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    Process for manufacturing an analysis module with accessible electrically conductive contact pads for a microfluidic analytical system
    3.
    发明申请
    Process for manufacturing an analysis module with accessible electrically conductive contact pads for a microfluidic analytical system 审中-公开
    用于制造具有用于微流体分析系统的可触及导电接触垫的分析模块的方法

    公开(公告)号：US20060065361A1

    公开(公告)日：2006-03-30

    申请号：US10957440

    申请日：2004-09-30

    申请人： Matthias Stiene ,  Tanja Richter ,  James Rodgers ,  Margaret MacLennan ,  James Moffat ,  Alan McNeilage

    发明人： Matthias Stiene ,  Tanja Richter ,  James Rodgers ,  Margaret MacLennan ,  James Moffat ,  Alan McNeilage

    IPC分类号： B32B37/00

    CPC分类号： B01L3/502715 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/0887 ,  G01N33/48785 ,  H05K1/0272 ,  H05K1/117 ,  H05K3/20

    摘要： A method for manufacturing an analysis module with accessible electrically conductive contact pads includes forming an insulating substrate with an upper surface, a microchannel(s) within the upper surface, and electrically conductive contact pad(s) disposed on the upper surface. The method also includes producing a laminate layer with a bottom surface, electrode(s) on the laminate layer bottom surface, and electrically conductive trace(s) on the laminate layer bottom surface. The method further includes adhering the laminate layer to the insulating substrate such that a portion of the bottom surface of the laminate layer is adhered to a portion of the upper surface of the insulating substrate, each electrode is exposed to at least one microchannel; and each electrically conductive trace is electrically contacted to at least one electrically conductive contact pad. Furthermore, the adhering is such that at least one surface of the electrically conductive contact pad remains exposed and accessible for electrical connection.

    摘要翻译： 用于制造具有可触及的导电接触焊盘的分析模块的方法包括：形成具有上表面的绝缘衬底，上表面内的微通道和设置在上表面上的导电接触焊盘。 该方法还包括制备具有底表面的层压层，层压层底表面上的电极以及层压层底表面上的导电迹线。 该方法还包括将层压层粘合到绝缘基板上，使得层压层的底表面的一部分粘附到绝缘基板的上表面的一部分，每个电极暴露于至少一个微通道; 并且每个导电迹线与至少一个导电接触焊盘电接触。 此外，粘合使得导电接触焊盘的至少一个表面保持暴露并且可访问用于电连接。

    Microfluidic analytical system with accessible electrically conductive contact pads
    4.
    发明申请
    Microfluidic analytical system with accessible electrically conductive contact pads 审中-公开
    具有可触及导电接触垫的微流体分析系统

    公开(公告)号：US20060065532A1

    公开(公告)日：2006-03-30

    申请号：US10957505

    申请日：2004-09-30

    申请人： Matthias Stiene ,  Tanja Richter ,  James Rodgers ,  Margaret MacLennan ,  James Moffat ,  Alan McNeilage

    发明人： Matthias Stiene ,  Tanja Richter ,  James Rodgers ,  Margaret MacLennan ,  James Moffat ,  Alan McNeilage

    IPC分类号： B01L3/00 ,  G01N27/447

    CPC分类号： B01L3/502707 ,  B01L3/502715 ,  B01L2200/0689 ,  B01L2300/0645 ,  B01L2300/0825 ,  B01L2300/0887 ,  G01N33/48792

    摘要： A microfluidic analytical system for monitoring an analyte (such as glucose) in a fluid sample (e.g., blood or ISF) includes an analysis module and an electrical device (for example, a meter or power supply). The analysis module includes an insulating substrate and a microchannel(s) within the insulating substrate's upper surface. The analysis module also includes a conductive contact pad(s) disposed on the upper surface of the insulating substrate and an electrode(s), with the electrode(s) being disposed over the microchannel. In addition, the analysis module includes an electrically conductive trace(s) that electrically connects the electrode to at least one electrically conductive contact pad. The analysis module also has a laminate layer disposed over the electrode, the electrically conductive trace, the microchannel and a portion of the upper surface of the insulating substrate. The electrically conductive contact pad of the analysis module has an accessible exposed surface for electrical connection to the electrical device.

