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公开(公告)号：US10392578B2
公开(公告)日：2019-08-27
申请号：US13151014
申请日：2011-06-01
申请人： Stephen Robert Cherinko , Robert Cody Kertis , Kirk E. Apt , Paul Warren Behrens , Jon Milton Hansen , Joseph W. Pfeifer, III , Tracey Lynn Stahl , Ross Zirkle , Nasrin Tabayeh Burke , Krishna Raman , Neil Francis Leininger
发明人： Stephen Robert Cherinko , Robert Cody Kertis , Kirk E. Apt , Paul Warren Behrens , Jon Milton Hansen , Joseph W. Pfeifer, III , Tracey Lynn Stahl , Ross Zirkle , Nasrin Tabayeh Burke , Krishna Raman , Neil Francis Leininger
摘要： The present invention relates to processes for obtaining a lipid from a cell by lysing the cell, contacting the cell with a base and/or salt, and separating the lipid. The present invention is also directed to a lipid prepared by the processes of the present invention. The present invention is also directed to microbial lipids having a particular anisidine value, peroxide value, and/or phosphorus content.
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公开(公告)号：US20110295028A1
公开(公告)日：2011-12-01
申请号：US13151014
申请日：2011-06-01
申请人： Stephen Robert Cherinko , Robert Cody Kertis , Kirk E. Apt , Paul Warren Behrens , Jon Milton Hansen , Joseph W. Pfeifer, III , Tracey Lynn Stahl , Ross Zirkle , Nasrin Tabayeh Burke , Krishna Raman , Neil Francis Leininger
发明人： Stephen Robert Cherinko , Robert Cody Kertis , Kirk E. Apt , Paul Warren Behrens , Jon Milton Hansen , Joseph W. Pfeifer, III , Tracey Lynn Stahl , Ross Zirkle , Nasrin Tabayeh Burke , Krishna Raman , Neil Francis Leininger
摘要： The present invention relates to processes for obtaining a lipid from a cell by lysing the cell, contacting the cell with a base and/or salt, and separating the lipid. The present invention is also directed to a lipid prepared by the processes of the present invention. The present invention is also directed to microbial lipids having a particular anisidine value, peroxide value, and/or phosphorus content.
摘要翻译： 本发明涉及通过裂解细胞，使细胞与碱和/或盐接触并分离脂质从细胞获得脂质的方法。 本发明还涉及通过本发明的方法制备的脂质。 本发明还涉及具有特定茴香胺值，过氧化值和/或磷含量的微生物脂质。
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3.发明申请Thraustochytrids, Fatty Acid Compositions, and Methods of Making and Uses Thereof 有权Thraustochytrids，脂肪酸组合物及其制备和使用方法公开(公告)号：US20100239533A1
公开(公告)日：2010-09-23
申请号：US12407687
申请日：2009-03-19
申请人： Kirk E. APT , Joseph W. Pfeifer, III , Jon Milton Hansen , Paul Warren Behrens , Ross Zirkle , Tracey Lynn Stahl
发明人： Kirk E. APT , Joseph W. Pfeifer, III , Jon Milton Hansen , Paul Warren Behrens , Ross Zirkle , Tracey Lynn Stahl
IPC分类号： A61K35/00 , C12N1/10 , C07C57/00 , C12P7/64 , C11B1/00 , A61K31/20 , A23D9/00 , A23C9/20 , A23L2/52 , A23K1/16 , A23K1/18
CPC分类号： A23K20/158 , A23D9/00 , A23K50/00 , A23K50/80 , A23L33/115 , A23L33/12 , A23L33/135 , A23V2002/00 , A61K8/99 , A61K31/20 , A61K31/202 , A61K36/02 , A61K2035/11 , A61K2800/74 , A61Q19/00 , C12P7/6427 , C12P7/6472 , C12R1/89
摘要： The present invention is directed to isolated thraustochytrid microorganisms as well as strains and mutants thereof. The invention is further directed to biomasses, microbial oils, compositions, cultures, methods of producing microbial oils, and methods of using the isolated thraustochytrids, biomasses, and microbial oils.
