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    Personal care compositions and methods for the beautification of mammalian skin and hair
    2.
    发明申请
    Personal care compositions and methods for the beautification of mammalian skin and hair 审中-公开
    用于美化哺乳动物皮肤和头发的个人护理组合物和方法

    公开(公告)号：US20070009474A1

    公开(公告)日：2007-01-11

    申请号：US11482314

    申请日：2006-07-07

    申请人： Sancai Xie ,  Kotikanyadanam Sreekrishna ,  Abby Newland ,  Charles Bascom ,  Joseph Kaczvinsky ,  Keren Lammers ,  Kristina Emma Vanoosthuyze

    发明人： Sancai Xie ,  Kotikanyadanam Sreekrishna ,  Abby Newland ,  Charles Bascom ,  Joseph Kaczvinsky ,  Keren Lammers ,  Kristina Emma Vanoosthuyze

    IPC分类号： A61K8/97 ,  A61K31/522

    CPC分类号： A61K8/63 ,  A61K8/345 ,  A61K8/42 ,  A61K8/4926 ,  A61K8/494 ,  A61K8/675 ,  A61K8/97 ,  A61K31/522 ,  A61Q19/00 ,  A61Q19/08

    摘要： Personal care composition comprising from about 0.05% to about 5% of at least one aquaporin-stimulating compound selected from the group consisting of xanthine, caffeine; 2-amino-6-methyl-mercaptopurine; 1-methyl xanthine; 2-aminopurine; theophylline; theobromine; adenine; adenosine; kinetin; p-chlorophenoxyacetic acid; 2,4-dichlorophenoxyacetic acid; indole-3-butyric acid; indole-3-acetic acid methyl ester; beta-naphthoxyacetic acid; 2,3,5-triiodobenzoic acid; adenine hemisulfate; n-benzyl-9-(2-tetrahydropyranyl)adenine; 1,3-diphenylurea; 1-phenyl-3-(1,2,3-thiadiazol-5-yl)urea; zeatin; indole-3-acetic acid; 6-benzylaminopurine; alpha-napthaleneacetic acid; 6-2-furoylaminopurine; green tea extract; white tea extract; menthol; tea tree oil; ginsenoside-RB1; ginsenoside-RB3; ginsenoside-RC; ginsenoside-RD; ginsenoside-RE; ginsenoside-RG1; ginseng root extract; ginseng flower extract; pomegranate extract, extracts from Ajuga turkestanica; extracts from viola tricolor and combinations thereof; an additional ingredient selected from the group consisting of niacinamide, glycerin and mixtures thereof, and a dermatologically-acceptable carrier.

    摘要翻译： 包含约0.05％至约5％的至少一种选自黄嘌呤，咖啡因， 2-氨基-6-甲基 - 巯基嘌呤; 1-甲基黄嘌呤; 2-氨基嘌呤; 茶碱 可可碱 腺嘌呤 腺苷; 激素 对氯苯氧乙酸; 2,4-二氯苯氧乙酸; 吲哚-3-丁酸; 吲哚-3-乙酸甲酯; β-萘氧乙酸; 2,3,5-三碘苯甲酸; 腺嘌呤半硫酸盐; 正 - 苄基-9-（2-四氢吡喃基）腺嘌呤; 1,3-二苯脲 1-苯基-3-（1,2,3-噻二唑-5-基）脲; 玉米素 吲哚-3-乙酸; 6-苄基氨基嘌呤; α-萘乙酸; 6-2-呋喃氨基嘌呤; 绿茶提取物; 白茶提取物; 薄荷醇 茶树油; 人参皂甙-RB1; 人参皂苷-RB3; 人参皂甙RC; 人参皂甙-RD; 人参皂甙RE 人参皂甙-RG1; 人参根提取物; 人参花提取物; 石榴提取物，土豆提取物; 三色提取物及其组合; 选自烟酰胺，甘油及其混合物的另外的成分，以及皮肤病学上可接受的载体。

    COMPOSITIONS AND METHODS FOR EARLY PREGNANCY DIAGNOSIS
    3.
    发明申请
    COMPOSITIONS AND METHODS FOR EARLY PREGNANCY DIAGNOSIS 有权
    早期怀孕诊断的组成和方法

