公开(公告)号：US5998384A

公开(公告)日：1999-12-07

申请号：US949137

申请日：1997-10-10

申请人： Takashi Shimada ,  Norio Matsukura ,  Osamu Iijima ,  Katsuhiko Akiyama ,  Takeshi Goto

发明人： Takashi Shimada ,  Norio Matsukura ,  Osamu Iijima ,  Katsuhiko Akiyama ,  Takeshi Goto

IPC分类号： A61K48/00 ,  A61P35/00 ,  C12N5/00 ,  C12N15/00

CPC分类号： A61K48/00

摘要： A therapy for a disease, e.g., gastric cancer, comprising endoscopic local administration of a vector having a gene for treatment or cells producing the vector to a lesion to transduce the gene into target cells. The direct in vivo transduction of a gene for treatment into the affected site is expected to produce therapeutic effects specific on the lesion. Since the gene is introduced also into lymph nodes which may have developed a metastatic lesion, both the primary lesion and the metastatic lesion in the surrounding lymph nodes can be treated simultaneously.

摘要翻译： 用于疾病例如胃癌的治疗方法，包括内窥镜局部施用具有用于治疗的基因的载体或产生所述载体的细胞以将所述基因转导入靶细胞。 用于治疗受影响部位的基因的直接体内转导预期产生对病变特异性的治疗效果。 由于该基因也被引入可能已经发展为转移性病变的淋巴结，所以可以同时治疗周围淋巴结中的原发性病变和转移性病变。

公开(公告)号：US06429308B1

公开(公告)日：2002-08-06

申请号：US09582224

申请日：2000-07-21

申请人： Osamu Iijima ,  Takeshi Goto ,  Takashi Shimada

发明人： Osamu Iijima ,  Takeshi Goto ,  Takashi Shimada

IPC分类号： C07H2104

CPC分类号： C12N15/1138 ,  A61K38/00 ,  C12N2310/315

摘要： An antisense oligonucleotide characterized in that it hybridizes specifically with chromosomal DNA and/or RNA encoding CXCR4 protein to thereby inhibit the expression of the CXCR4 protein, and a HIV infection inhibitor comprising the antisense oligonucleotide, are disclosed.

摘要翻译： 一种反义寡核苷酸，其特征在于其与编码CXCR4蛋白的染色体DNA和/或RNA特异性杂交，从而抑制CXCR4蛋白的表达，并且包含该反义寡核苷酸的HIV感染抑制剂。

公开(公告)号：US6048725A

公开(公告)日：2000-04-11

申请号：US913705

申请日：1997-09-12

申请人： Takashi Shimada ,  Katsuhiko Akiyama ,  Hidekazu Kuma ,  Yosuke Suzuki

发明人： Takashi Shimada ,  Katsuhiko Akiyama ,  Hidekazu Kuma ,  Yosuke Suzuki

IPC分类号： A61K48/00 ,  C12N15/867 ,  C12N15/00

CPC分类号： C12N15/86 ,  A61K48/00 ,  C12N2740/16043 ,  C12N2740/16052

摘要： Recombinant human immunodeficiency virus producing cell that is obtained by introducing into an animal cell a recombinant human immunodeficiency virus helper plasmid containing at least the sequences of gag, pol and env genes encoded by a human immunodeficiency virus genome and being deficient of a packaging signal and which sustains said genes stably.The human immunodeficiency virus producing cell of the invention is capable of large-scale and consistent preparation of HIV vectors more efficiently than in the prior art.

摘要翻译： PCT No.PCT / JP96 / 00653 Sec。 371日期：1997年9月12日 102（e）日期1997年9月12日PCT 1996年3月15日PCT公布。 公开号WO96 / 29393 日期1996年9月26日通过将至少包含由人免疫缺陷病毒基因组编码的gag，pol和env基因序列的重组人免疫缺陷病毒辅助质粒导入动物细胞而获得的重组人免疫缺陷病毒产生细胞， 一种包装信号，并稳定地维持所述基因。 本发明的人体免疫缺陷病毒产生细胞能够比现有技术更有效地大规模和一致地制备HIV载体。

公开(公告)号：US20140094555A1

公开(公告)日：2014-04-03

申请号：US14122501

申请日：2012-04-18

申请人： Takafumi Hashimoto ,  Hirohito Minowa ,  Takashi Shimada ,  Masahiro Hashimoto ,  Katsuhiro Miyoshi ,  Yoshihiro Naruse

