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1.发明申请GAMMA-L-PGA PRODUCING MICROORGANISM, METHOD OF PRODUCING GAMMA-L-PGA USING THE MICROORGANISM, CROSSLINKED SUBSTANCE PRODUCED USING THE MICROORGANISM, AND EXTERNAL DERMAL AGENT PRODUCED USING THE MICROORGANISM 有权生产微生物的GAMMA-L-PGA，使用微生物生产GAMMA-L-PGA的方法，使用微生物生产的交联物质和使用微生物生产的外源性物质公开(公告)号：US20090203790A1
公开(公告)日：2009-08-13
申请号：US12301411
申请日：2007-03-12
IPC分类号： A61K31/195 , C12N1/21 , C12P13/14 , C12Q1/04
CPC分类号： A61Q19/00 , A61K8/88 , C08G69/10 , C08L77/04 , C08L2205/02 , C12P21/02 , C08L2666/20
摘要： There are provided a microorganism characterized by producing poly-γ-L-glutamate with a molecular weight of 1,300,000 or greater and uniform optical purity under liquid culture conditions, a method of screening for the microorganism, a method of producing poly-γ-L-glutamate having large molecular weight by using the microorganism, and poly-γ-L-glutamate having an average molecular weight of 1,300,000 or greater. In addition, usages of these are provided.
摘要翻译： 提供了一种微生物，其特征在于在液体培养条件下生产分子量为130万或更大，光学纯度均匀的聚-γ-L-谷氨酸，筛选微生物的方法，生产聚-γ- 通过使用微生物具有大分子量的谷氨酸盐，以及平均分子量为130万以上的聚-γ-L-谷氨酸。 此外，还提供了这些用途。
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2.发明授权γ-L-PGA producing microorganism, method of producing γ-L-PGA using the microorganism, crosslinked substance produced using the microorganism, and external dermal agent produced using the microorganism 有权γ-L-PGA生产微生物，使用微生物生产γ-L-PGA的方法，使用该微生物生产的交联物质和使用该微生物产生的外部皮肤试剂公开(公告)号：US08703443B2
公开(公告)日：2014-04-22
申请号：US12301411
申请日：2007-03-12
IPC分类号： C12P21/06
CPC分类号： A61Q19/00 , A61K8/88 , C08G69/10 , C08L77/04 , C08L2205/02 , C12P21/02 , C08L2666/20
摘要： There are provided a microorganism characterized by producing poly-γ-L-glutamate with a molecular weight of 1,300,000 or greater and uniform optical purity under liquid culture conditions, a method of screening for the microorganism, a method of producing poly-γ-L-glutamate having large molecular weight by using the microorganism, and poly-γ-L-glutamate having an average molecular weight of 1,300,000 or greater. In addition, usages of these are provided.
摘要翻译： 提供一种微生物，其特征在于在液体培养条件下生产分子量为130万以上，光学纯度高的聚-γ-L-谷氨酸，筛选微生物的方法，生产聚-γ- 通过使用微生物具有大分子量的谷氨酸盐以及平均分子量为130万以上的聚-γ-L-谷氨酸。 此外，还提供了这些用途。
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3.发明申请ACTIVATOR INCLUDING BIOSURFACTANT AS ACTIVE INGREDIENT, MANNOSYL ERYTHRITOL LIPID, AND PRODUCTION METHOD THEREOF 有权活性成分包括生物活性成分作为活性成分，曼尼洛尔脂质体及其生产方法公开(公告)号：US20100228013A1
公开(公告)日：2010-09-09
申请号：US12367870
申请日：2009-02-09
申请人： Michiko Suzuki , Masaru Kitagawa , Shuhei Yamamoto , Atsushi Sogabe , Dai Kitamoto , Tomotake Morita , Tokuma Fukuoka , Tomohiro Imura
发明人： Michiko Suzuki , Masaru Kitagawa , Shuhei Yamamoto , Atsushi Sogabe , Dai Kitamoto , Tomotake Morita , Tokuma Fukuoka , Tomohiro Imura
CPC分类号： C07H15/04 , A23L33/10 , A61K8/60 , A61K31/7032 , A61K36/06 , A61Q19/08 , C07H15/06 , C11D1/662
摘要： The present invention includes as an active ingredient at least one biosurfactant, in particular mannosyl alditol lipid (such as MEL and MML) or triacylated mannosyl alditol lipid. This allows providing an activator and anti-aging agent that is excellent in activating and anti-aging effects on cells and that is safe enough to be used for a long time, and also providing cosmetics, quasi-drugs, drugs, and drinks and foods including the activator and the anti-aging agent as active ingredients. Further, the present invention provides MEL whose mannosyl erythritol skeleton in a molecular structure is 1-O-β-D-mannopyranosyl-meso-erythritol and a method for producing the MEL with use of a microorganism.
