公开(公告)号：US20070114439A1

公开(公告)日：2007-05-24

申请号：US10893427

申请日：2004-07-16

申请人： Stevan Bajic ,  Robert Bateman

发明人： Stevan Bajic ,  Robert Bateman

IPC分类号： H01J27/00

CPC分类号： H01J49/168 ,  H01J49/145

摘要： An Atmospheric Pressure Chemical Ionisation (“APCI”) ion source is disclosed comprising a housing 14 having a corona discharge chamber 1, a reaction chamber 2 and a passage 6 connecting the corona discharge chamber 1 to the reaction chamber 2. Reagent ions are formed in the corona discharge chamber 1 and pass to the reaction chamber 2 via the passage 6. Analyte is sprayed into a heated tube 3. Low to moderately polar analyte molecules pass from the heated tube 3 into the reaction chamber 2 whereupon the analyte molecules are ionised by interacting with reagent ions. In contrast, highly polar analytes are ionised by thermal ionisation processes within the heated tube 3 and hence highly polar analyte ions pass into the reaction chamber 2. Analyte ions entering the reaction chamber 2 are substantially shielded from the effects of an electric field generated in the corona discharge chamber 1 as part of the process of generating reagent ions. The APCI ion source according to the preferred embodiment is able to optimally ionise a sample containing both low to moderately polar analytes and also highly polar analytes.

摘要翻译： 公开了一种大气压化学电离（“APCI”）离子源，其包括具有电晕放电室1，反应室2和将电晕放电室1连接到反应室2的通道6的壳体14。 在电晕放电室1中形成试剂离子，并通过通道6进入反应室2。 将分析物喷入加热管3中。 低至中等极性的分析物分子从加热管3进入反应室2，于是分析物分子通过与试剂离子相互作用而离子化。 相比之下，高极性分析物通过加热管3内的热离子化过程进行电离，因此高极性分析物离子进入反应室2。 作为产生试剂离子的过程的一部分，进入反应室2的分析物离子基本上不受电晕放电室1中产生的电场的影响的影响。 根据优选实施方案的APCI离子源能够最佳地离子化含有低至中等极性的分析物和高极性分析物的样品。

公开(公告)号：US06462336B1

公开(公告)日：2002-10-08

申请号：US09214359

申请日：1999-09-16

申请人： Stevan Bajic

发明人： Stevan Bajic

IPC分类号： H01J4910

CPC分类号： H01J49/067 ,  H01J49/04

摘要： An ion source for a mass spectrometer operating at a low pressure has an atmospheric pressure sample ioniser which provides a sample flow containing desired sample ions. These ions are usually entrained with undesired gas and droplets. An interface chamber is held by a vacuum pump at a pressure between atmospheric and the operating pressure of the mass spectrometer. Sample ions with entrained gas are collected through an entrance orifice forming a stream of gas into the interface chamber. Sample ions exit the interface chamber through an exit orifice to the mass spectrometer. The interface chamber disrupts the stream of gas entering the interface chamber to provide a dead region having no net gas flow direction and the exit orifice is located in this dead region. The exit orifice should have no line of sight path to the entrance orifice or should be at least 30° off the flow axis of the stream entering the interface chamber through the entrance orifice. A flow disrupting pin is located in the interface chamber to disrupt the flow of the stream of gas entering through the entrance orifice.

摘要翻译： 用于在低压下操作的质谱仪的离子源具有提供含有所需样品离子的样品流的大气压样品离子发生器。 这些离子通常携带不想要的气体和液滴。 界面室由真空泵在大气压和质谱仪的工作压力之间的压力下保持。 具有夹带气体的样品离子通过形成气流的入口孔收集到界面室中。 样品离子通过出口孔离开界面室至质谱仪。 界面室破坏进入界面室的气体流，以提供没有净气体流动方向的死区，并且出口孔位于该死区。 出口孔应没有到入口孔的视线路线，或者应该离开通过入口孔进入界面室的流的流动轴线至少30°。 流动破坏销位于界面室中，以破坏通过入口孔进入的气流的流动。

公开(公告)号：US06380538B1

公开(公告)日：2002-04-30

申请号：US09269803

申请日：1999-06-21

申请人： Stevan Bajic

发明人： Stevan Bajic

IPC分类号： B01D5944

CPC分类号： H01J49/10

摘要： An ion source for a low pressure mass spectrometer has an atmospheric pressure sample ioniser operative at relatively higher pressure to provide a sample flow containing desired sample ions to the mass spectrometer via an inlet orifice. The sample flow invariably contains involatile components that are infused either as chromatographic buffers or which appear in the analyte as sample extraction byproducts. As the sample ions pass from the high pressure to the low pressure regions through the orifice, these involatile components are deposited on the peripheral regions of the inlet orifice. A conduit for the transportation of a cleaning fluid has an opening adjacent to the inlet orifice for dispensing the cleaning fluid onto at least a portion of a surface of the orifice member during operation of the ion source.