发明人： Takafumi Hashimoto ,  Hirohito Minowa ,  Takashi Shimada ,  Masahiro Hashimoto ,  Katsuhiro Miyoshi ,  Yoshihiro Naruse

IPC分类号： C08K3/04 ,  B29C70/06

CPC分类号： C08K3/04 ,  B29C70/06 ,  B29C70/14 ,  C08J5/042 ,  C08J5/24 ,  C08J2300/22 ,  C08J2377/00

摘要： A carbon-fiber-reinforced plastic prepared by impregnating a matrix resin into a sheet-like base material includes discontinuous carbon fibers, wherein a content ratio of carbon fibers having lengths of 10 mm or longer in the base material is 60 wt % or more relative to a total amount of the carbon fibers, and an average value of orientation degrees of carbon fibers contained in the base material is 2-10.

摘要翻译： 通过将基质树脂浸渍到片状基材中而制备的碳纤维增强塑料包括不连续的碳纤维，其中基材中长度为10mm以上的碳纤维的含量比例为60重量％以上 相对于碳纤维的总量，基材中所含的碳纤维的取向度的平均值为2-10。

公开(公告)号：US08518651B2

公开(公告)日：2013-08-27

申请号：US12527191

申请日：2008-02-15

申请人： Taka-aki Sato ,  Atsuhiko Toyama ,  Takashi Shimada ,  Tetsuyoshi Sugita ,  Daisuke Aoki ,  Atsushi Suzuki ,  Nobuyuki Susumu ,  Hiroyuki Nomura

发明人： Taka-aki Sato ,  Atsuhiko Toyama ,  Takashi Shimada ,  Tetsuyoshi Sugita ,  Daisuke Aoki ,  Atsushi Suzuki ,  Nobuyuki Susumu ,  Hiroyuki Nomura

IPC分类号： G01N33/53

CPC分类号： G01N33/57449 ,  G01N2800/56

摘要： It is provided a method for identification of the morbidity of epithelial ovarian cancer based on a tissue-type in view of molecular typing which is different from a conventional histopathology, and a marker for identification of a tissue-type of epithelial ovarian cancer. A method for identification of the morbidity of epithelial ovarian cancer based on a tissue-type, comprising: subjecting a sample originated from an individual of interest to a treatment for detecting at least one selected from the group consisting of biological molecules specifically showing an upregulation in expression in a specific tissue-type of epithelial ovarian cancer, and/or at least one selected from the group consisting of biological molecules specifically showing a downregulation in expression in a specific tissue-type of epithelial ovarian cancer, and identifying whether or not the significant detection of the protein is achieved, thereby identifying the tissue-type.

摘要翻译： 提供了一种鉴定与常规组织病理学不同的分子分型的基于组织型的上皮性卵巢癌的发病率的方法和用于鉴定组织型上皮性卵巢癌的标志物。 一种用于鉴定基于组织型的上皮性卵巢癌的发病率的方法，其包括：对来自感兴趣个体的样品进行处理，以检测选自特异性显示上调的生物分子中的至少一种 在特定组织型上皮性卵巢癌中的表达，和/或选自特异性显示特定组织型上皮性卵巢癌中的下调的生物分子中的至少一种，以及鉴定是否显着 实现蛋白质的检测，从而鉴定组织型。

公开(公告)号：US20120128392A1

公开(公告)日：2012-05-24

申请号：US13349912

申请日：2012-01-13

申请人： Ken Nakagawa ,  Kenji Kanari ,  Masaru Shimura ,  Takashi Shimada ,  Tomoo Akizuki ,  Masahiro Suzuki

发明人： Ken Nakagawa ,  Kenji Kanari ,  Masaru Shimura ,  Takashi Shimada ,  Tomoo Akizuki ,  Masahiro Suzuki

IPC分类号： G03G15/14

CPC分类号： G03G21/0047 ,  G03G21/10 ,  G03G2221/1627

摘要： A charge member charges secondary transfer remaining toner on an intermediate transfer member to a polarity opposite to a normal charge polarity. The remaining toner is moved by a transfer bias, from the intermediate transfer member onto an image bearing member. A BK station is arranged on the downstream of other stations. In a continuous BK monochromatic mode, by applying a reverse bias to transfer portions of the other stations and applying the transfer bias only to the BK station, remaining toner can be collected into the BK station (simultaneously with the transfer). In a full-color mode, remaining toner is collected into the station on the uppermost stream. Thus, the image bearing member for collecting remaining toner on the intermediate transfer member differs according to the mode, thereby suppressing the collection of remaining toner being concentrated on one image bearing member.