摘要翻译： 本发明包括作为活性成分的至少一种生物表面活性剂，特别是甘露糖基糖醇脂质（如MEL和MML）或三酰化甘露糖基糖醇脂质。 这提供了对细胞的活化和抗衰老作用优异的活化剂和抗老化剂，并且长时间安全使用，还提供化妆品，准药物，药物和饮料和食品 包括活化剂和抗老化剂作为活性成分。 此外，本发明提供了分子结构中的甘露糖基赤藓糖醇骨架为1-O-和 - D-吡喃甘露糖基 - 内消旋赤藓糖醇的MEL及使用微生物制备MEL的方法。
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4.发明申请BIOSURFACTANT-CONTAINING SKIN CARE COSMETIC AND SKIN ROUGHNESS-IMPROVING AGENT 审中-公开含有致敏物质的皮肤护理化妆品和皮肤粗糙度改善剂公开(公告)号：US20100004472A1
公开(公告)日：2010-01-07
申请号：US12094727
申请日：2006-11-21
申请人： Masaru Kitagawa , Michiko Suzuki , Shuhei Yamamoto , Atsushi Sogabe , Dai Kitamoto , Tomohiro Imura , Tokuma Fukuoka , Tomotake Morita
发明人： Masaru Kitagawa , Michiko Suzuki , Shuhei Yamamoto , Atsushi Sogabe , Dai Kitamoto , Tomohiro Imura , Tokuma Fukuoka , Tomotake Morita
IPC分类号： C07D309/10
CPC分类号： A61K8/602 , A61Q19/00 , A61Q19/008
摘要： The present invention relates to a cosmetic for skin roughness improvement/skin care containing a biosurfactant, particularly MEL-A, MEL-B or MEL-C.
摘要翻译： 本发明涉及含有生物表面活性剂，特别是MEL-A，MEL-B或MEL-C的用于皮肤粗糙度改善/护肤的化妆品。
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5.发明申请ACTIVATOR INCLUDING BIOSURFACTANT AS ACTIVE INGREDIENT, MANNOSYL ERYTHRITOL LIPID, AND PRODUCTION METHOD THEREOF 审中-公开活性成分包括生物活性成分作为活性成分，曼尼洛尔脂质体及其生产方法公开(公告)号：US20120070396A1
公开(公告)日：2012-03-22
申请号：US13276670
申请日：2011-10-19
申请人： Michiko Suzuki , Masaru Kitagawa , Shuhei Yamamoto , Atsushi Sogabe , Dai Kitamoto , Tomotake Morita , Tokuma Fukuoka , Tomohiro Imura
发明人： Michiko Suzuki , Masaru Kitagawa , Shuhei Yamamoto , Atsushi Sogabe , Dai Kitamoto , Tomotake Morita , Tokuma Fukuoka , Tomohiro Imura
CPC分类号： C07H15/04 , A23L33/10 , A61K8/60 , A61K31/7032 , A61K36/06 , A61Q19/08 , C07H15/06 , C11D1/662
摘要： The present invention includes as an active ingredient at least one biosurfactant, in particular mannosyl alditol lipid (such as MEL and MML) or triacylated mannosyl alditol lipid. This allows providing an activator and anti-aging agent that is excellent in activating and anti-aging effects on cells and that is safe enough to be used for a long time, and also providing cosmetics, quasi-drugs, drugs, and drinks and foods including the activator and the anti-aging agent as active ingredients. Further, the present invention provides MEL whose mannosyl erythritol skeleton in a molecular structure is 1-O-β-D-mannopyranosyl-meso-erythritol and a method for producing the MEL with use of a microorganism.
