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    CELL SHEET TRANSPLANTATION DEVICE AND METHOD FOR USING THE SAME
    5.
    发明申请
    CELL SHEET TRANSPLANTATION DEVICE AND METHOD FOR USING THE SAME 审中-公开
    细胞移植装置及其使用方法

    公开(公告)号：US20150032223A1

    公开(公告)日：2015-01-29

    申请号：US14008769

    申请日：2012-04-02

    申请人： Shigeru Miyagawa ,  Atsuhiro Saito ,  Yoshiki Sawa ,  Manabu Mizutani ,  Akima Harada

    发明人： Shigeru Miyagawa ,  Atsuhiro Saito ,  Yoshiki Sawa ,  Manabu Mizutani ,  Akima Harada

    IPC分类号： A61F2/02

    CPC分类号： A61F2/02 ,  A61F2230/0006 ,  A61L27/38 ,  A61L27/52 ,  C12M25/02 ,  C12M33/00

    摘要： A cell sheet transplantation device having a plane for transplanting a sheet of cultured cells, the device comprising, in the plane in the same direction, (1) a planar surface portion for capturing a cell sheet while maintaining a sheet-shaped form, and (2) suction holes for immobilizing a transplantation site by suction, the suction holes being positioned around the planar surface portion. By using the cell sheet transplantation device, a cultured cell sheet can be detached effectively, and the detached cultured cell sheet can be transplanted in an effective and simple manner.

    摘要翻译： 一种具有用于移植培养细胞片的平面的细胞移植装置，所述装置在相同方向的平面中包括（1）用于在保持片状形状的同时捕获细胞片的平面部分，以及（ 2）用于通过抽吸固定移植部位的吸孔，吸孔位于平面部分周围。 通过使用细胞移植装置，可以有效地剥离培养的细胞片，并且可以有效且简单地移植分离的培养细胞片。

    COMPOSITION FOR REGENERATION OF PERIODONTAL HARD TISSUE AND METHOD FOR REGENERATION OF PERIODONTAL HARD TISSUE
    6.
    发明申请
    COMPOSITION FOR REGENERATION OF PERIODONTAL HARD TISSUE AND METHOD FOR REGENERATION OF PERIODONTAL HARD TISSUE 审中-公开
    用于再生胸腔硬组织的组合物和再生胸腔硬组织的方法

    公开(公告)号：US20100068188A1

    公开(公告)日：2010-03-18

    申请号：US12311275

    申请日：2007-09-20

    申请人： Shinya Murakami ,  Tomoko Hashikawa ,  Yoshiki Sawa ,  Akifumi Matsuyama ,  Hiroshi Komoda

    发明人： Shinya Murakami ,  Tomoko Hashikawa ,  Yoshiki Sawa ,  Akifumi Matsuyama ,  Hiroshi Komoda

    IPC分类号： A61K45/00 ,  C12N5/071 ,  A61P1/02

    CPC分类号： A61L27/3865 ,  A61K35/12 ,  A61L27/3834 ,  A61L27/3895 ,  A61L2430/12 ,  C12N5/0654 ,  C12N2500/38 ,  C12N2500/42 ,  C12N2501/30 ,  C12N2501/39 ,  C12N2506/1384

    摘要： An object of the present invention is to provide technology of using a preadipocyte to restore comprehensively bone, cartilage and periodontal ligament, and cause a periodontal hard tissue to regenerate. By culturing a preadipocyte using a culture medium containing (i) at least one member selected from the group consisting of glycerophosphate and salts thereof, and (ii) at least one member selected from the group consisting of ascorbic acid, derivatives thereof and salts thereof and not containing an adrenal cortical hormone in such an amount that promotes differentiation of a preadipocyte into a periodontal hard tissue cell, differentiation of the cell into a periodontal hard tissue cell is induced efficiently. Furthermore, a scaffold is combined with the preadipocyte cultured with the above-mentioned culture medium to be transplanted into a periodontal tissue that requires regeneration.

