轴线细长的柔性导管，所述柔性导管具有近端和远端。 所述导管还包括至少一个输送波导和至少一个沿着柔性导管定位的收集波导，所述至少一个输送波导和所述至少一个收集波导被构造和布置成将波长范围为约250〜 2500纳米。 所述导管还包括围绕所述导管段的柔性可扩张第一表面，所述至少一个输送波导的透射输出和位于所述柔性可扩张第一表面内的所述至少一个收集波导的透射输入， 所述至少一个输送波导中的至少一个的至少一个远端和所述至少一个收集波导束缚于所述柔性可扩张第一表面，所述第一表面可相对于所述柔性可扩张第一表面径向平移，所述至少一个传输输入位于所述至少一个 的柔性可扩张的第一表面和第二表面的一部分。

公开(公告)号：US06706004B2

公开(公告)日：2004-03-16

申请号：US09871771

申请日：2001-05-31

申请人： Guillermo J. Tearney ,  Brett E. Bouma ,  S. Eric Ryan ,  Simon Furnish ,  Jing Tang ,  Andres Zuluaga

发明人： Guillermo J. Tearney ,  Brett E. Bouma ,  S. Eric Ryan ,  Simon Furnish ,  Jing Tang ,  Andres Zuluaga

IPC分类号： A61B5103

CPC分类号： A61B5/6853 ,  A61B5/0086 ,  A61B5/0507 ,  A61B5/6886

摘要： An apparatus includes a feedback loop for controlling an extent of a gap between a wall of a balloon mounted on a catheter and a wall of a lumen into which the catheter is inserted. The apparatus includes a radiation detector mounted within the balloon for generating a feedback signal having information indicative of whether the extent of the gap is greater than or less than a desired value. The feedback loop receives the feedback signal and controls a size of the balloon to cause the extent of the gap to approach the desired value.

摘要翻译： 一种装置包括用于控制安装在导管上的球囊的壁与插入其中的内腔的壁之间的间隙的程度的反馈回路。 该装置包括安装在气球内的放射线检测器，用于产生具有指示间隙的程度是否大于或小于期望值的信息的反馈信号。 反馈回路接收反馈信号并控制气囊的尺寸以使间隙的程度接近所需值。

公开(公告)号：US06701181B2

公开(公告)日：2004-03-02

申请号：US09871770

申请日：2001-05-31

申请人： Jing Tang ,  Guillermo J. Tearney ,  Brett E. Bouma ,  S. Eric Ryan ,  Simon Furnish ,  Andres Zuluaga

发明人： Jing Tang ,  Guillermo J. Tearney ,  Brett E. Bouma ,  S. Eric Ryan ,  Simon Furnish ,  Andres Zuluaga

IPC分类号： A61B600

CPC分类号： A61B1/0615 ,  A61B1/00096 ,  A61B1/00183 ,  A61B1/3137 ,  A61B5/0084 ,  A61B5/6853

摘要： First and second optical-redirectors mounted on a catheter couple radiation to a target along separate first and second paths. Either the first or second optical-redirectors, or both, can include a steering mechanism for selecting the first and/or second path.

摘要翻译： 安装在导管上的第一和第二光学重定向器沿着分离的第一和第二路径将辐射耦合到目标。 第一或第二光学重定向器或两者都可以包括用于选择第一和/或第二路径的转向机构。