摘要翻译： 本发明包括作为活性成分的至少一种生物表面活性剂，特别是甘露糖基糖醇脂质（如MEL和MML）或三酰化甘露糖基糖醇脂质。 这提供了对细胞的活化和抗衰老作用优异的活化剂和抗老化剂，并且长时间安全使用，还提供化妆品，准药物，药物和饮料和食品 包括活化剂和抗老化剂作为活性成分。 此外，本发明提供了分子结构中的甘露糖基赤藓糖醇骨架为1-O-和 - D-吡喃甘露糖基 - 内消旋赤藓糖醇的MEL及使用微生物制备MEL的方法。
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6.发明申请BIOSURFACTANT-CONTAINING SKIN CARE COSMETIC AND SKIN ROUGHNESS-IMPROVING AGENT 审中-公开含有致敏物质的皮肤护理化妆品和皮肤粗糙度改善剂公开(公告)号：US20110257116A1
公开(公告)日：2011-10-20
申请号：US13170432
申请日：2011-06-28
申请人： Masaru Kitagawa , Michiko Suzuki , Shuhei Yamamoto , Atsushi Sogabe , Dai Kitamoto , Tomohiro Imura , Tokuma Fukuoka , Tomotake Morita
发明人： Masaru Kitagawa , Michiko Suzuki , Shuhei Yamamoto , Atsushi Sogabe , Dai Kitamoto , Tomohiro Imura , Tokuma Fukuoka , Tomotake Morita
CPC分类号： A61K8/602 , A61Q19/00 , A61Q19/008
摘要： The present invention relates to a cosmetic for skin roughness improvement/skin care containing a biosurfactant, particularly MEL-A, MEL-B or MEL-C.
摘要翻译： 本发明涉及含有生物表面活性剂，特别是MEL-A，MEL-B或MEL-C的用于皮肤粗糙度改善/护肤的化妆品。
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7.发明申请公开(公告)号：US20100168405A1
公开(公告)日：2010-07-01
申请号：US12376805
申请日：2007-08-07
申请人： Michiko Suzuki , Masaru Kitagawa , Shuhei Yamamoto , Atsushi Sogabe , Dai Kitamoto , Tomotake Morita , Tokuma Fukuoka , Tomohiro Imura
发明人： Michiko Suzuki , Masaru Kitagawa , Shuhei Yamamoto , Atsushi Sogabe , Dai Kitamoto , Tomotake Morita , Tokuma Fukuoka , Tomohiro Imura
IPC分类号： C07H15/04
CPC分类号： C07H15/04 , A23L33/10 , A61K8/60 , A61K31/7032 , A61K36/06 , A61Q19/08 , C07H15/06 , C11D1/662
摘要： The present invention includes as an active ingredient at least one biosurfactant, in particular mannosyl alditol lipid (such as MEL and MML) or triacylated mannosyl alditol lipid. This allows providing an activator and anti-aging agent that is excellent in activating and anti-aging effects on cells and that is safe enough to be used for a long time, and also providing cosmetics, quasi-drugs, drugs, and drinks and foods including the activator and the anti-aging agent as active ingredients. Further, the present invention provides MEL whose mannosyl erythritol skeleton in a molecular structure is 1-O-β-D-mannopyranosyl-meso-erythritol and a method for producing the MEL with use of a microorganism.
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8.发明授权Activator including biosurfactant as active ingredient, mannosyl erythritol lipid, and production method thereof 有权包括生物表面活性剂作为活性成分的活化剂，甘露糖基赤藓糖醇脂质及其制备方法公开(公告)号：US07989599B2
公开(公告)日：2011-08-02
申请号：US12367870
申请日：2009-02-09
申请人： Michiko Suzuki , Masaru Kitagawa , Shuhei Yamamoto , Atsushi Sogabe , Dai Kitamoto , Tomotake Morita , Tokuma Fukuoka , Tomohiro Imura
发明人： Michiko Suzuki , Masaru Kitagawa , Shuhei Yamamoto , Atsushi Sogabe , Dai Kitamoto , Tomotake Morita , Tokuma Fukuoka , Tomohiro Imura
CPC分类号： C07H15/04 , A23L33/10 , A61K8/60 , A61K31/7032 , A61K36/06 , A61Q19/08 , C07H15/06 , C11D1/662
摘要： The present invention includes as an active ingredient at least one biosurfactant, in particular mannosyl alditol lipid (such as MEL and MML) or triacylated mannosyl alditol lipid. This allows providing an activator and anti-aging agent that is excellent in activating and anti-aging effects on cells and that is safe enough to be used for a long time, and also providing cosmetics, quasi-drugs, drugs, and drinks and foods including the activator and the anti-aging agent as active ingredients. Further, the present invention provides MEL whose mannosyl erythritol skeleton in a molecular structure is 1-O-β-D-mannopyranosyl-meso-erythritol and a method for producing the MEL with use of a microorganism.
