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    Process for producing benzo[f]quinoxaline compounds
    4.
    发明授权
    Process for producing benzo[f]quinoxaline compounds 有权
    苯并[f]喹喔啉化合物的制备方法

    公开(公告)号：US08772484B2

    公开(公告)日：2014-07-08

    申请号：US13412682

    申请日：2012-03-06

    申请人： Satoshi Inouye ,  Yuiko Miura ,  Suguru Yoshida ,  Takamitsu Hosoya

    发明人： Satoshi Inouye ,  Yuiko Miura ,  Suguru Yoshida ,  Takamitsu Hosoya

    IPC分类号： C07D487/12 ,  C07D241/10

    CPC分类号： C07D241/38 ,  C07D241/20 ,  C07D241/44 ,  C07D241/54 ,  C07D487/04 ,  Y02P20/55

    摘要： A simple process for producing v-coelenterazine compounds has been desired. Described is a process for producing a v-coelenterazine compound represented by general formula (II) comprising (1) the step of reacting a compound of general formula (VIII) with a methyltriphenylphosphonium salt in the presence of a base to give a compound represented by general formula (IX), (2) the step of performing a ring-closing metathesis reaction on any one selected from the group consisting of the compound represented by general formula (IX) and a compound of general formula (X) which is the compound of general formula (IX) wherein the amino is protected with R5, and then deprotecting R4 and, if any, R5 to give a v-coelenteramine compound represented by general formula (XIV), and (3) the step of reacting the compound of general formula (XIV) with a compound represented by general formula (XV) to give the compound of general formula (II).

    摘要翻译： 已经需要制备v-肠溶纤维素化合物的简单方法。 本发明描述了一种制备由通式（II）表示的β-环糊精化合物的方法，包括（1）在碱存在下使通式（Ⅷ）化合物与甲基三苯基鏻盐反应，得到由 通式（IX），（2）对选自由通式（IX）表示的化合物和作为化合物的通式（X）的化合物的任何一种进行闭环复分解反应的步骤 的通式（IX）的化合物，其中氨基被R 5保护，然后使R 4和（如果有的话）R 5脱保护，得到由通式（XIV）表示的v-内网络胺化合物，和（3） 通式（XIV）与通式（XV）表示的化合物反应，得到通式（II）的化合物。

    Coelenteramide analogs
    5.
    发明授权
    Coelenteramide analogs 有权
    Coelenteramide类似物

    公开(公告)号：US08431525B2

    公开(公告)日：2013-04-30

    申请号：US13146710

    申请日：2010-02-08

    申请人： Takamitsu Hosoya ,  Kohei Oka ,  Satoshi Inouye

    发明人： Takamitsu Hosoya ,  Kohei Oka ,  Satoshi Inouye

    IPC分类号： A61K38/00 ,  C07K1/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  C08H1/00

    CPC分类号： C07D241/20 ,  C07K14/43595

    摘要： There has been a need for coelenteramide analogs or the like that produce fluorescent proteins which exhibit different fluorescent characteristics from those of the existing fluorescent proteins. Disclosed is a compound represented by general formula (1) (wherein R1 represents a substituted or unsubstituted aryl, a substituted or unsubstituted arylalkyl, a straight or branched alkyl which may optionally be substituted with an alicyclic group, an alicyclic group or a heterocyclic group; R2 represents hydrogen or —(SO2)R4; R3 represents hydrogen, hydroxyl, methoxy or acetoxy; R4 represents a substituted or unsubstituted aryl, a substituted or unsubstituted arylalkyl or a straight or branched alkyl which may optionally be substituted with an alicyclic group; and X1 represents —C(═S)— or —SO2—).

    摘要翻译： 需要产生与现有荧光蛋白不同的荧光特性的荧光蛋白质的coelenteramide类似物等。 公开了由通式（1）表示的化合物（其中R 1表示取代或未取代的芳基，取代或未取代的芳烷基，可任选被脂环基，脂环基或杂环基取代的直链或支链烷基; R 2表示氢或 - （SO 2）R 4; R 3表示氢，羟基，甲氧基或乙酰氧基; R 4表示取代或未取代的芳基，取代或未取代的芳基烷基或可任选被脂环族基团取代的直链或支链烷基; X 1表示-C（= S） - 或-SO 2 - ）。

    PROCESS FOR PRODUCING v-COELENTERAZINE COMPOUNDS
    6.
    发明申请
    PROCESS FOR PRODUCING v-COELENTERAZINE COMPOUNDS 有权
    生产伏安康唑化合物的方法

    公开(公告)号：US20120232272A1

    公开(公告)日：2012-09-13

    申请号：US13412682

    申请日：2012-03-06

    申请人： Satoshi INOUYE ,  Yuiko Miura ,  Suguru Yoshida ,  Takamitsu Hosoya

    发明人： Satoshi INOUYE ,  Yuiko Miura ,  Suguru Yoshida ,  Takamitsu Hosoya

    IPC分类号： C07D487/04 ,  C07D241/38

    CPC分类号： C07D241/38 ,  C07D241/20 ,  C07D241/44 ,  C07D241/54 ,  C07D487/04 ,  Y02P20/55

    摘要： A simple process for producing v-coelenterazine compounds has been desired. Described is a process for producing a v-coelenterazine compound represented by general formula (II) comprising (1) the step of reacting a compound of general formula (VIII) with a methyltriphenylphosphonium salt in the presence of a base to give a compound represented by general formula (IX), (2) the step of performing a ring-closing metathesis reaction on any one selected from the group consisting of the compound represented by general formula (IX) and a compound of general formula (X) which is the compound of general formula (IX) wherein the amino is protected with R5, and then deprotecting R4 and, if any, R5 to give a v-coelenteramine compound represented by general formula (XIV), and (3) the step of reacting the compound of general formula (XIV) with a compound represented by general formula (XV) to give the compound of general formula (II).

