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13 条记录 (耗时 0.032 秒)

    In situ controlled release drug delivery system
    1.
    发明授权
    In situ controlled release drug delivery system 有权
    原位控释药物输送系统

    公开(公告)号：US08940311B2

    公开(公告)日：2015-01-27

    申请号：US11256416

    申请日：2005-10-21

    申请人： Tae-Hong Lim ,  Joon B. Park ,  Jin Whan Lee

    发明人： Tae-Hong Lim ,  Joon B. Park ,  Jin Whan Lee

    IPC分类号： A61K9/00 ,  A61K9/50 ,  A61K9/16 ,  A61K47/34

    CPC分类号： A61K47/34 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K9/1647 ,  A61K9/5031 ,  A61K9/5084 ,  A61K31/137 ,  A61K31/192 ,  A61K31/439 ,  A61K31/44 ,  A61K31/445 ,  A61K31/4741 ,  A61K31/485 ,  A61K31/55 ,  A61K31/60 ,  A61K31/606 ,  A61K31/655 ,  A61K36/66 ,  A61K45/06 ,  A61K47/36

    摘要： A system is described for long-term controlled release delivery of a drug or a therapeutic agent. According to the invention, one or more drugs or therapeutic agents contained in microspheres are mixed with a temperature sensitive hydrogel which is then introduced directly to the desired situs of the drug or therapeutic agent. The temperature sensitive hydrogel may also contain a drug or a therapeutic agent, for example, a pain relieving drug, for a short-term controlled release. The temperature sensitive hydrogel is in liquid state at room temperature, but upon injection, shortly becomes gelatinous. This system is particularly suitable for treatment of diseases, disorders, or conditions, for example, tumors, discogenic back pain, or arthritis, warranting localized administration of a drug or a therapeutic agent. In addition, the specification provides a method for production of a drug- or therapeutic agent-containing microspheres.

    摘要翻译： 描述了用于药物或治疗剂的长期控制释放递送的系统。 根据本发明，将微球中包含的一种或多种药物或治疗剂与温度敏感的水凝胶混合，然后将其直接引入药物或治疗剂的所需位置。 对于短期控释，温敏水凝胶也可含有药物或治疗剂，例如止痛药。 温度敏感的水凝胶在室温下处于液态，但注射后不久便变成凝胶状。 该系统特别适用于治疗疾病，病症或病症，例如肿瘤，椎间盘背痛或关节炎，需要局部施用药物或治疗剂。 此外，本说明书提供了制备含药物或治疗剂的微球体的方法。

    Precoated polymeric prosthesis and process for making same
    3.
    发明授权
    Precoated polymeric prosthesis and process for making same 失效
    预涂聚合物假体及其制备方法

    公开(公告)号：US06558428B2

    公开(公告)日：2003-05-06

    申请号：US09772795

    申请日：2001-01-30

    申请人： Joon B. Park

    发明人： Joon B. Park

    IPC分类号： A61F228

    CPC分类号： C09D133/12 ,  A61F2/30767 ,  A61F2/3094 ,  A61F2/32 ,  A61F2/34 ,  A61F2/36 ,  A61F2/3662 ,  A61F2/38 ,  A61F2/3859 ,  A61F2/389 ,  A61F2002/30014 ,  A61F2002/30153 ,  A61F2002/30878 ,  A61F2002/30929 ,  A61F2002/30934 ,  A61F2002/30968 ,  A61F2002/3611 ,  A61F2002/365 ,  A61F2002/4631 ,  A61F2230/0019 ,  A61F2250/0018 ,  A61F2310/00011 ,  A61F2310/00952 ,  A61L27/26 ,  A61L27/34 ,  A61L2420/02 ,  C08L23/06 ,  Y10S623/923 ,  C08L33/12 ,  C08L2666/04

    摘要： The present invention is directed to a polymeric prosthesis precoated with a bone cement compatible polymer. The bone cement compatible polymer coating, is provided by an activated powder mixture of polymethyl methacrylate and ultra high molecular weight polyethylene which is bonded to the outer surface of the prosthesis by sintering. Once bonded to a polymeric prosthesis in accordance with the present invention, the precoat strengthens the interface between a bone cement and a prosthesis when the prosthesis is later implanted. The inner layer of the prosthesis may be provided of cross-linked UHMWPE powder sintered with virgin UHMWPE powder or fibers to provide a intermediate layer(s) of the coating present on the prosthesis. The precoat also decreases the likelihood that the prosthesis will loosen and break away from the cement over time. The polymeric implant product of the present invention is particularly well suited for use as an acetabular cup or a tibia plateau in replacing hip joints and knee joints respectively.

