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    Hybridization chamber agitation device using pump and valves
    2.
    发明授权
    Hybridization chamber agitation device using pump and valves 失效
    使用泵和阀的杂化室搅拌装置

    公开(公告)号：US07544505B2

    公开(公告)日：2009-06-09

    申请号：US11295844

    申请日：2005-12-06

    申请人： Sung-ouk Jung ,  Nam Huh ,  Soo-suk Lee ,  Chang-eun Yoo ,  Hun-joo Lee

    发明人： Sung-ouk Jung ,  Nam Huh ,  Soo-suk Lee ,  Chang-eun Yoo ,  Hun-joo Lee

    IPC分类号： C12M1/34

    CPC分类号： B01L3/502738 ,  B01F13/0059 ,  B01F13/0222 ,  B01L3/50273 ,  B01L7/52 ,  B01L2300/0636 ,  B01L2300/0822 ,  B01L2300/0877

    摘要： Provided is an agitation device used to agitate a solution in a hybridization chamber, the agitation device including: the hybridization chamber; first and second air channels connected to ends of the hybridization chamber; a first valve disposed in the first air channel; a second valve disposed in the second air channel; an integrated air channel connecting the first and second air channels; and a pump disposed in the integrated air channel. The agitation device is suitable for effective diffusion of a sample when performing hybridization using a DNA chip. Therefore, a probe can be effectively hybridized with a target material.

    摘要翻译： 提供了用于搅拌杂交室中的溶液的搅拌装置，搅拌装置包括：杂交室; 第一和第二空气通道连接到杂交室的末端; 设置在第一空气通道中的第一阀; 设置在第二空气通道中的第二阀; 连接第一和第二空气通道的集成空气通道; 以及设置在集成空气通道中的泵。 搅拌装置适用于使用DNA芯片进行杂交时样品的有效扩散。 因此，探针可以有效地与靶材料杂交。

    Hybridization system using the control of pump and valves in closed system
    3.
    发明申请
    Hybridization system using the control of pump and valves in closed system 失效
    混合系统使用封闭系统中的泵和阀的控制

    公开(公告)号：US20060154360A1

    公开(公告)日：2006-07-13

    申请号：US11295843

    申请日：2005-12-06

    申请人： Soo-suk Lee ,  Sung-ouk Jung ,  Chang-eun Yoo ,  Hun-joo Lee ,  Christopher Ko ,  Nam Huh

    发明人： Soo-suk Lee ,  Sung-ouk Jung ,  Chang-eun Yoo ,  Hun-joo Lee ,  Christopher Ko ,  Nam Huh

    IPC分类号： C12M1/34

    CPC分类号： B01L7/00 ,  B01F13/0059 ,  B01F13/0222 ,  B01L3/5027 ,  B01L2200/0689 ,  B01L2300/0636 ,  B01L2300/14 ,  B01L2300/1822 ,  B01L2400/0487 ,  G01N2035/00544

    摘要： Provided is a hybridization system for hybridizing a biochip including: a chamber device including at least a hybridization chamber including a support for a biochip and a first cover having a sample inlet; an agitation device including: two air channels connected to ends of the hybridization chamber; two valves disposed in the air channels; an integrated air channel to which the two air channels are connected; and an air pump disposed in the integrated air channel; and a washing and drying device including: a flow channel connected to one of the two air channels through a branched valve; a flow pump disposed in the flow channel; and a buffer inlet disposed opposite the flow channel.

    摘要翻译： 提供了一种用于杂交生物芯片的杂交系统，包括：至少包括一个包括用于生物芯片的支撑物的杂交室的腔室装置和具有样品入口的第一盖子; 一种搅拌装置，包括：两个连接到杂交室端部的空气通道; 设置在空气通道中的两个阀; 两个空气通道连接的集成空气通道; 以及设置在所述集成空气通道中的空气泵; 以及洗涤干燥装置，包括：流路，其通过分支阀连接到所述两个空气通道中的一个; 设置在流路中的流量泵; 以及与流动通道相对设置的缓冲器入口。

    Packing device for chamber sample inlet
    5.
    发明申请
    Packing device for chamber sample inlet 审中-公开
    室样品进样口的包装装置