    摘要翻译： 已经需要制备v-肠溶纤维素化合物的简单方法。 本发明描述了一种制备由通式（II）表示的β-环糊精化合物的方法，包括（1）在碱存在下使通式（Ⅷ）化合物与甲基三苯基鏻盐反应，得到由 通式（IX），（2）对选自由通式（IX）表示的化合物和作为化合物的通式（X）的化合物的任何一种进行闭环复分解反应的步骤 的通式（IX）的化合物，其中氨基被R 5保护，然后使R 4和（如果有的话）R 5脱保护，得到由通式（XIV）表示的v-内网络胺化合物，和（3） 通式（XIV）与通式（XV）表示的化合物反应，得到通式（II）的化合物。

    COELENTERAMIDE ANALOGS
    7.
    发明申请
    COELENTERAMIDE ANALOGS 有权
    椰油胺类似物

    公开(公告)号：US20110288280A1

    公开(公告)日：2011-11-24

    申请号：US13146710

    申请日：2010-02-08

    申请人： Takamitsu Hosoya ,  Kohei Oka ,  Satoshi Inouye

    发明人： Takamitsu Hosoya ,  Kohei Oka ,  Satoshi Inouye

    IPC分类号： C07D241/20 ,  C07K2/00

    CPC分类号： C07D241/20 ,  C07K14/43595

    摘要： There has been a need for coelenteramide analogs or the like that produce fluorescent proteins which exhibit different fluorescent characteristics from those of the existing fluorescent proteins. Disclosed is a compound represented by general formula (1) (wherein R1 represents a substituted or unsubstituted aryl, a substituted or unsubstituted arylalkyl, a straight or branched alkyl which may optionally be substituted with an alicyclic group, an alicyclic group or a heterocyclic group; R2 represents hydrogen or —(SO2)R4; R3 represents hydrogen, hydroxyl, methoxy or acetoxy; R4 represents a substituted or unsubstituted aryl, a substituted or unsubstituted arylalkyl or a straight or branched alkyl which may optionally be substituted with an alicyclic group; and X1 represents —C(═S)— or —SO2—).

    摘要翻译： 需要产生与现有荧光蛋白不同的荧光特性的荧光蛋白质的coelenteramide类似物等。 公开了由通式（1）表示的化合物（其中R 1表示取代或未取代的芳基，取代或未取代的芳烷基，可任选被脂环基，脂环基或杂环基取代的直链或支链烷基; R 2表示氢或 - （SO 2）R 4; R 3表示氢，羟基，甲氧基或乙酰氧基; R 4表示取代或未取代的芳基，取代或未取代的芳基烷基或可任选被脂环族基团取代的直链或支链烷基; X 1表示-C（= S） - 或-SO 2 - ）。

    CYCLIC COMPOUND, METHOD FOR PRODUCING CYCLIC COMPOUND, AND METHOD FOR MODIFYING BIOLOGICAL MOLECULE
    9.
    发明申请
    CYCLIC COMPOUND, METHOD FOR PRODUCING CYCLIC COMPOUND, AND METHOD FOR MODIFYING BIOLOGICAL MOLECULE 有权
    循环化合物，生产环化合物的方法和用于修饰生物分子的方法

    公开(公告)号：US20130011901A1

    公开(公告)日：2013-01-10

    申请号：US13634263

    申请日：2011-03-09

    申请人： Takamitsu Hosoya ,  Isao Kii ,  Suguru Yoshida ,  Takeshi Matsushita

    发明人： Takamitsu Hosoya ,  Isao Kii ,  Suguru Yoshida ,  Takeshi Matsushita

    IPC分类号： C07D487/04 ,  C12N5/071 ,  C12N9/96

    CPC分类号： C07D487/04 ,  C07D249/04 ,  C07K1/1077

    摘要： The invention aims in establishing a method for modifying biomolecules using a reaction that efficiently modifies biomolecules and is widely applicable. The invention thus provides a cyclic compound containing two triazole rings formed by adding and ligating an azide compound possessing an azido group to each of the two carbon-carbon triple bond sites of an eight-membered cyclic skeleton of a cyclic diyne compound by a double click reaction; a method for producing a cyclic compound using a double click reaction; and a method for modifying biomolecules.

    摘要翻译： 本发明旨在建立一种使用有效修饰生物分子的反应来修饰生物分子的方法，并且是广泛适用的。 因此，本发明提供一种环状化合物，其包含通过双键加成并连接具有叠氮基的叠氮化合物与环状二炔化合物的八元环骨架的两个碳 - 碳三键位点形成的两个三唑环 反应; 使用双键反应制备环状化合物的方法; 和一种修饰生物分子的方法。