    摘要翻译： 本发明涉及预先涂覆有骨水泥相容性聚合物的聚合物假体。 骨水泥相容的聚合物涂层由聚甲基丙烯酸甲酯和超高分子量聚乙烯的活化粉末混合物提供，其通过烧结结合到假体的外表面。 一旦结合到根据本发明的聚合物假体，当稍后植入假体时，预涂层加强骨水泥和假体之间的界面。 假体的内层可以提供与原始UHMWPE粉末或纤维烧结的交联UHMWPE粉末，以提供假体上存在的涂层的中间层。 预涂也降低假体随着时间的推移松动和脱离水泥的可能性。 本发明的聚合物植入物特别适合用作分别替代髋关节和膝关节的髋臼杯或胫骨平台。

    Precoated polymeric prosthesis and process for making same
    7.
    发明授权
    Precoated polymeric prosthesis and process for making same 失效
    预涂聚合物假体及其制备方法

    公开(公告)号：US06203844B1

    公开(公告)日：2001-03-20

    申请号：US09283651

    申请日：1999-04-01

    申请人： Joon B. Park

    发明人： Joon B. Park

    IPC分类号： A61L2700

    CPC分类号： C09D133/12 ,  A61F2/30767 ,  A61F2/3094 ,  A61F2/32 ,  A61F2/34 ,  A61F2/36 ,  A61F2/3662 ,  A61F2/38 ,  A61F2/3859 ,  A61F2/389 ,  A61F2002/30014 ,  A61F2002/30153 ,  A61F2002/30878 ,  A61F2002/30929 ,  A61F2002/30934 ,  A61F2002/30968 ,  A61F2002/3611 ,  A61F2002/365 ,  A61F2002/4631 ,  A61F2230/0019 ,  A61F2250/0018 ,  A61F2310/00011 ,  A61F2310/00952 ,  A61L27/26 ,  A61L27/34 ,  A61L2420/02 ,  C08L23/06 ,  Y10S623/923 ,  C08L33/12 ,  C08L2666/04

    摘要： The present invention is directed to a polymeric prosthesis precoated with a bone cement compatible polymer. The bone cement compatible polymer coating, is provided by an activated powder mixture of polymethyl methacrylate and ultra high molecular weight polyethylene which is bonded to the outer surface of the prosthesis by sintering. Once bonded to a polymeric prosthesis in accordance with the present invention, the precoat strengthens the interface between a bone cement and a prosthesis when the prosthesis is later implanted. The inner layer of the prosthesis may be provided of cross-linked UHMWPE powder sintered with virgin UHMWPE powder or fibers to provide a intermediate layer(s) of the coating present on the prosthesis. The precoat also decreases the likelihood that the prosthesis will loosen and break away from the cement over time. The polymeric implant product of the present invention is particularly well suited for use as an acetabular cup or a tibia plateau in replacing hip joints and knee joints respectively.

    摘要翻译： 本发明涉及预先涂覆有骨水泥相容性聚合物的聚合物假体。 骨水泥相容的聚合物涂层由聚甲基丙烯酸甲酯和超高分子量聚乙烯的活化粉末混合物提供，其通过烧结结合到假体的外表面。 一旦结合到根据本发明的聚合物假体，当稍后植入假体时，预涂层加强骨水泥和假体之间的界面。 假体的内层可以提供与原始UHMWPE粉末或纤维烧结的交联UHMWPE粉末，以提供假体上存在的涂层的中间层。 预涂也降低假体随着时间的推移松动和脱离水泥的可能性。 本发明的聚合物植入物特别适合用作分别替代髋关节和膝关节的髋臼杯或胫骨平台。

    Precoated polymeric prosthesis and process for making same
    8.
    发明授权
    Precoated polymeric prosthesis and process for making same 失效
    预涂聚合物假体及其制备方法

    公开(公告)号：US5874123A

    公开(公告)日：1999-02-23

    申请号：US787246

    申请日：1997-01-24

    申请人： Joon B. Park

    发明人： Joon B. Park

    IPC分类号： A61F2/00 ,  A61F2/30 ,  A61F2/32 ,  A61F2/34 ,  A61F2/36 ,  A61F2/38 ,  A61F2/46 ,  A61L27/34 ,  B65D3/10 ,  B65D1/38

    CPC分类号： A61F2/30767 ,  A61L27/34 ,  A61F2/32 ,  A61F2/34 ,  A61F2/3662 ,  A61F2/38 ,  A61F2/3859 ,  A61F2/389 ,  A61F2002/30014 ,  A61F2002/30153 ,  A61F2002/30878 ,  A61F2002/30929 ,  A61F2002/3611 ,  A61F2002/365 ,  A61F2002/4631 ,  A61F2230/0019 ,  A61F2250/0018 ,  A61F2310/00011 ,  A61F2310/00952

    摘要： The present invention is directed to a polymeric prosthesis precoated with a bone cement compatible polymer. The bone cement compatible polymer coating, which can be polymethyl methacrylate, is bonded to the outer surface of the prosthesis. For instance, in one embodiment, the bone cement compatible polymer coating is believed to be copolymerized with the polymeric prosthesis. Once bonded to a polymeric prosthesis in accordance with the present invention, the precoat strengthens the interface between a bone cement and a prosthesis when the prosthesis is later implanted. The precoat also decreases the likelihood that the prosthesis will loosen and break away from the cement over time. The polymeric implant product of the present invention is particularly well suited for use as an acetabular cup or a tibia plateau in replacing hip joints and knee joints respectively.

    摘要翻译： 本发明涉及预先涂覆有骨水泥相容性聚合物的聚合物假体。 可以是聚甲基丙烯酸甲酯的骨水泥相容的聚合物涂层结合到假体的外表面。 例如，在一个实施方案中，认为骨水泥相容的聚合物涂层与聚合物假体共聚。 一旦结合到根据本发明的聚合物假体，当稍后植入假体时，预涂层加强骨水泥和假体之间的界面。 预涂也降低假体随着时间的推移松动和脱离水泥的可能性。 本发明的聚合物植入物特别适合用作分别替代髋关节和膝关节的髋臼杯或胫骨平台。