    公开(公告)号：US20060193751A1

    公开(公告)日：2006-08-31

    申请号：US11296023

    申请日：2005-12-06

    申请人： Sung-ouk Jung ,  Soo-suk Lee ,  Yu-jin Seo ,  Chang-eun Yoo ,  Hun-joo Lee

    发明人： Sung-ouk Jung ,  Soo-suk Lee ,  Yu-jin Seo ,  Chang-eun Yoo ,  Hun-joo Lee

    IPC分类号： B01L3/00 ,  C12M1/34

    CPC分类号： B01L3/508 ,  B01L2200/027 ,  B01L2200/0642 ,  B01L2300/048 ,  B01L2300/049 ,  B01L2300/0636 ,  B01L2300/0822

    摘要： A packing device used to pack a sample inlet formed in an upper cover of a chamber is provided. The packing device has an air vent formed in the surface of an upper portion of the sample inlet contacting a cap or in the surface of a lower portion of the cap contacting the sample inlet. The movement of the sample solution in the chamber can be prevented by using a structural design in which air pressure generated due to the volume of a packing cap inserted into the sample inlet after the sample is injected into the chamber through the sample inlet to react with reaction materials, such as biomolecules, is not generated inside of the chamber. In addition, in a hybridization chamber in which a biochip is placed, the spot area on the biochip can be effectively agitated with the sample solution, thus increasing hybridization efficiency.

    摘要翻译： 提供了用于包装形成在室的上盖中的样品入口的包装装置。 包装装置具有形成在样品入口的上部的表面中的与所述盖接触的表面或者与所述样品入口接触的所述盖的下部的表面中的通气孔。 可以通过使用结构设计来防止样品溶液在室中的移动，其中在将样品通过样品入口注入到室中之后，由于填充帽的体积而产生的空气压力插入到样品入口中，以与 在室内部不产生反应物质，如生物分子。 此外，在其中放置生物芯片的杂交室中，可以用样品溶液有效地搅拌生物芯片上的斑点区域，从而提高杂交效率。

    Microfluidic device using centrifugal force and pump to control fluid movement, microfluidic system comprising the same and method of manufacturing the microfluidic device
    6.
    发明授权
    Microfluidic device using centrifugal force and pump to control fluid movement, microfluidic system comprising the same and method of manufacturing the microfluidic device 有权
    使用离心力和泵来控制流体运动的微流体装置，包括其的微流体系统和制造微流体装置的方法

    公开(公告)号：US07819138B2

    公开(公告)日：2010-10-26

    申请号：US11869835

    申请日：2007-10-10

    申请人： Hun-joo Lee ,  Nam Huh ,  Soo-suk Lee ,  Sung-ouk Jung ,  Soo-hyung Choi

    发明人： Hun-joo Lee ,  Nam Huh ,  Soo-suk Lee ,  Sung-ouk Jung ,  Soo-hyung Choi

    IPC分类号： F15C1/04

    CPC分类号： G05D7/0694 ,  Y10T29/494 ,  Y10T137/0753 ,  Y10T137/2191 ,  Y10T137/86187

    摘要： The microfluidic device includes a rotatable platform, a plurality of connection ports disposed at a portion of the platform proximate to a shaft connection hole, the plurality of connection ports capable of being connected to an external connector for selectively injecting and discharging fluid and being closed by the connector, a trap chamber disposed at a portion of the platform further away from the shaft connection hole than the plurality of connection ports, the trap chamber including an inlet connected with at least one connection port of the plurality of connection ports, an outlet connected with another connection port of the plurality of connection ports and structures which enlarge a contact area with the fluid and a temporary storage including an inlet connected with the outlet of the trap chamber and an outlet connected with another connection port of the plurality of connection ports.

