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    Secreted protein HPEAD48
    2.
    发明授权
    Secreted protein HPEAD48 失效
    分泌蛋白HPEAD48

    公开(公告)号：US06433139B1

    公开(公告)日：2002-08-13

    申请号：US09288143

    申请日：1999-04-08

    申请人： Steven M. Ruben ,  Craig A. Rosen ,  Henrik S. Olsen

    发明人： Steven M. Ruben ,  Craig A. Rosen ,  Henrik S. Olsen

    IPC分类号： C07K100

    CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N2799/026

    摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

    摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

    Peptidoglycan recognition proteins
    8.
    发明授权
    Peptidoglycan recognition proteins 失效
    肽聚糖识别蛋白

    公开(公告)号：US07368244B2

    公开(公告)日：2008-05-06

    申请号：US11214796

    申请日：2005-08-31

    申请人： Paul E. Young ,  Steven M. Ruben ,  Craig A. Rosen ,  Henrik S. Olsen

    发明人： Paul E. Young ,  Steven M. Ruben ,  Craig A. Rosen ,  Henrik S. Olsen

    IPC分类号： C07H21/00

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The present invention related to three novel peptidoglican recognition binding protein expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A-B, FIGS. 2A-C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-c polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.

    摘要翻译： 本发明涉及由角质形成细胞，伤口愈合组织和软骨肉瘤组织表达的三种新型肽基识别结合蛋白。 更具体地，提供分离的核酸分子，其编码人胶原聚糖识别蛋白相关蛋白（本文称为PGRP-K（角质形成细胞），PGRP-W（伤口愈合）和PGRP-C（软骨肉瘤））。 图1A-B， 图2A-C， 3，分别与人肽聚糖识别蛋白（PGRP）以及鼠Tag-7都具有同源性。 还提供了PGRP-K，PGRP-W和PGRP-C多肽。 进一步提供载体，宿主细胞和用于制备其的重组方法。 本发明还涉及PGRP-K，PGRP-W和PGRP-c多肽的活性的抑制和增强以及用于检测PGRP-K，PGRP-W和PGRP-C基因表达的诊断方法。

    Peptidoglycan recognition proteins
    10.
    发明授权
    Peptidoglycan recognition proteins 失效
    肽聚糖识别蛋白

    公开(公告)号：US07041802B2

    公开(公告)日：2006-05-09

    申请号：US10180454

    申请日：2002-06-27

    申请人： Paul E. Young ,  Steven M. Ruben ,  Craig A. Rosen ,  Henrik S. Olsen

    发明人： Paul E. Young ,  Steven M. Ruben ,  Craig A. Rosen ,  Henrik S. Olsen

    IPC分类号： C07K16/00 ,  C12P21/08 ,  C12N5/06 ,  G01N33/53

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The present invention relates to three novel peptidoglycan recognition binding proteins expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A–B, FIGS. 2A–C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-c polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.

    摘要翻译： 本发明涉及由角质形成细胞，伤口愈合组织和软骨肉瘤组织表达的三种新的肽聚糖识别结合蛋白。 更具体地，提供分离的核酸分子，其编码人胶原聚糖识别蛋白相关蛋白（本文称为PGRP-K（角质形成细胞），PGRP-W（伤口愈合）和PGRP-C（软骨肉瘤））。 图1A-B， 图2A-C， 3，分别与人肽聚糖识别蛋白（PGRP）以及鼠Tag-7都具有同源性。 还提供了PGRP-K，PGRP-W和PGRP-C多肽。 进一步提供载体，宿主细胞和用于制备其的重组方法。 本发明还涉及PGRP-K，PGRP-W和PGRP-c多肽的活性的抑制和增强以及用于检测PGRP-K，PGRP-W和PGRP-C基因表达的诊断方法。