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    Multimode ionization mode separator
    3.
    发明授权
    Multimode ionization mode separator 有权
    多模电离模式分离器

    公开(公告)号：US07223968B2

    公开(公告)日：2007-05-29

    申请号：US11349469

    申请日：2006-02-06

    申请人： Steven M. Fischer ,  Darrell L. Gourley ,  Patricia H. Cormia

    发明人： Steven M. Fischer ,  Darrell L. Gourley ,  Patricia H. Cormia

    IPC分类号： H01J49/04

    CPC分类号： H01J49/107 ,  H01J49/06 ,  H01J49/165

    摘要： A multimode ionization source includes an electrospray ionization source for providing a charged aerosol, an atmospheric pressure ionization source downstream from the electrospray ionization source for further ionizing said charged aerosol, and a mode separator, or mask, situated so as to separate a portion of the charged aerosol and prevent the portion from being exposed to the atmospheric pressure ionization source.

    摘要翻译： 多模电离源包括用于提供带电气溶胶的电喷雾离子化源，用于电喷雾离子化源的下游的大气压电离源，用于进一步电离所述带电气体，以及模式分离器或掩模， 并且防止该部分暴露于大气压电离源。

    Multimode ionization source
    4.
    发明授权
    Multimode ionization source 有权

    公开(公告)号：US07078681B2

    公开(公告)日：2006-07-18

    申请号：US10640176

    申请日：2003-08-13

    申请人： Steven M. Fischer ,  Darrell L. Gourley ,  James L. Bertsch

    发明人： Steven M. Fischer ,  Darrell L. Gourley ,  James L. Bertsch

    IPC分类号： H01J49/10

    CPC分类号： H01J49/107 ,  H01J49/0445 ,  H01J49/162 ,  H01J49/165 ,  H01J49/168

    摘要： The present invention provides an apparatus and method for use with a mass spectrometer. The multimode ionization source of the present invention provides one or more atmospheric pressure ionization sources (e.g., electrospray, atmospheric pressure chemical ionization and/or atmospheric pressure photoionization) for ionizing molecules. A method of producing ions using the multimode ionization source is also disclosed. The apparatus and method provide the advantages of the combined ion sources without the inherent disadvantages of the individual sources. In an embodiment, the multimode ionization source includes an infrared emitter enclosed in an inner chamber for drying a charged aerosol. ESI/APCI multimode sources may include a corona needle shield and/or an auxiliary electrode.

    Atmospheric pressure photoionization source in mass spectrometry
    5.
    发明授权
    Atmospheric pressure photoionization source in mass spectrometry 有权
    质谱中大气压光电离源

    公开(公告)号：US06646256B2

    公开(公告)日：2003-11-11

    申请号：US10023140

    申请日：2001-12-18

    申请人： Darrell L. Gourley ,  Steven M. Fischer

    发明人： Darrell L. Gourley ,  Steven M. Fischer

    IPC分类号： H01V4928

    CPC分类号： H01J49/162

    摘要： Apparatus and methods are disclosed for an ion source that comprises a flow-through ultraviolet lamp for photoionization. One embodiment of the apparatus comprises a tubular outer element and a tubular inner element. The inner element is disposed within the outer element to provide a space between the inner and outer elements. The inner element is open at its ends to provide a pathway through that element. A gas discharge between the elements produces ultraviolet radiation, which transmits through the wall of the inner element into the region within the inner element and ionizes molecules that flow through the region. The ion source can be employed in conjunction with a mass analyzer for mass spectrometry. In the method for ionizing molecules in an ion source, vaporized molecules are flowed through the region within the inner element, the region being surrounded by UV radiation. The radiation ionizes vaporized molecules in the surrounded region.

    摘要翻译： 公开了用于离子源的装置和方法，其包括用于光电离的流过紫外线灯。 该装置的一个实施例包括管状外部元件和管状内部元件。 内部元件设置在外部元件内以在内部元件和外部元件之间提供空间。 内部元件在其端部是开放的以提供通过该元件的通路。 元件之间的气体放电产生紫外线辐射，其透射通过内部元件的壁进入内部元件内的区域并离子化流过该区域的分子。 离子源可以与质谱分析仪结合使用。 在离子源中离子化分子的方法中，蒸发的分子流过内部元件内的区域，该区域被紫外线辐射包围。 辐射电离被包围区域中的汽化分子。