    摘要翻译： 所述微流体装置包括可旋转平台，多个连接端口，设置在所述平台的靠近轴连接孔的部分处，所述多个连接端口能够连接到外部连接器，用于选择性地注入和排出流体并且由 所述连接器，设置在所述平台的远离所述轴连接孔的所述平台部分处的所述收集室，所述收集室包括与所述多个连接端口中的至少一个连接端口连接的入口，所述入口连接到所述入口 多个连接端口中的另一个连接端口和扩大与流体的接触面积的结构以及包括与捕集室的出口连接的入口的临时存储器和与多个连接端口中的另一连接端口连接的出口。

    Cell lysis method by immobilized metal-ligand complex
    7.
    发明申请
    Cell lysis method by immobilized metal-ligand complex 失效
    固定化金属配体复合物的细胞裂解法

    公开(公告)号：US20060099711A1

    公开(公告)日：2006-05-11

    申请号：US11267005

    申请日：2005-11-04

    申请人： Chang-eun Yoo ,  Joon-ho Kim ,  Kyu-youn Hwang ,  Hun-joo Lee ,  Hee-kyun Lim ,  Soo-min Ma ,  Nam Huh ,  Soo-suk Lee

    发明人： Chang-eun Yoo ,  Joon-ho Kim ,  Kyu-youn Hwang ,  Hun-joo Lee ,  Hee-kyun Lim ,  Soo-min Ma ,  Nam Huh ,  Soo-suk Lee

    IPC分类号： G01N1/00

    CPC分类号： C12Q1/6806 ,  Y10T436/25 ,  C12Q2523/308

    摘要： Provided is a lysis method for cells or viruses, including: immobilizing a metal-ligand complex on a solid support; and mixing the complex immobilized on the support with a cell or virus solution. According to the lysis method, by immobilizing a chemical on a solid support to perform cell lysis, the dilution problem according to the addition of a cell lysis solution can be resolved and a separate process of removing the chemical is not required so as to reduce the steps upon LOC implementation. In addition, since a variety of solid supports, such as chips, beads, nanoparticles etc. can be used, cell lysis apparatuses of various forms can be fabricated.

    摘要翻译： 提供了一种细胞或病毒的裂解方法，包括：将固定支持物上的金属 - 配体复合物固定; 并将固定在载体上的复合物与细胞或病毒溶液混合。 根据裂解方法，通过将化学物质固定在固体支持体上以进行细胞裂解，可以解决根据细胞溶解溶液的添加的稀释问题，并且不需要单独的除去化学品的方法，以减少 LOC实施步骤。 此外，由于可以使用各种固体支持体，例如芯片，珠粒，纳米粒子等，因此可以制造各种形式的细胞裂解装置。

    Cell lysis method by immobilized metal-ligand complex
    8.
    发明授权
    Cell lysis method by immobilized metal-ligand complex 失效
    固定化金属配体复合物的细胞裂解法

    公开(公告)号：US07648838B2

    公开(公告)日：2010-01-19

    申请号：US11267005

    申请日：2005-11-04

    申请人： Chang-eun Yoo ,  Joon-ho Kim ,  Kyu-youn Hwang ,  Hun-joo Lee ,  Hee-kyun Lim ,  Soo-min Ma ,  Nam Huh ,  Soo-suk Lee

    发明人： Chang-eun Yoo ,  Joon-ho Kim ,  Kyu-youn Hwang ,  Hun-joo Lee ,  Hee-kyun Lim ,  Soo-min Ma ,  Nam Huh ,  Soo-suk Lee

    IPC分类号： G01N33/48 ,  G01N33/20 ,  G01N1/00

    CPC分类号： C12Q1/6806 ,  Y10T436/25 ,  C12Q2523/308

    摘要： Provided is a lysis method for cells or viruses, including: immobilizing a metal-ligand complex on a solid support; and mixing the complex immobilized on the support with a cell or virus solution. According to the lysis method, by immobilizing a chemical on a solid support to perform cell lysis, the dilution problem according to the addition of a cell lysis solution can be resolved and a separate process of removing the chemical is not required so as to reduce the steps upon LOC implementation. In addition, since a variety of solid supports, such as chips, beads, nanoparticles etc. can be used, cell lysis apparatuses of various forms can be fabricated.

