摘要:
Compounds of the formula wherein R1, R2, R3, R4, X and Y are as defined, which have a superior cGMP specific phosphodiesterase (PDE) inhibitory activity, and can be used as an agent for the treatment of cardiovascular diseases such as angina pectoris, heart failure, cardiac infarction, hypertension, arteriosclerosis, and the like; allergic diseases such as asthma, or disorders of male or female genital function and the like.
摘要:
Novel compounds of the following general formula or salts thereof. ##STR1## wherein Ring M is a heterocyclic ring having --N.dbd.C
摘要翻译:下列通式的新化合物或其盐。 其中环M是具有-N = C,-CO-N或-CS-N(作为部分结构-X + E,ov)的杂环。 。 + EE Y < R a和R b彼此键合形成环A,或它们相同或不同,独立地表示环M上的氢原子或取代基; 环A和环B独立地表示任选取代的杂环或杂环,并且它们中的至少一个是任选取代的杂环; R C是任选取代的杂环或杂环; R Z是任选取代的环; n表示1〜6的整数,或其盐具有优异的速激肽受体拮抗作用及其制备及药物组合物。
摘要:
A compound represented by the formula ##STR1## wherein X is hydrogen or a substituent; R.sup.1 is an optionally substituted hydrocarbon residue; R.sup.2 and R.sup.3 are respectively hydrogen or a substituent; and ----- shows a single bond or a double bond, or a pharmacologically acceptable acid addition salt thereof, has an analgesic action and is useful as a medicine.
摘要:
In a non-aqueous electrolyte secondary battery, in order to adjust a cathode active material in which guest cation such as Na and Li is included, alkaline metal fluoride which is expressed by a general formula AF and transition metal fluoride which is expressed by a formula M′ F2 are subjected to a mechanical milling process to produce metal fluoride compound AM′ F3. The mechanical milling process desirably uses a planetary ball mill.
摘要:
Disclosed is a labeling substance capable of reversibly immobilizing (reversible detachment) to a solid surface and to reliably and accurately identify a target biological substance interacting with a probe substance bound to the labeling substance. A chimeric compound is provided, which includes a labeling substance L including (1) an organic compound S with a chemical structure capable of binding to a probe substance P, which can interact with a biological substance B and (2) a peptide bound to the organic compound S and specifically recognized by an antibody A, peptide and a probe substance P at least except a peptide or protein. In addition, a method for preparing the labeling substance L and a method for capturing, structurally analyzing and/or identifying the biological substance using the labeling substance L are provided.
摘要:
A display control device has: a shift register generating n shift pulses in series; a data hold block configured to hold n gradation data; and a DA converter for converting the n gradation data into corresponding gradation voltages. The data hold block includes: n first latch circuits configured to respectively latch the n gradation data in series in synchronization with the n shift pulses; and n second latch circuits provided between the DA converter and the n first latch circuits. An electrical connection between the first latch circuits and the second latch circuits is cut off while the first latch circuits receive the n gradation data. After the first latch circuits finish latching all the gradation data, the n gradation data are simultaneously supplied to the DA converter from the first latch circuits through the second latch circuits.
摘要:
Preventives/remedies for voiding disturbance containing a compound having both of an acetylcholinesterase inhibitory action and an α1 antagonistic action which exhibits an excellent effect of improving the urinary function of the bladder (i.e., effects of improving urine flow rate and voiding efficiency) without affecting the urinary pressure or the blood pressure.
摘要:
Disclosed are intermediates for the preparation of novel aminocoumaran derivatives of the general formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are a hydrogen atom, an acyl group, an alkoxycarbonyl group, an aliphatic group or aromatic group; R.sup.3, R.sup.4 and R.sup.5 are an optionally acylated hydroxyl, optionally substituted amino group, alkoxy group or aliphatic group, or two of R.sup.3, R.sup.4 and R.sup.5 may be linked together to form a carbocyclic group; R.sup.6 and R.sup.7 are an aliphatic group and at least one of them has a methylene group at the .alpha.-position; R.sup.8 and R.sup.9 are a hydrogen atom or an aliphatic group or aromatic group, or a salt thereof is useful for medicines for preventing and treating various diseases such as arterial sclerosis, hepatopathy, cerebrovascular diseases and the like.
摘要:
Novel compound represented by the formula: ##STR1## wherein A", B, C, D, E, G, Ar, X, Y, and Z are defined herein or a salt thereof. The compounds have excellent activity of inhibiting ACAT, lowering Cholesterol in blood and inhibiting tachykinin receptor, or a salt thereof, their production and use.
摘要:
A sodium ion secondary battery having far superior potential stability during discharge when repeatedly charging and discharging, and a negative electrode active material capable of being efficiently doped and dedoped with sodium ions used therefor are provided. The sodium ion secondary battery according to the present invention includes a positive electrode containing a positive electrode active material capable of being doped and dedoped with sodium ions, a negative electrode containing a negative electrode active material containing, as a sole component or as a main component, a glassy carbonaceous material capable of being doped and dedoped with sodium ions, and an electrolyte containing sodium ions. Further, the negative electrode active material for a non-aqueous electrolyte sodium ion secondary battery according to the present invention includes a glassy carbonaceous material as a sole component or as a main component.