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30 条记录 (耗时 0.025 秒)

    Novel Carbonyl Reductase, Gene Therefor and Use Thereof
    6.
    发明申请
    Novel Carbonyl Reductase, Gene Therefor and Use Thereof 失效
    新型羰基还原酶，其基因及其用途

    公开(公告)号：US20090029430A1

    公开(公告)日：2009-01-29

    申请号：US11665065

    申请日：2005-10-20

    申请人： Noriyuki Kizaki ,  Mokoto Ueda ,  Daisuke Moriyama ,  Naoaki Taoka ,  Yoshihiko Yasohara

    发明人： Noriyuki Kizaki ,  Mokoto Ueda ,  Daisuke Moriyama ,  Naoaki Taoka ,  Yoshihiko Yasohara

    IPC分类号： C12P7/02 ,  C07H21/04 ,  C07K14/00 ,  C12N15/63 ,  C12N1/21

    CPC分类号： C12N9/0006 ,  C12P7/04 ,  C12P7/62 ,  C12P13/002 ,  C12P41/002

    摘要： The present invention is to provide a process for efficiently producing an optically active alcohol including (R)-3-hydroxy-3-phenylpropanenitrile. One of the features of the present invention is a polypeptide having an activity of asymmetrically reducing 3-oxo-3-phenylpropanenitrile isolated from a microorganism belonging to the genus Candida to produce (R)-3-hydroxy-3-phenylpropanenitrile, DNA encoding the polypeptide and a transformant of producing the polypeptide. Another feature of the present invention is a process for producing an optically active alcohol such as (R)-3-hydroxy-3-phenylpropanenitrile by reducing a carbonyl compound such as 3-oxo-3-phenylpropanenitrile by use of the polypeptide or the transformant.

    摘要翻译： 本发明提供一种有效制备包含（R）-3-羟基-3-苯基丙腈的光学活性醇的方法。 本发明的特征之一是具有不对称还原从属于念珠菌属的微生物分离的3-氧代-3-苯基丙腈的活性的多肽，以产生（R）-3-羟基-3-苯基丙腈，编码 多肽和产生多肽的转化体。 本发明的另一个特征是通过使用多肽或转化体还原羰基化合物如3-氧代-3-苯基丙腈来制备光学活性醇如（R）-3-羟基-3-苯基丙腈的方法 。

    Substituted acetylpyridine derivatives and process for the preparation of intermediates for optically active &bgr;3 agonist by the use of the same
    7.
    发明授权
    Substituted acetylpyridine derivatives and process for the preparation of intermediates for optically active &bgr;3 agonist by the use of the same 失效
    取代的乙酰基吡啶衍生物及其制备用于光学活性β3激动剂的中间体的方法

    公开(公告)号：US06642387B2

    公开(公告)日：2003-11-04

    申请号：US10305105

    申请日：2002-11-27

    申请人： Susumu Amano ,  Naoaki Taoka ,  Masaru Mitsuda ,  Kenji Inoue

    发明人： Susumu Amano ,  Naoaki Taoka ,  Masaru Mitsuda ,  Kenji Inoue

    IPC分类号： C07D21346

    CPC分类号： C07D213/30 ,  C07D213/50 ,  C07D213/74 ,  C07D213/75 ,  C07D405/04

    摘要： It is an objective to produce intermediates of optically active beta-3 adrenaline receptor agonists from readily available raw materials in a safe, efficient and industrially advantageous manner. A substituted acetylpyridine derivative represented by the general formula (9) is reduced by enantioselective reduction to produce an optically active hydroxyethylpyridine derivative represented by the general formula (10) (wherein * represents an asymmetric carbon atom), and it is further derivatized to an intermediate of an optically active beta-3 adrenaline receptor agonist, such as an optically active dihydroxyethylpyridine derivative represented by the general formula (14) or an optically active oxirane derivative represented by the general formula (16)

    摘要翻译： 目的是以安全，有效和工业上有利的方式从容易获得的原料生产光学活性β-3肾上腺素受体激动剂的中间体。 由通式（9）表示的取代的乙酰基吡啶衍生物通过对映选择性还原反应来制备由通式（10）表示的光学活性羟乙基吡啶衍生物（其中*表示不对称碳原子），并进一步衍生为中间体 的光学活性β-3肾上腺素受体激动剂，例如由通式（14）表示的光学活性二羟基乙基吡啶衍生物或由通式（16）表示的光学活性环氧乙烷衍生物，

    Process for producing simvastatin
    8.
    发明授权
    Process for producing simvastatin 有权
    辛伐他汀生产工艺

    公开(公告)号：US06331641B1

    公开(公告)日：2001-12-18

    申请号：US09601794

    申请日：2000-09-28

    申请人： Naoaki Taoka ,  Kenji Inoue

    发明人： Naoaki Taoka ,  Kenji Inoue

    IPC分类号： C07D30930

    CPC分类号： C07D319/06 ,  C07D309/30 ,  Y02P20/55

    摘要： This invention provides an easy and efficient process for producing a simvastatin of great use as an HMG-CoA reductase inhibitor, which comprises deacylation of lovastatin with an inorganic base and a secondary or tertiary alcohol and subjecting the resulting diol lactone to selective protection with a ketal or acetal protective group, acylation and deprotection-lactonization to give simvastatin.

