-
公开(公告)号:US06747023B1
公开(公告)日:2004-06-08
申请号:US09762888
申请日:2001-02-12
申请人: Syozo Kobayashi , Satoshi Komoriya , Noriyasu Haginoya , Masanori Suzuki , Toshiharu Yoshino , Takayasu Nagahara , Tsutomu Nagata , Haruhiko Horino , Masayuki Ito , Akiyoshi Mochizuki
发明人: Syozo Kobayashi , Satoshi Komoriya , Noriyasu Haginoya , Masanori Suzuki , Toshiharu Yoshino , Takayasu Nagahara , Tsutomu Nagata , Haruhiko Horino , Masayuki Ito , Akiyoshi Mochizuki
IPC分类号: C07D51304
CPC分类号: C07D207/08 , C07D207/12 , C07D207/22 , C07D211/34 , C07D211/70 , C07D213/56 , C07D213/61 , C07D213/73 , C07D213/75 , C07D213/82 , C07D213/84 , C07D213/89 , C07D233/18 , C07D233/64 , C07D233/88 , C07D239/42 , C07D239/48 , C07D243/08 , C07D277/40 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要: Described in the present invention are a sulfonyl derivative represented by the following formula (I): Q1—Q2—T1—Q3—SO2—QA (I) [wherein Q1 represents a saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group, 5- or 6-membered heterocyclic group, dicyclic fused ring or tricyclic fused ring group which may have a substituent; Q2 represents a single bond, an oxygen atom, a sulfur atom, a linear or branched C1-6 alkylene group or the like; QA represents an arylalkenyl group which may have a substituent or a heteroarylalkenyl group which may have a substituent; and T1 represents a carbonyl group or the like] and a medicament comprising the same. The compound has strong FXa inhibitory action, provides prompt, sufficient and long-lasting anti-thrombus effects when orally administered, and has low side effects and is therefore useful as an excellent anticoagulant.
摘要翻译: 在本发明中描述的是由下式(I)表示的磺酰基衍生物:其中Q 1表示饱和或不饱和的5或6元环烃基,5或6元杂环基,双环稠合 可以具有取代基的环或三环稠环; Q 2表示单键,氧原子,硫原子,直链或支链C 1-6亚烷基等; Q表示芳基烯基 其可以具有取代基或可以具有取代基的杂芳基烯基; 和T 1表示羰基等]和包含该羰基的药物。 该化合物具有强的FXa抑制作用,在口服给药时提供及时,充足和持久的抗血栓作用,副作用小,因此可用作优异的抗凝血剂。
-
公开(公告)号:US06525042B1
公开(公告)日:2003-02-25
申请号:US09508680
申请日:2000-03-28
申请人: Syozo Kobayashi , Satoshi Komoriya , Masayuki Ito , Tsutomu Nagata , Akiyoshi Mochizuki , Noriyasu Haginoya , Takayasu Nagahara , Haruhiko Horino
发明人: Syozo Kobayashi , Satoshi Komoriya , Masayuki Ito , Tsutomu Nagata , Akiyoshi Mochizuki , Noriyasu Haginoya , Takayasu Nagahara , Haruhiko Horino
IPC分类号: C07D24302
CPC分类号: C07D207/08 , C07C2601/14 , C07D207/12 , C07D207/22 , C07D207/38 , C07D211/34 , C07D211/70 , C07D213/26 , C07D213/73 , C07D213/74 , C07D213/82 , C07D213/89 , C07D215/48 , C07D217/02 , C07D233/64 , C07D235/06 , C07D239/42 , C07D239/48 , C07D277/40 , C07D295/26 , C07D307/84 , C07D333/68 , C07D401/10 , C07D401/12 , C07D405/04 , C07D409/04 , C07D495/04 , C07D513/04
摘要: Sulfonyl derivatives represented by general formula (I), salts of the same, and solvates of both: and application of them as drugs: [wherein R1 is hydrogen, hydroxyl, nitro or the like; R2 and R3 are each independently hydrogen, halogeno or the like; R4 and R5 are each dependently hydrogen, halogeno or the like; Q1 is an optionally substituted saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group or the like; Q2 is a single bond, oxygen or the like; Q3 is, e.g., a group represented by formula (a): T1 is carbonyl or the like; and X1 and X2 are each independently methylidyne or nitrogen]. These compounds exhibit potent Fxa inhibiting activities and serve as excellent anticoagulants which speedily exert satisfactory and persistent anti-thrombotic effects through oral administration and little cause adverse effects.
