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1.发明申请GAMMA-L-PGA PRODUCING MICROORGANISM, METHOD OF PRODUCING GAMMA-L-PGA USING THE MICROORGANISM, CROSSLINKED SUBSTANCE PRODUCED USING THE MICROORGANISM, AND EXTERNAL DERMAL AGENT PRODUCED USING THE MICROORGANISM 有权生产微生物的GAMMA-L-PGA，使用微生物生产GAMMA-L-PGA的方法，使用微生物生产的交联物质和使用微生物生产的外源性物质公开(公告)号：US20090203790A1
公开(公告)日：2009-08-13
申请号：US12301411
申请日：2007-03-12
IPC分类号： A61K31/195 , C12N1/21 , C12P13/14 , C12Q1/04
CPC分类号： A61Q19/00 , A61K8/88 , C08G69/10 , C08L77/04 , C08L2205/02 , C12P21/02 , C08L2666/20
摘要： There are provided a microorganism characterized by producing poly-γ-L-glutamate with a molecular weight of 1,300,000 or greater and uniform optical purity under liquid culture conditions, a method of screening for the microorganism, a method of producing poly-γ-L-glutamate having large molecular weight by using the microorganism, and poly-γ-L-glutamate having an average molecular weight of 1,300,000 or greater. In addition, usages of these are provided.
摘要翻译： 提供了一种微生物，其特征在于在液体培养条件下生产分子量为130万或更大，光学纯度均匀的聚-γ-L-谷氨酸，筛选微生物的方法，生产聚-γ- 通过使用微生物具有大分子量的谷氨酸盐，以及平均分子量为130万以上的聚-γ-L-谷氨酸。 此外，还提供了这些用途。
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2.发明授权γ-L-PGA producing microorganism, method of producing γ-L-PGA using the microorganism, crosslinked substance produced using the microorganism, and external dermal agent produced using the microorganism 有权γ-L-PGA生产微生物，使用微生物生产γ-L-PGA的方法，使用该微生物生产的交联物质和使用该微生物产生的外部皮肤试剂公开(公告)号：US08703443B2
公开(公告)日：2014-04-22
申请号：US12301411
申请日：2007-03-12
IPC分类号： C12P21/06
CPC分类号： A61Q19/00 , A61K8/88 , C08G69/10 , C08L77/04 , C08L2205/02 , C12P21/02 , C08L2666/20
摘要： There are provided a microorganism characterized by producing poly-γ-L-glutamate with a molecular weight of 1,300,000 or greater and uniform optical purity under liquid culture conditions, a method of screening for the microorganism, a method of producing poly-γ-L-glutamate having large molecular weight by using the microorganism, and poly-γ-L-glutamate having an average molecular weight of 1,300,000 or greater. In addition, usages of these are provided.
摘要翻译： 提供一种微生物，其特征在于在液体培养条件下生产分子量为130万以上，光学纯度高的聚-γ-L-谷氨酸，筛选微生物的方法，生产聚-γ- 通过使用微生物具有大分子量的谷氨酸盐以及平均分子量为130万以上的聚-γ-L-谷氨酸。 此外，还提供了这些用途。
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3.发明授权Activator including biosurfactant as active ingredient, mannosyl erythritol lipid, and production method thereof 有权包括生物表面活性剂作为活性成分的活化剂，甘露糖基赤藓糖醇脂质及其制备方法公开(公告)号：US07989599B2
公开(公告)日：2011-08-02
申请号：US12367870
申请日：2009-02-09
申请人： Michiko Suzuki , Masaru Kitagawa , Shuhei Yamamoto , Atsushi Sogabe , Dai Kitamoto , Tomotake Morita , Tokuma Fukuoka , Tomohiro Imura
发明人： Michiko Suzuki , Masaru Kitagawa , Shuhei Yamamoto , Atsushi Sogabe , Dai Kitamoto , Tomotake Morita , Tokuma Fukuoka , Tomohiro Imura
CPC分类号： C07H15/04 , A23L33/10 , A61K8/60 , A61K31/7032 , A61K36/06 , A61Q19/08 , C07H15/06 , C11D1/662
摘要： The present invention includes as an active ingredient at least one biosurfactant, in particular mannosyl alditol lipid (such as MEL and MML) or triacylated mannosyl alditol lipid. This allows providing an activator and anti-aging agent that is excellent in activating and anti-aging effects on cells and that is safe enough to be used for a long time, and also providing cosmetics, quasi-drugs, drugs, and drinks and foods including the activator and the anti-aging agent as active ingredients. Further, the present invention provides MEL whose mannosyl erythritol skeleton in a molecular structure is 1-O-β-D-mannopyranosyl-meso-erythritol and a method for producing the MEL with use of a microorganism.
