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13 条记录 (耗时 0.032 秒)

    Three dimensional micro-environments and methods of making and using same
    1.
    发明申请
    Three dimensional micro-environments and methods of making and using same 审中-公开
    三维微环境及其使用方法

    公开(公告)号：US20070003595A1

    公开(公告)日：2007-01-04

    申请号：US11407002

    申请日：2006-04-19

    申请人： Shaopeng Wang ,  Nicholas Kotov ,  Jun Zhang

    发明人： Shaopeng Wang ,  Nicholas Kotov ,  Jun Zhang

    IPC分类号： C12M3/00 ,  A61K35/12 ,  A61F2/02

    CPC分类号： C12N5/0068 ,  A61K38/00 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/258 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2300/602 ,  C12M25/14 ,  C12N2533/30

    摘要： The presently claimed and disclosed invention relates, in general, to three dimensional micro-environments and, in particular, to three dimensional (“3D”) micro-environments found in inverted-opal scaffolds made from hydrogel therein for controlled release of nutrients. Specifically, the scaffolds have exceptionally ordered, three-dimensional organization that provides excellent porosity, permeability, and transportation properties can that are especially well suited for use as a nutrient carrier in the emerging technologies of drug delivery and cell culture. Methods for incorporation of or to control the release of nutrients and other substances from such scaffold materials are also herein disclosed and claimed.

    摘要翻译： 本发明要求和公开的发明一般涉及三维微环境，特别涉及在其中由其中的水凝胶制成的倒置蛋白石支架中发现的三维（“3D”）微环境，以控制营养物质的释放。 具体来说，支架具有非常有序的，提供优异的孔隙率，渗透性和运输性质的三维组织，特别适合用作药物递送和细胞培养的新兴技术中的营养载体。 还公开并要求保护并结合或控制营养物质和其他物质从这种支架材料释放的方法。

    Materials containing multiple layers of vesicles
    2.
    发明授权
    Materials containing multiple layers of vesicles 有权
    含有多层囊泡的材料

    公开(公告)号：US07901706B2

    公开(公告)日：2011-03-08

    申请号：US11981208

    申请日：2007-10-31

    申请人： John Martin Lally ,  Nicholas Kotov

    发明人： John Martin Lally ,  Nicholas Kotov

    IPC分类号： A61K9/00 ,  A61K9/127

    CPC分类号： G02B1/043 ,  A61K9/127

    摘要： The present invention provides a composite material, preferably an ophthalmic device, more preferably a contact lens, which comprises a vesicle-containing coating including at least one layer of a vesicle and one layer of a polyionic material having charges opposite the charges of the vesicle. Such composite material can find use in biomedical applications, for example, a device for localized drug delivery and an in vivo analyte sensor such as glucose sensing contact lens. By lifting off the vesicle-containing coating from a substrate, a self-standing membrane (film) capable of encapsulating a wide variety of guest materials can be prepared. In addition, the invention provides methods for making vesicle-containing composite and film materials of the present invention.

    摘要翻译： 本发明提供一种复合材料，优选眼科装置，更优选隐形眼镜，其包括含囊泡的涂层，其包含至少一层囊泡和一层具有与囊泡的电荷相反的电荷的聚离子材料。 这种复合材料可用于生物医学应用，例如用于局部药物递送的装置和体内分析物传感器，例如葡萄糖感测隐形眼镜。 通过从基材上取出含囊泡的涂层，可以制备能够包封各种客体材料的自立膜（膜）。 另外，本发明提供了制造本发明的含囊泡复合材料和薄膜材料的方法。

    Layer-by-layer assemblies having preferential alignment of deposited axially anisotropic species and methods for preparation and use thereof
    3.
    发明申请
    Layer-by-layer assemblies having preferential alignment of deposited axially anisotropic species and methods for preparation and use thereof 审中-公开
    层叠组件具有沉积的轴向各向异性物质的优先排列及其制备和使用方法

    公开(公告)号：US20100098902A1

    公开(公告)日：2010-04-22

    申请号：US11514053

    申请日：2006-08-31

    申请人： Nicholas Kotov ,  Bong Sup Shim ,  Paul Podsiadlo

    发明人： Nicholas Kotov ,  Bong Sup Shim ,  Paul Podsiadlo

    IPC分类号： B32B5/12 ,  B05D1/38

    CPC分类号： B05D7/54 ,  B05D5/00 ,  B05D2203/30 ,  B05D2203/35 ,  B05D2602/00 ,  Y10T428/24058

    摘要： Methods are provided for making layer-by-layer assemblies that comprise axial geometry nanoparticles. Such methods include forming a first layer on a substrate that comprises an axial nanoparticle, forming a second layer on the substrate that comprises an axial nanoparticle, where the first and second layers are aligned to respective first and second orientations. The disclosure also provides for multilayer materials having a first layer including a first polyelectrolyte and a first axial geometry nanoparticle which is substantially aligned along a first orientation. The multilayer material also includes a second layer including a second polyelectrolyte and a second axial geometry nanoparticle species having axial geometry, where the second nanoparticle species is substantially aligned along a second orientation which is distinct from the first orientation.