摘要翻译： 本发明涉及分离的破釜状菌属微生物以及其菌株和突变体。 本发明进一步涉及生物量，微生物油，组合物，培养物，生产微生物油的方法，以及使用分离的破釜蛇疮，生物质和微生物油的方法。
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4.发明申请Thraustochytrids, Fatty Acid Compositions, and Methods of Making and Uses Thereof 有权Thraustochytrids，脂肪酸组合物及其制备和使用方法公开(公告)号：US20120088831A1
公开(公告)日：2012-04-12
申请号：US13220259
申请日：2011-08-29
申请人： Kirk E. APT , Joseph W. Pfeifer, III , Jon Milton Hansen , Paul Warren Behrens , Ross Zirkle , Tracey Lynn Stahl
发明人： Kirk E. APT , Joseph W. Pfeifer, III , Jon Milton Hansen , Paul Warren Behrens , Ross Zirkle , Tracey Lynn Stahl
IPC分类号： A61K31/20 , A23L2/00 , A23D9/00 , C12N1/11 , C12P7/64 , C12N1/10 , C11B3/00 , C07C57/03 , A23C9/00 , A23K1/00
CPC分类号： A23K20/158 , A23D9/00 , A23K50/00 , A23K50/80 , A23L33/115 , A23L33/12 , A23L33/135 , A23V2002/00 , A61K8/99 , A61K31/20 , A61K31/202 , A61K36/02 , A61K2035/11 , A61K2800/74 , A61Q19/00 , C12P7/6427 , C12P7/6472 , C12R1/89
摘要： The present invention is directed to isolated thraustochytrid microorganisms as well as strains and mutants thereof. The invention is further directed to biomasses, microbial oils, compositions, cultures, methods of producing microbial oils, and methods of using the isolated thraustochytrids, biomasses, and microbial oils.
摘要翻译： 本发明涉及分离的破釜状菌属微生物以及其菌株和突变体。 本发明进一步涉及生物量，微生物油，组合物，培养物，生产微生物油的方法，以及使用分离的破釜蛇疮，生物质和微生物油的方法。
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5.发明授权Thraustochytrids, fatty acid compositions, and methods of making and uses thereof 有权Thraustochytrids，脂肪酸组合物及其制备方法和用途公开(公告)号：US09414612B2
公开(公告)日：2016-08-16
申请号：US13220259
申请日：2011-08-29
申请人： Kirk E. Apt , Joseph W. Pfeifer, III , Jon Milton Hansen , Paul Warren Behrens , Ross Zirkle , Tracey Lynn Stahl
发明人： Kirk E. Apt , Joseph W. Pfeifer, III , Jon Milton Hansen , Paul Warren Behrens , Ross Zirkle , Tracey Lynn Stahl
CPC分类号： A23K20/158 , A23D9/00 , A23K50/00 , A23K50/80 , A23L33/115 , A23L33/12 , A23L33/135 , A23V2002/00 , A61K8/99 , A61K31/20 , A61K31/202 , A61K36/02 , A61K2035/11 , A61K2800/74 , A61Q19/00 , C12P7/6427 , C12P7/6472 , C12R1/89
摘要： The present invention is directed to isolated thraustochytrid microorganisms as well as strains and mutants thereof. The invention is further directed to biomasses, microbial oils, compositions, cultures, methods of producing microbial oils, and methods of using the isolated thraustochytrids, biomasses, and microbial oils.
摘要翻译： 本发明涉及分离的破釜状菌属微生物以及其菌株和突变体。 本发明进一步涉及生物量，微生物油，组合物，培养物，生产微生物油的方法，以及使用分离的破釜蛇疮，生物质和微生物油的方法。
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公开(公告)号：US09924733B2
公开(公告)日：2018-03-27
申请号：US12729013
申请日：2010-03-22
申请人： Kirk E. Apt , Paul Warren Behrens , Jon Milton Hansen , Joseph W. Pfeifer, III , Tracey Lynn Stahl , Ross Zirkle
发明人： Kirk E. Apt , Paul Warren Behrens , Jon Milton Hansen , Joseph W. Pfeifer, III , Tracey Lynn Stahl , Ross Zirkle
IPC分类号： A23D9/00 , C11B1/00 , C12P7/64 , A61K31/202 , A23K1/16 , A61K8/36 , A61K31/201 , A61Q19/00 , A23L2/52 , A23C9/152 , A23D9/007 , C11B1/10 , C11B3/04 , C12R1/89 , C12R1/90 , A61K35/68 , A23K10/12 , A23K20/158 , A23K50/00 , A23K50/40 , A23K50/80 , A23L33/00 , A23L33/115
CPC分类号： A23K20/158 , A23C9/1528 , A23D9/00 , A23D9/007 , A23K10/12 , A23K50/00 , A23K50/40 , A23K50/80 , A23L2/52 , A23L33/115 , A23L33/40 , A23V2002/00 , A61K8/361 , A61K31/201 , A61K31/202 , A61K35/68 , A61K2800/10 , A61Q19/00 , C11B1/10 , C11B3/04 , C12P7/6427 , C12P7/6472 , C12R1/89 , C12R1/90
摘要： The present invention is directed to isolated microorganisms as well as strains and mutants thereof, biomasses, microbial oils, compositions, and cultures; methods of producing the microbial oils, biomasses, and mutants; and methods of using the isolated microorganisms, biomasses, and microbial oils.