摘要翻译: 由通式(I)表示的磺酰基衍生物,它们的盐和两者的溶剂合物:和它们作为药物的应用:[其中R1是氢,羟基,硝基等; R2和R3各自独立地为氢,卤代等; R4和R5各自为氢,卤代等; Q1是任选取代的饱和或不饱和的5-或6-元环烃基等; Q2是单键,氧等; Q3是例如由式(a)表示的基团:T1是羰基等; X1和X2各自独立地是亚甲基或氮]。 这些化合物显示出有力的Fxa抑制活性,并且作为优异的抗凝血剂,其通过口服给药快速发挥令人满意且持久的抗血栓形成作用,并且几乎不引起不良反应。
-
公开(公告)号:US08877393B2
公开(公告)日:2014-11-04
申请号:US13383084
申请日:2010-05-21
申请人: Hiroaki Takeuchi , Tomohiro Ogawa , Ryouichi Nanba , Takumi Taniguchi , Shinji Jomori , Koichiro Ikeda , Shigeki Hasegawa , Masayuki Ito , Hitoshi Hamada , Naohiro Takeshita
发明人: Hiroaki Takeuchi , Tomohiro Ogawa , Ryouichi Nanba , Takumi Taniguchi , Shinji Jomori , Koichiro Ikeda , Shigeki Hasegawa , Masayuki Ito , Hitoshi Hamada , Naohiro Takeshita
CPC分类号: H01M8/04089 , H01M4/8605 , H01M4/8668 , H01M8/0267 , H01M8/0273 , H01M8/04119 , H01M8/242 , H01M2008/1095 , Y02E60/50
摘要: A fuel cell is disclosed comprising: a power generation layer including an electrolyte membrane, and an anode and a cathode provided on respective surfaces of the electrolyte membrane; a fuel gas flow path layer located on a side of the anode of the power generation layer to supply a fuel gas to the anode while flowing the fuel gas along a flow direction of the fuel gas approximately orthogonal to a stacking direction in which respective layers of the fuel cell are stacked; and an oxidizing gas flow path layer located on a side of the cathode of the power generation layer to supply an oxidizing gas to the cathode while flowing the oxidizing gas along a flow direction of the oxidizing gas opposed to the flow direction of the fuel gas. A power generation area of the fuel cell, in which electric power is generated, has an upstream region including a most upstream position along the flow direction of the fuel gas and a downstream region including a most downstream position along the flow direction of the fuel gas. A midstream region, which is a remaining region of the power generation area other than the upstream region and the downstream region, has higher water vapor transfer resistance between the anode side and the cathode side than the upstream region and the downstream region.
