公开(公告)号：US11098702B2

公开(公告)日：2021-08-24

申请号：US16496740

申请日：2017-04-26

Applicant: Shimadzu Corporation

Inventor： Jun Yanagibayashi

IPC: F04B11/00 ,  F04B27/02 ,  F04B27/12 ,  G01N30/32 ,  B01D15/40

Abstract: A liquid delivery device includes a pump head having a pump chamber provided in the inside, a plunger whose tip is slidably inserted into the pump chamber, and at least one plunger pump having a drive mechanism that reciprocates the plunger in its axial direction. Then, at least one of the plunger pumps is a pressurizing pump that pressurizes a mobile phase including a compressible fluid sucked into the pump chamber and then discharges the mobile phase from the pump chamber, and at least the pump head of the pressurizing pump includes a cooling part that is connected to an outlet channel from the pump chamber, and allows the pump head to absorb heat of the mobile phase discharged from the pump chamber to cool the mobile phase.

公开(公告)号：US11946585B2

公开(公告)日：2024-04-02

申请号：US17710318

申请日：2022-03-31

Applicant: SHIMADZU CORPORATION

Inventor： Jun Yanagibayashi ,  Kenichi Yasunaga

IPC: F16L9/00 ,  B29C63/34 ,  F16L9/18 ,  B29L23/00

CPC classification number: F16L9/006 ,  B29C63/341 ,  F16L9/18 ,  B29L2023/22

Abstract: A bioinert piping (1) that has a flow path (2) provided inside and a main body portion (10) between end portions (8, 8) includes a resin tube (4) that forms an inner wall of the flow path (2) over an entire length of the flow path (2), and a metal tube (6) that accommodates the resin tube (4) inside so as to cover the outer peripheral surface of the resin tube (4) over at least an entire length of the main body portion (10). The metal tube (6) is plastically deformed toward an inner side so that the outer peripheral surface of the resin tube (4) and an inner peripheral surface of the metal tube (6) are in liquid-tight contact with each other.

公开(公告)号：US11819859B2

公开(公告)日：2023-11-21

申请号：US17046510

申请日：2018-04-11

Applicant: SHIMADZU CORPORATION

Inventor： Shigeyoshi Horiike ,  Jun Yanagibayashi ,  Yukio Oikawa ,  Maiko Nakaya ,  Masaki Kanai

IPC: B03B5/62 ,  G01N1/10 ,  G01N30/00 ,  B01D63/08

CPC classification number: B03B5/62 ,  G01N1/10 ,  B01D63/088 ,  G01N2001/1006 ,  G01N2030/0025

Abstract: A field-flow fractionation device includes a separation channel, a carrier fluid supplier, a separation membrane, a waste liquid chamber, a cross-flow flow rate adjuster, and a carrier fluid adder. The carrier fluid adder is configured to add, to a flow of a carrier fluid having passed through the separation membrane, a flow of another carrier fluid at a carrier fluid adding position set on an upstream side of the cross-flow flow rate adjuster so that the flow rate of the carrier fluid flowing into the cross-flow flow rate adjuster is larger than the flow rate of the carrier fluid having passed through the separation membrane.

公开(公告)号：US11413555B2

公开(公告)日：2022-08-16

申请号：US16611331

申请日：2017-05-10

Applicant: Shimadzu Corporation

Inventor： Jun Yanagibayashi

IPC: B01D15/10 ,  G01N30/88 ,  F04B23/04 ,  G01N30/34 ,  G01N30/32

Abstract: A liquid delivery device includes at least one liquid delivery pump that delivers liquid, at least one main channel communicating with an outlet of the liquid delivery pump, at least one branch channel branched from the main channel, and a switching valve that has, as a port for connecting channels, at least a port to which the main channel is connected, a port to which the branch channel is connected, at least one output port for outputting liquid delivered by the liquid delivery pump through the main channel, and at least one drain port leading to a drain, and is configured to be selectively switched to a first state, in which the main channel is connected to the output port while the branch channel is not connected to any channel, and a second state in which the branch channel is connected to the drain port while the main channel is not connected to any channel.

公开(公告)号：US12173834B2

公开(公告)日：2024-12-24

申请号：US17726082

申请日：2022-04-21

Applicant: SHIMADZU CORPORATION

Inventor： Jun Yanagibayashi ,  Shinji Tanaka ,  Ryo Hosono ,  Kenichi Yasunaga

IPC: F16L9/147 ,  G01N30/38

Abstract: A bioinert pipe includes a flow path inside, an inner wall of the flow path is composed of a resin tube and an outer peripheral surface of the resin tube is covered with a metal tube. The bioinert pipe includes an end portion extension member attached to an end portion of the metal tube, and the end portion extension member is made from a material harder than the resin tube and has a first surface and a second surface. The first surface is facing and in contact with an end surface of the metal tube and the second surface is directed opposite to the first surface. a through hole having an inner diameter substantially the same as an inner diameter of the metal tube is provided so as to pass from the first surface to the second surface in the end portion extension member. An edge of the through hole on the second surface of the end portion extension member has a chamfered shape, and the resin tube is inserted into the through hole. An end portion of the resin tube forms a flange portion by being by being bent outward in a radial direction of the flow path along the chamfered shape of the edge of the through hole.