    公开(公告)号：US20070166773A1

    公开(公告)日：2007-07-19

    申请号：US11552454

    申请日：2006-10-24

    申请人： Robert Roberts ,  Jonathan Green ,  Sancai Xie

    发明人： Robert Roberts ,  Jonathan Green ,  Sancai Xie

    IPC分类号： G01N33/53 ,  C07K16/26

    CPC分类号： G01N33/689 ,  C07K14/47 ,  G01N2333/471 ,  G01N2800/368 ,  Y10S435/973

    摘要： Pregnancy-associated glycoproteins (PAGs) are structurally related to the pepsins, thought to be restricted to the hoofed (ungulate) mammals and characterized by being expressed specifically in the outer epithelial cell layer (chorion/trophectoderm) of the placenta. By cloning expressed genes from ovine and bovine placental cDNA libraries, the inventors estimate that cattle, sheep, and most probably all ruminant Artiodactyla, possess possibly 100 or more PAG genes, many of which are placentally expressed. The PAGs are highly diverse in sequence, with regions of hypervariability confined largely to surface-exposed loops. Selected PAG that are products of the i0nvasive binucleate cells, expressed highly in early pregnancy at the time of trophoblast invasion and expressed weakly, if at all, in late gestation are useful in the early diagnosis of pregnancy. In a preferred embodiment, the invention relates to immunoassays for detecting these PAGs.

    摘要翻译： 妊娠相关糖蛋白（PAG）在结构上与胃蛋白酶相关，被认为限于蹄（有蹄类）的哺乳动物，其特征在于在胎盘的外上皮细胞层（绒毛膜/滋养外胚层）中特异性表达。 通过克隆来自绵羊和牛胎盘cDNA文库的表达基因，本发明人估计，牛，绵羊和大多数所有反刍动物偶蹄类动物都具有100个或更多个PAG基因，其中许多是胎盘表达的。 PAG的序列高度多样化，高变区域主要局限于表面暴露的环路。 选择的PAG是i0navasive双核细胞的产物，在滋养层侵袭时早期表达高度表达，如果在妊娠晚期，在妊娠早期诊断中有用。 在优选的实施方案中，本发明涉及用于检测这些PAG的免疫测定。

    Compositions and methods for early pregnancy diagnosis
    4.
    发明授权
    Compositions and methods for early pregnancy diagnosis 有权
    早孕诊断的组成和方法

    公开(公告)号：US08182999B2

    公开(公告)日：2012-05-22

    申请号：US12825223

    申请日：2010-06-28

    申请人： Robert Michael Roberts ,  Jonathan Andrew Green ,  Sancai Xie

    发明人： Robert Michael Roberts ,  Jonathan Andrew Green ,  Sancai Xie

    IPC分类号： G01N33/53

    CPC分类号： G01N33/689 ,  C07K14/47 ,  G01N2333/471 ,  G01N2800/368 ,  Y10S435/973

    摘要： Pregnancy-associated glycoproteins (PAGs) are structurally related to the pepsins, thought to be restricted to the hoofed (ungulate) mammals and characterized by being expressed specifically in the outer epithelial cell layer (chorion/trophectoderm) of the placenta. By cloning expressed genes from ovine and bovine placental cDNA libraries, the inventors estimate that cattle, sheep, and most probably all ruminant Artiodactyla, possess possibly 100 or more PAG genes, many of which are placentally expressed. The PAGs are highly diverse in sequence, with regions of hypervariability confined largely to surface-exposed loops. Selected PAG that are products of the invasive binucleate cells, expressed highly in early pregnancy at the time of trophoblast invasion and expressed weakly, if at all, in late gestation are useful in the early diagnosis of pregnancy. In a preferred embodiment, the invention relates to immunoassays for detecting these PAGs.