    摘要翻译： 用于监测流体样品（例如血液或ISF）中的分析物（例如葡萄糖）的微流体分析系统包括分析模块和电气装置（例如，仪表或电源）。 分析模块包括绝缘基板和绝缘基板的上表面内的微通道。 分析模块还包括设置在绝缘基板的上表面上的导电接触焊盘和电极，其中电极设置在微通道上。 另外，分析模块包括将电极电连接到至少一个导电接触焊盘的导电迹线。 分析模块还具有设置在电极，导电迹线，微通道和绝缘基板的上表面的一部分上的层压层。 分析模块的导电接触焊盘具有可触及的暴露表面，用于电连接到电气设备。

    Device and method for extracting body fluid
    7.
    发明申请
    Device and method for extracting body fluid 审中-公开
    用于提取体液的装置和方法

    公开(公告)号：US20050113739A1

    公开(公告)日：2005-05-26

    申请号：US10718818

    申请日：2003-11-21

    申请人： Matthias Stiene ,  Michael Hilgers ,  Tanja Richter

    发明人： Matthias Stiene ,  Michael Hilgers ,  Tanja Richter

    IPC分类号： A61B5/00 ,  A61B5/145 ,  A61B5/15 ,  A61B5/151 ,  A61B5/157 ,  A61B17/20 ,  A61M1/00

    CPC分类号： A61B5/15117 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150396 ,  A61B5/150511 ,  A61B5/150526 ,  A61B5/15087 ,  A61B5/15107 ,  A61B5/1519

    摘要： A device for extracting bodily fluid (such as an ISF sample) includes a penetration member with a channel (e.g., a hollow needle) and a fluid flow regulator (for example, a narrow-bore cylinder) disposed within the channel. The penetration member is configured for penetrating a target site (such as a dermal tissue target site) and subsequently residing within the target site and extracting a bodily fluid sample therefrom. The fluid flow regulator is adapted to control (e.g., reduce or minimize variation in) bodily fluid flow rate through the penetration member. In addition, the presence of the fluid flow regulator in the channel of the penetration member serves to reduce sensor lag by reducing the dead volume of the penetration member. A method for extracting bodily fluid from a target site includes providing the aforementioned device. Next, the target site is penetrated with the penetration member of the device. Subsequently, bodily fluid is extracted from the target site via the penetration member and the fluid flow regulator of the device.

    摘要翻译： 用于提取体液（例如ISF样品）的装置包括具有通道（例如空心针）的穿透构件和设置在通道内的流体流量调节器（例如，窄孔缸）。 穿透构件被构造成用于穿透靶部位（例如真皮组织靶位点）并随后驻留在靶位点内并从其中提取体液样品。 流体流量调节器适于通过穿透构件控制（例如，减小或最小化）体液流速的变化。 此外，流体流量调节器在穿透构件的通道中的存在用于通过减少穿透构件的死体积来减小传感​​器滞后。 从目标部位提取体液的方法包括提供上述装置。 接下来，目标部位用装置的穿透部件穿透。 随后，通过穿透构件和装置的流体流动调节器从目标部位提取体液。

    Analyte test system for determining the concentration of an analyte in a physiological or aqueous fluid
    8.
    发明授权
    Analyte test system for determining the concentration of an analyte in a physiological or aqueous fluid 失效
    用于测定生理或含水流体中分析物浓度的分析物测试系统

    公开(公告)号：US07901875B2

    公开(公告)日：2011-03-08

    申请号：US11073254

    申请日：2005-03-04

    申请人： Matthias Stiene

    发明人： Matthias Stiene

    IPC分类号： C12Q1/00 ,  G01N15/06 ,  G01N25/08

    CPC分类号： G01N33/526 ,  B01L3/502707 ,  B01L3/502792 ,  B01L2300/0803 ,  B01L2300/0812 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2300/089 ,  B01L2400/0406 ,  G01N33/54366 ,  Y10T156/1039 ,  Y10T156/1051 ,  Y10T156/1052

    摘要： This invention provides a device for determining the concentration of an analyte like glucose, cholesterol, free fatty acids, triglycerides, proteins, ketones, phenylalanine or enzymes, in a physiological or aqueous fluid like blood, serum, plasma, saliva, urine, interstitial and/or intra-cellular fluid, the device having an integrated calibration and quality control system suitable for dry reagent test strips with a very small sample volume of about 0.5 μL based on to a new sample distribution system. The production of the inventive analyte test element involves only a small number of uncomplicated production steps enabling an inexpensive production of the strips.

    摘要翻译： 本发明提供一种用于在诸如血液，血清，血浆，唾液，尿液，间质的生理或水性流体中测定分析物如葡萄糖，胆固醇，游离脂肪酸，甘油三酸酯，蛋白质，酮，苯丙氨酸或酶的浓度的装置， /或细胞内液体，该装置具有集成的校准和质量控制系统，其适用于基于新样品分配系统的具有约0.5μL的非常小的样品体积的干试剂测试条。 本发明的分析物测试元件的生产仅涉及少量不复杂的生产步骤，从而能够廉价地生产条带。

    Coagulation test system
    9.
    发明申请
    Coagulation test system 审中-公开
    凝血试验系统