    Apparatus for forming liquid droplets having a mechanically fixed inner microtube
    6.
    发明授权
    Apparatus for forming liquid droplets having a mechanically fixed inner microtube 失效
    用于形成具有机械固定内微管的液滴的装置

    公开(公告)号：US5868322A

    公开(公告)日：1999-02-09

    申请号：US722644

    申请日：1996-09-27

    申请人： Harvey D. Loucks, Jr. ,  Steven M. Fischer ,  Darrell L. Gourley

    发明人： Harvey D. Loucks, Jr. ,  Steven M. Fischer ,  Darrell L. Gourley

    IPC分类号： G01N27/62 ,  G01N21/31 ,  G01N21/73 ,  G01N30/72 ,  G01N30/84 ,  H01J49/04 ,  F23D11/10

    CPC分类号： H01J49/0431 ,  B05B15/06 ,  B05B5/0255 ,  B05B7/066 ,  B05B7/068 ,  G01N30/7246 ,  H01J49/167 ,  B05B13/0278 ,  B05B7/0876 ,  G01N2030/847

    摘要： The invention relates to an apparatus for forming liquid droplets, such as a micro nebulizer, useful for preparing samples for subsequent analysis via MS, AA, ICP, CE/MS, and similar analytical systems. The apparatus has a mechanically stabilized inner microtube or needle, thereby ensuring controllably uniform droplet size The mechanical stabilization is provided by securing the inner microtube or needle, such as by narrowing the inner diameter of the outer microtube or otherwise narrowing the annular intermediate space between the inner and outer microtubes for a predetermined length. Thus, the inner microtube is secured in a centered or otherwise predetermined fixed radial position, with minimum perturbation of the fluid flow. Further, a tip, when coupled with the exit end of the outer microtube, provides a region in which the sheath fluid flow in the outer microtube stabilizes prior to both exiting the tip and colliding with the liquid analyte exiting the inner microtube.

    摘要翻译： 本发明涉及用于形成液滴的装置，例如微型喷雾器，可用于制备样品用于随后通过MS，AA，ICP，CE / MS和类似分析系统的分析。 该装置具有机械稳定的内部微管或针，从而确保可控地均匀的液滴尺寸通过固定内部微管或针来提供机械稳定性，例如通过使外部微管的内径变窄或以其他方式使第二微管之间的环形中间空间变窄 内部和外部微管，预定长度。 因此，内部微管被固定在中心或另外预定的固定的径向位置，同时具有最小的流体流扰动。 此外，当与外部微管的出口端耦合时，尖端提供了一个区域，其中外部微管中的鞘液流动在两个离开尖端之前稳定，并且与离开内微管的液体分析物碰撞。

    Multimode ionization source
    9.
    发明授权
    Multimode ionization source 有权
    多模电离源

    公开(公告)号：US07488953B2

    公开(公告)日：2009-02-10

    申请号：US11444095

    申请日：2006-05-31

    申请人： Steven M. Fischer ,  Darrell L. Gourley ,  James L. Bertsch

    发明人： Steven M. Fischer ,  Darrell L. Gourley ,  James L. Bertsch

    IPC分类号： H01J27/02

    CPC分类号： H01J49/107 ,  H01J49/0445 ,  H01J49/162 ,  H01J49/165 ,  H01J49/168

    摘要： The present invention provides an apparatus and method for use with a mass spectrometer. The multimode ionization source of the present invention provides one or more atmospheric pressure ionization sources (e.g., electrospray, atmospheric pressure chemical ionization and/or atmospheric pressure photoionization) for ionizing molecules. A method of producing ions using the multimode ionization source is also disclosed. The apparatus and method provide the advantages of the combined ion sources without the inherent disadvantages of the individual sources. In an embodiment, the multimode ionization source includes an infrared emitter enclosed in an inner chamber for drying a charged aerosol. ESI/APCI multimode sources may include a corona needle shield and/or an auxiliary electrode.

    摘要翻译： 本发明提供了一种与质谱仪一起使用的装置和方法。 本发明的多模电离源提供用于电离分子的一个或多个大气压电离源（例如电喷雾，大气压化学电离和/或大气压光电离）。 还公开了使用多模电离源产生离子的方法。 该装置和方法提供了组合离子源的优点，而没有各个源的固有缺点。 在一个实施例中，多模式电离源包括封闭在内室中用于干燥带电气溶胶的红外发射器。 ESI / APCI多模式源可以包括电晕针护罩和/或辅助电极。