摘要翻译： 充电构件将中间转印构件上的二次转印剩余调色剂充电到与正常电荷极性相反的极性。 剩余的调色剂通过转印偏压从中间转印部件移动到图像承载部件上。 其他车站下游设有BK车站。 在连续的BK单色模式中，通过施加反向偏压来转移其它工位的部分并将转印偏压施加到BK工位，剩余的调色剂可以被收集到BK工位（与转印同时）。 在全色模式下，剩余碳粉被收集到最上游的车站。 因此，根据模式，用于收集中间转印部件上的剩余调色剂的图像承载部件不同，从而抑制剩余调色剂的收集集中在一个图像承载部件上。

公开(公告)号：US08158638B2

公开(公告)日：2012-04-17

申请号：US12442094

申请日：2007-09-14

申请人： Satoru Ohsuki ,  Atsushi Tengeiji ,  Masahiro Ikeda ,  Yoshihiro Shibata ,  Chikahiro Nagata ,  Takashi Shimada

发明人： Satoru Ohsuki ,  Atsushi Tengeiji ,  Masahiro Ikeda ,  Yoshihiro Shibata ,  Chikahiro Nagata ,  Takashi Shimada

IPC分类号： A61K31/505 ,  A61K31/415 ,  C07D491/00 ,  C07D487/02

CPC分类号： C07D495/16 ,  C07D495/20 ,  C07D495/22 ,  C07D498/22

摘要： Problem to be SolvedTo provide a novel compound inhibiting the effect of HSP90, in particular a novel compound inhibiting the function of HSP90 as a chaperone protein and having antitumor activity.SolutionThe present invention provides a pyrazolopyrimidine compound represented by the formula (1) having various substituents which inhibits the ATPase activity of HSP90 and which has antitumor activity, an HSP90 inhibitor comprising the compound represented by the formula (1), a medicament comprising the compound represented by the formula (1), an anticancer agent comprising the compound represented by the formula (1), a pharmaceutical composition comprising the compound represented by the formula (1) and a method for treating cancer using the compound represented by the formula (1).

摘要翻译： 要解决的问题提供抑制HSP90的作用的新型化合物，特别是抑制HSP90作为伴侣蛋白的功能并具有抗肿瘤活性的新化合物。 溶液本发明提供了具有抑制HSP90的ATP酶活性且具有抗肿瘤活性的各种取代基的式（1）表示的吡唑并嘧啶化合物，包含由式（1）表示的化合物的HSP90抑制剂，包含化合物 （1）代表的抗癌剂，包含由式（1）表示的化合物的抗癌剂，包含式（1）表示的化合物的药物组合物和使用式（1）表示的化合物治疗癌症的方法 ）。

公开(公告)号：US08036574B2

公开(公告)日：2011-10-11

申请号：US12415822

申请日：2009-03-31

申请人： Masaru Shimura ,  Michio Uchida ,  Ken Nakagawa ,  Seiji Saito ,  Kenji Kanari ,  Takamitsu Soda ,  Takaaki Akamatsu ,  Kazuhiro Doda ,  Takashi Shimada ,  Shuuichi Tetsuno ,  Shigeru Hoashi ,  Tomoya Kuruma

发明人： Masaru Shimura ,  Michio Uchida ,  Ken Nakagawa ,  Seiji Saito ,  Kenji Kanari ,  Takamitsu Soda ,  Takaaki Akamatsu ,  Kazuhiro Doda ,  Takashi Shimada ,  Shuuichi Tetsuno ,  Shigeru Hoashi ,  Tomoya Kuruma

IPC分类号： G03G15/00

CPC分类号： G03G15/0131 ,  G03G15/1615 ,  G03G15/50 ,  G03G21/1647 ,  G03G21/168 ,  G03G2215/0129 ,  G03G2215/0141 ,  G03G2215/0193 ,  G03G2221/1657

摘要： An image forming apparatus for forming image on a recording medium includes a photosensitive member, a motor, a belt, and a drive member to rotate the belt, the drive member including a driven coupling. The apparatus also includes a drive coupling to rotate by a driving force generated by the motor, the drive coupling being movable in an axial direction to take an engagement position at which the driving force is transmittable to the driven coupling, and a release position. The apparatus further includes a transfer member to transfer a toner image onto the recording medium or the belt, a voltage application unit to apply a voltage to the transfer member, and a control unit to cause the voltage application unit to apply the voltage to the transfer member after the drive coupling moves to the engagement position and the driving force is transmitted to the driven coupling.

