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    REAGENT AND METHOD FOR PROVIDING COATINGS ON SURFACES
    2.
    发明申请
    REAGENT AND METHOD FOR PROVIDING COATINGS ON SURFACES 失效
    用于提供表面涂层的试剂和方法

    公开(公告)号：US20070292596A1

    公开(公告)日：2007-12-20

    申请号：US11846955

    申请日：2007-08-29

    申请人： Ralph Chappa ,  Sean Stucke ,  Richard Amos ,  Terrence Everson ,  Stephen Chudzik ,  Dale Swan ,  Peter Duquette

    发明人： Ralph Chappa ,  Sean Stucke ,  Richard Amos ,  Terrence Everson ,  Stephen Chudzik ,  Dale Swan ,  Peter Duquette

    IPC分类号： A61L27/28 ,  A61L2/00

    CPC分类号： B82Y30/00 ,  A61L27/34 ,  C09D4/00 ,  Y10S522/904 ,  Y10T428/249991 ,  Y10T428/249992 ,  C08F220/56 ,  C08F220/54

    摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.

    摘要翻译： 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。

    RETENTION COATINGS FOR DELIVERY SYSTEMS
    3.
    发明申请
    RETENTION COATINGS FOR DELIVERY SYSTEMS 审中-公开
    用于输送系统的保持涂层

    公开(公告)号：US20080114451A1

    公开(公告)日：2008-05-15

    申请号：US12016343

    申请日：2008-01-18

    申请人： Sean Stucke ,  Kimberly Lindsoe ,  Ralph Chappa ,  Dale Swan

    发明人： Sean Stucke ,  Kimberly Lindsoe ,  Ralph Chappa ,  Dale Swan

    IPC分类号： A61L27/34 ,  A61F2/82 ,  C09K3/16

    CPC分类号： A61L31/16 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/258 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/606 ,  C08L71/02

    摘要： A coating composition, in both its uncrosslinked and crosslinked forms, for use in increasing the static friction of a surface of a delivery system comprising a medical device having a surface in contact with the surface of a delivery component, the static friction of the surface being increased in an amount sufficient to substantially maintain the position of the medical device on the delivery component against forces asserted on the delivery system as it navigates through a vessel of the body. The delivery system may comprise a balloon catheter as the delivery component and a stent as the medical device. A composition includes a polyether monomer, such as an alkoxy poly(alkylene glycol), a carboxylic acid-containing monomer, such as (meth)acrylic acid, optionally a photoderivatized monomer, and a hydrophilic monomer such as (meth)acrylamide.

    摘要翻译： 一种涂料组合物，以其未交联和交联的形式，用于增加递送系统的表面的静摩擦力，其包括具有与输送组分表面接触的表面的医疗装置，表面的静摩擦力 增加的量足以基本上保持医疗装置在输送部件上的位置，抵抗在输送系统导航通过身体的血管时所断言的力。 输送系统可以包括作为输送部件的气囊导管和作为医疗装置的支架。 组合物包括聚醚单体，例如烷氧基聚（亚烷基二醇），含羧酸的单体，例如（甲基）丙烯酸，任选的光衍生单体和亲水性单体如（甲基）丙烯酰胺。