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    PIGR-1, a member of immunoglobulin gene superfamily
    2.
    发明授权
    PIGR-1, a member of immunoglobulin gene superfamily 失效
    PIGR-1是免疫球蛋白基因超家族的成员

    公开(公告)号：US06232441B1

    公开(公告)日：2001-05-15

    申请号：US09300985

    申请日：1999-04-28

    申请人： Shujian Wu ,  Raymond W Sweet ,  Alemseged Truneh ,  Mark Robert Hurle

    发明人： Shujian Wu ,  Raymond W Sweet ,  Alemseged Truneh ,  Mark Robert Hurle

    IPC分类号： C07K14435

    CPC分类号： C07K14/70503 ,  A61K38/00

    摘要： PIGR-1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing PIGR-1 polypeptides and polynucleotides in the design of protocols for the treatment of rheumatoid arthritis (RA), multiple sclerosis (MS), psoriasis, systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD), among others and diagnostic assays for such conditions.

    摘要翻译： 公开了PIGR-1多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗类风湿性关节炎（RA），多发性硬化症（MS），牛皮癣，系统性红斑狼疮（SLE）和炎症性肠病（IBD））的方案中使用PIGR-1多肽和多核苷酸的方法，其中 其他和诊断测定这些条件。

    Variants of the TRP channel family member, LTRPC3G
    5.
    发明授权
    Variants of the TRP channel family member, LTRPC3G 有权
    TRP通道家族成员LTRPC3G的变体

    公开(公告)号：US07459532B2

    公开(公告)日：2008-12-02

    申请号：US11985981

    申请日：2007-11-19

    申请人： Ning Lee ,  Jian Chen ,  Shujian Wu ,  Michael A. Blanar ,  Paul C. Levesque ,  Lucy Sun

    发明人： Ning Lee ,  Jian Chen ,  Shujian Wu ,  Michael A. Blanar ,  Paul C. Levesque ,  Lucy Sun

    IPC分类号： C07K14/435 ,  C07K14/705 ,  C12P21/02 ,  A61K38/17

    CPC分类号： C07K14/705 ,  C07H21/04 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/622

    摘要： The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供编码LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding variants of the TRP channel family member, LTRPC3
    6.
    发明授权
    Polynucleotides encoding variants of the TRP channel family member, LTRPC3 有权
    编码TRP通道家族成员LTRPC3变体的多核苷酸

    公开(公告)号：US07344882B2

    公开(公告)日：2008-03-18

    申请号：US10842313

    申请日：2004-05-10

    申请人： Ning Lee ,  Jian Chen ,  Shujian Wu ,  Michael A. Blanar ,  Paul C. Levesque ,  Lucy Sun

    发明人： Ning Lee ,  Jian Chen ,  Shujian Wu ,  Michael A. Blanar ,  Paul C. Levesque ,  Lucy Sun

    IPC分类号： C12N5/10 ,  C12N15/12 ,  C12N15/63 ,  C12N1/21

    CPC分类号： C07K14/705 ,  C07H21/04 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/622

    摘要： The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides, fragments and homologues thereof Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供编码LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽的新型多核苷酸，其片段和同系物。还提供了用于产生所述多肽的载体，宿主细胞，抗体以及重组和合成方法。 本发明还涉及将这些新型LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding three novel human cell surface proteins with leucine rich repeats and immunologobulin folds, BGS2, 3, and 4 and variants thereof
    7.
    发明授权
    Polynucleotides encoding three novel human cell surface proteins with leucine rich repeats and immunologobulin folds, BGS2, 3, and 4 and variants thereof 失效
    编码具有富含亮氨酸重复序列和免疫球蛋白折叠的三种新型人细胞表面蛋白的多核苷酸，BGS2,3和4及其变体

    公开(公告)号：US07223558B2

    公开(公告)日：2007-05-29

    申请号：US10193477

    申请日：2002-07-11

    申请人： Shujian Wu ,  Stanley R. Krystek ,  Liana Lee ,  John N. Feder ,  Janet D. Cheng

    发明人： Shujian Wu ,  Stanley R. Krystek ,  Liana Lee ,  John N. Feder ,  Janet D. Cheng

