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    Amino acid derivatives and pharmaceutical composition comprising, as active ingredients, them
    1.
    发明申请
    Amino acid derivatives and pharmaceutical composition comprising, as active ingredients, them 失效
    作为活性成分的氨基酸衍生物和药物组合物

    公开(公告)号：US20050009890A1

    公开(公告)日：2005-01-13

    申请号：US10892366

    申请日：2004-07-16

    申请人： Takuya Seko ,  Masashi Kato

    发明人： Takuya Seko ,  Masashi Kato

    IPC分类号： C07D277/06 ,  C07D401/12 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  A61K31/44 ,  A61K31/195 ,  A61K31/405 ,  A61K31/4172

    CPC分类号： C07D417/12 ,  C07D277/06 ,  C07D417/06 ,  C07D417/14

    摘要： The present invention relates to the compounds of the formula (I) and salts thereof (all the symbols are the same meanings as described in the specification). The compounds of the formula (I) possess inhibitory activity of N-type calcium channel, so they are useful as drug for prevention and/or treatment of cerebral infarct, transient ischemic attack, encephalomyelopathy after cardiac operation, spinal angiopathy, hypertension with stress, neurosis, epilepsy, asthma and pollakiuria etc. or agent for the treatment of pain.

    摘要翻译： 本发明涉及式（I）的化合物及其盐（所有符号与说明书中所述的相同）。 式（I）化合物具有N型钙通道的抑制活性，因此可用作预防和/或治疗脑梗死，短暂性脑缺血发作，心脏手术后脑炎，脊柱血管病，应激性高血压， 神经症，癫痫，哮喘和尿频等等，或用于治疗疼痛的药剂。

    Amino acid derivatives and pharmaceutical composition comprising, as active ingredients, them
    2.
    发明授权
    Amino acid derivatives and pharmaceutical composition comprising, as active ingredients, them 失效
    作为活性成分的氨基酸衍生物和药物组合物

    公开(公告)号：US07427634B2

    公开(公告)日：2008-09-23

    申请号：US10892366

    申请日：2004-07-16

    申请人： Takuya Seko ,  Masashi Kato

    发明人： Takuya Seko ,  Masashi Kato

    IPC分类号： A61K31/425 ,  C07D277/04

    CPC分类号： C07D417/12 ,  C07D277/06 ,  C07D417/06 ,  C07D417/14

    摘要： The present invention relates to the compounds of the formula (I) and salts thereof (all the symbols are the same meanings as described in the specification). The compounds of the formula (I) possess inhibitory activity of N-type calcium channel, so they are useful as drug for prevention and/or treatment of cerebral infarct, transient ischemic attack, encephalomyelopathy after cardiac operation, spinal angiopathy, hypertension with stress, neurosis, epilepsy, asthma and pollakiuria etc. or agent for the treatment of pain.

    摘要翻译： 本发明涉及式（I）的化合物及其盐（所有符号与说明书中所述的相同）。 式（I）化合物具有N型钙通道的抑制活性，因此可用作预防和/或治疗脑梗死，短暂性脑缺血发作，心脏手术后脑炎，脊柱血管病，应激性高血压， 神经症，癫痫，哮喘和尿频等等，或用于治疗疼痛的药剂。

    Amino acid derivatives and drugs containing the same as the active ingredient
    6.
    发明授权
    Amino acid derivatives and drugs containing the same as the active ingredient 失效
    氨基酸衍生物和含有与活性成分相同的药物

    公开(公告)号：US06903119B1

    公开(公告)日：2005-06-07

    申请号：US09743393

    申请日：1999-07-13

    申请人： Takuya Seko ,  Masashi Kato

    发明人： Takuya Seko ,  Masashi Kato

    IPC分类号： C07D277/06 ,  C07D401/12 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  A61K31/454 ,  A61K31/445 ,  A61K31/5377 ,  C07D413/14

    CPC分类号： C07D417/12 ,  C07D277/06 ,  C07D417/06 ,  C07D417/14

    摘要： The present invention relates to the compounds of the formula (I) and salts thereof (all the symbols are the same meanings as described in the specification). The compounds of the formula (I) possess inhibitory activity of N-type calcium channel, so they are useful as drug for prevention and/or treatment of cerebral infarct, transient ischemic attack, encephalomyelopathy after cardiac operation, spinal angiopathy, hypertension with stress, neurosis, epilepsy, asthma and pollakiuria etc. or agent for the treatment of pain.

    摘要翻译： 本发明涉及式（I）的化合物及其盐（所有符号与说明书中所述的相同）。 式（I）化合物具有N型钙通道的抑制活性，因此可用作预防和/或治疗脑梗死，短暂性脑缺血发作，心脏手术后脑炎，脊柱血管病，应激性高血压， 神经症，癫痫，哮喘和尿频等等，或用于治疗疼痛的药剂。

    Remedy for chronic disease
    10.
    发明授权
    Remedy for chronic disease 失效
    缓解慢性病的治疗方法

    公开(公告)号：US07300917B2

    公开(公告)日：2007-11-27

    申请号：US10519106

    申请日：2003-05-28

    申请人： Shinji Nakade ,  Hiromu Habashita ,  Takuya Seko

    发明人： Shinji Nakade ,  Hiromu Habashita ,  Takuya Seko

    IPC分类号： A61K38/00 ,  C12P13/06

    CPC分类号： C07D213/40 ,  A61K31/4406 ,  C07C233/51 ,  C07C233/66 ,  C07C233/73 ,  C07C233/83 ,  C07C235/48 ,  C07C235/52 ,  C07D231/12 ,  C07D235/12 ,  C07D261/14

    摘要： A remedy and/or a preventive for a chronic disease which contains an EDG-2 antagonist. Because of binding to a subtype EDG-2 of LPA receptor, an EDG-2 antagonist is useful in treating and/or preventing chronic diseases (for example, diseases caused by the progress of chronic asthma, glomerular nephritis, obesity, arteriosclerosis, rheumatoid and atopic diseases) induced and made chronic by tissue cells whose proliferation is accelerated by LPA mediated by EDG-2.

    摘要翻译： 含有EDG-2拮抗剂的慢性疾病的补救措施和/或预防措施。 由于与EDA-2的LPA受体的结合，EDG-2拮抗剂可用于治疗和/或预防慢性疾病（例如由慢性哮喘，肾小球肾炎，肥胖症，动脉硬化，类风湿病， 特应性疾病）由EDG-2介导的LPA加速的组织细胞诱导和慢性。