    摘要翻译： 妊娠相关糖蛋白（PAG）在结构上与胃蛋白酶相关，被认为限于蹄（有蹄类）的哺乳动物，其特征在于在胎盘的外上皮细胞层（绒毛膜/滋养外胚层）中特异性表达。 通过克隆来自绵羊和牛胎盘cDNA文库的表达基因，本发明人估计，牛，绵羊和大多数所有反刍动物偶蹄类动物都具有100个或更多个PAG基因，其中许多是胎盘表达的。 PAG的序列高度多样化，高变区域主要局限于表面暴露的环路。 选择的PAG是侵入性双核细胞的产物，在滋养层侵袭时早期表达高度表达，如果在妊娠晚期，在妊娠早期诊断中很有用。 在优选的实施方案中，本发明涉及用于检测这些PAG的免疫测定。

    COMPOSITIONS AND METHODS FOR EARLY PREGNANCY DIAGNOSIS
    7.
    发明申请
    COMPOSITIONS AND METHODS FOR EARLY PREGNANCY DIAGNOSIS 有权
    早期怀孕诊断的组成和方法

    公开(公告)号：US20100331206A1

    公开(公告)日：2010-12-30

    申请号：US12825223

    申请日：2010-06-28

    申请人： Robert Michael Roberts ,  Jonathan Andrew Green ,  Sancai Xie

    发明人： Robert Michael Roberts ,  Jonathan Andrew Green ,  Sancai Xie

    IPC分类号： C40B30/04 ,  A61J1/00 ,  G01N33/53 ,  C07K16/18 ,  C12N5/16 ,  C12P21/04 ,  C12Q1/68 ,  C07K14/47 ,  C07H21/04

    CPC分类号： G01N33/689 ,  C07K14/47 ,  G01N2333/471 ,  G01N2800/368 ,  Y10S435/973

    摘要： Pregnancy-associated glycoproteins (PAGs) are structurally related to the pepsins, thought to be restricted to the hoofed (ungulate) mammals and characterized by being expressed specifically in the outer epithelial cell layer (chorion/trophectoderm) of the placenta. By cloning expressed genes from ovine and bovine placental cDNA libraries, the inventors estimate that cattle, sheep, and most probably all ruminant Artiodactyla, possess possibly 100 or more PAG genes, many of which are placentally expressed. The PAGs are highly diverse in sequence, with regions of hypervariability confined largely to surface-exposed loops. Selected PAG that are products of the invasive binucleate cells, expressed highly in early pregnancy at the time of trophoblast invasion and expressed weakly, if at all, in late gestation are useful in the early diagnosis of pregnancy. In a preferred embodiment, the invention relates to immunoassays for detecting these PAGs.

    摘要翻译： 妊娠相关糖蛋白（PAG）在结构上与胃蛋白酶相关，被认为限于蹄（有蹄类）的哺乳动物，其特征在于在胎盘的外上皮细胞层（绒毛膜/滋养外胚层）中特异性表达。 通过克隆来自绵羊和牛胎盘cDNA文库的表达基因，本发明人估计，牛，绵羊和大多数所有反刍动物偶蹄类动物都具有100个或更多个PAG基因，其中许多是胎盘表达的。 PAG的序列高度多样化，高变区域主要局限于表面暴露的环路。 选择的PAG是侵入性双核细胞的产物，在滋养层侵袭时早期表达高度表达，如果在妊娠晚期，在妊娠早期诊断中很有用。 在优选的实施方案中，本发明涉及用于检测这些PAG的免疫测定。

    Compositions and methods for early pregnancy diagnosis
    8.
    发明授权
    Compositions and methods for early pregnancy diagnosis 有权
    早孕诊断的组成和方法