    摘要翻译： 提供了用于制造包含轴向几何形状纳米颗粒的逐层组件的方法。 这样的方法包括在包括轴向纳米颗粒的基底上形成第一层，在包括轴向纳米颗粒的基底上形成第二层，其中第一层和第二层与相应的第一和第二取向对准。 本公开还提供了具有包括第一聚电解质和第一轴向几何形状纳米颗粒的第一层的多层材料，其基本上沿着第一取向对齐。 多层材料还包括第二层，其包括第二聚电解质和具有轴向几何形状的第二轴向几何形状纳米颗粒物质，其中第二纳米颗粒物质沿着与第一取向不同的第二取向基本对准。

    Assembly of free-standing films using a layer-by-layer process
    6.
    发明申请
    Assembly of free-standing films using a layer-by-layer process 审中-公开
    使用逐层过程组装独立电影

    公开(公告)号：US20070023957A1

    公开(公告)日：2007-02-01

    申请号：US11342725

    申请日：2006-01-30

    申请人： Nicholas Kotov ,  Arif Mamedov

    发明人： Nicholas Kotov ,  Arif Mamedov

    IPC分类号： B28B7/22

    CPC分类号： B82Y30/00 ,  B01D67/0069 ,  B01D69/12 ,  B01D69/122 ,  B01D69/141 ,  B01D71/02 ,  B01D2325/04 ,  B01D2325/14 ,  B01D2325/16 ,  B05D1/185 ,  B05D7/56 ,  B29C41/14 ,  B29C41/22 ,  B29D7/01 ,  B82Y40/00 ,  C08J5/18

    摘要： A method for the layer-by-layer assembly of a free standing thin film includes the steps of preparing a support with a suitable substrate; forming a thin film having a plurality of layers onto the substrate utilizing a layer-by-layer assembly process; removing the substrate and thin film from the support; and separating the substrate from the thin film. Various compounds improving the strength, flexibility, tension and other mechanical properties may be included in the assembly to improve the structural quality of the film. Similar effect may also be achieved by cross-linking the applied layers.

    摘要翻译： 独立式薄膜的逐层组装方法包括以下步骤：用合适的基材制备载体; 利用逐层组装工艺在基板上形成具有多个层的薄膜; 从支撑体上去除基底和薄膜; 并将基板与薄膜分离。 可以在组件中包括提高强度，柔性，张力和其它机械性能的各种化合物，以改善膜的结构质量。 也可以通过交联所施加的层来实现类似的效果。

    ROLLING CONTACT LAYER-BY-LAYER ASSEMBLY
    7.
    发明申请
    ROLLING CONTACT LAYER-BY-LAYER ASSEMBLY 有权
    滚动接触层 - 层组件

    公开(公告)号：US20100189913A1

    公开(公告)日：2010-07-29

    申请号：US12630822

    申请日：2009-12-03

    申请人： Nicholas Kotov ,  Javier Canavati Leal ,  Justin Lefevre ,  Neil H. Patel ,  Brett M. Perry ,  Anastasios J. Hart

    发明人： Nicholas Kotov ,  Javier Canavati Leal ,  Justin Lefevre ,  Neil H. Patel ,  Brett M. Perry ,  Anastasios J. Hart

    IPC分类号： B05D1/36 ,  B05D1/28 ,  B05D3/02 ,  B05D3/00 ,  B05C1/08 ,  B05C9/12

    CPC分类号： B05C1/022 ,  B05C1/10 ,  B05D1/002 ,  B05D1/283 ,  B05D7/52 ,  B05D7/56 ,  B82Y30/00 ,  B82Y40/00

    摘要： A rolling contact layer-by-layer assembly device comprises at least one roller, a cylinder substrate and a motor to rotate the cylinder substrate. The assembly device optionally includes at least one rinsing nozzle and air applicator. The rollers each provide a polyelectrolyte solution to the surface of the cylinder substrate, the polyelectrolyte solutions having an affinity for each other. Excess polyelectrolyte solution can be washed using the rinsing nozzle followed by a drying step prior to the application of the second polyelectrolyte solution. A plurality of bilayers is produced by the continuous application of polyelectrolyte solutions to form an LBL article such as a nano-composite article or film. The film is then removed from the surface of the cylinder substrate.

    摘要翻译： 滚动接触层逐层组装装置包括至少一个辊，气缸基板和马达以旋转气缸基板。 组装装置可选地包括至少一个冲洗喷嘴和空气喷射器。 辊子各自提供聚电解质溶液到圆筒基材的表面，聚电解质溶液彼此具有亲和力。 可以使用漂洗喷嘴洗涤过量的聚电解质溶液，然后在施加第二聚电解质溶液之前进行干燥步骤。 通过连续施加聚电解质溶液以形成诸如纳米复合制品或膜的LBL制品来制备多个双层。 然后从圆筒基材的表面除去薄膜。

    Materials containing multiple layers of vesicles
    9.
    发明授权
    Materials containing multiple layers of vesicles 有权

    公开(公告)号：US07329415B2

    公开(公告)日：2008-02-12

    申请号：US10387190

    申请日：2003-03-12

    申请人： John Martin Lally ,  Nicholas Kotov

    发明人： John Martin Lally ,  Nicholas Kotov

    IPC分类号： A61K9/00 ,  A61K424/45

    CPC分类号： G02B1/043 ,  A61K9/127

    摘要： The present invention provides a composite material, preferably an ophthalmic device, more preferably a contact lens, which comprises a vesicle-containing coating including at least one layer of a vesicle and one layer of a polyionic material having charges opposite the charges of the vesicle. Such composite material can find use in biomedical applications, for example, a device for localized drug delivery and an in vivo analyte sensor such as glucose sensing contact lens. By lifting off the vesicle-containing coating from a substrate, a self-standing membrane (film) capable of encapsulating a wide variety of guest materials can be prepared. In addition, the invention provides methods for making vesicle-containing composite and film materials of the present invention.