公开(公告)号：US20160166634A1

公开(公告)日：2016-06-16

申请号：US15053316

申请日：2016-02-25

申请人： Shari Lynn CAPLAN ,  Andrei GOLOSOV ,  Philipp GROSCHE ,  Carla GUIMARAES ,  Aaron KANTER ,  Changgang LOU ,  David Thomas PARKER ,  Eric C. Peters ,  Aimee Richardson USERA ,  Kayo YASOSHIMA ,  Jun YUAN ,  Federic ZECRI ,  Hongjuan ZHAO

发明人： Shari Lynn CAPLAN ,  Andrei GOLOSOV ,  Philipp GROSCHE ,  Carla GUIMARAES ,  Aaron KANTER ,  Changgang LOU ,  David Thomas PARKER ,  Eric C. Peters ,  Aimee Richardson USERA ,  Kayo YASOSHIMA ,  Jun YUAN ,  Federic ZECRI ,  Hongjuan ZHAO

IPC分类号： A61K38/10 ,  A61K45/06 ,  C07K16/00 ,  C07K7/08 ,  C07K14/765 ,  A61K47/48

CPC分类号： A61K38/10 ,  A61K38/00 ,  A61K45/06 ,  A61K47/542 ,  A61K47/643 ,  A61K47/68 ,  A61K47/6811 ,  C07K14/47 ,  C07K14/765 ,  C07K2319/30 ,  C07K2319/31

摘要： The invention provides a bioconjugates comprising a synthetic polypeptide of Formula I′ (SEQ ID NO: 1): or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are defined herein and a half-life extending moiety wherein the peptide and the half-life extending moiety are covalently linked or fuse, optionally via a linker. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the bioconjugates of the invention, and its therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US07111115B2

公开(公告)日：2006-09-19

申请号：US10883387

申请日：2004-07-01

申请人： Eric C. Peters ,  Stanley Rabinowitz ,  Herbert R. Jacobs

发明人： Eric C. Peters ,  Stanley Rabinowitz ,  Herbert R. Jacobs

IPC分类号： G06F12/06

CPC分类号： H04L67/1097 ,  G06F11/1076 ,  G06F11/1662 ,  G06F11/2094 ,  G06F11/2097 ,  G06F17/30194 ,  G06F17/30212 ,  G06F17/30215 ,  G06F17/30781 ,  G06F2211/1028 ,  H04L65/4084 ,  H04L67/1002 ,  H04L67/1029 ,  H04L67/16 ,  H04L67/42 ,  H04N7/17336 ,  H04N21/2182 ,  H04N21/23103 ,  H04N21/23116 ,  H04N21/2312 ,  H04N21/2315 ,  H04N21/232 ,  H04N21/2393 ,  H04N21/2396 ,  H04N21/2405 ,  H04N21/241 ,  H04N21/262 ,  H04N21/44004 ,  H04N21/442 ,  H04N21/47202 ,  H04N21/8456 ,  Y10S707/99953 ,  Y10S707/99956

摘要： Multiple applications request data from multiple storage units over a computer network. The data is divided into segments and each segment is distributed randomly on one of several storage units, independent of the storage units on which other segments of the media data are stored. At least one additional copy of each segment also is distributed randomly over the storage units, such that each segment is stored on at least two storage units. This random distribution of multiple copies of segments of data improves both scalability and reliability. When an application requests a selected segment of data, the request is processed by the storage unit with the shortest queue of requests. Random fluctuations in the load applied by multiple applications on multiple storage units are balanced nearly equally over all of the storage units. This combination of techniques results in a system which can transfer multiple, independent high-bandwidth streams of data in a scalable manner in both directions between multiple applications and multiple storage units.

公开(公告)号：US06901211B2

公开(公告)日：2005-05-31

申请号：US10440767

申请日：2003-05-19

申请人： Eric C. Peters ,  John J. Walsh

发明人： Eric C. Peters ,  John J. Walsh

IPC分类号： G11B27/034 ,  G11B27/10 ,  G11B27/32 ,  H04N5/91 ,  H04N5/781

CPC分类号： H04N5/2228 ,  G11B27/034 ,  G11B27/105 ,  G11B27/329 ,  G11B2220/20 ,  G11B2220/61 ,  H04N5/91

摘要： The invention disclosed herein is a media recorder for recording live and prerecorded analog audio and/or video information. It is capable of receiving, digitizing, and storing analog audio and/or video information in real time. The invention detects discontinuities in the reception of the analog information and automatically terminates the storage of the information, so the previously received audio and/or video information is stored as a self-contained clip of digitized information. The invention is also capable of receiving and storing digital audio and/or video information from other sources, so that the system can play both the digital audio and/or video information digitized by it and that received from the other sources. This allows both the newly recorded and previously recorded media segments to be evaluated both individually and in context with other segments.

