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公开(公告)号：US20060276975A1
公开(公告)日：2006-12-07
申请号：US10560311
申请日：2004-04-09
IPC分类号： G06F19/00
CPC分类号： G01N33/49 , Y10T137/2224
摘要： The present invention provides a quantitative measurement method and quantitative measurement chip which can perform quantitative measurement of a target substance in a short period of time. The invention provides a quantitative measurement method in which a three dimensional mesh structure material is formed, and quantitative measurements are taken of the target substance using a structure which contains a reagent that reacts with the target substance in the mesh. This method includes a contacting step in which a test specimen which includes the target substance is brought into contact with the structure; a detecting step which, in a process in which a substance whose quantity will increase or decrease by means of the reaction between the target substance and the reagent, detects the substance whose quantity is increasing or decreasing within the structure at a contact interface between the test specimen and the reagent; and a quantitative measurement step which performs quantitative measurement of the target substance based on the results of the detecting step. The mesh structure will allow at least the target substance to pass therethrough.
摘要翻译： 本发明提供了能够在短时间内进行目标物质的定量测定的定量测定方法和定量测定用芯片。 本发明提供了一种定量测量方法，其中形成三维网格结构材料，并且使用包含与网格中的目标物质反应的试剂的结构对目标物质进行定量测量。 该方法包括使包含目标物质的试样与该结构体接触的接触工序; 检测步骤，其中通过所述目标物质与所述试剂之间的反应使其量增加或减少的物质的过程中，在所述测试中的接触界面处检测所述结构内的物质的数量增加或减少的物质 标本和试剂; 以及基于检测步骤的结果进行目标物质的定量测定的定量测定步骤。 网格结构将允许至少目标物质通过。
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2.发明授权Quantitative measurement method and quantitative measurement chip for target substance 有权目标物质的定量测量方法和定量测量芯片公开(公告)号：US07184894B2
公开(公告)日：2007-02-27
申请号：US10560311
申请日：2004-04-09
IPC分类号： G01N21/25
CPC分类号： G01N33/49 , Y10T137/2224
摘要： The present invention provides a quantitative measurement method and quantitative measurement chip which can perform quantitative measurement of a target substance in a short period of time. The invention provides a quantitative measurement method in which a three dimensional mesh structure material is formed, and quantitative measurements are taken of the target substance using a structure which contains a reagent that reacts with the target substance in the mesh. This method includes a contacting step in which a test specimen which includes the target substance is brought into contact with the structure; a detecting step which, in a process in which a substance whose quantity will increase or decrease by means of the reaction between the target substance and the reagent, detects the substance whose quantity is increasing or decreasing within the structure at a contact interface between the test specimen and the reagent; and a quantitative measurement step which performs quantitative measurement of the target substance based on the results of the detecting step. The mesh structure will allow at least the target substance to pass therethrough.
摘要翻译： 本发明提供了能够在短时间内进行目标物质的定量测定的定量测定方法和定量测定用芯片。 本发明提供了一种定量测量方法，其中形成三维网格结构材料，并且使用包含与网格中的目标物质反应的试剂的结构对目标物质进行定量测量。 该方法包括使包含目标物质的试样与该结构体接触的接触工序; 检测步骤，其中通过所述目标物质与所述试剂之间的反应使其量增加或减少的物质的过程中，在所述测试中的接触界面处检测所述结构内的物质的数量增加或减少的物质 标本和试剂; 以及基于检测步骤的结果进行目标物质的定量测定的定量测定步骤。 网格结构将允许至少目标物质通过。
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公开(公告)号：US08197774B2
公开(公告)日：2012-06-12
申请号：US12343973
申请日：2008-12-24
申请人： Akinori Yokogawa , Shun Momose
发明人： Akinori Yokogawa , Shun Momose
CPC分类号： B01L3/5027 , B01L3/502723 , B01L3/50273 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0867 , B01L2400/0409 , G01N21/07 , G01N2035/0444
摘要： A microchip is provided, in which dead space provided only for holding excess fluid is made smaller. The microchip is formed by joining at least a first substrate with a trench formed on the substrate surface and a second substrate, and it has a fluid circuit formed by the trench and a surface of the second substrate facing the first substrate. The first substrate and/or the second substrate has a projection for moving fluid and/or air in a direction opposite to the direction of gravity during an operation of the microchip, and the projection is provided near an end portion of a through hole and/or an air vent.