    摘要翻译： 本发明的目的是提供使用前脂肪细胞全面恢复骨，软骨和牙周韧带并使牙周硬组织再生的技术。 通过使用培养基培养前脂肪细胞，所述培养基含有（i）选自甘油磷酸盐及其盐的至少一种，和（ii）至少一种选自抗坏血酸，其衍生物和盐及其盐的成员，以及 不含有促进前脂肪细胞分化为牙周硬组织细胞的量的肾上腺皮质激素，有效诱导细胞向牙周硬组织细胞的分化。 此外，将支架与与上述培养基一起培养的前脂肪细胞组合以移植到需要再生的牙周组织中。

    Method of producing three-dimensional tissue and method of producing extracellular matrix used in the same
    9.
    发明申请
    Method of producing three-dimensional tissue and method of producing extracellular matrix used in the same 有权
    制备三维组织的方法及其制备方法

    公开(公告)号：US20070207540A1

    公开(公告)日：2007-09-06

    申请号：US11514468

    申请日：2006-09-01

    申请人： Mitsuru Akashi ,  Yoshiki Sawa ,  Michiya Matsusaki ,  Yoshio Nakahara

    发明人： Mitsuru Akashi ,  Yoshiki Sawa ,  Michiya Matsusaki ,  Yoshio Nakahara

    IPC分类号： C12N5/06

    CPC分类号： C12N5/0068 ,  C12N5/0062 ,  C12N2533/52 ,  C12N2533/54 ,  Y10S977/902

    摘要： The present invention provides a novel method of producing a three-dimensional tissue by which cell lamination can be carried out easily. According to the method, a three-dimensional tissue in which cell layers are laminated with an extracellular matrix intervening between each pair of the adjacent cell layers is produced by: (A) forming a cell layer on a substrate; (B) bringing the cell layer formed on the substrate into contact with a solution containing a first substance and a solution containing a second substance alternately, thus forming, on the cell layer, an extracellular matrix in which the first substance and the second substance are laminated alternately; and (C) culturing a cell on the extracellular matrix to form a further cell layer. In the present invention, a combination of the first substance and the second substance is (a) a combination of a protein or polymer having an RGD sequence and a protein or polymer that interacts with the protein or polymer having the RGD sequence or (b) a combination of a protein or polymer that is positively charged and a protein or polymer that is negatively charged.

    摘要翻译： 本发明提供一种可以容易地进行细胞层压的三维组织的制造方法。 根据该方法，通过以下方法制造细胞层与介于每对相邻细胞层之间的细胞外基质层叠的三维组织：（A）在基材上形成细胞层; （B）使形成在基板上的细胞层与含有第一物质的溶液和含有第二物质的溶液交替接触，从而在细胞层上形成第一物质和第二物质为细胞外基质 交替叠层; 和（C）在细胞外基质上培养细胞以形成另外的细胞层。 在本发明中，第一物质和第二物质的组合是（a）具有RGD序列的蛋白质或聚合物和与具有RGD序列的蛋白质或聚合物相互作用的蛋白质或聚合物的组合，或（b） 带正电荷的蛋白质或聚合物和带负电荷的蛋白质或聚合物的组合。

    Reagent-introducing medical device configured to create laminar flow and rotating flow
    10.
    发明申请
    Reagent-introducing medical device configured to create laminar flow and rotating flow 审中-公开
    试剂引入医疗装置，其构造成产生层流和旋转流

    公开(公告)号：US20070140914A1

    公开(公告)日：2007-06-21

    申请号：US11314493

    申请日：2005-12-21

    申请人： Yoshiki Sawa ,  Satoshi Taketani ,  Yoshiho Toyota ,  Shinji Ozawa ,  Nobuyoshi Watanabe

    发明人： Yoshiki Sawa ,  Satoshi Taketani ,  Yoshiho Toyota ,  Shinji Ozawa ,  Nobuyoshi Watanabe

    IPC分类号： B01L3/02

    CPC分类号： A61M25/1002 ,  A61M25/0026 ,  A61M25/0084

    摘要： The invention provides a reagent-introducing medical device that can guide a reagent into a reagent injector while maintaining all biological materials contained in the reagent in a healthy state. In an embodiment of the reagent-introducing medical device, an apparatus body (12) comprises a channel (77, 78, 80, 50e) through which a reagent flows, as well as a reagent inlet (76) and outlet (21), and further comprises a first control mechanism (58, 64) for controlling the flow of the reagent to create a laminar reagent flow in the channel (77, 78, 80, 50e) and a second control mechanism (70) for further controlling the laminar reagent flow in the channel to create a rotational reagent flow.

    摘要翻译： 本发明提供了一种试剂导入医疗装置，其能够将试剂引导到试剂注射器中，同时将包含在试剂中的所有生物材料保持在健康状态。 在试剂导入医疗装置的一个实施方案中，装置主体（12）包括试剂流过的通道（77,78,80,450e）以及试剂入口（76）和出口（21）， ，还包括用于控制所述试剂的流动以在所述通道（77,78,80,450e）中产生层流试剂流的第一控制机构（58,64）和用于进一步控制的第二控制机构（70） 通道中的层流试剂流动以产生旋转试剂流。