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公开(公告)号：US5559326A
公开(公告)日：1996-09-24
申请号：US508729
申请日：1995-07-28
CPC分类号： H01J49/0468 , H01J49/045 , H01J49/14
摘要： An improved method and apparatus for creating ions through shearing forces of high velocity liquid and gas streams without application of an external electrical field. Ions are susceptible to customary of analysis such as mass spectrometry.
摘要翻译： 一种用于通过高速液体和气流的剪切力产生离子而不施加外部电场的改进的方法和装置。 离子易受诸如质谱等常规分析。
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公开(公告)号：US07423261B2
公开(公告)日：2008-09-09
申请号：US11398163
申请日：2006-04-05
申请人： Jean-Luc Truche , Paul C. Goodley , Steven M. Fischer , Jian Bal
发明人： Jean-Luc Truche , Paul C. Goodley , Steven M. Fischer , Jian Bal
CPC分类号： H01J49/062
摘要： An ion sampling apparatus for use in a mass spectrometry system. The ion sampling apparatus includes a target support for receiving a sample, an irradiation source for emitting energetic radiation or particles toward the target support, and a conduit having a curved end and a longitudinal axis, the curved end having an inlet with a central axis, the conduit being adjacent to the target support. The longitudinal axis of the conduit and the central axis of the inlet intersect to define an angle that is between about 20 degrees and about 210 degrees.
摘要翻译： 用于质谱系统的离子取样装置。 离子采样设备包括用于接收样品的目标支撑体，用于向目标支撑体发射能量辐射或颗粒的辐射源，以及具有弯曲端部和纵向轴线的导管，该弯曲端部具有带有中心轴线的入口， 导管与目标支撑件相邻。 导管的纵向轴线和入口的中心轴线相交以限定约20度至约210度之间的角度。
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3.发明授权Micro concentric tube nebulizer for coupling liquid devices to chemical analysis devices 失效用于将液体装置耦合到化学分析装置的微同心管雾化器
公开(公告)号：US5752663A
公开(公告)日：1998-05-19
申请号：US592040
申请日：1996-01-26
申请人： Steven M. Fischer , Paul C. Goodley
发明人： Steven M. Fischer , Paul C. Goodley
CPC分类号： H01J49/045 , B05B7/066 , G01N21/714
摘要： A method and apparatus for improving pneumatic nebulization of liquids is taught providing for controllable production of droplet size range generated. The improvement is aimed at nebulizers comprised of concentric tubes, the inner transporting analyte liquid, the outer--inert gas. The improvement comprises altering the outer lip of the free end of the inner tube so as to allow laminar flow of the exiting gas. By alteration of the tip, droplets in a controlled size range can be routinely produced with a minimum of operator adjusting.
摘要翻译： 教导了用于改善液体的气动雾化的方法和装置，其提供可控制造产生的液滴尺寸范围。 改进的目的在于由同心管，内部输送分析物液体，外部惰性气体组成的喷雾器。 该改进包括改变内管的自由端的外唇以便允许排出气体的层流。 通过尖端的改变，可以通过最小的操作者调整来常规地产生在受控尺寸范围内的液滴。
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4.再颁专利
公开(公告)号：USRE36892E
公开(公告)日：2000-10-03
申请号：US792303
申请日：1997-01-31
CPC分类号： H01J49/165 , G01N30/7253 , H01J49/04
摘要： .[.The invention teaches the uses of a plurality of electric fields and of orthogonal spray configurations of vaporized analyte which combine so as to operate to enhance the efficiency of analyte detection and mass analysis with a mass spectrometer by reducing vapor in the vacuum system and concomitant noise. Several embodiments of the invention are described for purposes of illustration..]. .Iadd.The invention relates to a method and apparatus for improving signal relative to noise without loss of ion collection efficiency in electrospray mass spectrometry, including liquid chromatography/mass spectrometry..Iaddend.
摘要翻译： [本发明教导了多个电场和汽化分析物的正交喷雾构型的使用，其结合起来以便通过减少真空系统中的蒸气和伴随的噪声来提高分析物检测和质谱分析的效率 。 为了说明的目的，描述了本发明的几个实施例。]本发明涉及一种用于在电喷雾质谱（包括液相色谱/质谱）中改善相对于噪声的信号而不损失离子收集效率的方法和装置。
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公开(公告)号：US5750988A
公开(公告)日：1998-05-12
申请号：US794248
申请日：1997-02-03
CPC分类号： H01J49/165 , G01N30/7253
摘要： A method apparatus wherein a plurality of electric fields and of orthogonal spray configurations of vaporized analyte are so combined as to enhance the efficiency of analyte detection and mass analysis. The method and apparatus provides reduced noise and increased signal sensitivity in both API electrospray and APCI operating modes.