摘要翻译： 本发明包括作为活性成分的至少一种生物表面活性剂，特别是甘露糖基糖醇脂质（如MEL和MML）或三酰化甘露糖基糖醇脂质。 这提供了对细胞的活化和抗衰老作用优异的活化剂和抗老化剂，并且长时间安全使用，还提供化妆品，准药物，药物和饮料和食品 包括活化剂和抗老化剂作为活性成分。 此外，本发明提供了分子结构中的甘露糖基赤藓糖醇骨架为1-O-和 - D-吡喃甘露糖基 - 内消旋赤藓糖醇的MEL及使用微生物制备MEL的方法。
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4.发明申请ACTIVATOR INCLUDING BIOSURFACTANT AS ACTIVE INGREDIENT, MANNOSYL ERYTHRITOL LIPID, AND PRODUCTION METHOD THEREOF 有权活性成分包括生物活性成分作为活性成分，曼尼洛尔脂质体及其生产方法公开(公告)号：US20100228013A1
公开(公告)日：2010-09-09
申请号：US12367870
申请日：2009-02-09
申请人： Michiko Suzuki , Masaru Kitagawa , Shuhei Yamamoto , Atsushi Sogabe , Dai Kitamoto , Tomotake Morita , Tokuma Fukuoka , Tomohiro Imura
发明人： Michiko Suzuki , Masaru Kitagawa , Shuhei Yamamoto , Atsushi Sogabe , Dai Kitamoto , Tomotake Morita , Tokuma Fukuoka , Tomohiro Imura
CPC分类号： C07H15/04 , A23L33/10 , A61K8/60 , A61K31/7032 , A61K36/06 , A61Q19/08 , C07H15/06 , C11D1/662
摘要： The present invention includes as an active ingredient at least one biosurfactant, in particular mannosyl alditol lipid (such as MEL and MML) or triacylated mannosyl alditol lipid. This allows providing an activator and anti-aging agent that is excellent in activating and anti-aging effects on cells and that is safe enough to be used for a long time, and also providing cosmetics, quasi-drugs, drugs, and drinks and foods including the activator and the anti-aging agent as active ingredients. Further, the present invention provides MEL whose mannosyl erythritol skeleton in a molecular structure is 1-O-β-D-mannopyranosyl-meso-erythritol and a method for producing the MEL with use of a microorganism.
摘要翻译： 本发明包括作为活性成分的至少一种生物表面活性剂，特别是甘露糖基糖醇脂质（如MEL和MML）或三酰化甘露糖基糖醇脂质。 这提供了对细胞的活化和抗衰老作用优异的活化剂和抗老化剂，并且长时间安全使用，还提供化妆品，准药物，药物和饮料和食品 包括活化剂和抗老化剂作为活性成分。 此外，本发明提供了分子结构中的甘露糖基赤藓糖醇骨架为1-O-和 - D-吡喃甘露糖基 - 内消旋赤藓糖醇的MEL及使用微生物制备MEL的方法。
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5.发明申请BIOSURFACTANT-CONTAINING SKIN CARE COSMETIC AND SKIN ROUGHNESS-IMPROVING AGENT 审中-公开含有致敏物质的皮肤护理化妆品和皮肤粗糙度改善剂公开(公告)号：US20100004472A1
公开(公告)日：2010-01-07
申请号：US12094727
申请日：2006-11-21
申请人： Masaru Kitagawa , Michiko Suzuki , Shuhei Yamamoto , Atsushi Sogabe , Dai Kitamoto , Tomohiro Imura , Tokuma Fukuoka , Tomotake Morita
发明人： Masaru Kitagawa , Michiko Suzuki , Shuhei Yamamoto , Atsushi Sogabe , Dai Kitamoto , Tomohiro Imura , Tokuma Fukuoka , Tomotake Morita
IPC分类号： C07D309/10
CPC分类号： A61K8/602 , A61Q19/00 , A61Q19/008
摘要： The present invention relates to a cosmetic for skin roughness improvement/skin care containing a biosurfactant, particularly MEL-A, MEL-B or MEL-C.
