摘要:
The present invention provides compositions and methods for reducing the immunogenicity and increasing the circulating half-life of therapeutic proteins such as Factor VIII. The compositions comprise lipidic structures such as liposomes, micelles and cochleates comprising a negatively charged lipid and polyethylene glycol derivatized phospatidyl ethanolamine.
摘要:
Methods and composition are described for low immunogenic protein, polypeptide or peptide formulations. The method comprises forming complexes of the protein, polypeptide or peptide with a binding agent which can be a serine containing compound or other phosphatidyl compounds or phospholipids. The complexes formed include simple complexes, micelles, cochleate structures, liposomes, non-bilayer and novel lipidic structures. The antigenicity and imminogenicity of the protein, polypeptides or peptides is reduced upon formation of such complexes.
摘要:
The present invention provides compositions and methods for reducing the immunogenicity and increasing the circulating half-life of therapeutic proteins such as Factor VIII. The compositions comprise lipidic structures such as liposomes, micelles and cochleates comprising a negatively charged lipid and polyethylene glycol derivatized phosphatidyl ethanolamine.
摘要:
The present invention provides compositions and methods for reducing the immunogenicity and increasing the circulating half-life of therapeutic proteins such as Factor VIII. The compositions comprise lipidic structures such as liposomes, micelles and cochleates comprising a negatively charged lipid and polyethylene glycol derivatized phosphatidyl ethanolamine.
摘要:
The present invention relates to methods for complexing a protein in a dispersed medium. Also disclosed are associated proteins produced by the methods of complexing of the present invention. Pharmaceutically effective stabilized protein dosages are also disclosed. The present invention also relates to a method for associating AHF protein in a dispersed medium.
摘要:
When an instruction is executed on an integrated circuit (IC), an activity level and temperature are measured. A relationship between the activity level and temperature is determined, to estimate the temperature from the activity level. The activity level is monitored and is input to a scheduler, which estimates the IC temperature based on the activity level. The scheduler distributes work taking into account the temperature of various IC regions and may include distributing work to the IC region that has a lowest estimated temperature or relatively lower estimated temperature (e.g., lower than the average IC or IC region temperature). When the utilization level of one or more IC regions is high, the scheduler is configured to reduce the clock speed or the voltage of the one or more IC regions, or flag the regions as being unavailable for additional workload.
摘要:
A method for fabricating a dynamic random access memory (DRAM) capacitor stack is disclosed wherein the stack includes a first electrode, a dielectric layer, and a second electrode. The first electrode is formed from a conductive binary metal compound and the conductive binary metal compound is annealed in a reducing atmosphere to promote the formation of a desired crystal structure. The binary metal compound may be a metal oxide. Annealing the metal oxide (i.e. molybdenum oxide) in a reducing atmosphere may result in the formation of a first electrode material (i.e. MoO2) with a rutile-phase crystal structure. This facilitates the formation of the rutile-phase crystal structure when TiO2 is used as the dielectric layer. The rutile-phase of TiO2 has a higher k value than the other possible crystal structures of TiO2 resulting in improved performance of the DRAM capacitor.
摘要翻译:公开了一种用于制造动态随机存取存储器(DRAM)电容器堆叠的方法,其中堆叠包括第一电极,电介质层和第二电极。 第一电极由导电二元金属化合物形成,并且导电二元金属化合物在还原气氛中退火以促进所需晶体结构的形成。 二元金属化合物可以是金属氧化物。 在还原气氛中退火金属氧化物(即氧化钼)可导致形成具有金红石相晶体结构的第一电极材料(即MoO 2)。 当使用TiO 2作为电介质层时,这有助于金红石相晶体结构的形成。 TiO 2的金红石相具有比其他可能的TiO 2晶体结构更高的k值,从而改善了DRAM电容器的性能。
摘要:
A method of receiving input image data for an image search engine includes providing a two-dimensional input image on a display screen, enabling a user to rotate the input image on the display screen about an axis that is non-perpendicular to a plane of the input image, and enabling the user to electronically draw modifications on the rotated input image.
摘要:
The present invention relates to methods for complexing a protein in a dispersed medium. Also disclosed are associated proteins produced by the methods of complexing of the present invention. Pharmaceutically effective stabilized protein dosages are also disclosed. The present invention also relates to a method for associating AHF protein in a dispersed medium.
摘要:
There are disclosed methods to provide stable pose determinations of various three dimensional shapes. Methods are also disclosed for determining multiple, unique drawing descriptors for two dimensional drawings, and for obtaining intermediate three dimensional representations of two dimensional drawings as one way to determine the descriptor. Methods are also disclosed to provide for searching of two dimensional drawings and three dimensional shapes using user-defined input, which may be a drawing or sketch. User interactivity is provided to further refine search results.