摘要翻译： 本发明包括作为活性成分的至少一种生物表面活性剂，特别是甘露糖基糖醇脂质（如MEL和MML）或三酰化甘露糖基糖醇脂质。 这提供了对细胞的活化和抗衰老作用优异的活化剂和抗老化剂，并且长时间安全使用，还提供化妆品，准药物，药物和饮料和食品 包括活化剂和抗老化剂作为活性成分。 此外，本发明提供了分子结构中的甘露糖基赤藓糖醇骨架为1-O-和 - D-吡喃甘露糖基 - 内消旋赤藓糖醇的MEL及使用微生物制备MEL的方法。
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9.发明申请公开(公告)号：US20060052318A1
公开(公告)日：2006-03-09
申请号：US10530789
申请日：2003-10-10
申请人： Yutaka Tokiwa , Masaru Kitagawa , Kenji Yoshino , Shusaku Yanagidani , Takao Raku , Tetsuzo Totani , Hiromi Shimakawa
发明人： Yutaka Tokiwa , Masaru Kitagawa , Kenji Yoshino , Shusaku Yanagidani , Takao Raku , Tetsuzo Totani , Hiromi Shimakawa
IPC分类号： A61K31/704 , C07H15/00
CPC分类号： C07H15/203 , A61K8/602 , A61K31/201 , A61K31/375 , A61K31/7024 , A61K31/7034 , A61K2800/782 , A61Q5/08 , A61Q19/02 , A61Q19/08 , C07H13/06 , C12P19/46
摘要： Disclosed is a tyrosinase activity controlling agent comprising, as an active ingredient, a compound that has tyrosinase inhibiting or promoting activity, an external preparation comprising the controlling agent, and a process for producing the compound.
摘要翻译： 公开了一种酪氨酸酶活性控制剂，其包含具有酪氨酸酶抑制或促进活性的化合物作为活性成分，包含所述控制剂的外用制剂及其制备方法。
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10.发明申请STRESS-REDUCING AGENT INCLUDING PLANT-DERIVED POLYAMINE-CONTAINING EXTRACT SERVING AS ACTIVE COMPONENT 审中-公开减压剂，包括作为活性组分的植物衍生的含聚氨酯的提取物公开(公告)号：US20110236512A1
公开(公告)日：2011-09-29
申请号：US13133184
申请日：2009-09-28
IPC分类号： A61K36/899 , A61K36/00 , A61K36/48 , A61P25/22
CPC分类号： A61K31/132 , A61K8/97 , A61K36/48 , A61Q19/08
摘要： [Object] An object of the present invention is to provide, for the purpose of preventing or suppressing stress at a cellular level, a composition containing a plant-derived polyamine-containing extract that has a stress-reducing action, an anti-stress action, a stress-suppressing action, a stress-preventing action, a stress-inhibiting action, a stress protective action, or the like. Another object of the present invention is to provide cosmetics, quasi drugs, medical supplies, sanitary goods, pharmaceuticals, foods, or drinks that each contain such a composition.[Solution] A stress-reducing agent including a plant-derived polyamine-containing extract serving as an active component is provided.
摘要翻译： 本发明的目的在于提供含有含有植物来源的含多胺的提取物的组合物，为了防止或抑制细胞水平的应力，其具有减轻作用，抗应激作用 ，应力抑制作用，应力防止作用，应力抑制作用，应力保护作用等。 本发明的另一个目的是提供各自含有这种组合物的化妆品，准药物，医疗用品，卫生用品，药品，食品或饮料。 [解决方案]提供了包含植物来源的含多胺的提取物作为活性成分的减压剂。
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