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公开(公告)号：US20170296695A1
公开(公告)日：2017-10-19
申请号：US15504035
申请日：2016-04-05
申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION , NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO. LTD
发明人： Yoon Jeong Park , Jin Sook Suh , Chong-Pyoung Chung , Jue-Yeon Lee , Yeonsu Kim
CPC分类号： A61L27/04 , A61L27/00 , A61L27/306 , A61L27/50 , A61L27/54 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2430/02 , A61L2430/12 , C07K7/00 , C07K7/08 , C07K19/00 , C07K2319/00 , C07K2319/20
摘要： The present invention relates to a peptide that binds specifically to the surface of zirconia, and more particularly, to a peptide conjugate obtained by linking a functional drug to the peptide so as to enable the drug to be securely fixed to the surface of zirconia to thereby maintain the activity of the drug over a long period of time. The zirconia-binding peptide according to the present invention can be securely fixed to the surface of zirconia so that the activity of a physiologically active substance introduced into the peptide can be maintained on the zirconia surface over a long period of time. Thus, the zirconia-binding peptide is useful for surgical regenerative treatment.
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公开(公告)号：US09993519B2
公开(公告)日：2018-06-12
申请号：US15113823
申请日：2016-03-03
申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION , NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO., LTD.
摘要： The present invention relates to an anticancer composition comprising a peptide that inhibits the proliferation of cancer stem cells present in tumor tissue and that induces apoptosis of such cancer stem cells, and more particularly, to an anticancer peptide that inhibits the activity of NF-κB which is overexpressed specifically in cancer stem cells present in tumors.
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3.发明申请ANTICANCER PEPTIDE FOR INHIBITING PROLIFERATION OF CANCER STEM CELLS AND USE THEREOF 有权用于抑制癌细胞增殖的抗癌肽及其用途公开(公告)号：US20170042963A1
公开(公告)日：2017-02-16
申请号：US15113823
申请日：2016-03-03
申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION , NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO., LTD.
摘要： The present invention relates to an anticancer composition comprising a peptide that inhibits the proliferation of cancer stem cells present in tumor tissue and that induces apoptosis of such cancer stem cells, and more particularly, to an anticancer peptide that inhibits the activity of NF-κB which is overexpressed specifically in cancer stem cells present in tumors.
摘要翻译： 本发明涉及包含抑制肿瘤组织中存在的癌干细胞增殖并诱导这种癌干细胞凋亡的肽的抗癌成分，更具体地，涉及抑制NF-κB活性的抗癌肽， 特异性地在肿瘤中存在的癌干细胞中过度表达。
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公开(公告)号：US10155022B2
公开(公告)日：2018-12-18
申请号：US15666506
申请日：2017-08-01
申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION , NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO., LTD.
发明人： Chong-Pyoung Chung , Yoon Jeong Park , Jue-Yeon Lee , Jin Sook Suh , In Ho Jo , Yoon Shin Park
摘要： The disclosure relates to a fat accumulation inhibitory peptide which essentially comprises an amino acid sequence represented by SEQ ID NO: 1, a pharmaceutical composition for preventing or treating obesity, which contains the peptide, and a health functional food for preventing or alleviating obesity, which contains the peptide. The fat accumulation inhibitory peptide according to the present invention has the function of inhibiting the differentiation of mesenchymal stem cells into adipocytes to thereby inhibit the accumulation of adipose tissue. Thus, the peptide according to the present invention is highly useful for the prevention or treatment of obesity.
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公开(公告)号：US10066212B2
公开(公告)日：2018-09-04
申请号：US15514337
申请日：2016-07-19
申请人： Seoul National University R&DB Foundation , Nano Intelligent Biomedical Engineering Corporation Co. Ltd.
