公开(公告)号：US20120049689A1

公开(公告)日：2012-03-01

申请号：US13222812

申请日：2011-08-31

申请人： Steven Bennett ,  Nathaniel Mast ,  Kevin Lavigne ,  Walter Skalla ,  Timothy Sargeant ,  Joshua Stopek ,  Saumya Banerjee ,  Arpan Desai

发明人： Steven Bennett ,  Nathaniel Mast ,  Kevin Lavigne ,  Walter Skalla ,  Timothy Sargeant ,  Joshua Stopek ,  Saumya Banerjee ,  Arpan Desai

IPC分类号： H02K1/06

CPC分类号： A61K41/00 ,  A61K9/0024 ,  A61K9/06 ,  A61K31/00 ,  A61K47/34 ,  A61L24/0015 ,  A61L24/0031 ,  A61L26/0066 ,  A61L26/008 ,  A61L27/52 ,  A61L27/54 ,  A61L29/145 ,  A61L29/16 ,  A61L31/145 ,  A61L31/16 ,  A61L2300/622 ,  A61L2300/626 ,  C08J3/075 ,  C08J3/246 ,  C08J2371/02

摘要： The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.

公开(公告)号：US08734930B2

公开(公告)日：2014-05-27

申请号：US13222801

申请日：2011-08-31

申请人： Steven Bennett ,  Nathaniel Mast ,  Kevin Lavigne ,  Walter Skalla ,  Timothy Sargeant ,  Joshua Stopek ,  Saumya Banerjee ,  Arpan Desai

发明人： Steven Bennett ,  Nathaniel Mast ,  Kevin Lavigne ,  Walter Skalla ,  Timothy Sargeant ,  Joshua Stopek ,  Saumya Banerjee ,  Arpan Desai

IPC分类号： B32B3/00

CPC分类号： A61K9/06 ,  A61K47/32 ,  A61K47/34 ,  A61L27/50 ,  A61L27/52 ,  Y10T428/24479

摘要： The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.

公开(公告)号：US08883185B2

公开(公告)日：2014-11-11

申请号：US13115049

申请日：2011-05-24

申请人： Steven Bennett ,  Nathaniel Mast ,  Kevin Lavigne ,  Walter Skalla ,  Saumya Banerjee ,  Timothy Sargeant ,  Joshua Stopek

发明人： Steven Bennett ,  Nathaniel Mast ,  Kevin Lavigne ,  Walter Skalla ,  Saumya Banerjee ,  Timothy Sargeant ,  Joshua Stopek

IPC分类号： A61F2/00 ,  A61K31/00 ,  A61L31/14 ,  A61K9/06 ,  A61L27/52 ,  A61K47/34 ,  A61K47/32

CPC分类号： A61L27/16 ,  A61K9/06 ,  A61K31/00 ,  A61K47/08 ,  A61K47/18 ,  A61K47/32 ,  A61K47/34 ,  A61L27/18 ,  A61L27/52 ,  A61L27/54 ,  A61L31/145 ,  A61L2430/38

摘要： The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.

公开(公告)号：US20110293687A1

公开(公告)日：2011-12-01

申请号：US13115049

申请日：2011-05-24

申请人： Steven Bennett ,  Nathaniel Mast ,  Kevin Lavigne ,  Walter Skalla ,  Saumya Banerjee ,  Timothy Sargeant ,  Joshua Stopek

发明人： Steven Bennett ,  Nathaniel Mast ,  Kevin Lavigne ,  Walter Skalla ,  Saumya Banerjee ,  Timothy Sargeant ,  Joshua Stopek

IPC分类号： A61K9/00 ,  A61P17/00 ,  A61P9/00 ,  A61P19/00 ,  A61K47/30 ,  A61K47/32

CPC分类号： A61L27/16 ,  A61K9/06 ,  A61K31/00 ,  A61K47/08 ,  A61K47/18 ,  A61K47/32 ,  A61K47/34 ,  A61L27/18 ,  A61L27/52 ,  A61L27/54 ,  A61L31/145 ,  A61L2430/38

摘要： The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.

公开(公告)号：US08754564B2

公开(公告)日：2014-06-17

申请号：US13222812

申请日：2011-08-31

申请人： Steven Bennett ,  Nathaniel Mast ,  Kevin Lavigne ,  Walter Skalla ,  Timothy Sargeant ,  Joshua Stopek

发明人： Steven Bennett ,  Nathaniel Mast ,  Kevin Lavigne ,  Walter Skalla ,  Timothy Sargeant ,  Joshua Stopek

IPC分类号： H02K1/06

CPC分类号： A61K41/00 ,  A61K9/0024 ,  A61K9/06 ,  A61K31/00 ,  A61K47/34 ,  A61L24/0015 ,  A61L24/0031 ,  A61L26/0066 ,  A61L26/008 ,  A61L27/52 ,  A61L27/54 ,  A61L29/145 ,  A61L29/16 ,  A61L31/145 ,  A61L31/16 ,  A61L2300/622 ,  A61L2300/626 ,  C08J3/075 ,  C08J3/246 ,  C08J2371/02

摘要： The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.

公开(公告)号：US20110293699A1

公开(公告)日：2011-12-01

申请号：US13115079

申请日：2011-05-24

申请人： Steven Bennett ,  Nathaniel Mast ,  Kevin Lavigne ,  Walter Skalla ,  Timothy Sargeant ,  Joshua Stopek

发明人： Steven Bennett ,  Nathaniel Mast ,  Kevin Lavigne ,  Walter Skalla ,  Timothy Sargeant ,  Joshua Stopek

IPC分类号： A61K47/30 ,  A61K9/00 ,  A61K9/127 ,  A61P31/00 ,  A61P29/00 ,  A61P1/00 ,  A61P25/08 ,  A61P9/00 ,  A61P21/02 ,  A61P35/00 ,  A61P37/06 ,  A61K47/32 ,  A61P23/00

CPC分类号： A61K31/00 ,  A61K9/0024 ,  A61K9/06 ,  A61K47/34 ,  C08J3/075 ,  C08J3/246 ,  C08J2371/02 ,  A61K2300/00

摘要： The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.