摘要翻译: 公开了一种燃料电池,包括:包括电解质膜的发电层和设置在电解质膜的各个表面上的阳极和阴极; 位于所述发电层的阳极侧的燃料气体流路层,用于向所述阳极供给燃料气体,同时使所述燃料气体沿所述燃料气体的流动方向大致垂直于层叠方向 燃料电池堆叠; 以及氧化气体流路层,其位于发电层的阴极侧,以向氧化剂气体沿与燃料气体的流动方向相反的氧化气体的流动方向流动而向氧化气体供给氧化气体。 燃料电池的产生电力的发电区域沿着燃料气体的流动方向具有包括最上游位置的上游区域和沿着燃料气体的流动方向的包括最下游位置的下游区域 。 作为上游区域和下游区域以外的发电区域的剩余区域的中游区域,在阳极侧和阴极侧之间比上游区域和下游区域具有更高的水蒸气传递阻力。
-
公开(公告)号:US08623510B2
公开(公告)日:2014-01-07
申请号:US12448411
申请日:2007-12-21
申请人: Akiyoshi Takeda , Masayuki Ito
发明人: Akiyoshi Takeda , Masayuki Ito
CPC分类号: H01L23/373 , C04B35/522 , C04B35/532 , C04B35/6303 , C04B35/6316 , C04B2235/3208 , C04B2235/3225 , C04B2235/3232 , C04B2235/3241 , C04B2235/3244 , C04B2235/3251 , C04B2235/3256 , C04B2235/3262 , C04B2235/3272 , C04B2235/3275 , C04B2235/3279 , C04B2235/3289 , C04B2235/3418 , C04B2235/3817 , C04B2235/3826 , C04B2235/3839 , C04B2235/3843 , C04B2235/402 , C04B2235/407 , C04B2235/5436 , C04B2235/602 , C04B2235/6021 , C04B2235/616 , C04B2235/725 , C04B2235/728 , C04B2235/761 , C04B2235/77 , C04B2235/80 , C04B2235/9607 , C22C1/1036 , C22C1/1084 , C22C2001/1073 , H01L2924/0002 , Y10T428/30 , H01L2924/00
摘要: Provided are a graphite material, which has excellent bonding characteristics to semiconductor and efficiently dissipates heat generated from the semiconductor, and a method for manufacturing such material. The graphite material is provided by adding at least two kinds of elements selected from among silicon, zirconium, calcium, titanium, chromium, manganese, iron, cobalt, nickel, calcium, yttrium, niobium, molybdenum, technetium, ruthenium and compounds containing such elements, and by performing heat treatment. The graphite material is characterized in having a thickness of the 112 face of the graphite crystal of 15 nm or more by X-ray diffraction, and an average heat conductivity of 250 W/(m·K) or more in the three directions of the X, Y and Z axes.
摘要翻译: 提供了一种石墨材料,其具有优异的半导体结合特性并有效地散发由半导体产生的热量,以及这种材料的制造方法。 通过添加选自硅,锆,钙,钛,铬,锰,铁,钴,镍,钙,钇,铌,钼,锝,钌中的至少两种元素来提供石墨材料,以及含有这些元素的化合物 ,并进行热处理。 石墨材料的特征在于,通过X射线衍射,石墨晶体的112面的厚度为15nm以上,平均导热率为250W /(m·K)以上 X,Y和Z轴。
-
公开(公告)号:US08115790B2
公开(公告)日:2012-02-14
申请号:US11691537
申请日:2007-03-27
申请人: Masayuki Ito
发明人: Masayuki Ito
CPC分类号: B41J11/0095
摘要: A medium detecting apparatus and an image forming apparatus are supplied capable of making medium move without hitting sensor lever while skew adjustment or medium setting operation. In the image forming apparatus, a medium hit surface of the sensor lever to detect skew holds inclinations in plural directions and a guider to limit the medium is furnished on the inclined side; or a medium hit surface of the sensor lever to detect skew holds inclinations in plural directions and position detections in movement direction of carriage and in conveyance direction of medium are performed by one sensor; or a sheet guider is further furnished and the sensor lever whose medium hit surface holds inclinations in plural directions is used as a sensor to detect a paper setting; or a hand-operated adjustment print function is further furnished and the sensor lever whose medium hit surface holds inclinations in plural directions is used as a sensor to detect a paper setting.