摘要翻译： 提供了一种微芯片，其中仅用于容纳多余流体的死空间较小。 微芯片通过将至少第一基板与形成在基板表面上的沟槽和第二基板接合而形成，并且其具有由沟槽和第二基板的面向第一基板的表面形成的流体回路。 第一基板和/或第二基板具有用于在微芯片的操作期间沿与重力方向相反的方向移动流体和/或空气的突起，并且突起设置在通孔的端部附近和/ 或通风口。
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公开(公告)号：US07691328B2
公开(公告)日：2010-04-06
申请号：US10595262
申请日：2004-10-04
申请人： Yasuhiro Horiike , Akinori Yokogawa
发明人： Yasuhiro Horiike , Akinori Yokogawa
CPC分类号： B01L3/502753 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2200/10 , B01L2300/0654 , B01L2300/0672 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2400/0409 , B01L2400/0478 , B01L2400/0683 , B01L2400/086
摘要： An object of the invention is to provide a test chip which allows efficient and convenient separation and measurement. This invention provides a measuring chip for separating and measuring a target component in a sample by rotation around first and second axes of rotation. The measuring chip includes a centrifugal separation tube that centrifugally separates the target component from the sample by rotating the measuring chip around the first axis of rotation; a first holding section installed in the bottom of the centrifugal separation tube, wherein non-target components other than the target component in the sample are introduced therein by rotation around the first axis of rotation, and the first holding section holds the non-target components during rotation around the second axis of rotation; and a measuring section connected to one end of the centrifugal separation tube that measures the non-target components introduced from the centrifugal separation tube by rotation around the second axis of rotation.
摘要翻译： 本发明的一个目的是提供一种允许有效和方便的分离和测量的测试芯片。 本发明提供了一种用于通过围绕第一和第二旋转轴线旋转来分离和测量样品中的目标部件的测量芯片。 测量芯片包括离心分离管，其通过围绕第一旋转轴线旋转测量芯片将目标部件与样品离心分离; 安装在离心分离管的底部的第一保持部，其中，除了样品中的目标成分以外的非目标成分通过围绕第一旋转轴线的旋转导入其中，第一保持部保持非目标成分 围绕第二旋转轴旋转; 以及测量部分，其连接到离心分离管的一端，其通过围绕第二旋转轴线的旋转来测量从离心分离管引入的非目标部件。
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公开(公告)号：US20090098658A1
公开(公告)日：2009-04-16
申请号：US12250592
申请日：2008-10-14
申请人： Shun Momose , Akinori Yokogawa , Toshihiro Mori
发明人： Shun Momose , Akinori Yokogawa , Toshihiro Mori
CPC分类号： B01L3/50273 , B01L3/5025 , B01L3/5027 , B01L2200/12 , B01L2200/16 , B01L2300/0819 , B01L2300/0829 , B01L2300/0887 , B01L2300/168 , G01N21/07 , G01N33/5002 , G01N2021/0325
摘要： A microchip includes fluid circuits therein, formed by uniting together at least a first substrate that is a transparent substrate and a second substrate having grooves provided at the substrate surface and/or through holes penetrating in a thickness direction. The fluid circuits include a liquid reagent receptacle unit to store a liquid reagent, a quantification unit to quantify the liquid reagent or specimen, and an overflow liquid storage unit connected to the quantification unit to store the liquid reagent or specimen overflowing from the quantification unit during quantification. There is also provided a method of using the microchip.
摘要翻译： 微芯片包括其中的流体回路，至少通过将至少第一基板作为透明基板和具有设置在基板表面处的凹槽和/或穿过厚度方向的通孔的第二基板结合在一起。 流体回路包括：液体试剂容纳单元，用于存储液体试剂;定量单元，用于量化液体试剂或试样;以及溢流液储存单元，连接到定量单元，以存储从定量单元溢出的液体试剂或试样 量化。 还提供了使用微芯片的方法。
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公开(公告)号：US20090232708A1
公开(公告)日：2009-09-17
申请号：US12343973
申请日：2008-12-24
申请人： Akinori Yokogawa , Shun Momose
发明人： Akinori Yokogawa , Shun Momose
IPC分类号： B01L3/00
CPC分类号： B01L3/5027 , B01L3/502723 , B01L3/50273 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0867 , B01L2400/0409 , G01N21/07 , G01N2035/0444
摘要： A microchip is provided, in which dead space provided only for holding excess fluid is made smaller. The microchip is formed by joining at least a first substrate with a trench formed on the substrate surface and a second substrate, and it has a fluid circuit formed by the trench and a surface of the second substrate facing the first substrate. The first substrate and/or the second substrate has a projection for moving fluid and/or air in a direction opposite to the direction of gravity during an operation of the microchip, and the projection is provided near an end portion of a through hole and/or an air vent.