    摘要翻译： 提供了一种细胞或病毒的裂解方法，包括：将固定支持物上的金属 - 配体复合物固定; 并将固定在载体上的复合物与细胞或病毒溶液混合。 根据裂解方法，通过将化学物质固定在固体支持体上以进行细胞裂解，可以解决根据细胞溶解溶液的添加的稀释问题，并且不需要单独的除去化学品的方法，以减少 LOC实施步骤。 此外，由于可以使用各种固体支持物，例如芯片，珠粒，纳米粒子等，因此可以制造各种形式的细胞裂解装置。

    Electrodialysis apparatus and electrodialysis method using the same
    9.
    发明授权
    Electrodialysis apparatus and electrodialysis method using the same 有权
    电渗析装置及使用其的电渗析方法

    公开(公告)号：US08343325B2

    公开(公告)日：2013-01-01

    申请号：US11737448

    申请日：2007-04-19

    申请人： Hun-joo Lee ,  Soo-suk Lee ,  Joon-ho Kim ,  Sung-ouk Jung ,  In-ho Lee

    发明人： Hun-joo Lee ,  Soo-suk Lee ,  Joon-ho Kim ,  Sung-ouk Jung ,  In-ho Lee

    IPC分类号： B01D61/44

    CPC分类号： B01D61/422 ,  B01D2311/243 ,  B01D2313/02 ,  B01D2313/10 ,  B01D2313/26 ,  B01D2313/30 ,  B01D2313/50 ,  B01D2321/185

    摘要： An electrodialysis apparatus includes a sample chamber including first and second dialysis membranes and filled with a sample between the first dialysis membrane and the second dialysis membrane, an anode chamber including an anode and filled with a first chamber solution between the anode and the first dialysis membrane, and a cathode chamber including a cathode and filled with a second chamber solution between the cathode and the second dialysis membrane. In particular, when a voltage is applied to the anode and the cathode, ionic materials of the sample move to the anode and cathode chambers.

    摘要翻译： 电渗透装置包括：样品室，包括第一和第二透析膜，并在第一透析膜和第二透析膜之间填充样品;阳极室，包括阳极，并在阳极和第一透析膜之间填充第一室溶液 以及包括阴极并在阴极和第二透析膜之间填充有第二室溶液的阴极室。 特别地，当向阳极和阴极施加电压时，样品的离子材料移动到阳极室和阴极室。

    Microarray holding device
    10.
    发明申请
    Microarray holding device 审中-公开
    微阵列保持装置

    公开(公告)号：US20050271557A1

    公开(公告)日：2005-12-08

    申请号：US11106209

    申请日：2005-04-14

    申请人： Hun-joo Lee ,  Nam Huh ,  Sang-hyun Paek ,  Chang-eun Yoo

    发明人： Hun-joo Lee ,  Nam Huh ,  Sang-hyun Paek ,  Chang-eun Yoo

    IPC分类号： G01N33/52 ,  B01L9/00

    CPC分类号： B01L9/52 ,  B01J2219/00608 ,  B01J2219/00621 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01L2300/0819

    摘要： Provided is a microarray holding device. The microarray holding device includes: a solid substrate in the form of a plate in which an engaging-receiving portion for receiving a microarray substrate to be engaged therewith is formed, the engaging-receiving portion being composed of an opening; sidewalls to be aligned with sidewalls of the microarray substrate to be engaged with the engaging-receiving portion; and a base surface on which a top or bottom surface of the microarray substrate to be engaged with the engaging-receiving portion is to be placed, wherein the base surface is depressed from a top or bottom surface of the solid substrate such that the other surface of the microarray substrate is lower than the top or bottom surface of the solid substrate when the microarray substrate is engaged with the engaging-receiving portion.

    摘要翻译： 提供了一种微阵列保持装置。 微阵列保持装置包括：形成板状的固体基板，其中形成用于接收与其接合的微阵列基板的接合部分，所述接合部分由开口构成; 与微阵列基板的侧壁对准以与接合部接合的侧壁; 以及要在其上放置要与所述接合部分接合的所述微阵列基板的顶表面或底表面的基面，其中所述基底表面从所述固体基底的顶表面或底表面压下，使得所述另一表面 的微阵列基板与接合部接合时，低于固体基板的顶面或底面。