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12 条记录 (耗时 0.033 秒)

    Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof
    5.
    发明申请
    Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof 审中-公开
    四唑衍生物及其代谢相关病症的治疗方法

    公开(公告)号：US20070072924A1

    公开(公告)日：2007-03-29

    申请号：US11601252

    申请日：2006-11-17

    申请人： Graeme Semple ,  Thomas Schrader ,  Philip Skinner ,  Steven Colletti ,  Tawfik Gharbaoui ,  Jason Imbriglio ,  Jae-Kyu Jung ,  Rui Liang ,  Subharekha Raghavan ,  Darby Schmidt ,  James Tata

    发明人： Graeme Semple ,  Thomas Schrader ,  Philip Skinner ,  Steven Colletti ,  Tawfik Gharbaoui ,  Jason Imbriglio ,  Jae-Kyu Jung ,  Rui Liang ,  Subharekha Raghavan ,  Darby Schmidt ,  James Tata

    IPC分类号： A61K31/416 ,  C07D403/04

    CPC分类号： C07D491/04 ,  C07D403/04 ,  C07D495/04

    摘要： The present invention relates to certain tetrazole derivatives of Formula (I), and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists for the RUP25 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of α-glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers and the like.

    摘要翻译： 本发明涉及式（I）的某些四唑衍生物及其药学上可接受的盐，其表现出有用的药理学性质，例如作为RUP25受体的激动剂。 本发明还提供含有本发明化合物的药物组合物，以及使用本发明化合物和组合物治疗代谢相关疾病包括血脂异常，动脉粥样硬化，冠心病，胰岛素抵抗，2型糖尿病 ，综合征-X等。 此外，本发明还提供本发明化合物与其它活性剂如属于α-葡糖苷酶抑制剂类，醛糖还原酶抑制剂，双胍类，HMG-CoA还原酶抑制剂，角鲨烯合成 抑制剂，贝特类，LDL分解代谢增强剂，血管紧张素转换酶（ACE）抑制剂，胰岛素分泌增强剂等。

    Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof
    6.
    发明申请
    Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof 失效
    四唑衍生物及其代谢相关病症的治疗方法

    公开(公告)号：US20060217562A1

    公开(公告)日：2006-09-28

    申请号：US10535345

    申请日：2004-10-29

    申请人： Graeme Semple ,  Thomas Schrader ,  Philip Skinner ,  Steven Colletti ,  Tawfik Gharbaoui ,  Jason Imbriglio ,  Jae-Kyu Jung ,  Rui Liang ,  Subharekha Raghavan ,  Darby Schmidt ,  James Tata

    发明人： Graeme Semple ,  Thomas Schrader ,  Philip Skinner ,  Steven Colletti ,  Tawfik Gharbaoui ,  Jason Imbriglio ,  Jae-Kyu Jung ,  Rui Liang ,  Subharekha Raghavan ,  Darby Schmidt ,  James Tata

    IPC分类号： A61K31/416 ,  C07D403/02

    CPC分类号： C07D491/04 ,  C07D403/04 ,  C07D495/04

    摘要： The present invention relates to certain tetrazole derivatives of Formula (I), and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists for the RUP25 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of α-glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers and the like.

    摘要翻译： 本发明涉及式（I）的某些四唑衍生物及其药学上可接受的盐，其表现出有用的药理学性质，例如作为RUP25受体的激动剂。 本发明还提供含有本发明化合物的药物组合物，以及使用本发明化合物和组合物治疗代谢相关疾病包括血脂异常，动脉粥样硬化，冠心病，胰岛素抵抗，2型糖尿病的方法 ，综合征-X等。 此外，本发明还提供本发明化合物与其它活性剂如属于α-葡糖苷酶抑制剂类，醛糖还原酶抑制剂，双胍类，HMG-CoA还原酶抑制剂，角鲨烯合成 抑制剂，贝特类，LDL分解代谢增强剂，血管紧张素转换酶（ACE）抑制剂，胰岛素分泌增强剂等。

    Piperidines promote release of growth hormone
    9.
    发明授权
    Piperidines promote release of growth hormone 失效
    皮质激素促进生长激素的释放

    公开(公告)号：US5877182A

    公开(公告)日：1999-03-02

    申请号：US926212

    申请日：1997-09-09

    申请人： Ravi Nargund ,  Arthur A. Patchett ,  James Tata

    发明人： Ravi Nargund ,  Arthur A. Patchett ,  James Tata

    IPC分类号： C07D401/06 ,  C07D471/10 ,  A61K31/445 ,  C07D221/20

    CPC分类号： A61K31/663 ,  C07D401/06 ,  C07D471/10

    摘要： The present invention is directed to certain piperidines, pyrrolidines, and hexahydro-1H-azepines of the general structural formula: ##STR1## wherein B is selected from: ##STR2## and R.sup.1, R.sup.1a, R.sup.2a, R.sup.3a, R.sup.3b, R.sup.4, R.sup.4a, R.sup.4b, R.sup.5, D,E, X, Y, n, x and y are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.

    摘要翻译： 本发明涉及以下通式结构式的某些哌啶，吡咯烷和六氢-1H-吖庚因：其中B选自：其中R 1，R 1a，R 2a，R 3a，R 3b，R 4，R 4a， R4b，R5，D，E，X，Y，n，x和y如本文所定义。 这些化合物促进人和动物中生长激素的释放。 这种性质可以用于促进食用动物的生长，使食用肉制品的生产更有效，并且在人类中，用于治疗以生长激素分泌不足为特征的生理或医学病症，例如生长激素缺乏的身材矮小 儿童，并且治疗通过生长激素的合成代谢作用改善的医疗状况。 还公开了含有这些化合物作为其活性成分的生长激素释放组合物。