    摘要翻译： 本发明提供了一种用于生产作为HMG-CoA还原酶抑制剂的伟大用途的辛伐他汀的简单和有效的方法，其包括用无机碱和仲或叔醇脱氢洛伐他汀，并使所得二醇内酯用缩酮进行选择性保护 或缩醛保护基，酰化和去保护 - 内酯化得到辛伐他汀。

    Method for producing L-amino acid
    9.
    发明授权
    Method for producing L-amino acid 有权
    生产L-氨基酸的方法

    公开(公告)号：US09464306B2

    公开(公告)日：2016-10-11

    申请号：US13126534

    申请日：2009-10-28

    申请人： Masutoshi Nojiri ,  Tozo Nishiyama ,  Naoaki Taoka

    发明人： Masutoshi Nojiri ,  Tozo Nishiyama ,  Naoaki Taoka

    IPC分类号： C12P13/04 ,  C12P13/00 ,  C12N9/10 ,  C12N9/90 ,  C07C227/30 ,  C07C233/47 ,  C12P13/22 ,  C12P41/00

    CPC分类号： C12P13/04 ,  C07C227/30 ,  C07C233/47 ,  C12N9/104 ,  C12N9/90 ,  C12P13/222 ,  C12P41/007 ,  Y02P20/52 ,  C07C229/30 ,  C07C229/32 ,  C07C229/36

    摘要： The present invention relates to a method for producing an L-amino acid by reacting an enantiomeric mixture of an N-succinyl amino acid with L-succinylase in the presence of N-acylamino acid racemase to specifically hydrolyze the L-form. In particular, the present invention relates to a method for producing an L-amino acid in high yield by using an N-succinyl amino acid whose dissolved concentration is particularly low as a raw material to perform a reaction while precipitating the produced L-amino acid out of the reaction system. The present invention enables efficient production of an L-amino acid having high optical purity, particularly an L-amino acid useful as a raw material for products such as pharmaceutical products and agricultural chemicals.

    摘要翻译： 本发明涉及通过在N-酰基氨基酸消旋酶存在下使N-琥珀酰氨基酸与L-琥珀酰基酶的对映异构体混合物反应以特异性水解L型而生产L-氨基酸的方法。 特别地，本发明涉及通过使用溶解浓度特别低的N-琥珀酰氨基酸作为原料进行反应，同时使生成的L-氨基酸沉淀而以高产率生产L-氨基酸的方法 出了反应体系。 本发明能够有效地生产具有高光学纯度的L-氨基酸，特别是可用作药物产品和农药等产品的原料的L-氨基酸。

    Novel (S,S) -Butanediol Dehydrogenase, Gene for the Same, and Use of the Same
    10.
    发明申请
    Novel (S,S) -Butanediol Dehydrogenase, Gene for the Same, and Use of the Same 审中-公开
    新型（S，S） - 丁二醇脱氢酶，其基因及其用途

    公开(公告)号：US20110143406A1

    公开(公告)日：2011-06-16

    申请号：US12223319

    申请日：2007-02-02

    申请人： Daisuke Moriyama ,  Naoaki Taoka

    发明人： Daisuke Moriyama ,  Naoaki Taoka

    IPC分类号： C12P7/26 ,  C07H21/04 ,  C12N9/04 ,  C12N15/63 ,  C12N1/21 ,  C12P7/18

    CPC分类号： C12Y101/01304 ,  C12N9/0006 ,  C12P7/18 ,  C12P41/002

    摘要： The present invention has its object to provide a novel (S,S)-butanediol dehydrogenase. The present invention also has its object to provide a gene coding for the enzyme protein, a vector containing the gene, a transformant harboring the vector, and a method of producing an optically active alcohol using the transformant. The polypeptide according to one embodiment of the present invention has the physicochemical properties including actions such as: acting on (2S,3S)-2,3-butanediol to form (S)-acetoin in the presence of NAD+ as a coenzyme; and reducing 2,3-butanedione to form (2S,3S)-2,3-butanediol in the presence of NADH as a coenzyme.

    摘要翻译： 本发明的目的是提供一种新型（S，S） - 丁二醇脱氢酶。 本发明的目的还在于提供编码酶蛋白的基因，含有该基因的载体，携带该载体的转化体，以及使用该转化体制造光学活性醇的方法。 根据本发明一个实施方案的多肽具有包括以下作用的物理化学性质：如在NAD +作为辅酶存在下作用于（2S，3S）-2,3-丁二醇以形成（S） - 乙酰胸苷; 并在NADH作为辅酶存在下还原2,3-丁二酮以形成（2S，3S）-2,3-丁二醇。