公开(公告)号：US06618547B1

公开(公告)日：2003-09-09

申请号：US09304932

申请日：1999-05-04

申请人： Eric C. Peters ,  Patrick D. O'Connor ,  Michael E. Phillips

发明人： Eric C. Peters ,  Patrick D. O'Connor ,  Michael E. Phillips

IPC分类号： H04N576

CPC分类号： G11B27/031 ,  G11B27/028 ,  G11B27/032 ,  G11B27/034 ,  G11B27/06 ,  G11B27/10 ,  G11B27/34 ,  G11B2220/2562 ,  G11B2220/90 ,  H04N7/0112

摘要： A system for generating a digital representation of a video signal comprised of a sequence of video frames which each include two video fields of a duration such that the video plays at a first prespecified rate of frames per second. The sequence of video frames includes a prespecified number of redundant video fields. Redundant video fields in the video frame sequence are identified by a video processor, and the video frame sequence is digitized by an analog to digital convertor, excluding the identified redundant video fields. The digitized video frames are then compressed by a video compressor to generate a digital representation of the video signal which plays at a second prespecified rate of frames per second.

摘要翻译： 一种用于产生由视频帧序列组成的视频信号的数字表示的系统，每个视频帧包括持续时间的两个视频场，使得视频以每秒的帧的首个预定速率播放。 视频帧的序列包括预定数量的冗余视频字段。 视频帧序列中的冗余视频字段由视频处理器识别，视频帧序列由模数转换器数字化，不包括识别的冗余视频字段。 数字化的视频帧然后被视频压缩器压缩以产生以秒/秒的第二预定速率播放的视频信号的数字表示。

公开(公告)号：US06415373B1

公开(公告)日：2002-07-02

申请号：US09006070

申请日：1998-01-12

申请人： Eric C. Peters ,  Stanley Rabinowitz ,  Herbert R. Jacobs ,  Peter J. Fasciano

发明人： Eric C. Peters ,  Stanley Rabinowitz ,  Herbert R. Jacobs ,  Peter J. Fasciano

IPC分类号： G06F1200

CPC分类号： G06F17/30781 ,  G06F11/1076 ,  G06F11/1662 ,  G06F11/2094 ,  G06F11/2097 ,  G06F17/30212 ,  G06F2211/1028 ,  H04L65/4084 ,  H04L67/1095 ,  H04L67/1097 ,  H04L69/40 ,  H04N7/17336 ,  H04N21/2182 ,  H04N21/23103 ,  H04N21/23116 ,  H04N21/2312 ,  H04N21/2315 ,  H04N21/232 ,  H04N21/2393 ,  H04N21/2396 ,  H04N21/2405 ,  H04N21/241 ,  H04N21/262 ,  H04N21/44004 ,  H04N21/442 ,  H04N21/47202 ,  H04N21/6581 ,  H04N21/8456 ,  Y10S707/99953 ,  Y10S707/99956

摘要： Multiple applications request data from multiple storage units over a computer network. The data is divided into segments and each segment is distributed randomly on one of several storage units, independent of the storage units on which other segments of the media data are stored. At least one additional copy of each segment also is distributed randomly over the storage units, such that each segment is stored on at least two storage units. This random distribution of multiple copies of segments of data improves both scalability and reliability. When an application requests a selected segment of data, the request is processed by the storage unit with the shortest queue of requests. Random fluctuations in the load applied by multiple applications on multiple storage units are balanced nearly equally over all of the storage units. This combination of techniques results in a system which can transfer multiple, independent high-bandwidth streams of data in a scalable manner in both directions between multiple applications and multiple storage units.

摘要翻译： 多个应用程序通过计算机网络从多个存储单元请求数据。 数据被划分成段，并且每个段在几个存储单元中的一个上随机分布，独立于存储媒体数据的其他段的存储单元。 每个段的至少一个附加副本也随机地分布在存储单元上，使得每个段被存储在至少两个存储单元上。 数据段的多个副本的随机分布提高了可扩展性和可靠性。 当应用程序请求所选择的数据段时，请求由具有最短请求队列的存储单元处理。 在多个存储单元上由多个应用程序施加的负载的随机波动在所有存储单元上几乎相等。 这种技术的组合导致一种系统，其可以在多个应用和多个存储单元之间的两个方向上以可扩展的方式传输多个独立的高带宽数据流。

