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公开(公告)号：US6100069A
公开(公告)日：2000-08-08
申请号：US196857
申请日：1998-11-20
申请人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Katz , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong
发明人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Katz , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , C07K14/315 , C12N1/21 , C12N5/02 , C12N9/90 , C12N15/61 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C07K14/3156 , C12N9/90 , C12Y502/01008 , A61K38/00 , A61K39/00
摘要： The invention provides tig polypeptides and polynucleotides encoding tig polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tig polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了tig多肽和编码tig多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用tig多肽筛选抗菌化合物的方法。
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公开(公告)号：US07202071B2
公开(公告)日：2007-04-10
申请号：US10437581
申请日：2003-05-14
申请人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Shilling , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong , John Peter Throup , Karen Anne Ingraham , Alison Frances Chalker , David John Holmes , Christopher Michael Traini
发明人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Shilling , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong , John Peter Throup , Karen Anne Ingraham , Alison Frances Chalker , David John Holmes , Christopher Michael Traini
摘要： The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供第p多肽和编码第p多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用第p多肽筛选抗菌化合物的方法。
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公开(公告)号：US06303771B1
公开(公告)日：2001-10-16
申请号：US09080643
申请日：1998-05-18
申请人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Shilling , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong , John Peter Throup , Karen Anne Ingraham , Alison Frances Chalker , David John Holmes , Christopher Michael Traini
发明人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Shilling , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong , John Peter Throup , Karen Anne Ingraham , Alison Frances Chalker , David John Holmes , Christopher Michael Traini
IPC分类号： C12N1531
摘要： The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供第p多肽和编码第p多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用第p多肽筛选抗菌化合物的方法。
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公开(公告)号：US6162619A
公开(公告)日：2000-12-19
申请号：US81686
申请日：1998-05-20
申请人： Sanjoy Biswas , Alexander Bryant , Yigong Ge , David John Holmes , Karen A Ingraham , Deborah Dee Jaworski , Andrea Marra , Lisa Kathleen Shilling , John P. Throup , Min Wang , Nicola Gail Wallis , Magdalena Zalacain
发明人： Sanjoy Biswas , Alexander Bryant , Yigong Ge , David John Holmes , Karen A Ingraham , Deborah Dee Jaworski , Andrea Marra , Lisa Kathleen Shilling , John P. Throup , Min Wang , Nicola Gail Wallis , Magdalena Zalacain
CPC分类号： C12N9/1205
摘要： The invention provides Histidine kinase polypeptides and polynucleotides encoding Histidine kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Histidine kinase polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供组氨酸激酶多肽和编码组氨酸激酶多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用组氨酸激酶多肽筛选抗菌化合物的方法。
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公开(公告)号：US06228625B1
公开(公告)日：2001-05-08
申请号：US09273686
申请日：1999-03-22
申请人： Sanjoy Biswas , James Raymond Brown , Martin Karl Russel Burnham , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Chi Young So , Richard Lloyd Warren , Magdalena Zalacain
发明人： Sanjoy Biswas , James Raymond Brown , Martin Karl Russel Burnham , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Chi Young So , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号： C12N900
CPC分类号： C12Q1/6876 , A61K38/00 , C07K14/3156
摘要： The invention provides metK polypeptides and polynucleotides encoding metK polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing metK polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了metK多肽和编码metK多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用metK多肽来筛选抗菌化合物的方法。
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公开(公告)号：US06225457B1
公开(公告)日：2001-05-01
申请号：US09305001
申请日：1999-05-04
申请人： Sanjoy Biswas , James Raymond Brown , Martin K R Burnham , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain
发明人： Sanjoy Biswas , James Raymond Brown , Martin K R Burnham , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号： C07H2104
CPC分类号： C07K14/3156 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The invention provides murF2 polypeptides and polynucleotides encoding murF2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing murF2 polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了编码murF2多肽的murF2多肽和多核苷酸以及通过重组技术产生这种多肽的方法。 还提供了利用murF2多肽筛选抗菌化合物的方法。
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公开(公告)号：US06399343B1
公开(公告)日：2002-06-04
申请号：US09574912
申请日：2000-05-19
申请人： Sanjoy Biswas , James Raymond Brown , Martin Karl Russel Burnham , Alison Francis Chalker , Richard Lloyd Warren , Magdalena Zalacain , Chi Young So , Christopher M Traini , David John Holmes , Karen Anne Ingraham , Thomas B Mathie
发明人： Sanjoy Biswas , James Raymond Brown , Martin Karl Russel Burnham , Alison Francis Chalker , Richard Lloyd Warren , Magdalena Zalacain , Chi Young So , Christopher M Traini , David John Holmes , Karen Anne Ingraham , Thomas B Mathie
IPC分类号： C12N900
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , A61K48/00 , Y10S435/885
摘要： The invention provides infB polypeptides and polynucleotides encoding infB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing in polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供编码infB多肽的infB多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了在多肽中利用筛选抗菌化合物的方法。
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公开(公告)号：US06350600B1
公开(公告)日：2002-02-26
申请号：US09627769
申请日：2000-07-28
申请人： Sanjoy Biswas , James Raymond Brown , Chi Young So , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain
发明人： Sanjoy Biswas , James Raymond Brown , Chi Young So , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号： C12N900
CPC分类号： C12N9/1007 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The invention provides trmA methyl transferase (trmD) polypeptides and polynucleotides encoding trmD polypeptides and methods for producing such polypeptides by recominant techniques from strepococcus pneumoniae. Also provided are methods for utilizing polypepides to screen for antibacterial compounds.
摘要翻译： 本发明提供trmA甲基转移酶（trmD）多肽和编码trmD多肽的多核苷酸以及通过来自肺炎链球菌的重组技术产生此类多肽的方法。 还提供了利用多肽来筛选抗菌化合物的方法。
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公开(公告)号：US06261817B1
公开(公告)日：2001-07-17
申请号：US09197063
申请日：1998-11-20
申请人： Sanjoy Biswas , James Raymond Brown , Lisa Kathleen Shilling , Richard Lloyd Warren , Magdalena Zalacain
发明人： Sanjoy Biswas , James Raymond Brown , Lisa Kathleen Shilling , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号： C12P2106
CPC分类号： C12N9/93 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K14/3156 , G01N33/56944 , G01N33/573 , G01N33/9446 , Y10S435/822
摘要： The invention provides guaA polypeptides and polynucleotides encoding guaA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing guaA polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了guaA多肽和编码guaA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用guaA多肽筛选抗菌化合物的方法。
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公开(公告)号：US06245542B1
公开(公告)日：2001-06-12
申请号：US09306276
申请日：1999-05-06
申请人： Sanjoy Biswas , Alexander Bryant , James Raymond Brown , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Chi Young So , Stephanie Van Horn , Richard Lloyd Warren , Magdalena Zalacain
发明人： Sanjoy Biswas , Alexander Bryant , James Raymond Brown , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Chi Young So , Stephanie Van Horn , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号： C12N910
CPC分类号： C12N9/1007 , A61K38/00
摘要： The invention provides yfjO polypeptides and polynucleotides encoding yfjO polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing yfjO polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了yfjO多肽和编码yfjO多肽的多核苷酸，以及通过重组技术产生此类多肽的方法。 还提供了利用yfj多肽筛选抗菌化合物的方法。
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