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公开(公告)号：US06962823B2
公开(公告)日：2005-11-08
申请号：US10405992
申请日：2003-04-01
申请人： Stephen Empedocles , Larry Bock , Calvin Chow , Xianfeng Duan , Chungming Niu , George Pontis , Vijendra Sahi , Linda T. Romano , David Stumbo
发明人： Stephen Empedocles , Larry Bock , Calvin Chow , Xianfeng Duan , Chungming Niu , George Pontis , Vijendra Sahi , Linda T. Romano , David Stumbo
CPC分类号： H01L51/0048 , B01J23/52 , B81B2203/0361 , B81B2207/015 , B81C3/005 , B81C99/008 , B81C2203/057 , B82B3/00 , B82Y10/00 , B82Y30/00 , B82Y40/00 , G11B5/743 , G11C2213/81 , H01L29/7869 , H01L51/0001 , H01L51/0595 , H01L2924/0002 , Y10S438/962 , Y10S977/762 , Y10S977/856 , Y10S977/857 , Y10S977/858 , Y10S977/89 , H01L2924/00
摘要： Nanostructure manufacturing methods and methods for assembling nanostructures into functional elements such as junctions, arrays and devices are provided. Systems for practicing the methods are also provided.
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2.发明授权Methods of making, positioning and orienting nanostructures, nanostructure arrays and nanostructure devices 有权制备，定位和取向纳米结构，纳米结构阵列和纳米结构器件的方法公开(公告)号：US07151209B2
公开(公告)日：2006-12-19
申请号：US11142563
申请日：2005-05-31
申请人： Stephen Empedocles , Larry Bock , Calvin Y. H. Chow , Xianfeng Duan , Chunming Niu , George Pontis , Vijendra Sahi , Linda T. Romano , David Stumbo
发明人： Stephen Empedocles , Larry Bock , Calvin Y. H. Chow , Xianfeng Duan , Chunming Niu , George Pontis , Vijendra Sahi , Linda T. Romano , David Stumbo
IPC分类号： H01L21/302
CPC分类号： H01L51/0048 , B01J23/52 , B81B2203/0361 , B81B2207/015 , B81C3/005 , B81C99/008 , B81C2203/057 , B82B3/00 , B82Y10/00 , B82Y30/00 , B82Y40/00 , G11B5/743 , G11C2213/81 , H01L29/7869 , H01L51/0001 , H01L51/0595 , H01L2924/0002 , Y10S438/962 , Y10S977/762 , Y10S977/856 , Y10S977/857 , Y10S977/858 , Y10S977/89 , H01L2924/00
摘要： Nanostructure manufacturing methods and methods for assembling nanostructures into functional elements such as junctions, arrays and devices are provided. Systems for practicing the methods are also provided.
摘要翻译： 提供了将纳米结构组装成功能元件如结，阵列和器件的纳米结构制造方法和方法。 还提供了实施方法的系统。
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3.发明申请Methods of making, positioning and orienting nanostructures, nanostructure arrays and nanostructure devices 有权制备，定位和取向纳米结构，纳米结构阵列和纳米结构器件的方法公开(公告)号：US20050230356A1
公开(公告)日：2005-10-20
申请号：US11142563
申请日：2005-05-31
申请人： Stephen Empedocles , Larry Bock , Calvin Chow , Xianfeng Duan , Chunming Niu , George Pontis , Vijendra Sahi , Linda Romano , David Stumbo
发明人： Stephen Empedocles , Larry Bock , Calvin Chow , Xianfeng Duan , Chunming Niu , George Pontis , Vijendra Sahi , Linda Romano , David Stumbo
CPC分类号： H01L51/0048 , B01J23/52 , B81B2203/0361 , B81B2207/015 , B81C3/005 , B81C99/008 , B81C2203/057 , B82B3/00 , B82Y10/00 , B82Y30/00 , B82Y40/00 , G11B5/743 , G11C2213/81 , H01L29/7869 , H01L51/0001 , H01L51/0595 , H01L2924/0002 , Y10S438/962 , Y10S977/762 , Y10S977/856 , Y10S977/857 , Y10S977/858 , Y10S977/89 , H01L2924/00
摘要： Nanostructure manufacturing methods and methods for assembling nanostructures into functional elements such as junctions, arrays and devices are provided. Systems for practicing the methods are also provided.
