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公开(公告)号：US11365218B2
公开(公告)日：2022-06-21
申请号：US16882648
申请日：2020-05-25
申请人： Seoul National University R&DB Foundation , Nano Intelligent Biomedical Engineering Corporation Co. Ltd.
摘要： Disclosed are a bifunctional peptide having the capability to reduce inflammation and the capability to facilitate differentiation of stem cells into chondrocytes and the use thereof. Advantageously, the bifunctional peptide is useful for the prevention or treatment of arthritis accompanied by inflammation and damage of cartilage tissue due to excellent effects of reducing inflammation and facilitating differentiation of stem cells into chondrocytes, can be easily applied to various surgical regenerative treatments including orthopedic treatments, and can shorten the treatment period.
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2.发明申请ANTICANCER PEPTIDE FOR INHIBITING PROLIFERATION OF CANCER STEM CELLS AND USE THEREOF 有权用于抑制癌细胞增殖的抗癌肽及其用途公开(公告)号：US20170042963A1
公开(公告)日：2017-02-16
申请号：US15113823
申请日：2016-03-03
申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION , NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO., LTD.
摘要： The present invention relates to an anticancer composition comprising a peptide that inhibits the proliferation of cancer stem cells present in tumor tissue and that induces apoptosis of such cancer stem cells, and more particularly, to an anticancer peptide that inhibits the activity of NF-κB which is overexpressed specifically in cancer stem cells present in tumors.
摘要翻译： 本发明涉及包含抑制肿瘤组织中存在的癌干细胞增殖并诱导这种癌干细胞凋亡的肽的抗癌成分，更具体地，涉及抑制NF-κB活性的抗癌肽， 特异性地在肿瘤中存在的癌干细胞中过度表达。
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公开(公告)号：US10155022B2
公开(公告)日：2018-12-18
申请号：US15666506
申请日：2017-08-01
申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION , NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO., LTD.
发明人： Chong-Pyoung Chung , Yoon Jeong Park , Jue-Yeon Lee , Jin Sook Suh , In Ho Jo , Yoon Shin Park
摘要： The disclosure relates to a fat accumulation inhibitory peptide which essentially comprises an amino acid sequence represented by SEQ ID NO: 1, a pharmaceutical composition for preventing or treating obesity, which contains the peptide, and a health functional food for preventing or alleviating obesity, which contains the peptide. The fat accumulation inhibitory peptide according to the present invention has the function of inhibiting the differentiation of mesenchymal stem cells into adipocytes to thereby inhibit the accumulation of adipose tissue. Thus, the peptide according to the present invention is highly useful for the prevention or treatment of obesity.
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公开(公告)号：US10066212B2
公开(公告)日：2018-09-04
申请号：US15514337
申请日：2016-07-19
申请人： Seoul National University R&DB Foundation , Nano Intelligent Biomedical Engineering Corporation Co. Ltd.
IPC分类号： C12N15/00 , C12N5/074 , C07K14/00 , C07K14/47 , C12N5/0775 , C07K14/485 , C07K14/50 , C12N5/00
CPC分类号： C12N5/0696 , C07K14/00 , C07K14/001 , C07K14/4703 , C07K14/4723 , C07K14/485 , C07K14/50 , C12N5/0037 , C12N5/0043 , C12N5/005 , C12N5/0056 , C12N5/0607 , C12N5/0662 , C12N2501/998 , C12N2506/1307 , C12N2510/00
摘要： Provided is a method of preparing induced pluripotent stem cells using a synthetic peptide, and more particularly, to a method of preparing induced pluripotent stem cells using a peptide capable of inhibiting the activity of NF-κB and promoting mesenchymal-epithelial transition (MET). Since undifferentiated multipotent stem cells may be efficiently prepared under xenopathogen-free or feeder cell-free conditions without requiring co-culture with animal serum or xenogeneic cells, the method for preparing the induced pluripotent stem cells using the synthetic peptide according to the present disclosure is very useful for developing stem cell therapeutic agents that are clinically applicable.
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公开(公告)号：US20170326201A1
公开(公告)日：2017-11-16
申请号：US15666506
申请日：2017-08-01
申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION , NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO., LTD.
发明人： Chong-Pyoung Chung , Yoon Jeong Park , Jue-Yeon Lee , Jin Sook Suh , In Ho Jo , Yoon Shin Park
CPC分类号： A61K38/16 , A23L33/18 , A23V2002/00 , A61K9/0019 , A61K38/08 , C07K7/06 , C07K14/001 , A23V2200/332
摘要： The disclosure relates to a fat accumulation inhibitory peptide which essentially comprises an amino acid sequence represented by SEQ ID NO: 1, a pharmaceutical composition for preventing or treating obesity, which contains the peptide, and a health functional food for preventing or alleviating obesity, which contains the peptide. The fat accumulation inhibitory peptide according to the present invention has the function of inhibiting the differentiation of mesenchymal stem cells into adipocytes to thereby inhibit the accumulation of adipose tissue. Thus, the peptide according to the present invention is highly useful for the prevention or treatment of obesity.