摘要翻译： 本发明涉及含有生物表面活性剂，特别是MEL-A，MEL-B或MEL-C的用于皮肤粗糙度改善/护肤的化妆品。
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6.发明申请ACTIVATOR INCLUDING BIOSURFACTANT AS ACTIVE INGREDIENT, MANNOSYL ERYTHRITOL LIPID, AND PRODUCTION METHOD THEREOF 审中-公开活性成分包括生物活性成分作为活性成分，曼尼洛尔脂质体及其生产方法公开(公告)号：US20120070396A1
公开(公告)日：2012-03-22
申请号：US13276670
申请日：2011-10-19
申请人： Michiko Suzuki , Masaru Kitagawa , Shuhei Yamamoto , Atsushi Sogabe , Dai Kitamoto , Tomotake Morita , Tokuma Fukuoka , Tomohiro Imura
发明人： Michiko Suzuki , Masaru Kitagawa , Shuhei Yamamoto , Atsushi Sogabe , Dai Kitamoto , Tomotake Morita , Tokuma Fukuoka , Tomohiro Imura
CPC分类号： C07H15/04 , A23L33/10 , A61K8/60 , A61K31/7032 , A61K36/06 , A61Q19/08 , C07H15/06 , C11D1/662
摘要： The present invention includes as an active ingredient at least one biosurfactant, in particular mannosyl alditol lipid (such as MEL and MML) or triacylated mannosyl alditol lipid. This allows providing an activator and anti-aging agent that is excellent in activating and anti-aging effects on cells and that is safe enough to be used for a long time, and also providing cosmetics, quasi-drugs, drugs, and drinks and foods including the activator and the anti-aging agent as active ingredients. Further, the present invention provides MEL whose mannosyl erythritol skeleton in a molecular structure is 1-O-β-D-mannopyranosyl-meso-erythritol and a method for producing the MEL with use of a microorganism.
摘要翻译： 本发明包括作为活性成分的至少一种生物表面活性剂，特别是甘露糖基糖醇脂质（如MEL和MML）或三酰化甘露糖基糖醇脂质。 这提供了对细胞的活化和抗衰老作用优异的活化剂和抗老化剂，并且长时间安全使用，还提供化妆品，准药物，药物和饮料和食品 包括活化剂和抗老化剂作为活性成分。 此外，本发明提供了分子结构中的甘露糖基赤藓糖醇骨架为1-O-和 - D-吡喃甘露糖基 - 内消旋赤藓糖醇的MEL及使用微生物制备MEL的方法。
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7.发明申请BIOSURFACTANT-CONTAINING SKIN CARE COSMETIC AND SKIN ROUGHNESS-IMPROVING AGENT 审中-公开含有致敏物质的皮肤护理化妆品和皮肤粗糙度改善剂公开(公告)号：US20110257116A1
公开(公告)日：2011-10-20
申请号：US13170432
申请日：2011-06-28
申请人： Masaru Kitagawa , Michiko Suzuki , Shuhei Yamamoto , Atsushi Sogabe , Dai Kitamoto , Tomohiro Imura , Tokuma Fukuoka , Tomotake Morita
发明人： Masaru Kitagawa , Michiko Suzuki , Shuhei Yamamoto , Atsushi Sogabe , Dai Kitamoto , Tomohiro Imura , Tokuma Fukuoka , Tomotake Morita
CPC分类号： A61K8/602 , A61Q19/00 , A61Q19/008
摘要： The present invention relates to a cosmetic for skin roughness improvement/skin care containing a biosurfactant, particularly MEL-A, MEL-B or MEL-C.