公开(公告)号：US5905841A

公开(公告)日：1999-05-18

申请号：US393886

申请日：1995-02-24

申请人： Eric C. Peters ,  Patrick D. O'Connor ,  Michael E. Phillips

发明人： Eric C. Peters ,  Patrick D. O'Connor ,  Michael E. Phillips

IPC分类号： G11B27/028 ,  G11B27/031 ,  G11B27/032 ,  G11B27/034 ,  G11B27/06 ,  G11B27/10 ,  G11B27/34 ,  H04B7/185 ,  H04N5/76 ,  H04N7/01 ,  H04N7/26

CPC分类号： G11B27/031 ,  G11B27/028 ,  G11B27/034 ,  G11B27/10 ,  G11B27/34 ,  H04N7/0112 ,  G11B2220/2562 ,  G11B2220/90 ,  G11B27/032 ,  G11B27/06

摘要： A system for generating a digital representation of a video signal comprised of a sequence of video frames which each include two video fields of a duration such that the video plays at a first prespecified rate of frames per second. The sequence of video frames includes a prespecified number of redundant video fields. Redundant video fields in the video frame sequence are identified by a video processor, and the video frame sequence is digitized by an analog to digital convertor, excluding the identified redundant video fields. The digitized video frames are then compressed by a video compressor to generate a digital representation of the video signal which plays at a second prespecified rate of frames per second.

公开(公告)号：US5644364A

公开(公告)日：1997-07-01

申请号：US347394

申请日：1995-03-06

申请人： Jeffrey Kurtze ,  Ray Cacciatore ,  Peter Zawojski ,  Eric C. Peters ,  John Walsh, Jr.

发明人： Jeffrey Kurtze ,  Ray Cacciatore ,  Peter Zawojski ,  Eric C. Peters ,  John Walsh, Jr.

IPC分类号： G11B27/031 ,  H04N5/262 ,  H04N5/265 ,  H04N7/26 ,  H04N21/2365 ,  H04N21/434

CPC分类号： H04N19/00 ,  G11B27/031 ,  H04N19/48 ,  H04N19/90 ,  H04N21/2365 ,  H04N21/242 ,  H04N21/431 ,  H04N21/4347 ,  H04N21/44004 ,  H04N21/8153 ,  H04N5/262 ,  H04N5/265

摘要： The invention improves over the prior art by providing a media pipeline with two channels for processing sequences of digital still images. A blender is provided so as to enable simple effects on these two streams of video data such as dissolves, wipes and chroma keys. Complex arbitrary three-dimensional effects and other effects may also be provided using an external interface.Thus, a system for processing sequences of digital still images to provide real-time digital video effects includes first and second channels for communicating first and second sequences of digital still images at a rate for simulating video. A controller directs still images to one of the first and second channels. A blender, having a first input connected to the first channel, a second input connected to the second channel, and an output, provides a combination of the first and second sequences of digital still images at a rate for simulating video.

摘要翻译： PCT No.PCT / US94 / 04253 Sec。 371日期：1995年3月6日 102（e）1995年3月6日PCT PCT 1994年4月18日PCT公布。 出版物WO94 / 24815 日期1994年10月27日本发明通过提供具有用于处理数字静止图像序列的两个通道的媒体管线来改进现有技术。 提供了一种混合器，以便能够对这两个视频数据流（如溶解，擦除和色度键）产生简单的影响。 也可以使用外部接口提供复杂的任意三维效果和其他效果。 因此，用于处理数字静止图像序列以提供实时数字视频效果的系统包括用于以用于模拟视频的速率传送第一和第二数字静止图像序列的第一和第二信道。 控制器将静止图像引导到第一和第二通道之一。 具有连接到第一通道的第一输入端的连接器，连接到第二通道的第二输入端和输出端以用于模拟视频的速率提供第一和第二数字静止图像序列的组合。

公开(公告)号：US5640601A

公开(公告)日：1997-06-17

申请号：US589301

申请日：1996-01-22

申请人： Eric C. Peters

发明人： Eric C. Peters

IPC分类号： G06F5/06 ,  G06F17/30 ,  G06T9/00 ,  G11B27/034 ,  G11B27/28 ,  H03M7/30 ,  H04N5/76 ,  H04N5/85 ,  H04N5/907 ,  H04N5/926 ,  H04N7/24 ,  H04N7/26 ,  H04N7/30 ,  H04N7/32 ,  H04N9/804 ,  H04N19/00 ,  H04N5/14 ,  G06F3/05 ,  G06F3/14

CPC分类号： G06F5/06 ,  G11B27/034 ,  G11B27/28 ,  H04N19/126 ,  H04N19/15 ,  H04N19/152 ,  H04N5/9264 ,  H04N7/24 ,  H04N9/8042 ,  H04N19/124 ,  H04N19/50 ,  H04N19/60 ,  H04N5/85 ,  H04N5/907

摘要： A data buffer that compensates the differences in data rates, between a storage device and an image compression processor. A method and apparatus for the real time indexing of frames in a video data sequence.