摘要翻译： 提供了一种微芯片，其中仅用于容纳多余流体的死空间较小。 微芯片通过将至少第一基板与形成在基板表面上的沟槽和第二基板接合而形成，并且其具有由沟槽和第二基板的面向第一基板的表面形成的流体回路。 第一基板和/或第二基板具有用于在微芯片的操作期间沿与重力方向相反的方向移动流体和/或空气的突起，并且突起设置在通孔的端部附近和/ 或通风口。
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公开(公告)号：USD596310S1
公开(公告)日：2009-07-14
申请号：US29302408
申请日：2008-01-16
申请人： Akinori Yokogawa , Shun Momose , Toshihiro Mori
设计人： Akinori Yokogawa , Shun Momose , Toshihiro Mori
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公开(公告)号：US20090111675A1
公开(公告)日：2009-04-30
申请号：US12257589
申请日：2008-10-24
申请人： Akinori Yokogawa , Toshihiro Mori
发明人： Akinori Yokogawa , Toshihiro Mori
CPC分类号： B01L3/5027 , B01L3/50273 , B01L2200/10 , B01L2200/16 , B01L2300/0809 , B01L2300/0864 , B01L2300/168 , B01L2400/0409 , G01N21/07 , G01N2021/0325 , G01N2021/0346 , Y10T137/206 , Y10T137/2169 , Y10T137/2224
摘要： A microchip including a first substrate with a groove formed on a substrate surface or a pass-through hole passing in a thickness direction of the substrate, and one or more second substrates laminated on a surface of the first substrate; the microchip including an optical measurement cuvette consisting of a space configured by the groove or the pass-through hole, and a substrate surface of the second substrate; wherein a side wall surface of the second substrate is positioned on an inner side than a side wall surface of the first substrate in at least one part of a side wall surface of the microchip, and a method of using the same are provided.
摘要翻译： 一种微芯片，包括：在基板表面上形成有沟槽的第一基板或沿着基板的厚度方向通过的贯通孔;以及层叠在第一基板的表面上的一个或多个第二基板; 所述微芯片包括由所述凹槽或所述通孔构成的空间和所述第二基板的基板表面构成的光学测量比色杯; 其特征在于，所述第二基板的侧壁面位于所述微芯片的侧壁面的至少一部分中位于比所述第一基板的侧壁面的内侧，并且提供其使用方法。
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公开(公告)号：US08343428B2
公开(公告)日：2013-01-01
申请号：US12257589
申请日：2008-10-24
申请人： Akinori Yokogawa , Toshihiro Mori
发明人： Akinori Yokogawa , Toshihiro Mori
CPC分类号： B01L3/5027 , B01L3/50273 , B01L2200/10 , B01L2200/16 , B01L2300/0809 , B01L2300/0864 , B01L2300/168 , B01L2400/0409 , G01N21/07 , G01N2021/0325 , G01N2021/0346 , Y10T137/206 , Y10T137/2169 , Y10T137/2224
摘要： A microchip including a first substrate with a groove formed on a substrate surface or a pass-through hole passing in a thickness direction of the substrate, and one or more second substrates laminated on a surface of the first substrate; the microchip including an optical measurement cuvette consisting of a space configured by the groove or the pass-through hole, and a substrate surface of the second substrate; wherein a side wall surface of the second substrate is positioned on an inner side than a side wall surface of the first substrate in at least one part of a side wall surface of the microchip, and a method of using the same are provided.
摘要翻译： 一种微芯片，包括：在基板表面上形成有沟槽的第一基板或沿着基板的厚度方向通过的贯通孔;以及层叠在第一基板的表面上的一个或多个第二基板; 所述微芯片包括由所述凹槽或所述通孔构成的空间和所述第二基板的基板表面构成的光学测量比色杯; 其特征在于，所述第二基板的侧壁面位于所述微芯片的侧壁面的至少一部分中位于比所述第一基板的侧壁面的内侧，并且提供其使用方法。
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公开(公告)号：US20100158757A1
公开(公告)日：2010-06-24
申请号：US12707399
申请日：2010-02-17
申请人： Yasuhiro Horiike , Akinori Yokogawa
发明人： Yasuhiro Horiike , Akinori Yokogawa
IPC分类号： B04B5/10
CPC分类号： B01L3/502753 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2200/10 , B01L2300/0654 , B01L2300/0672 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2400/0409 , B01L2400/0478 , B01L2400/0683 , B01L2400/086
摘要： A measuring chip is configured for separating and measuring a target component in a sample by rotation around first and second axes of rotation. The measuring chip includes a centrifugal separation tube that centrifugally separates the target component from the sample by rotating the measuring chip around the first axis of rotation; a first holding section installed in the bottom of the centrifugal separation tube, wherein non-target components other than the target component in the sample are introduced therein by rotation around the first axis of rotation, and the first holding section holds the non-target components during rotation around the second axis of rotation; and a measuring section connected to one end of the centrifugal separation tube that measures the non-target components introduced from the centrifugal separation tube by rotation around the second axis of rotation.
摘要翻译： 测量芯片被配置为通过绕第一和第二旋转轴线旋转来分离和测量样品中的目标部件。 测量芯片包括离心分离管，其通过围绕第一旋转轴线旋转测量芯片将目标部件与样品离心分离; 安装在离心分离管的底部的第一保持部，其中，除了样品中的目标成分以外的非目标成分通过围绕第一旋转轴线的旋转导入其中，第一保持部保持非目标成分 围绕第二旋转轴旋转; 以及测量部分，其连接到离心分离管的一端，其通过围绕第二旋转轴线的旋转来测量从离心分离管引入的非目标部件。
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