IPC分类号： C12N15/00 , C12N5/074 , C07K14/00 , C07K14/47 , C12N5/0775 , C07K14/485 , C07K14/50 , C12N5/00
CPC分类号： C12N5/0696 , C07K14/00 , C07K14/001 , C07K14/4703 , C07K14/4723 , C07K14/485 , C07K14/50 , C12N5/0037 , C12N5/0043 , C12N5/005 , C12N5/0056 , C12N5/0607 , C12N5/0662 , C12N2501/998 , C12N2506/1307 , C12N2510/00
摘要： Provided is a method of preparing induced pluripotent stem cells using a synthetic peptide, and more particularly, to a method of preparing induced pluripotent stem cells using a peptide capable of inhibiting the activity of NF-κB and promoting mesenchymal-epithelial transition (MET). Since undifferentiated multipotent stem cells may be efficiently prepared under xenopathogen-free or feeder cell-free conditions without requiring co-culture with animal serum or xenogeneic cells, the method for preparing the induced pluripotent stem cells using the synthetic peptide according to the present disclosure is very useful for developing stem cell therapeutic agents that are clinically applicable.
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公开(公告)号：US20170326201A1
公开(公告)日：2017-11-16
申请号：US15666506
申请日：2017-08-01
申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION , NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO., LTD.
发明人： Chong-Pyoung Chung , Yoon Jeong Park , Jue-Yeon Lee , Jin Sook Suh , In Ho Jo , Yoon Shin Park
CPC分类号： A61K38/16 , A23L33/18 , A23V2002/00 , A61K9/0019 , A61K38/08 , C07K7/06 , C07K14/001 , A23V2200/332
摘要： The disclosure relates to a fat accumulation inhibitory peptide which essentially comprises an amino acid sequence represented by SEQ ID NO: 1, a pharmaceutical composition for preventing or treating obesity, which contains the peptide, and a health functional food for preventing or alleviating obesity, which contains the peptide. The fat accumulation inhibitory peptide according to the present invention has the function of inhibiting the differentiation of mesenchymal stem cells into adipocytes to thereby inhibit the accumulation of adipose tissue. Thus, the peptide according to the present invention is highly useful for the prevention or treatment of obesity.
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公开(公告)号：US09801973B1
公开(公告)日：2017-10-31
申请号：US15504035
申请日：2016-04-05
申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION , NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO. LTD
发明人： Yoon Jeong Park , Jin Sook Suh , Chong-Pyoung Chung , Jue-Yeon Lee , Yeonsu Kim
CPC分类号： A61L27/04 , A61L27/00 , A61L27/306 , A61L27/50 , A61L27/54 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2430/02 , A61L2430/12 , C07K7/00 , C07K7/08 , C07K19/00 , C07K2319/00 , C07K2319/20
摘要： The present invention relates to a peptide that binds specifically to the surface of zirconia, and more particularly, to a peptide conjugate obtained by linking a functional drug to the peptide so as to enable the drug to be securely fixed to the surface of zirconia to thereby maintain the activity of the drug over a long period of time. The zirconia-binding peptide according to the present invention can be securely fixed to the surface of zirconia so that the activity of a physiologically active substance introduced into the peptide can be maintained on the zirconia surface over a long period of time. Thus, the zirconia-binding peptide is useful for surgical regenerative treatment.
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公开(公告)号：US20170275594A1
公开(公告)日：2017-09-28
申请号：US15514337
申请日：2016-07-19
申请人： Seoul National University R&DB Foundation , Nano Intelligent Biomedical Engineering Corporation Co. Ltd.
IPC分类号： C12N5/074 , C12N5/0775 , C07K14/00 , C07K14/47
CPC分类号： C12N5/0696 , C07K14/00 , C07K14/001 , C07K14/4703 , C07K14/4723 , C07K14/485 , C07K14/50 , C12N5/0037 , C12N5/0043 , C12N5/005 , C12N5/0056 , C12N5/0607 , C12N5/0662 , C12N2501/998 , C12N2506/1307 , C12N2510/00
摘要： Provided is a method of preparing induced pluripotent stem cells using a synthetic peptide, and more particularly, to a method of preparing induced pluripotent stem cells using a peptide capable of inhibiting the activity of NF-κB and promoting mesenchymal-epithelial transition (MET). Since undifferentiated multipotent stem cells may be efficiently prepared under xenopathogen-free or feeder cell-free conditions without requiring co-culture with animal serum or xenogeneic cells, the method for preparing the induced pluripotent stem cells using the synthetic peptide according to the present disclosure is very useful for developing stem cell therapeutic agents that are clinically applicable.