摘要翻译： 数据缓冲器，用于补偿存储设备和图像压缩处理器之间的数据速率差异。 一种用于在视频数据序列中实时索引帧的方法和装置。

公开(公告)号：US5451397A

公开(公告)日：1995-09-19

申请号：US994026

申请日：1992-12-21

申请人： Robert L. Albright ,  Eric C. Peters ,  Larry W. Steffier

发明人： Robert L. Albright ,  Eric C. Peters ,  Larry W. Steffier

IPC分类号： A61K31/785 ,  A61K47/30 ,  A61P3/06 ,  A61P43/00 ,  C08F220/60

CPC分类号： A61K31/785 ,  C08F220/60

摘要： A bile acid sequestrant having a crosslinked polymeric matrix and having branches supported on the polymeric matrix and providing bonding sites for binding bile acid conjugates to the sequestrant, pharmaceutical compositions containing the sequestrant for treatment of elevated plasma cholesterol level are described.

摘要翻译： 一种胆汁酸螯合剂，其具有交联的聚合物基质并且具有支撑在聚合物基质上的分支，并提供了将胆汁酸结合物结合至螯合剂的结合位点，含有治疗升高的血浆胆固醇水平的螯合剂的药物组合物被描述。

公开(公告)号：US20080147678A1

公开(公告)日：2008-06-19

申请号：US11986226

申请日：2007-11-20

申请人： Eric C. Peters ,  Stanley Rabinowitz ,  Herbert R. Jacobs ,  Peter J. Fasciano

发明人： Eric C. Peters ,  Stanley Rabinowitz ,  Herbert R. Jacobs ,  Peter J. Fasciano

IPC分类号： G06F17/30

CPC分类号： H04L67/1097 ,  G06F11/1076 ,  G06F11/1662 ,  G06F11/2094 ,  G06F11/2097 ,  G06F17/30194 ,  G06F17/30212 ,  G06F17/30215 ,  G06F17/30781 ,  G06F2211/1028 ,  H04L65/4084 ,  H04L67/1002 ,  H04L67/1029 ,  H04L67/16 ,  H04L67/42 ,  H04N7/17336 ,  H04N21/2182 ,  H04N21/23103 ,  H04N21/23116 ,  H04N21/2312 ,  H04N21/2315 ,  H04N21/232 ,  H04N21/2393 ,  H04N21/2396 ,  H04N21/2405 ,  H04N21/241 ,  H04N21/262 ,  H04N21/44004 ,  H04N21/442 ,  H04N21/47202 ,  H04N21/8456 ,  Y10S707/99953 ,  Y10S707/99956

摘要： Multiple applications request data from multiple storage units over a computer network. The data is divided into segments and each segment is distributed randomly on one of several storage units, independent of the storage units on which other segments of the media data are stored. At least one additional copy of each segment also is distributed randomly over the storage units, such that each segment is stored on at least two storage units. This random distribution of multiple copies of segments of data improves both scalability and reliability. When an application requests a selected segment of data, the request is processed by the storage unit with the shortest queue of requests. Random fluctuations in the load applied by multiple applications on multiple storage units are balanced nearly equally over all of the storage units. This combination of techniques results in a system which can transfer multiple, independent high-bandwidth streams of data in a scalable manner in both directions between multiple applications and multiple storage units.

摘要翻译： 多个应用程序通过计算机网络从多个存储单元请求数据。 数据被划分成段，并且每个段在几个存储单元中的一个上随机分布，独立于存储媒体数据的其他段的存储单元。 每个段的至少一个附加副本也随机地分布在存储单元上，使得每个段被存储在至少两个存储单元上。 数据段的多个副本的随机分布提高了可扩展性和可靠性。 当应用程序请求所选择的数据段时，请求由具有最短请求队列的存储单元处理。 在多个存储单元上由多个应用程序施加的负载的随机波动在所有存储单元上几乎相等。 这种技术的组合导致一种系统，其可以在多个应用和多个存储单元之间的两个方向上以可扩展的方式传输多个独立的高带宽数据流。