摘要翻译： 一种方法装置，其中多个电场和蒸发分析物的正交喷雾构型如此组合以提高分析物检测和质量分析的效率。 该方法和装置在API电喷雾和APCI操作模式中提供降低的噪声和增加的信号灵敏度。
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6.发明授权Apparatuses, methods and compositions for ionization of samples and mass calibrants 有权用于电离样品和质量卡尺的装置，方法和组合物公开(公告)号：US07737395B2
公开(公告)日：2010-06-15
申请号：US11757369
申请日：2007-06-02
IPC分类号： B01D59/44
CPC分类号： H01J49/168 , H01J49/0009
摘要： The present invention provides, inter alia, apparatuses and methods for ionizing samples that are in gaseous phase or can be vaporized/sublimated. The samples include samples to be analyzed and mass calibrants that serve as standards. In addition, the present invention also provides calibrant formulations that release mass calibrants in a slow, controlled manner.
摘要翻译： 本发明尤其提供了用于电离处于气相或可蒸发/升华的样品的装置和方法。 样品包括要分析的样品和用作标准品的质量标准。 此外，本发明还提供了以缓慢且受控的方式释放大量校准物的校准剂制剂。
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7.发明授权公开(公告)号：US07723678B2
公开(公告)日：2010-05-25
申请号：US11398305
申请日：2006-04-04
申请人： Jean-Luc Truche , Paul C. Goodley , Gregor Overney
发明人： Jean-Luc Truche , Paul C. Goodley , Gregor Overney
IPC分类号： H01J49/14
CPC分类号： H01J49/142
摘要： An apparatus and method for generating analyte ions from a sample. An ion generating device is provided having a chamber with an outlet and a surface having a material and means for applying a high velocity gas flow through the chamber toward the outlet such that charged particles are produced by physical interaction between the high velocity gas and the material. The charged particles then induce the generation of primary ions by interaction with molecules of the high velocity gas. The primary ions are emitted from the outlet of the ion generating device toward a sample-bearing surface and analyte ions are generated by impact of the primary ions on the analyte sample on the surface.
摘要翻译： 一种用于从样品中产生分析物离子的装置和方法。 提供一种离子产生装置，其具有具有出口的腔室和具有材料的表面，以及用于将高速气流经由腔室朝向出口施加的装置，使得通过高速气体和材料之间的物理相互作用产生带电粒子 。 带电粒子然后通过与高速气体分子的相互作用诱导产生初级离子。 主要离子从离子产生装置的出口朝向样品承载表面发射，分析物离子通过主离子冲击表面上的分析物样品而产生。
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公开(公告)号：US07115860B2
公开(公告)日：2006-10-03
申请号：US11065516
申请日：2005-02-23
申请人： Paul C. Goodley , Jean-Luc Truche
发明人： Paul C. Goodley , Jean-Luc Truche
CPC分类号： H01J49/167 , H01J49/0018 , H01J49/04
摘要： A source of ions for an analyzer includes a reservoir for containing a liquid, a manifold having a plurality of nozzles, a conduit connecting the reservoir to the manifold and a counter electrode having a potential different between the counter electrode and the nozzles to enable liquid to be ejected from the nozzles in droplets and to enable ions to be ejected from the droplets.
摘要翻译： 用于分析器的离子源包括用于容纳液体的储存器，具有多个喷嘴的歧管，将储存器连接到歧管的导管和在对电极和喷嘴之间具有不同电位的对电极， 从喷嘴喷出液滴，并使离子从液滴中喷出。
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公开(公告)号：US06294779B1
公开(公告)日：2001-09-25
申请号：US09204213
申请日：1998-12-02
IPC分类号： H01J4926
CPC分类号： H01J49/145 , G01N30/7253 , H01J49/0431 , H01J49/165 , H01J49/168
摘要： A method and apparatus are disclosed wherein a plurality of electric fields and of orthogonal spray configurations of vaporized analyte are so combined as to enhance the efficiency of analyte detection and mass analysis. The invention provides reduced noise and increased signal sensitivity in both API electrospray and APCI operating modes.
摘要翻译： 公开了一种方法和装置，其中将多个电场和蒸发的分析物的正交喷雾构型组合，以提高分析物检测和质量分析的效率。 本发明在API电喷雾和APCI操作模式中提供降低的噪声和增加的信号灵敏度。
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公开(公告)号：US4960991A
公开(公告)日：1990-10-02
申请号：US422936
申请日：1989-10-17
申请人： Paul C. Goodley , Stuart C. Hansen
发明人： Paul C. Goodley , Stuart C. Hansen
CPC分类号： H01J49/107 , H01J27/08 , H01J49/145
摘要： A multimode ionization source includes a resistive filament aligned with an exit cone orifice. The filament generates electrons that bombard molecules near the orifice. In electron impact mode, a pressure regulator selects a low pressure within an ionization chamber and gaseous analyte is injected through a gas inlet and ionized by electron bombardment. In chemical ionization mode, an intermediate pressure of reagent gas established; electrons ionize the reagent gas. Gaseous analyte is introduced is ionized by the reagent gas through chemical interaction. In thermospray mode, a high pressure is established and heated liquid analyte is introduced into the chamber as a spray which is ionized by ion evaporation; in a thermospray/chemical ionization submode, filament activation supplements ion evaporation. Ions produced in all modes can be directed to a mass analyzer for analysis.
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