摘要翻译: 提供介质检测装置和图像形成装置,其能够在不偏转调节或介质设置操作的情况下进行介质移动而不会碰到传感器杆。 在图像形成装置中,检测偏斜的传感器杆的介质撞击面保持多个方向的倾斜,并且在倾斜侧设置限制介质的导向器; 或传感器杆的中等撞击表面,以检测倾斜保持多个方向的倾斜,并且通过一个传感器执行托架移动方向和介质传送方向上的位置检测; 或者进一步布置纸张引导器,并且使用中等命中表面保持多个方向的倾斜度的传感器杆作为检测纸张设置的传感器; 或者进一步配置手动调节打印功能,并且使用中等命中表面保持多个方向倾斜的传感器杆作为检测纸张设置的传感器。
-
公开(公告)号:US08087008B2
公开(公告)日:2011-12-27
申请号:US11512337
申请日:2006-08-30
申请人: Masayuki Ito , Tooru Higeta , Koutarou Matsuo
发明人: Masayuki Ito , Tooru Higeta , Koutarou Matsuo
IPC分类号: G06F9/44 , G06F9/45 , G06F15/173
CPC分类号: G06F11/3414 , G06F11/3433 , G06F2201/875
摘要: The web load test apparatus includes a virtual web client generation section to generate virtual web clients each of which transmits a request message to a web server and receives a response message according to a scenario; a memory section to store synchronous point that specifies an order in the scenario of the response message, which is a synchronous point among the response messages, into a storage; a waiting section to interrupt the accesses by the clients until a time when all the clients receive the response messages whose orders are indicated by the synchronous point; a resumption section to resume the accesses when all the clients receive the response messages whose orders are indicated by the synchronous point; and a rewrite section to replace the synchronous point stored in the storage with synchronous point that specifies another response message.
摘要翻译: web负载测试装置包括虚拟Web客户端生成部分,用于生成虚拟web客户端,每个虚拟Web客户端根据场景向web服务器发送请求消息并接收响应消息; 存储器部分,用于存储将响应消息中的同步点的响应消息的场景中的顺序指定到存储器中的同步点; 等待部分中断客户端的访问,直到所有客户端接收到其同步点指示的响应消息的时间; 当所有客户机接收到其同步点指示的响应消息时,恢复部分恢复访问; 以及重写部分,以同步点替换存储在存储器中的同步点,该同步点指定另一个响应消息。
-
公开(公告)号:US07415576B2
公开(公告)日:2008-08-19
申请号:US10521552
申请日:2002-09-30
申请人: Tatsuya Kamei , Masayuki Ito
发明人: Tatsuya Kamei , Masayuki Ito
IPC分类号: G06F13/38
CPC分类号: G06F12/1027 , G06F12/1081
摘要: A data processor arranged so that a block transfer control unit (12) can initiate block transfer in response to the execution of a particular instruction by a CPU, in order to increase the speed and efficiency of the data transfer between a CPU-accessible internal memory (5) and an external memory (25,26). When an address specified by the addressing field coincides with an address mapped to the internal memory, the particular instruction sets a logical address as one of the transfer source or transfer destination addresses of the data block transfer. The internal memory is allotted to a part of virtual address space; the internal memory allotted so is associated with the physical address space, to which the external memory set as the other address is allotted, by a process in which a TLB is used when the MMU is in ON, and a given register is used when the MMU is in OFF.
摘要翻译: 数据处理器被布置成使得块传送控制单元(12)可以响应于CPU执行特定指令而启动块传送,以便增加CPU可访问的内部存储器之间的数据传输的速度和效率 (5)和外部存储器(25,26)。 当寻址字段指定的地址与映射到内部存储器的地址一致时,特定指令将逻辑地址设置为数据块传输的传送源或传送目标地址之一。 内部存储器分配给虚拟地址空间的一部分; 所分配的内部存储器与通过在MMU处于ON时使用TLB的处理与被分配了外部存储器设置为另一地址的物理地址空间相关联,并且当使用给定的寄存器时 MMU处于关闭状态。
-
公开(公告)号:US20080002962A1
公开(公告)日:2008-01-03
申请号:US11428005
申请日:2006-06-30
申请人: Masayuki Ito , Minoru Matsushima
发明人: Masayuki Ito , Minoru Matsushima
IPC分类号: G03B17/18
摘要: A photographic device equipped with a camera capable of photographing a 360-degree all-round image at a time includes a memory for recording the all-round image photographed by the camera, a control unit for specifying a predetermined range within the all-round image, extracting an image of the predetermined range from the memory to display the image, and for extracting and displaying the image within the all-round image recorded in the memory by changing a position of the predetermined range, thereby displaying the image as if the predetermined range moves in a circumferential direction, and a display unit for displaying at least the image of the predetermined range.