摘要翻译： 本发明涉及含有生物表面活性剂，特别是MEL-A，MEL-B或MEL-C的用于皮肤粗糙度改善/护肤的化妆品。
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8.发明申请公开(公告)号：US20100168405A1
公开(公告)日：2010-07-01
申请号：US12376805
申请日：2007-08-07
申请人： Michiko Suzuki , Masaru Kitagawa , Shuhei Yamamoto , Atsushi Sogabe , Dai Kitamoto , Tomotake Morita , Tokuma Fukuoka , Tomohiro Imura
发明人： Michiko Suzuki , Masaru Kitagawa , Shuhei Yamamoto , Atsushi Sogabe , Dai Kitamoto , Tomotake Morita , Tokuma Fukuoka , Tomohiro Imura
IPC分类号： C07H15/04
CPC分类号： C07H15/04 , A23L33/10 , A61K8/60 , A61K31/7032 , A61K36/06 , A61Q19/08 , C07H15/06 , C11D1/662
摘要： The present invention includes as an active ingredient at least one biosurfactant, in particular mannosyl alditol lipid (such as MEL and MML) or triacylated mannosyl alditol lipid. This allows providing an activator and anti-aging agent that is excellent in activating and anti-aging effects on cells and that is safe enough to be used for a long time, and also providing cosmetics, quasi-drugs, drugs, and drinks and foods including the activator and the anti-aging agent as active ingredients. Further, the present invention provides MEL whose mannosyl erythritol skeleton in a molecular structure is 1-O-β-D-mannopyranosyl-meso-erythritol and a method for producing the MEL with use of a microorganism.
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公开(公告)号：US08003851B2
公开(公告)日：2011-08-23
申请号：US12063888
申请日：2006-08-10
CPC分类号： C12P19/26 , C12N15/8257
摘要： It is intended to provide by improving a known method of producing hyaluronic acid in a plant, a plant or a cultured plant cells which can produce hyaluronic acid at a lower cost and a further higher yield than before, a method of preparing the same, an expression vector for transformation, a method of producing hyaluronic acid using the plant or the cultured plant cells and the like. The method of producing hyaluronic acid comprising obtaining hyaluronic acid by co-expressing a protein with hyaluronic acid synthase activity and an exogenous protein with sugar-nucleotide synthase activity in a plant cell or a plant is provided.
摘要翻译： 本发明旨在通过改善可以以比以前更低的成本和更高的产量生产透明质酸的植物，植物或培养的植物细胞中制备透明质酸的已知方法，其制备方法， 用于转化的表达载体，使用植物或培养的植物细胞等产生透明质酸的方法。 提供了通过在植物细胞或植物中共同表达具有透明质酸合成酶活性的蛋白质和具有糖 - 核苷酸合成酶活性的外源蛋白质来获得透明质酸的方法。
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10.发明申请Surface-Treating Agents, Surface-Treated Powders, And Cosmetics Comprising The Same 审中-公开表面处理剂，表面处理粉末和包含其的化妆品公开(公告)号：US20080081029A1
公开(公告)日：2008-04-03
申请号：US11576705
申请日：2005-10-06
申请人： Shuji Nishihama , Isamu Kaneda , Atsushi Sogabe , Tomo Osawa , Shin-ichi Yusa
发明人： Shuji Nishihama , Isamu Kaneda , Atsushi Sogabe , Tomo Osawa , Shin-ichi Yusa
CPC分类号： C09C3/10 , A61K8/11 , A61K8/8158 , A61K2800/412 , A61Q1/02 , A61Q1/04 , A61Q1/10 , A61Q1/12 , A61Q17/04 , C01P2004/10 , C01P2004/20 , C08F220/28 , C09C1/027 , C09C1/28 , C09C1/3676 , C09C1/405 , C09C3/12
摘要： To provide surface-treating agents that can provide excellent hydrophobicity to powder and can improve its rinsability, to provide surface-treated powders that are treated with the surface-treating agent, and to provide cosmetics that comprise the surface-treated powder. A surface-treating agent consisting of a polymer which comprises a monomer (A) represented by the general formula (1) described below as a constituent monomer. (wherein R1 represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, R2 represents an alkylene group having 4 to 22 carbon atoms, X1 represents an —NH— group or an oxygen atom, and M1 represents a hydrogen atom or a monovalent inorganic or organic cation.)
摘要翻译： 为了提供能够为粉末提供优异的疏水性并可提高其漂洗性的表面处理剂，提供用表面处理剂处理的表面处理粉末，以及提供包含表面处理粉末的化妆品。 由下述通式（1）表示的单体（A）作为构成单体的聚合物构成的表面处理剂。 （其中R 1表示氢原子或具有1至3个碳原子的烷基，R 2表示具有4至22个碳原子的亚烷基，X < 1表示-NH-基或氧原子，M 1表示氢原子或一价无机或有机阳离子。）
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