    IPC分类号： C12N15/12 ,  C12N5/10 ,  C12P21/02 ,  C07K14/47

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： The present invention provides novel polynucleotides encoding BGS-2, 3, and 4 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-2, 3, and 4 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码BGS-2,3和4多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型BGS-2,3和4多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding novel adiponectin receptor variants
    8.
    发明申请
    Polynucleotides encoding novel adiponectin receptor variants 有权
    编码新型脂联素受体变体的多核苷酸

    公开(公告)号：US20050032166A1

    公开(公告)日：2005-02-10

    申请号：US10874923

    申请日：2004-06-23

    申请人： Jian Chen ,  Shujian Wu ,  Ning Lee

    发明人： Jian Chen ,  Shujian Wu ,  Ning Lee

    IPC分类号： C07H21/04 ,  C07K14/705 ,  C07K14/72 ,  C12N20060101 ,  C12P21/04

    CPC分类号： C07K14/72

    摘要： The present invention provides novel polynucleotides encoding human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1 polypeptides, rat AdipoR1 polypeptides, rat AdipoR2 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1 polypeptides, rat AdipoR1 polypeptides, rat AdipoR2 polypeptides, to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供编码人AdipoR2v1多肽，小鼠AdipoR2v1多肽，人AdipoR3多肽，人AdipoR2v2多肽，人AdipoR3v1多肽，大鼠AdipoR1多肽，大鼠AdipoR2多肽，其片段及其同源物的新型多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新的人AdipoR2v1多肽，小鼠AdipoR2v1多肽，人AdipoR3多肽，人AdipoR2v2多肽，人AdipoR3v1多肽，大鼠AdipoR1多肽，大鼠AdipoR2多肽应用于诊断，治疗和/或治疗的诊断和治疗方法。 预防与这些多肽相关的各种疾病和/或病症。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding novel adiponectin receptor variant, AdipoR2v2
    9.
    发明授权
    Polynucleotides encoding novel adiponectin receptor variant, AdipoR2v2 有权
    编码新型脂联素受体变体的多核苷酸AdipoR2v2

    公开(公告)号：US07435808B2

    公开(公告)日：2008-10-14

    申请号：US10874923

    申请日：2004-06-23

    申请人： Shujian Wu ,  Ning Lee ,  Dong Cheng

    发明人： Shujian Wu ,  Ning Lee ,  Dong Cheng

    IPC分类号： C07H21/04 ,  C12N15/12 ,  C12N15/63 ,  C12N1/21 ,  C12N5/10

    CPC分类号： C07K14/72

    摘要： The present invention provides novel polynucleotides encoding human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1 polypeptides, rat AdipoR1 polypeptides, rat AdipoR2 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1 polypeptides, rat AdipoR1 polypeptides, rat AdipoR2 polypeptides, to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供编码人AdipoR2v1多肽，小鼠AdipoR2v1多肽，人AdipoR3多肽，人AdipoR2v2多肽，人AdipoR3v1多肽，大鼠AdipoR1多肽，大鼠AdipoR2多肽，其片段及其同源物的新型多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新的人AdipoR2v1多肽，小鼠AdipoR2v1多肽，人AdipoR3多肽，人AdipoR2v2多肽，人AdipoR3v1多肽，大鼠AdipoR1多肽，大鼠AdipoR2多肽应用于诊断，治疗和/或治疗的诊断和治疗方法。 预防与这些多肽相关的各种疾病和/或病症。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Antibodies directed to the testis-specific tubulin tyrosine-ligase-like protein, BGS42
    10.
    发明授权
    Antibodies directed to the testis-specific tubulin tyrosine-ligase-like protein, BGS42 有权
    针对睾丸特异性微管蛋白酪氨酸连接酶样蛋白BGS42的抗体

    公开(公告)号：US07309779B2

    公开(公告)日：2007-12-18

    申请号：US11445988

    申请日：2006-06-02

    申请人： John N. Feder ,  Shujian Wu ,  Thomas C. Nelson ,  Liana M. Lee

    发明人： John N. Feder ,  Shujian Wu ,  Thomas C. Nelson ,  Liana M. Lee

    IPC分类号： C07K16/40 ,  C12N5/12

    CPC分类号： C12N9/93 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  C07K2319/00 ,  G01N33/57423 ,  G01N2333/9015 ,  Y10S435/81

    摘要： The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码BGS-42多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型BGS-42多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。