公开(公告)号：US12123533B2

公开(公告)日：2024-10-22

申请号：US17092381

申请日：2020-11-09

Applicant: SHIMADZU CORPORATION

Inventor： Jun Yanagibayashi ,  Kenichi Yasunaga ,  Shinji Tanaka ,  Shinya Imamura ,  Ryo Hosono ,  Hiromu Yamasaki ,  Koshi Abe

IPC: F16L47/14 ,  B01L3/00 ,  B29C57/00 ,  F16L13/007 ,  F16L13/02 ,  F16L47/02 ,  G01N30/60

CPC classification number: F16L47/02 ,  B01L3/561 ,  B01L3/563 ,  B29C57/005 ,  F16L13/007 ,  F16L13/02 ,  F16L47/14 ,  G01N30/6026 ,  B01L2200/12 ,  B01L2200/141

Abstract: A resin tube is prepared. Further, a formation tool having a pressing surface and a projection that projects from the pressing surface and is insertable into the resin tube is prepared. The projection of the formation tool is inserted from an end of the resin tube into the resin tube. The pressing surface of the formation tool is pressed against an end surface of the resin tube. Thermal energy is applied to the end of the resin tube, whereby a shape of the pressing surface of the formation tool is transferred to the end surface of the resin tube, and the end of the resin tube is formed into a flange shape.

公开(公告)号：US11319951B2

公开(公告)日：2022-05-03

申请号：US16762399

申请日：2017-11-29

Applicant: SHIMADZU CORPORATION

Inventor： Jun Yanagibayashi ,  Shinya Imamura

IPC: F04B53/22 ,  F04B53/14 ,  F04B53/16

Abstract: Even though a pump head part is finally fixed to a pump body with a fixing member, the pump head part is movable relative to the pump body perpendicular to the axial direction of a plunger at a stage before the pump head part is fixed with the fixing member. In this state, if a plunger driving part is moved to a predetermined location on the front end side of the pump body and the pump head part and the plunger driving part are fitted to each other, the pump head part is positioned where the center axis of the plunger and the center axis of the pump chamber are substantially aligned. By fixing the pump head part to the pump body with the fixing member at this location, it is possible to assemble a plunger pump with the center axis of the plunger and the center axis substantially aligned.

公开(公告)号：US10384174B2

公开(公告)日：2019-08-20

申请号：US15526374

申请日：2014-11-17

Applicant: SHIMADZU CORPORATION ,  KAZUSA DNA RESEARCH INSTITUTE

Inventor： Jun Yanagibayashi ,  Tetsuo Ohashi ,  Osamu Ohara

IPC: B01F3/12 ,  B01J8/20 ,  B01F9/02 ,  B01J19/08 ,  B03C1/00 ,  B01F9/10 ,  B03C1/01 ,  B03C1/033 ,  B03C1/28 ,  C12M1/42 ,  B01F11/00 ,  B01F13/08

Abstract: The present invention relates to a particle manipulation method to disperse magnetic particles 70 in a liquid 35 filling up a tube container 10, wherein a circumferential direction moving step to move the magnetic particles 70 along the circumferential direction of the container 10 in the liquid 35 and in a radial direction moving step to move the magnetic particles 70 as crossing the radial direction of the container 10 in the liquid 35 are implemented repeatedly. Such manipulations can be achieved by combining rotation of the container and gravity force and magnetic field manipulations.

公开(公告)号：US12146868B2

公开(公告)日：2024-11-19

申请号：US17778832

申请日：2020-11-05

Applicant: SHIMADZU CORPORATION ,  Kyoto University

Inventor： Jun Yanagibayashi ,  Shinya Imamura ,  Kenichi Yasunaga ,  Yasushi Ishihama ,  Koshi Imami ,  Tomoya Niinae ,  Yumi Komori

IPC: G01N30/32 ,  G01N30/14 ,  G01N30/02

Abstract: A pump unit includes a pump and a metal ion trap. The pump includes a metal member that comes into contact with a mobile phase. The pump pumps a mobile phase through a flow path. The metal ion trap includes a filter element. The filter element includes a metal ion retention structure for retaining metal ions by interacting with the metal ions included in a mobile phase. The filter element is provided in the flow path for a mobile phase pumped by the pump. The pump unit may be provided in a chromatograph.

公开(公告)号：US12031961B2

公开(公告)日：2024-07-09

申请号：US17615561

申请日：2019-06-26

Applicant: SHIMADZU CORPORATION

Inventor： Jun Yanagibayashi

IPC: G01N30/32 ,  F04B41/06 ,  F04B49/06 ,  G01N30/02

CPC classification number: G01N30/32 ,  F04B41/06 ,  F04B49/06 ,  G01N2030/027 ,  G01N2030/326

Abstract: A binary pump in which an operation controller causes each of two liquid delivery pumps to execute, while a secondary discharge process is executed, a suction process, a first pre-pressurizing process, and a standby process. The operation controller causes each of the two liquid delivery pumps to execute a second pre-pressurizing process before proceeding from the secondary discharge process to the primary discharge process. Furthermore, the operation controller causes, as long as continuous liquid delivery by each of the two liquid delivery pumps is not interrupted, at least one of the two liquid delivery pumps to execute avoidance operation of interrupting the standby process and proceeding to the second pre-pressurizing process by using the operation state of each of the two liquid delivery pumps, so as to avoid overlap of execution time zones of the primary discharge processes of the two liquid delivery pumps.