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7.发明授权Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof 有权产生二十碳五烯酸的微生物，脂肪酸组合物及其制备方法和用途公开(公告)号：US09222112B2
公开(公告)日：2015-12-29
申请号：US13554852
申请日：2012-07-20
申请人： Kirk E. Apt , Paul Warren Behrens , Jon Milton Hansen , Joseph W. Pfeifer, III , Tracey Lynn Stahl , Ross Zirkle
发明人： Kirk E. Apt , Paul Warren Behrens , Jon Milton Hansen , Joseph W. Pfeifer, III , Tracey Lynn Stahl , Ross Zirkle
IPC分类号： A23D9/00 , C12P7/64 , A61K31/202
CPC分类号： A61K31/202 , A23K20/158 , A23K50/80 , A23L2/52 , A23L33/12 , A23L33/40 , A23V2002/00 , A61K8/361 , A61K2800/10 , A61Q19/00 , C12P7/6427 , A61K2300/00
摘要： The invention is directed to microbial oils containing omega-3 polyunsaturated fatty acids comprising docosahexaenoic acid, eicosapentaenoic acid, and optionally docosapentaenoic acid and dosage forms containing such oils.
摘要翻译： 本发明涉及含有ω-3多不饱和脂肪酸的微生物油，其包含二十二碳六烯酸，二十碳五烯酸和任选的二十二碳五烯酸以及含有这些油的剂型。
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公开(公告)号：US20130190520A1
公开(公告)日：2013-07-25
申请号：US13554852
申请日：2012-07-20
申请人： Kirk E. APT , Paul Warren Behrens , Jon Milton Hansen , Joseph W. Pfeifer, III , Tracey Lynn Stahl , Ross Zirkle
发明人： Kirk E. APT , Paul Warren Behrens , Jon Milton Hansen , Joseph W. Pfeifer, III , Tracey Lynn Stahl , Ross Zirkle
IPC分类号： C12P7/64
CPC分类号： A61K31/202 , A23K20/158 , A23K50/80 , A23L2/52 , A23L33/12 , A23L33/40 , A23V2002/00 , A61K8/361 , A61K2800/10 , A61Q19/00 , C12P7/6427 , A61K2300/00
摘要： The invention is directed to microbial oils containing omega-3 polyunsaturated fatty acids comprising docosahexaenoic acid, eicosapentaenoic acid, and optionally docosapentaenoic acid and dosage forms containing such oils.
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9.发明授权Thraustochytrids, fatty acid compositions, and methods of making and uses thereof 有权Thraustochytrids，脂肪酸组合物及其制备方法和用途公开(公告)号：US08207363B2
公开(公告)日：2012-06-26
申请号：US12407687
申请日：2009-03-19
申请人： Kirk E. Apt , Joseph W. Pfeifer, III , Jon Milton Hansen , Paul Warren Behrens , Ross Zirkle , Tracey Lynn Stahl
发明人： Kirk E. Apt , Joseph W. Pfeifer, III , Jon Milton Hansen , Paul Warren Behrens , Ross Zirkle , Tracey Lynn Stahl
IPC分类号： A23D9/00 , C11B1/00 , C12P7/64 , A61K31/202
CPC分类号： A23K20/158 , A23D9/00 , A23K50/00 , A23K50/80 , A23L33/115 , A23L33/12 , A23L33/135 , A23V2002/00 , A61K8/99 , A61K31/20 , A61K31/202 , A61K36/02 , A61K2035/11 , A61K2800/74 , A61Q19/00 , C12P7/6427 , C12P7/6472 , C12R1/89
摘要： The present invention is directed to isolated thraustochytrid microorganisms as well as strains and mutants thereof. The invention is further directed to biomasses, microbial oils, compositions, cultures, methods of producing microbial oils, and methods of using the isolated thraustochytrids, biomasses, and microbial oils.
摘要翻译： 本发明涉及分离的破釜状菌属微生物以及其菌株和突变体。 本发明进一步涉及生物量，微生物油，组合物，培养物，生产微生物油的方法，以及使用分离的破釜蛇疮，生物质和微生物油的方法。
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公开(公告)号：US08637651B2
公开(公告)日：2014-01-28
申请号：US12724403
申请日：2010-03-15
申请人： Kirk E. Apt , James Casey Lippmeier , David Simpson , Jun Wang , James P. Wynn , Ross Zirkle
发明人： Kirk E. Apt , James Casey Lippmeier , David Simpson , Jun Wang , James P. Wynn , Ross Zirkle
CPC分类号： C12P21/00 , C07K14/37 , C07K14/705 , C12N9/2431 , C12N15/79 , C12N15/80 , C12P21/005 , C12R1/90 , C12Y302/01026
摘要： The present invention relates to recombinant cells and microorganisms of the phylum Labyrinthulomycota and their use in heterologous protein production. Novel promoter, terminator, and signal sequences for efficient production and, optionally, secretion of polypeptides from recombinant host cells and microorganisms are also encompassed by the present invention.
摘要翻译： 本发明涉及神经胶霉病菌门的重组细胞和微生物及其在异源蛋白质生产中的用途。 用于有效生产和任选地从重组宿主细胞和微生物分泌多肽的新型启动子，终止子和信号序列也包括在本发明中。
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