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    Method for detecting artifacts in data
    2.
    发明申请
    Method for detecting artifacts in data 有权
    检测数据中伪像的方法

    公开(公告)号：US20050165316A1

    公开(公告)日：2005-07-28

    申请号：US10763548

    申请日：2004-01-23

    申请人： Michael Lowery ,  Eric Shain ,  Omar Khalil

    发明人： Michael Lowery ,  Eric Shain ,  Omar Khalil

    IPC分类号： A61B5/00 ,  G01N21/35 ,  G01N21/47 ,  G01N21/49 ,  G01N33/487 ,  A61B5/02 ,  A61B5/103 ,  A61B5/117 ,  A61B6/00

    CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/7207 ,  G01N21/49

    摘要： A method for identifying artifacts occurring during a measurement of the concentration of an analyte in a biological sample by means of an apparatus that employs temperature-controlled optical probes, introduces electromagnetic radiation into tissue, and collects and detects radiation emitted at a distance from the point at which the electromagnetic radiation is introduced. The values of intensity of radiation emitted at different wavelengths, at different distances between the light introduction site(s) and the light collection site(s), and at different temperatures are collected and used in the method to generate a relationship between these values and the concentration of an analyte in the tissue or the disease state of a patient. The method involves the use of an algorithm that identifies artifacts in the data resulting from motion of the patient and allows the rejection of data sets that contain these artifacts. The algorithm identifies sudden changes in the magnitude and direction in a sequence of collected signals.

    摘要翻译： 一种用于识别通过使用温度控制的光学探针的装置测量生物样品中的分析物的浓度而发生的伪影的方法，将电磁辐射引入组织中，并且收集并检测距离该点 电磁辐射被引入。 收集在不同波长下，在光引入部位与光采集部位之间的不同距离以及不同温度下发射的辐射强度值，并用于该方法中以产生这些值与 组织中分析物的浓度或患者的疾病状态。 该方法涉及使用识别由患者运动产生的数据中的伪影的算法，并允许拒绝包含这些伪像的数据集。 该算法识别收集信号序列中的幅度和方向的突变。

    Multi-mechanistic accommodating intraocular lenses
    3.
    发明授权
    Multi-mechanistic accommodating intraocular lenses 有权
    多机能适应人工晶状体

    公开(公告)号：US07150759B2

    公开(公告)日：2006-12-19

    申请号：US10661410

    申请日：2003-09-12

    申请人： Marlene L. Paul ,  Daniel G. Brady ,  Michael Lowery

    发明人： Marlene L. Paul ,  Daniel G. Brady ,  Michael Lowery

    IPC分类号： A61F2/16

    CPC分类号： A61F2/1613 ,  A61F2/1629 ,  A61F2/1635 ,  A61F2/1694 ,  A61F2002/1682 ,  A61F2002/169 ,  A61F2002/16901

    摘要： An intraocular lens (IOL) includes an optic for focusing light and an accommodation assembly for axially moving and/or deforming the optic in response to naturally occurring actions of the eye, thus allowing a patient to more effectively focus on near objects. In addition, the optic may be multifocal or aspheric, wherein the maximum add power of the lens is combined with the increase in diopter power obtained through axial movement and/or deformation of the optic, resulting in enhanced accommodation.

    摘要翻译： 眼内透镜（IOL）包括用于聚焦光的光学元件和用于响应于眼睛的自然发生的动作而轴向地移动和/或变形光学元件的容纳组件，从而允许患者更有效地将焦点集中在近物体上。 此外，光学元件可以是多焦点或非球面，其中透镜的最大附加功率与通过光学元件的轴向移动和/或变形获得的屈光度功率的增加相结合，导致增强的调节。

    Lens surface enhancement
    4.
    发明申请
    Lens surface enhancement 审中-公开
    镜片表面增强

    公开(公告)号：US20070197681A1

    公开(公告)日：2007-08-23

    申请号：US11360237

    申请日：2006-02-22

    申请人： Michael Lowery ,  Laurent Hoffmann

    发明人： Michael Lowery ,  Laurent Hoffmann

    IPC分类号： A61F2/16

    CPC分类号： A61L27/50 ,  A61F2/16 ,  A61L27/34 ,  A61L2430/16 ,  C08L71/02

    摘要： An intraocular lens with a hydrophilic polymer coating composition and methods for using same are provided. Specifically, a composition suitable for reducing tackiness in intraocular lens is provided wherein an acrylic intraocular lens is treated by vapor deposition with an alkoxy silyl terminated polyethylene glycol polymer composition. Methods for making an intraocular lens with a hydrophilic polymer coating are also provided.