    公开(公告)号：US07763432B2

    公开(公告)日：2010-07-27

    申请号：US11552454

    申请日：2006-10-24

    申请人： Robert Michael Roberts ,  Jonathan Andrew Green ,  Sancai Xie

    发明人： Robert Michael Roberts ,  Jonathan Andrew Green ,  Sancai Xie

    IPC分类号： G01N33/53

    CPC分类号： G01N33/689 ,  C07K14/47 ,  G01N2333/471 ,  G01N2800/368 ,  Y10S435/973

    摘要： Pregnancy-associated glycoproteins (PAGs) are structurally related to the pepsins, thought to be restricted to the hoofed (ungulate) mammals and characterized by being expressed specifically in the outer epithelial cell layer (chorion/trophectoderm) of the placenta. By cloning expressed genes from ovine and bovine placental cDNA libraries, the inventors estimate that cattle, sheep, and most probably all ruminant Artiodactyla, possess possibly 100 or more PAG genes, many of which are placentally expressed. The PAGs are highly diverse in sequence, with regions of hypervariability confined largely to surface-exposed loops. Selected PAG that are products of the invasive binucleate cells, expressed highly in early pregnancy at the time of trophoblast invasion and expressed weakly, if at all, in late gestation are useful in the early diagnosis of pregnancy. In a preferred embodiment, the invention relates to immunoassays for detecting these PAGs.

    摘要翻译： 妊娠相关糖蛋白（PAG）在结构上与胃蛋白酶相关，被认为限于蹄（有蹄类）的哺乳动物，其特征在于在胎盘的外上皮细胞层（绒毛膜/滋养外胚层）中特异性表达。 通过克隆来自绵羊和牛胎盘cDNA文库的表达基因，本发明人估计，牛，绵羊和大多数所有反刍动物偶蹄类动物都具有100个或更多个PAG基因，其中许多是胎盘表达的。 PAG的序列高度多样化，高变区域主要局限于表面暴露的环路。 选择的PAG是侵入性双核细胞的产物，在滋养层侵袭时早期表达高度表达，如果在妊娠晚期，在妊娠早期诊断中很有用。 在优选的实施方案中，本发明涉及用于检测这些PAG的免疫测定。

    Compositions and methods for early pregnancy diagnosis
    10.
    发明授权
    Compositions and methods for early pregnancy diagnosis 有权
    早孕诊断的组成和方法

    公开(公告)号：US06869770B1

    公开(公告)日：2005-03-22

    申请号：US09273164

    申请日：1999-03-19

    申请人： Robert Michael Roberts ,  Jonathan Andrew Green ,  Sancai Xie

    发明人： Robert Michael Roberts ,  Jonathan Andrew Green ,  Sancai Xie

    IPC分类号： C07K14/47 ,  G01N33/53 ,  G01N33/68

    CPC分类号： G01N33/689 ,  C07K14/47 ,  G01N2333/471 ,  G01N2800/368 ,  Y10S435/973

    摘要： Pregnancy-associated glycoproteins (PAGs) are structurally related to the pepsins, thought to be restricted to the hoofed (ungulate) mammals and characterized by being expressed specifically in the outer epithelial cell layer (chorion/trophectoderm) of the placenta. By cloning expressed genes from ovine and bovine placental cDNA libraries, the inventors estimate that cattle, sheep, and most probably all ruminant Artiodactyla, possess possibly 100 or more PAG genes, many of which are placentally expressed. The PAGs are highly diverse in sequence, with regions of hypervariability confined largely to surface-exposed loops. Selected PAG that are products of the iOnvasive binucleate cells, expressed highly in early pregnancy at the time of trophoblast invasion and expressed weakly, if at all, in late gestation are useful in the early diagnosis of pregnancy. In a preferred embodiment, the invention relates to immunoassays for detecting these PAGs.

    摘要翻译： 妊娠相关糖蛋白（PAG）在结构上与胃蛋白酶相关，被认为限于蹄（有蹄类）的哺乳动物，其特征在于在胎盘的外上皮细胞层（绒毛膜/滋养外胚层）中特异性表达。 通过克隆来自绵羊和牛胎盘cDNA文库的表达基因，本发明人估计，牛，绵羊和大多数所有反刍动物偶蹄类动物都具有100个或更多个PAG基因，其中许多是胎盘表达的。 PAG的序列高度多样化，高变区域主要局限于表面暴露的环路。 选择的PAG是iOnvasive双核细胞的产物，在滋养层侵袭时早期表达高度表达，在妊娠晚期如果有的话在早期诊断怀孕中有用。 在优选的实施方案中，本发明涉及用于检测这些PAG的免疫测定。