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公开(公告)号：US09801973B1
公开(公告)日：2017-10-31
申请号：US15504035
申请日：2016-04-05
申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION , NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO. LTD
发明人： Yoon Jeong Park , Jin Sook Suh , Chong-Pyoung Chung , Jue-Yeon Lee , Yeonsu Kim
CPC分类号： A61L27/04 , A61L27/00 , A61L27/306 , A61L27/50 , A61L27/54 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2430/02 , A61L2430/12 , C07K7/00 , C07K7/08 , C07K19/00 , C07K2319/00 , C07K2319/20
摘要： The present invention relates to a peptide that binds specifically to the surface of zirconia, and more particularly, to a peptide conjugate obtained by linking a functional drug to the peptide so as to enable the drug to be securely fixed to the surface of zirconia to thereby maintain the activity of the drug over a long period of time. The zirconia-binding peptide according to the present invention can be securely fixed to the surface of zirconia so that the activity of a physiologically active substance introduced into the peptide can be maintained on the zirconia surface over a long period of time. Thus, the zirconia-binding peptide is useful for surgical regenerative treatment.
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公开(公告)号：US20170275594A1
公开(公告)日：2017-09-28
申请号：US15514337
申请日：2016-07-19
申请人： Seoul National University R&DB Foundation , Nano Intelligent Biomedical Engineering Corporation Co. Ltd.
IPC分类号： C12N5/074 , C12N5/0775 , C07K14/00 , C07K14/47
CPC分类号： C12N5/0696 , C07K14/00 , C07K14/001 , C07K14/4703 , C07K14/4723 , C07K14/485 , C07K14/50 , C12N5/0037 , C12N5/0043 , C12N5/005 , C12N5/0056 , C12N5/0607 , C12N5/0662 , C12N2501/998 , C12N2506/1307 , C12N2510/00
摘要： Provided is a method of preparing induced pluripotent stem cells using a synthetic peptide, and more particularly, to a method of preparing induced pluripotent stem cells using a peptide capable of inhibiting the activity of NF-κB and promoting mesenchymal-epithelial transition (MET). Since undifferentiated multipotent stem cells may be efficiently prepared under xenopathogen-free or feeder cell-free conditions without requiring co-culture with animal serum or xenogeneic cells, the method for preparing the induced pluripotent stem cells using the synthetic peptide according to the present disclosure is very useful for developing stem cell therapeutic agents that are clinically applicable.
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8.发明申请NOVEL FAT ACCUMULATION INHIBITORY PEPTIDE AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OBESITY CONTAINING THE SAME 审中-公开新型脂肪蓄积抑制肽和药物组合物，用于预防或治疗含有其的药物公开(公告)号：US20160296593A1
公开(公告)日：2016-10-13
申请号：US14899607
申请日：2015-07-24
申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION , NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO. LTD.
发明人： Chong-Pyoung Chung , Yoon Jeong Park , Jue-Yeon Lee , Jin Sook Suh , In Ho Jo , Yoon Shin Park
CPC分类号： A61K38/16 , A23L33/18 , A23V2002/00 , A61K9/0019 , A61K38/08 , C07K7/06 , C07K14/001 , A23V2200/332
摘要： The present invention relates to a fat accumulation inhibitory peptide which essentially comprises an amino acid sequence represented by SEQ ID NO: 1, a pharmaceutical composition for preventing or treating obesity, which contains the peptide, and a health functional food for preventing or alleviating obesity, which contains the peptide. The fat accumulation inhibitory peptide according to the present invention has the function of inhibiting the differentiation of mesenchymal stem cells into adipocytes to thereby inhibit the accumulation of adipose tissue. Thus, the peptide according to the present invention is highly useful for the prevention or treatment of obesity.
摘要翻译： 本发明涉及一种脂肪蓄积抑制肽，其基本上包含SEQ ID NO：1所示的氨基酸序列，含有该肽的预防或治疗肥胖症的药物组合物，以及用于预防或减轻肥胖症的健康功能性食品， 其含有肽。 根据本发明的脂肪蓄积抑制肽具有抑制间充质干细胞分化为脂肪细胞从而抑制脂肪组织积累的功能。 因此，根据本发明的肽对于预防或治疗肥胖是非常有用的。
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公开(公告)号：US20190284237A1
公开(公告)日：2019-09-19
申请号：US16297670
申请日：2019-03-10
申请人： Seoul National University R&DB Foundation , Nano Intelligent Biomedical Engineering Corporation Co. Ltd.
摘要： Disclosed are a bifunctional peptide having the capability to reduce inflammation and the capability to facilitate differentiation of stem cells into chondrocytes and the use thereof. Advantageously, the bifunctional peptide is useful for the prevention or treatment of arthritis accompanied by inflammation and damage of cartilage tissue due to excellent effects of reducing inflammation and facilitating differentiation of stem cells into chondrocytes, can be easily applied to various surgical regenerative treatments including orthopedic treatments, and can shorten the treatment period.
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公开(公告)号：US10406264B2
公开(公告)日：2019-09-10
申请号：US15545679
申请日：2017-03-07
申请人： NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION. CO. LTD , SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
发明人： Chong-Pyoung Chung , Yoon Jeong Park , Jue-Yeon Lee , Yeonsu Kim , Dong Woo Lee
IPC分类号： A61K47/62 , A61L27/54 , A61L27/22 , C07K14/51 , C07K7/08 , A61K47/18 , A61L27/06 , C07K17/14
摘要： The present invention relates to a peptide having the ability to bind specifically to the surface of titanium. The titanium-binding peptide according to the present invention is fixed securely to the titanium surface so that the activity of a physiologically active substance linked to the peptide can be stably maintained over a long period of time. Thus, the peptide can be effectively used for surgical regeneration therapy.
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