    摘要翻译： 提供具有亲水性聚合物涂层组合物的人工晶状体及其使用方法。 具体地说，提供一种适用于降低人工晶状体粘合性的组合物，其中丙烯酸类眼内透镜通过气相沉积用烷氧基甲硅烷基封端的聚乙二醇聚合物组合物进行处理。 还提供了制备具有亲水性聚合物涂层的眼内透镜的方法。

    Biocompatible polymeric compositions for use in making anterior chamber intraocular lenses
    5.
    发明申请
    Biocompatible polymeric compositions for use in making anterior chamber intraocular lenses 有权
    用于制造前房人工晶状体的生物相容性聚合物组合物

    公开(公告)号：US20060004163A1

    公开(公告)日：2006-01-05

    申请号：US11219021

    申请日：2005-09-01

    申请人： Harish Makker ,  Michael Lowery ,  Can Hu

    发明人： Harish Makker ,  Michael Lowery ,  Can Hu

    IPC分类号： A61F2/14

    CPC分类号： A61L27/26 ,  A61L2430/16 ,  C08F220/18

    摘要： Biocompatible polymers useful for making anterior chamber intraocular lenses (AC-IOL) are provided. The biocompatible polymers are generally composed of one or more acrylate monomers, crosslinked with at least one diacrylate ester and may include one or more additional components such as ultraviolet light and/or blue-violate light absorbing dyes. The AC-IOLs made using the biocompatible polymers disclosed herein are suitable for placement in phakic or aphakic eyes and are intended for refractive correction including myopia, hyperopia, presbyopia and astigmatisms.

    摘要翻译： 提供了可用于制备前房人工晶状体（AC-IOL）的生物相容性聚合物。 生物相容性聚合物通常由一种或多种丙烯酸酯单体组成，与至少一种二丙烯酸酯交联，并且可以包括一种或多种另外的组分，例如紫外线和/或蓝色的光吸收染料。 使用本文公开的生物相容性聚合物制备的AC-IOL适于放置在晶状体或无晶状体眼睛中，并且用于屈光矫正，包括近视，远视，老花眼和散光。

    WHEEL POLISHING DEVICE
    6.
    发明申请
    WHEEL POLISHING DEVICE 有权

    公开(公告)号：US20220371148A1

    公开(公告)日：2022-11-24

    申请号：US17749490

    申请日：2022-05-20

    申请人： Todd Kaptein ,  Michael Lowery

    发明人： Todd Kaptein ,  Michael Lowery

    IPC分类号： B24B29/02 ,  B24B41/06

    摘要： A wheel polishing device is provided and configured to be used with a polishing stand. The device includes a base plate defining a plurality of tracks and a plurality of peg members. Each of the plurality of peg members configured to slidably engage a least one of the plurality of tracks defined by the plate. A peg expanding hub is configured to expand into the plurality of peg members when a nut is tightened on a center screw that passes through the peg expanding hub.

    MULTI-MECHANISTIC ACCOMMODATING INTRAOCULAR LENSES
    7.
    发明申请
    MULTI-MECHANISTIC ACCOMMODATING INTRAOCULAR LENSES 审中-公开
    多机械摄影内窥镜

    公开(公告)号：US20070043437A1

    公开(公告)日：2007-02-22

    申请号：US11551636

    申请日：2006-10-20

    申请人： Marlene Paul ,  Daniel Brady ,  Michael Lowery

    发明人： Marlene Paul ,  Daniel Brady ,  Michael Lowery

    IPC分类号： A61F2/16

    CPC分类号： A61F2/1613 ,  A61F2/1629 ,  A61F2/1635 ,  A61F2/1694 ,  A61F2002/1682 ,  A61F2002/169 ,  A61F2002/16901

    摘要： An intraocular lens (IOL) includes an optic for focusing light and an accommodation assembly for axially moving and/or deforming the optic in response to naturally occurring actions of the eye, thus allowing a patient to more effectively focus on near objects. In addition, the optic may be multifocal or aspheric, wherein the maximum add power of the lens is combined with the increase in diopter power obtained through axial movement and/or deformation of the optic, resulting in enhanced accommodation.

    摘要翻译： 眼内透镜（IOL）包括用于聚焦光的光学元件和用于响应于眼睛的自然发生的动作而轴向地移动和/或变形光学元件的容纳组件，从而允许患者更有效地将焦点集中在近物体上。 此外，光学元件可以是多焦点或非球面，其中透镜的最大附加功率与通过光学元件的轴向移动和/或变形获得的屈光度功率的增加相结合，导致增强的调节。

    Intraocular lens insertion plunger with low stimulus soft tip
    8.
    发明申请
    Intraocular lens insertion plunger with low stimulus soft tip 审中-公开
    眼内透镜插入柱塞，低刺激软尖

    公开(公告)号：US20070005135A1

    公开(公告)日：2007-01-04

    申请号：US11173337

    申请日：2005-07-01

    申请人： Harish Makker ,  Can Hu ,  Michael Lowery

    发明人： Harish Makker ,  Can Hu ,  Michael Lowery

    IPC分类号： A61F2/16

    CPC分类号： A61F2/1678 ,  A61F2/167

    摘要： An intraocular lens (IOL) insertion apparatus for implanting IOLs through smaller incisions. The insertion apparatus includes an insertion cartridge that receives the IOL and cooperates with a handpiece. The cartridge includes a longitudinal lumen from a loading chamber to an open distal mouth that gradually narrows in dimension. A push rod having an extremely soft tip thereon urges the IOL through the cartridge and from the open distal mouth. The soft tip is made of low-stimulus material having a minimum ultimate elongation of 400%. Because of the extremely soft material of the tip, the outside diameter of the open distal mouth can be reduced to no more than 2.0 mm, enabling passage through incisions of 2.2 mm or less. The soft tip may be a thermoplastic elastomer having a relatively high elongation and relatively low modulus at elongations of 100-300%.