摘要翻译： 用于在记录介质上形成图像的图像形成装置包括感光部件，马达，皮带以及用于旋转皮带的驱动部件，该驱动部件包括从动联轴器。 该装置还包括通过由电动机产生的驱动力来旋转的驱动联接器，该驱动联接器可在轴向方向上移动以采取将驱动力传递到从动联接器的接合位置和释放位置。 所述设备还包括用于将调色剂图像转印到所述记录介质或所述带上的转印部件，向所述转印部件施加电压的电压施加单元，以及使所述电压施加单元向所述转印部施加电压的控制单元 驱动联轴器移动到接合位置并且驱动力被传递到从动联轴器之后的构件。

公开(公告)号：US20100166719A1

公开(公告)日：2010-07-01

申请号：US12656139

申请日：2010-01-19

申请人： Katsutoshi Yoshizato ,  Takashi Shimada ,  Koei Toyoshima ,  Mikaru Matsunaga

发明人： Katsutoshi Yoshizato ,  Takashi Shimada ,  Koei Toyoshima ,  Mikaru Matsunaga

IPC分类号： A61K35/12 ,  A61P43/00

CPC分类号： A61L27/3869 ,  A61F2/10 ,  A61K35/12 ,  A61L27/362 ,  A61L27/3666 ,  A61L27/3813 ,  A61L2430/18 ,  C12N5/0627 ,  C12N2501/115

摘要： A method of enabling effective hair growth and furthermore, inducing hair growth closely similar to the natural hair state in the case of transplanting dermal papillae or cultured dermal papilla cells into the skin to regenerate the hair, characterized by comprising transplanting a composition containing the following components into an epidermis defect site: (a) dermal papillae or dermal papilla cells, (b) an epidermal tissue or epidermal cells and/or (c) a tissue constituting hair follicles or cells thereof.

摘要翻译： 此外，在将真皮乳头或培养的真皮乳头细胞移植到皮肤中以再生毛发的情况下，能够有效地进行毛发生长的方法，此外，诱导与天然毛发状态非常相似的毛发生长，其特征在于，包括移植含有以下成分的组合物 进入表皮缺损部位：（a）真皮乳头或真皮乳头细胞，（b）表皮组织或表皮细胞和/或（c）构成毛囊或其细胞的组织。

公开(公告)号：US20100086938A1

公开(公告)日：2010-04-08

申请号：US12516790

申请日：2007-10-02

申请人： Takashi Shimada ,  Atsuhiko Toyama ,  Taka-aki Sato

发明人： Takashi Shimada ,  Atsuhiko Toyama ,  Taka-aki Sato

IPC分类号： G01N33/53 ,  G01N33/543 ,  G01N33/553 ,  G01N33/552 ,  G01N33/544

CPC分类号： G01N33/6848

摘要： It is intended to provide an analysis method for a biological sample with clinical significance, which is a system being simple to such an extent that it can be applied to a clinical field, and capable of capping a molecule ionization suppression in mass spectrometry. Mass spectrometry of a biological sample using immunoprecipitation, comprising the steps of: preparing a sample containing an objective biological molecule; concentrating the biological molecule in the sample by immunoprecipitation using an antibody-bound carrier or a carrier to which a molecule capable of specifically binding to an antibody is bound; washing an immunoprecipitate of the biological molecule by using an aqueous solution containing a charge neutralizing agent as a washing liquid; and detecting the biological molecule by subjecting the washed immunoprecipitate to mass spectrometry.

摘要翻译： 旨在为具有临床意义的生物样品提供分析方法，该方法简单到能够应用于临床领域并且能够在质谱法中限制分子离子化抑制的系统。 使用免疫沉淀的生物样品的质谱法，包括以下步骤：制备含有客观生物分子的样品; 通过使用抗体结合的载体或能够与抗体特异性结合的分子结合的载体通过免疫沉淀将生物分子浓缩在样品中; 通过使用含有电荷中和剂的水溶液作为洗涤液来洗涤生物分子的免疫沉淀物; 并通过对洗涤的免疫沉淀物进行质谱检测来检测生物分子。