摘要翻译： 提供了将纳米结构组装成功能元件如结，阵列和器件的纳米结构制造方法和方法。 还提供了实施方法的系统。
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公开(公告)号：US20070264634A1
公开(公告)日：2007-11-15
申请号：US10683583
申请日：2003-10-09
申请人： Larry Bock , R. Daniels , Stephen Empedocles , Chumming Niu , John Owicki , Vijendra Sahi , Calvin Chow , George Pontis
发明人： Larry Bock , R. Daniels , Stephen Empedocles , Chumming Niu , John Owicki , Vijendra Sahi , Calvin Chow , George Pontis
CPC分类号： G01N27/4146 , B82Y5/00 , C12Q1/001 , C12Q1/6825 , G01N33/54366 , Y10T436/144444
摘要： Methods of detecting a component of interest, a change in charge, a pH, a cellular response using nanosensors are provided. Nanosensors, including nanowires and nanowire arrays comprising functionalized and/or non-functionalized nanowires are provided. Nanosensors are, used for detection in cellular fragmentation, multiple concentration analysis, glucose detection, and intracellular analysis.
摘要翻译： 提供了检测感兴趣的组分，电荷变化，pH，使用纳米传感器的细胞反应的方法。 提供纳米传感器，包括纳米线和包含官能化和/或非官能化纳米线的纳米线阵列。 纳米传感器用于细胞分裂检测，多重浓度分析，葡萄糖检测和细胞内分析。
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公开(公告)号：US07888292B2
公开(公告)日：2011-02-15
申请号：US11874412
申请日：2007-10-18
IPC分类号： C40B30/00
CPC分类号： G01N27/4146 , B82Y5/00 , C12Q1/001 , C12Q1/6825 , G01N33/54366 , Y10T436/144444
摘要： Methods of detecting a component of interest, a change in charge, a pH, a cellular response using nanosensors are provided. Nanosensors, including nanowires and nanowire arrays comprising functionalized and/or non-functionalized nanowires are provided. Nanosensors are used for detection in cellular fragmentation, multiple concentration analysis, glucose detection, and intracellular analysis.
摘要翻译： 提供了检测感兴趣的组分，电荷变化，pH，使用纳米传感器的细胞反应的方法。 提供包括纳米线和包含官能化和/或非官能化纳米线的纳米线阵列的纳米传感器。 纳米传感器用于细胞分裂，多重浓度分析，葡萄糖检测和细胞内分析中的检测。
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公开(公告)号：US20080044911A1
公开(公告)日：2008-02-21
申请号：US11874412
申请日：2007-10-18
申请人： Larry Bock , R. Daniels , Stephen Empedocles , John Owicki
发明人： Larry Bock , R. Daniels , Stephen Empedocles , John Owicki
CPC分类号： G01N27/4146 , B82Y5/00 , C12Q1/001 , C12Q1/6825 , G01N33/54366 , Y10T436/144444
摘要： Methods of detecting a component of interest, a change in charge, a pH, a cellular response using nanosensors are provided. Nanosensors, including nanowires and nanowire arrays comprising functionalized and/or non-functionalized nanowires are provided. Nanosensors are used for detection in cellular fragmentation, multiple concentration analysis, glucose detection, and intracellular analysis.
摘要翻译： 提供了检测感兴趣的组分，电荷变化，pH，使用纳米传感器的细胞反应的方法。 提供纳米传感器，包括纳米线和包含官能化和/或非官能化纳米线的纳米线阵列。 纳米传感器用于细胞分裂，多重浓度分析，葡萄糖检测和细胞内分析中的检测。
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公开(公告)号：US07303875B1
公开(公告)日：2007-12-04
申请号：US10683583
申请日：2003-10-09
申请人： Larry Bock , R. Hugh Daniels , Stephen Empedocles
发明人： Larry Bock , R. Hugh Daniels , Stephen Empedocles
IPC分类号： C12Q1/68
CPC分类号： G01N27/4146 , B82Y5/00 , C12Q1/001 , C12Q1/6825 , G01N33/54366 , Y10T436/144444
摘要： Methods of detecting components of interest, e.g., nucleic acids and sugars, are provided. The methods comprise contacting one or more nanowires comprising a functional group with a sample containing the component or components of interest. In one embodiment, the functional group comprises a hairpin oligonucleotide, e.g., a hairpin that changes conformation upon binding the component of interest, e.g., a nucleic acid. The change in conformation produces a change in charge that is detected. In another embodiment, the functional group comprises an enzyme, e.g., glucose oxidase, which produces a change in pH when glucose is present in a sample.
摘要翻译： 提供检测目的成分的方法，例如核酸和糖。 所述方法包括将包含官能团的一个或多个纳米线与含有感兴趣的组分或成分的样品接触。 在一个实施方案中，官能团包括发夹寡核苷酸，例如在结合感兴趣组分例如核酸时改变构象的发夹。 构象的变化产生检测到的电荷变化。 在另一个实施方案中，官能团包含酶，例如葡萄糖氧化酶，当葡萄糖存在于样品中时，其产生pH的变化。
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