摘要翻译: 配备有能够一次拍摄360度全景图像的相机的摄影装置包括用于记录由相机拍摄的全方位图像的存储器,用于指定全方位图像内的预定范围的控制单元 从存储器提取预定范围的图像以显示图像,并且通过改变预定范围的位置来提取和显示记录在存储器中的全方位图像内的图像,从而显示图像,如同预定的 范围在圆周方向上移动,以及用于至少显示预定范围的图像的显示单元。
-
公开(公告)号:US20050234109A1
公开(公告)日:2005-10-20
申请号:US10500156
申请日:2002-12-27
IPC分类号: C07C311/28 , C07C317/14 , C07C317/18 , C07C317/20 , C07C317/22 , C07C317/44 , C07C323/65 , C07D207/32 , C07D207/325 , C07D211/24 , C07D211/54 , C07D213/34 , C07D213/61 , C07D213/65 , C07D213/71 , C07D213/74 , C07D213/82 , C07D215/12 , C07D215/36 , C07D233/54 , C07D233/68 , C07D233/84 , C07D235/06 , C07D235/28 , C07D239/26 , C07D239/38 , C07D257/04 , C07D263/22 , C07D263/32 , C07D277/26 , C07D277/36 , C07D277/76 , C07D295/096 , C07D307/10 , C07D307/38 , C07D309/08 , C07D311/56 , C07D333/18 , C07D335/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , A61K31/44 , A61K31/165 , A61K31/40 , C07C317/32 , C07C323/29
CPC分类号: C07D213/34 , C07D207/325 , C07D211/24 , C07D211/54 , C07D213/61 , C07D213/65 , C07D213/71 , C07D213/74 , C07D213/82 , C07D215/12 , C07D215/36 , C07D233/64 , C07D233/68 , C07D233/84 , C07D235/06 , C07D235/28 , C07D239/26 , C07D239/38 , C07D257/04 , C07D263/22 , C07D263/32 , C07D277/26 , C07D277/36 , C07D277/76 , C07D295/096 , C07D307/10 , C07D307/38 , C07D309/08 , C07D311/56 , C07D333/18 , C07D335/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06
摘要: Provided are novel compounds having an inhibitory activity against production or secretion of β-amyloid protein. They embrace compounds represented by the following formula (1): and capable of being replaced with a variety of substituents; and salts thereof, and solvates of any one of them.
摘要翻译: 提供了对β-淀粉样蛋白的产生或分泌具有抑制活性的新化合物。 它们包括由下式(1)表示的化合物:并且能够被各种取代基取代; 及其盐,以及它们中任何一种的溶剂合物。
-
公开(公告)号:US20050172049A1
公开(公告)日:2005-08-04
申请号:US10521552
申请日:2002-09-30
申请人: Tatsuya Kamei , Masayuki Ito
发明人: Tatsuya Kamei , Masayuki Ito
CPC分类号: G06F12/1027 , G06F12/1081
摘要: A data processor arranged so that a block transfer control unit (12) can initiate block transfer in response to the execution of a particular instruction by a CPU, in order to increase the speed and efficiency of the data transfer between a CPU-accessible internal memory (5) and an external memory (25,26). When an address specified by the addressing field coincides with an address mapped to the internal memory, the particular instruction sets a logical address as one of the transfer source or transfer destination addresses of the data block transfer. The internal memory is allotted to a part of virtual address space; the internal memory allotted so is associated with the physical address space, to which the external memory set as the other address is allotted, by a process in which a TLB is used when the MMU is in ON, and a given register is used when the MMU is in OFF.
摘要翻译: 数据处理器被布置成使得块传送控制单元(12)可以响应于CPU执行特定指令而启动块传送,以便增加CPU可访问的内部存储器之间的数据传输的速度和效率 (5)和外部存储器(25,26)。 当寻址字段指定的地址与映射到内部存储器的地址一致时,特定指令将逻辑地址设置为数据块传输的传送源或传送目标地址之一。 内部存储器分配给虚拟地址空间的一部分; 所分配的内部存储器与通过在MMU处于ON时使用TLB的处理与被分配了外部存储器设置为另一地址的物理地址空间相关联,并且当使用给定的寄存器时 MMU处于关闭状态。
-
-
-
-
-
-
-
-
-