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9.发明申请NOVEL FAT ACCUMULATION INHIBITORY PEPTIDE AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OBESITY CONTAINING THE SAME 审中-公开新型脂肪蓄积抑制肽和药物组合物，用于预防或治疗含有其的药物公开(公告)号：US20160296593A1
公开(公告)日：2016-10-13
申请号：US14899607
申请日：2015-07-24
申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION , NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO. LTD.
发明人： Chong-Pyoung Chung , Yoon Jeong Park , Jue-Yeon Lee , Jin Sook Suh , In Ho Jo , Yoon Shin Park
CPC分类号： A61K38/16 , A23L33/18 , A23V2002/00 , A61K9/0019 , A61K38/08 , C07K7/06 , C07K14/001 , A23V2200/332
摘要： The present invention relates to a fat accumulation inhibitory peptide which essentially comprises an amino acid sequence represented by SEQ ID NO: 1, a pharmaceutical composition for preventing or treating obesity, which contains the peptide, and a health functional food for preventing or alleviating obesity, which contains the peptide. The fat accumulation inhibitory peptide according to the present invention has the function of inhibiting the differentiation of mesenchymal stem cells into adipocytes to thereby inhibit the accumulation of adipose tissue. Thus, the peptide according to the present invention is highly useful for the prevention or treatment of obesity.
摘要翻译： 本发明涉及一种脂肪蓄积抑制肽，其基本上包含SEQ ID NO：1所示的氨基酸序列，含有该肽的预防或治疗肥胖症的药物组合物，以及用于预防或减轻肥胖症的健康功能性食品， 其含有肽。 根据本发明的脂肪蓄积抑制肽具有抑制间充质干细胞分化为脂肪细胞从而抑制脂肪组织积累的功能。 因此，根据本发明的肽对于预防或治疗肥胖是非常有用的。
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10.发明申请公开(公告)号：US20150165060A1
公开(公告)日：2015-06-18
申请号：US14395807
申请日：2013-09-16
IPC分类号： A61K47/48 , A61K49/00 , A61K31/704 , C07K7/08 , A61K38/46
CPC分类号： A61K47/64 , A61K31/704 , A61K38/00 , A61K49/0056 , C07K7/08 , C07K14/47 , C07K2319/10 , C12Q1/26 , C12Q1/58 , C12Q1/66 , C12Y301/13 , G01N33/574
摘要： The present invention relates a peptide having cancer selective translocation function, and the use thereof, and more particularly to a VEGF-binding protein transduction domain (VPTD) represented as SEQ ID NO: 1 or a heparin-binding protein transduction domain (HPTD) represented as SEQ ID NO: 2, which bind specifically to VEGF and heparin, which are overexpressed specifically in tumor cells or tumor tissues, and to a conjugate comprising a drug linked to the peptide.The peptide and the peptide-drug conjugate bind specifically to VEGF and heparin in tumor cells or tumor tissue and accumulate in the tumor cells or tumor tissue, and thus can be used for the accurate diagnosis and treatment of cancer. Also, the non-specific distribution of the peptide or the conjugate in the body after administration is inhibited, and thus the side effects thereof can be minimized. Accordingly, the peptide or the conjugate is useful for the diagnosis and treatment of cancer.
摘要翻译： 本发明涉及具有癌症选择性易位功能的肽及其用途，更具体地涉及以SEQ ID NO：1表示的VEGF结合蛋白转导结构域（VPTD）或代表的肝素结合蛋白转导结构域（HPTD） 如SEQ ID NO：2，其特异性结合VEGF和肝素，其特异性地在肿瘤细胞或肿瘤组织中过表达，以及包含与肽连接的药物的缀合物。 肽和肽 - 药物缀合物在肿瘤细胞或肿瘤组织中特异性结合VEGF和肝素并积聚在肿瘤细胞或肿瘤组织中，因此可用于癌症的准确诊断和治疗。 此外，肽或结合物在给药后体内的非特异性分布被抑制，因此其副作用可以最小化。 因此，肽或缀合物可用于癌症的诊断和治疗。
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