公开(公告)号：US08591950B2

公开(公告)日：2013-11-26

申请号：US13115079

申请日：2011-05-24

申请人： Steven Bennett ,  Nathaniel Mast ,  Kevin Lavigne ,  Walter Skalla ,  Timothy Sargeant ,  Joshua Stopek

发明人： Steven Bennett ,  Nathaniel Mast ,  Kevin Lavigne ,  Walter Skalla ,  Timothy Sargeant ,  Joshua Stopek

IPC分类号： A61K47/30 ,  A61K9/00 ,  A61K9/127 ,  A61P31/00 ,  A61P29/00 ,  A61P1/00 ,  A61P25/08 ,  A61P9/00 ,  A61P21/02 ,  A61P35/00 ,  A61P37/06 ,  A61K47/32 ,  A61P23/00

CPC分类号： A61K31/00 ,  A61K9/0024 ,  A61K9/06 ,  A61K47/34 ,  C08J3/075 ,  C08J3/246 ,  C08J2371/02 ,  A61K2300/00

摘要： The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.

公开(公告)号：US20120064299A1

公开(公告)日：2012-03-15

申请号：US13222801

申请日：2011-08-31

申请人： Steven Bennett ,  Nathaniel Mast ,  Kevin Lavigne ,  Walter Skalla ,  Timothy Sargeant ,  Joshua Stopek

发明人： Steven Bennett ,  Nathaniel Mast ,  Kevin Lavigne ,  Walter Skalla ,  Timothy Sargeant ,  Joshua Stopek

IPC分类号： B32B3/00 ,  B29C35/08 ,  C08J3/28 ,  A61K9/00

CPC分类号： A61K9/06 ,  A61K47/32 ,  A61K47/34 ,  A61L27/50 ,  A61L27/52 ,  Y10T428/24479

摘要： The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.

摘要翻译： 本公开涉及水凝胶组合物及其使用方法。 水凝胶组合物可包括在接触时彼此反应的前体以及与引发剂接触时反应的前体。 在实施方案中，所得到的水凝胶可具有不同密度和较不致密区域的交联水平。

公开(公告)号：US09833225B2

公开(公告)日：2017-12-05

申请号：US12897011

申请日：2010-10-04

申请人： Timothy Sargeant ,  Joshua Stopek ,  Michael Bettuchi ,  Arpan Desai ,  Atu Agawu ,  Saumya Banerjee

发明人： Timothy Sargeant ,  Joshua Stopek ,  Michael Bettuchi ,  Arpan Desai ,  Atu Agawu ,  Saumya Banerjee

IPC分类号： A61B17/08 ,  A61B17/00 ,  A61L31/04 ,  A61L31/14

CPC分类号： A61B17/0057 ,  A61B2017/00588 ,  A61B2017/00592 ,  A61B2017/00597 ,  A61B2017/0061 ,  A61B2017/00628 ,  A61B2017/00637 ,  A61B2017/00641 ,  A61B2017/0065 ,  A61L31/04 ,  A61L31/14

摘要： Biocompatible wound closure devices including an elongate body and a plug member are useful for wound repair.

公开(公告)号：US08617206B2

公开(公告)日：2013-12-31

申请号：US12897001

申请日：2010-10-04

申请人： Timothy Sargeant ,  Gregory Fischvogt ,  Michael Bettuchi ,  Gerald Hodgkinson ,  Joshua Stopek ,  Arpan Desai ,  Atu Agawu ,  Saumya Banerjee

发明人： Timothy Sargeant ,  Gregory Fischvogt ,  Michael Bettuchi ,  Gerald Hodgkinson ,  Joshua Stopek ,  Arpan Desai ,  Atu Agawu ,  Saumya Banerjee

IPC分类号： A61B17/08 ,  A61D1/00

CPC分类号： A61B17/0057 ,  A61B2017/00637 ,  A61B2017/00884 ,  A61B2017/00898 ,  A61F2/0063 ,  A61L31/145 ,  A61L31/148

摘要： Biocompatible wound closure devices including an elongate body and a plug member are useful for wound repair. A wound closure device includes an elongate body defining a longitudinal axis and having a proximal end and a distal end, and a plug member having a tissue facing surface and including a first shaped section and a second shaped section, each of the first and second shaped sections having an abutment surface. The first and second shaped sections are movable about a hinge between a collapsed position in which the abutment surfaces extend away from the longitudinal axis of the elongate body and a deployed position in which the abutment surfaces abut and are substantially aligned with the longitudinal axis of the elongate body, the abutment surfaces controlling a deployed angle of the tissue facing surface of the plug member with respect to the elongate body.

摘要翻译： 包括细长主体和塞子部件的生物相容的伤口闭合装置可用于伤口修复。 伤口闭合装置包括限定纵向轴线并具有近端和远端的细长主体以及具有面向组织的表面并包括第一成形部分和第二成形部分的插塞部件，每个第一和第二成形部分 具有邻接表面的部分。 第一和第二成形部分可在关闭位置之间围绕铰链移动，在折叠位置中，邻接表面延伸远离细长主体的纵向轴线和展开位置，在该展开位置中，邻接表面邻接并与其基本对齐 所述邻接表面控制所述插塞构件相对于所述细长主体的面向组织的表面的展开角度。