摘要翻译： 用于低压质谱仪的离子源具有在相对较高压力下操作的大气压样品离子发生器，以通过入口孔向质谱仪提供含有所需样品离子的样品流。 样品流量总是含有作为色谱缓冲液或作为样品提取副产物出现在分析物中的不挥发成分。 当样品离子通过孔口从高压到低压区域时，这些非挥发性组分沉积在入口孔的周边区域上。 用于输送清洁流体的导管具有邻近入口孔的开口，用于在离子源操作期间将清洁流体分配到孔口构件的表面的至少一部分上。

公开(公告)号：US20090242749A1

公开(公告)日：2009-10-01

申请号：US12297089

申请日：2007-04-24

申请人： Stevan Bajic

发明人： Stevan Bajic

IPC分类号： B01D59/44 ,  H01J27/00 ,  H01J49/00

CPC分类号： H01J49/167 ,  H01J49/04

摘要： An Electrospray ionisation ion source is disclosed comprising a capillary tube (3) surrounded by a gas nebuliser tube (2). One or more wires (4) are provided within the capillary tube (3). An analyte solution is supplied to the capillary tube (3) and a nebulising gas is supplied to the gas nebuliser tube (2).

摘要翻译： 公开了一种电喷雾离子源，其包括由气体雾化器管（2）包围的毛细管（3）。 在毛细管（3）内设置一根或多根线（4）。 将分析物溶液供应到毛细管（3），并将雾化气体供应到气体雾化器管（2）。

公开(公告)号：US07265362B2

公开(公告)日：2007-09-04

申请号：US11051608

申请日：2005-02-04

申请人： Stevan Bajic ,  Robert Harold Bateman

发明人： Stevan Bajic ,  Robert Harold Bateman

IPC分类号： H01J27/00

CPC分类号： H01J49/168 ,  H01J49/044 ,  H01J49/045 ,  H01J49/0468 ,  H01J49/165

摘要： An Electrospray Ionisation ion source and an Atmospheric Pressure Chemical Ionisation ion source are disclosed which comprise a probe 1 comprising two co-axial capillary tubes 2,3. A blue-flame gas torch 6 is provided downstream of the probe 1 as a combustion source. An analyte solution is sprayed from an inner capillary tube 2 of the probe 1 and a combustible gas is supplied to an outer capillary tube 3 of the probe 1. The combustible gas supplies heat to aid desolvation of the droplets emerging from the probe 1 via combustion with the surrounding oxygen-containing atmosphere when combusted by the blue flame torch 6.

摘要翻译： 公开了一种电喷雾离子源和大气压化学电离离子源，其包括包含两个同轴毛细管2,3的探针1。 蓝色火焰焰炬6设置在探头1的下游，作为燃烧源。 从探针1的内部毛细管2喷射分析物溶液，将可燃气体供给到探针1的外部毛细管3。 当由蓝色火焰焰炬6燃烧时，可燃气体通过与周围的含氧气氛的燃烧而提供热量以帮助从探针1出来的液滴的去溶剂化。

公开(公告)号：US20050269518A1

公开(公告)日：2005-12-08

申请号：US11051609

申请日：2005-02-04

申请人： Stevan Bajic ,  Robert Bateman

发明人： Stevan Bajic ,  Robert Bateman

IPC分类号： B01D59/44 ,  H01J49/16

CPC分类号： H01J49/165 ,  H01J49/044 ,  H01J49/045 ,  H01J49/0468 ,  H01J49/168

摘要： An Electrospray Ionisation ion source and an Atmospheric Pressure Chemical Ionisation ion source are disclosed which comprise a probe 1 comprising three co-axial capillary tubes 2,3,3′. A blue-flame gas torch 6 is provided downstream of the probe 1 as a combustion source. An analyte solution is sprayed from an inner capillary tube 2 of the probe 1, a combustible gas is supplied to an intermediate capillary tube 3 of the probe 1 and oxygen or air is supplied to an outer capillary tube 3′ of the probe 1. The combustible gas supplies heat to aid desolvation of the droplets emerging from the probe 1 via combustion with the surrounding oxygen-containing atmosphere when combusted by the blue flame torch 6.

摘要翻译： 公开了一种电喷雾离子源和大气压化学离子源，其包括包含三个同轴毛细管2,3,3'的探针1。 蓝色火焰焰炬6设置在探头1的下游，作为燃烧源。 从探针1的内部毛细管2喷射分析物溶液，向探针1的中间毛细管3供给可燃性气体，将氧气或空气供给到探针1的外部毛细管3'。 当由蓝色火焰焰炬6燃烧时，可燃气体通过与周围的含氧气氛的燃烧而提供热量以帮助从探针1出来的液滴的去溶剂化。

公开(公告)号：US08026478B2

公开(公告)日：2011-09-27

申请号：US12297089

申请日：2007-04-24

申请人： Stevan Bajic

发明人： Stevan Bajic

IPC分类号： G01N30/72 ,  H01J49/04

CPC分类号： H01J49/167 ,  H01J49/04

摘要： An Electrospray ionization ion source is disclosed comprising a capillary tube surrounded by a gas nebulizer tube. One or more wires are provided within the capillary tube. An analyte solution is supplied to the capillary tube and a nebulizing gas is supplied to the gas nebuliser tube.