    摘要翻译： 一种用于通过较小切口植入IOL的人工晶状体（IOL）插入装置。 插入装置包括容纳IOL并与手持件配合的插入盒。 药筒包括从装载室到开口的远端口的纵向腔，其逐渐变窄。 具有非常软的尖端的推杆通过药筒和从开放的远端口引导IOL。 软尖端由具有最小极限伸长率为400％的低刺激材料制成。 由于尖端的材料非常柔软，所以开放式远端口的外径可以减小到不超过2.0mm，能够穿过2.2mm以下的切口。 软末端可以是在100-300％的伸长率下具有相对高的伸长率和相对低的模量的热塑性弹性体。

    Lubricious, biocompatible coatings for medical devices
    9.
    发明申请
    Lubricious, biocompatible coatings for medical devices 审中-公开
    适用于医疗器械的生物相容性涂层

    公开(公告)号：US20050147735A1

    公开(公告)日：2005-07-07

    申请号：US11021869

    申请日：2004-12-22

    申请人： Michael Lowery ,  Harish Makker ,  Can Hu

    发明人： Michael Lowery ,  Harish Makker ,  Can Hu

    IPC分类号： A61F2/16 ,  A61F9/00 ,  A61L27/34 ,  A61L27/44 ,  A61L29/12 ,  A61L31/10 ,  A61L31/12 ,  B05D3/00

    CPC分类号： A61L27/34 ,  A61F2/1662 ,  A61L31/10 ,  A61L2400/10 ,  C08L39/06

    摘要： A lubricous coating composition and methods for using same are provided. Specifically, a composition suitable for providing hydrophobic polymer surfaces with lubricious coatings is described wherein a polyolefin surface is reiteratively treated with hydrophilic polymer solutions and cross-linking solutions. Methods for reiterative coating polymer surfaces are also provided including methods wherein the hydrophobic polymer surface is pretreated using plasma energy.

    摘要翻译： 提供了一种润滑涂料组合物及其使用方法。 具体而言，描述了适用于提供具有光滑涂层的疏水性聚合物表面的组合物，其中聚合物表面用亲水聚合物溶液和交联溶液反复进行处理。 还提供了重复涂布聚合物表面的方法，包括其中使用等离子体能预处理疏水性聚合物表面的方法。

    Biocompatible polymeric compositions for use in making posterior chamber intraocular lenses
    10.
    发明申请
    Biocompatible polymeric compositions for use in making posterior chamber intraocular lenses 审中-公开
    用于制备后房人工晶状体的生物相容性聚合物组合物

    公开(公告)号：US20060135642A1

    公开(公告)日：2006-06-22

    申请号：US11281085

    申请日：2005-11-17

    申请人： Harish Makker ,  Massoud Ghazizadeh ,  Michael Lowery

    发明人： Harish Makker ,  Massoud Ghazizadeh ,  Michael Lowery

    IPC分类号： A61L24/00 ,  A61F2/16

    CPC分类号： A61L27/14 ,  A61F2/16 ,  A61L27/16 ,  A61L27/26 ,  A61L2430/16 ,  C08F220/18 ,  C08F220/28 ,  C08F222/1006 ,  C08L2312/00 ,  C08L33/08 ,  C08L33/10

    摘要： Biocompatible polymers useful for making intraocular lenses are provided. The biocompatible polymers are generally composed of one or more acrylate monomers, crosslinked with at least one diacrylate ester and may include one or more additional components such as ultraviolet light and/or blue-violet light absorbing dyes. The posterior chamber IOLs made using the biocompatible polymers disclosed herein are suitable for placement in phakic or aphakic eyes and are intended for refractive correction including myopia, hyperopia, presbyopia, astigmatisms and for implantation after removal of the natural crystalline lens as warranted by medical conditions such as cataracts.

    摘要翻译： 提供了可用于制造眼内透镜的生物相容性聚合物。 生物相容性聚合物通常由一种或多种丙烯酸酯单体组成，与至少一种二丙烯酸酯交联，并且可以包括一种或多种另外的组分，例如紫外光和/或蓝紫色光吸收染料。 使用本文公开的生物相容性聚合物制备的后室IOL适合于放置在晶状体或无晶状体眼中，并且用于屈光矫正，包括近视，远视，老花眼，散光，以及在除去天然晶状体之后，由医疗条件 作为白内障。