    公开(公告)号：US20090221011A1

    公开(公告)日：2009-09-03

    申请号：US11990695

    申请日：2005-08-31

    申请人： Matthias Stiene ,  Eurig Wyn Jones ,  Sladjana Nincic ,  Elke Horstkotte

    发明人： Matthias Stiene ,  Eurig Wyn Jones ,  Sladjana Nincic ,  Elke Horstkotte

    IPC分类号： C12Q1/56 ,  G01N33/49 ,  B05D3/00

    CPC分类号： G01N33/4905 ,  B01L3/502715 ,  B01L3/502792 ,  B01L2200/027 ,  B01L2300/0627 ,  B01L2300/0809 ,  B01L2300/0864 ,  B01L2300/089 ,  B01L2300/161

    摘要： A test element for the determination of coagulation in a plasma or whole blood sample having a first surface (2a) and a second surface (4a) in a predetermined distance opposite from each other, said both surfaces being provided with two substantially equivalent patterns forming areas of high and low surface energy which are aligned mostly congruent, whereby the areas of high surface energy create a sample distribution system (6) with at least one detection area (6a), wherein the detection area(s) (6a, 6′a) of the first and second surfaces (2a, 4a) is/are provided with at least one coagulation stimulation reagent. The coagulation test element is provided with an integrated quality control system suitable for dry reagent test strip format with a very small sample volume of about 0.5 μL. The production of the inventive coagulation test element involves only a small number of uncomplicated production steps enabling an inexpensive production of the element.

    摘要翻译： 一种用于确定具有第一表面（2a）和第二表面（4a）的等离子体或全血样品中的凝固的测试元件，所述第一表面（2a）和第二表面（4a）彼此相对于预定距离，所述两个表面设置有两个基本相等的图案形成区域 高表面能和低表面能，其大部分是一致的，由此高表面能的区域产生具有至少一个检测区域（6a）的样品分配系统（6），其中检测区域（6a，6'a ）的第一和第二表面（2a，4a）设置有至少一种凝血刺激试剂。 凝固测试元件提供了一个综合质量控制系统，适用于干试剂测试条格式，样品体积非常小约为0.5微升。 本发明的凝结测试元件的生产仅涉及少量不复杂的生产步骤，从而能够廉价地生产元件。

    Analyte test system using non-enzymatic analyte recognition elements
    10.
    发明申请
    Analyte test system using non-enzymatic analyte recognition elements 审中-公开
    使用非酶分析物识别元素的分析物测试系统

    公开(公告)号：US20100035245A1

    公开(公告)日：2010-02-11

    申请号：US11990701

    申请日：2005-08-31

    申请人： Matthias Stiene ,  Elke Horstkotte ,  Dirk Kuhlmeier ,  Eurig Wyn Jones

    发明人： Matthias Stiene ,  Elke Horstkotte ,  Dirk Kuhlmeier ,  Eurig Wyn Jones

    IPC分类号： C12Q1/68 ,  C12M1/34 ,  G01N33/53

    CPC分类号： C12Q1/6834 ,  B01L3/502707 ,  B01L3/502761 ,  B01L3/502792 ,  B01L2200/0684 ,  B01L2300/0816 ,  B01L2300/0825 ,  B01L2300/0864 ,  B01L2300/0887 ,  B01L2300/089 ,  B01L2400/0406 ,  B82Y5/00 ,  G01N21/8483 ,  G01N33/526 ,  G01N33/54386 ,  G01N33/54393

    摘要： An analyte test element for the qualitative and/or quantitative determination of at least one analyte in a physiological or aqueous sample fluid having a first surface (2a) and a second surface (4a) in a predetermined distance opposite from each other, said both surfaces are provided with two substantially equivalent patterns forming areas of high and low surface energy which are aligned mostly congruent, whereby the areas of high surface energy (6, 6′) create a sample distribution system with at least two detection areas (6a, 6′a), said at least one of the detection areas (6a, 6′a) of the first and second surfaces (2a, 4a) is provided with at least one non-enzymatic recognition element (32). The analyte test element is suitable for analyte test systems evaluating the affinity reaction between an analyte of interest and a recognition element and therefore provides a suitable test system to perform immunoassays, receptor-assays, or other affinity assays with a simple test element containing qualitative or quantitative calibration mechanisms suitable for point of care and home settings.

    摘要翻译： 一种分析物测试元件，用于定性和/或定量测定具有第一表面（2a）和第二表面（4a）的生理或水性样品流体中至少一种分析物彼此相对的预定距离，所述两个表面 具有两个基本上等效的图案，其形成高度和低表面能的区域，其大体上等同排列，由此高表面能（6,6'）的区域产生具有至少两个检测区域（6a，6'）的样品分布系统， 所述第一和第二表面（2a，4a）的所述检测区域（6a，6'a）中的至少一个设置有至少一个非酶识别元件（32）。 分析物测试元件适用于分析物测试系统，用于评估感兴趣分析物与识别元件之间的亲和力反应，因此提供合适的测试系​​统，以进行免疫测定，受体测定或其他亲和力测定，其中包含定性或 定量校准机制适用于护理点和家庭设置。