摘要翻译： 公开了一种电喷雾离子源，其包括由气体雾化器管包围的毛细管。 在毛细管内设置一根或多根线。 将分析物溶液供应到毛细管，并将雾化气体供应到气体雾化器管。

公开(公告)号：US07294841B2

公开(公告)日：2007-11-13

申请号：US11051609

申请日：2005-02-04

申请人： Stevan Bajic ,  Robert Harold Bateman

发明人： Stevan Bajic ,  Robert Harold Bateman

IPC分类号： H01J27/00

CPC分类号： H01J49/165 ,  H01J49/044 ,  H01J49/045 ,  H01J49/0468 ,  H01J49/168

摘要： An Electrospray Ionisation ion source and an Atmospheric Pressure Chemical Ionisation ion source are disclosed which comprise a probe 1 comprising three co-axial capillary tubes 2,3,3′. A blue-flame gas torch 6 is provided downstream of the probe 1 as a combustion source. An analyte solution is sprayed from an inner capillary tube 2 of the probe 1, a combustible gas is supplied to an intermediate capillary tube 3 of the probe 1 and oxygen or air is supplied to an outer capillary tube 3′ of the probe 1. The combustible gas supplies heat to aid desolvation of the droplets emerging from the probe 1 via combustion with the surrounding oxygen-containing atmosphere when combusted by the blue flame torch 6.

摘要翻译： 公开了一种电喷雾离子源和大气压化学离子源，其包括包含三个同轴毛细管2,3,3'的探针1。 蓝色火焰焰炬6设置在探头1的下游，作为燃烧源。 从探针1的内部毛细管2喷射分析物溶液，向探针1的中间毛细管3供给可燃性气体，将氧气或空气供给到探针1的外部毛细管3'。 当由蓝色火焰焰炬6燃烧时，可燃气体通过与周围的含氧气氛的燃烧而提供热量以帮助从探针1出来的液滴的去溶剂化。

公开(公告)号：US5756994A

公开(公告)日：1998-05-26

申请号：US766299

申请日：1996-12-13

申请人： Stevan Bajic

发明人： Stevan Bajic

IPC分类号： G01N27/62 ,  H01J49/04 ,  H01J49/10 ,  H01J49/26

CPC分类号： H01J49/165 ,  H01J49/0445 ,  H01J49/067

摘要： Atmospheric Pressure Chemical Ionization (APCI) and electrospray ionization sources for the mass spectrometric analysis of solutions, and associated methods. The apparatus and methods are characterised in that ions generated by APCI or electrospray are directed such that their directions of travel immediately on formation can be resolved into two perpendicular components, one of which is aligned with a linear first trajectory which passes through an entrance orifice, an extraction chamber and into an evacuation port through which the extraction chamber is evacuated. The direction of travel is such that the component of velocity so aligned is smaller than the component perpendicular to it. Ions leave the chamber along a second trajectory which is inclined at an angle between 30.degree. and 150.degree. to the linear first trajectory and may pass into a mass analyzer. The apparatus and method provide improved sensitivity and a lower noise level in comparison with prior apparatus and methods using APCI and electrospray ionization sources.

摘要翻译： 大气压化学电离（APCI）和电喷雾离子源用于溶液的质谱分析及相关方法。 该装置和方法的特征在于，由APCI或电喷雾产生的离子被定向成使得其立即形成的行进方向可以分解成两个垂直分量，其中一个垂直分量与通过入口孔的线性第一轨迹对齐， 提取室并进入抽空口，抽空室通过该抽空口排出。 行进方向是这样排列的速度分量小于垂直于它的分量。 离子室沿着与线性第一轨迹倾斜30°至150°之间的角度的第二轨迹离开，并且可以进入质量分析器。 与使用APCI和电喷雾电离源的现有装置和方法相比，该装置和方法提供了改进的灵敏度和较低的噪声水平。

公开(公告)号：US08809777B2

公开(公告)日：2014-08-19

申请号：US14113151

申请日：2012-04-20

申请人： Stevan Bajic

发明人： Stevan Bajic

IPC分类号： H01J49/14

CPC分类号： H01J49/10 ,  G01N27/624 ,  G01N30/724 ,  H01J49/0445 ,  H01J49/0468 ,  H01J49/061 ,  H01J49/14 ,  H01J49/16 ,  H01J49/24 ,  H01J49/26

摘要： An ion source is disclosed comprising a nebulizer and a target. The nebulizer is arranged and adapted to emit, in use, a stream of analyte droplets which are caused to impact upon the target and to ionise analyte to form a plurality of analyte ions.

摘要翻译： 公开了一种包括雾化器和靶的离子源。 喷雾器布置并适于在使用中发射被分析物液滴流，其被引起撞击目标物并使分析物离子化以形成多个分析物离子。