公开(公告)号：US11518768B2

公开(公告)日：2022-12-06

申请号：US15953331

申请日：2018-04-13

Applicant: The Regents of the University of California

Inventor： John F. Hartwig ,  Hanna M. Key ,  Pawel Dydio ,  Douglas S. Clark

IPC: C12N9/02 ,  C12N15/65 ,  C12P13/00 ,  C07D487/22 ,  C07K14/805 ,  B01J31/18 ,  C07K14/795 ,  C07K14/80 ,  B01J31/00 ,  C12N9/00

Abstract: The present invention is drawn to artificial metalloenzymes for use in cyclopropanation reactions, amination and C—H insertion.

公开(公告)号：US20210284972A1

公开(公告)日：2021-09-16

申请号：US17200715

申请日：2021-03-12

Applicant: The Regents of the University of California

Inventor： Jing Huang ,  Zhennan Liu ,  Douglas S. Clark ,  Jay D. Keasling ,  Aindrila Mukhopadhyay ,  John F. Hartwig

IPC: C12N5/10 ,  C12N9/02 ,  C07D487/22

Abstract: The present invention provides for a genetically modified host cell capable of producing an unnatural compound, such as terpenoid, comprising a P450 enzyme comprising an artificial cofactor, and the host cell is capable of uptaking the artificial cofactor by comprising a heterologous heme transport transmembrane protein, or homologue thereof.

公开(公告)号：US20230287204A1

公开(公告)日：2023-09-14

申请号：US17921516

申请日：2021-04-29

Applicant: The Regents Of The University Of California

Inventor： John F. Hartwig ,  Liye Chen

IPC: C08L23/22 ,  C08F110/10

CPC classification number: C08L23/22 ,  C08F110/10 ,  C08F2810/20 ,  C08L2312/08

Abstract: Disclosed herein, inter alia, are oxidized polyisobutene compounds and compositions and methods of making the same.

公开(公告)号：US20180305368A1

公开(公告)日：2018-10-25

申请号：US15953331

申请日：2018-04-13

Applicant: The Regents of the University of California

Inventor： John F. Hartwig ,  Hanna M. Key ,  Pawel Dydio ,  Douglas S. Clark

IPC: C07D487/22

CPC classification number: C07D487/22 ,  B01J31/18 ,  C07K14/795 ,  C07K14/80 ,  C07K14/805

Abstract: The present invention is drawn to artificial metalloenzymes for use in cyclopropanation reactions, amination and C—H insertion.

公开(公告)号：US11512040B2

公开(公告)日：2022-11-29

申请号：US17257080

申请日：2019-07-02

Applicant: BASF SE ,  BASF CORPORATION ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Martin Ernst ,  Stephan Zuend ,  Bo Su ,  Ala Bunescu ,  John F. Hartwig

IPC: C07C213/00

Abstract: A process for the preparation of amino alcohols includes condensing a compound of Formula (II), a stereoisomer, a tautomer, or a salt thereof with a compound of Formula (IIIa) or Formula (IIIb), a stereoisomer, a tautomer, or a salt thereof to form a condensation product; hydroxylating or acyloxylating the condensation product in the presence of an oxidant to obtain a hydroxylation or acyloxylation product; and subjecting the hydroxylation or acyloxylation product to one or more subsequent reactions comprising a hydrolysis reaction, alcohol deprotection, an amino lysis reaction, or a combination of two or more thereof to obtain an amino alcohol of Formula (I).

公开(公告)号：US09598340B2

公开(公告)日：2017-03-21

申请号：US14782402

申请日：2014-04-07

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： John F. Hartwig ,  Shaozhong Ge ,  Wojciech Chaładaj

IPC: C07F15/00 ,  C07C45/86 ,  C07C49/80 ,  B01J23/44 ,  C07C45/68 ,  B01J31/24 ,  C07B39/00 ,  C07C17/361 ,  C07C41/18 ,  C07C45/00 ,  C07C67/297 ,  C07C67/343 ,  C07C67/42 ,  C07C69/612 ,  C07C69/76 ,  C07C201/12 ,  C07C205/45 ,  C07C221/00 ,  C07C225/22 ,  C07C231/12 ,  C07C269/06 ,  C07C319/20 ,  C07C323/22 ,  C07D213/50 ,  C07D213/56 ,  C07D215/12 ,  C07D215/14 ,  C07D217/18 ,  C07D295/104 ,  C07D317/16 ,  C07D317/26 ,  C07D317/54 ,  C07D333/24 ,  C07F7/08

CPC classification number: C07C45/68 ,  B01J23/44 ,  B01J31/2404 ,  B01J2531/824 ,  C07B39/00 ,  C07C17/361 ,  C07C41/18 ,  C07C45/004 ,  C07C45/86 ,  C07C49/80 ,  C07C67/297 ,  C07C67/343 ,  C07C67/42 ,  C07C69/612 ,  C07C69/76 ,  C07C201/12 ,  C07C205/45 ,  C07C221/00 ,  C07C225/22 ,  C07C231/12 ,  C07C269/06 ,  C07C319/20 ,  C07C323/22 ,  C07D213/50 ,  C07D213/56 ,  C07D215/12 ,  C07D215/14 ,  C07D217/18 ,  C07D295/104 ,  C07D317/16 ,  C07D317/26 ,  C07D317/54 ,  C07D333/24 ,  C07F7/081 ,  C07F7/083 ,  C07F15/006 ,  C07C49/84

Abstract: The coupling of aryl, heteroaryl, and vinyl halides with α,α-difluoroketones or silyl ethers or siylenol ethers of α,α-difluoroketones and α,α-difluoroamides and esters are described. Further derivatization of the coupling products (such as ketone cleavage and Baeyer-Villiger oxidation) is also described.

公开(公告)号：US12129493B2

公开(公告)日：2024-10-29

申请号：US17200715

申请日：2021-03-12

Applicant: The Regents of the University of California

Inventor： Jing Huang ,  Zhennan Liu ,  Douglas S. Clark ,  Jay D Keasling ,  Aindrila Mukhopadhyay ,  John F. Hartwig

IPC: C12N5/10 ,  C07D487/22 ,  C12N9/02

CPC classification number: C12N5/10 ,  C07D487/22 ,  C12N9/0069 ,  C12N2510/00

Abstract: The present invention provides for a genetically modified host cell capable of producing an unnatural compound, such as terpenoid, comprising a P450 enzyme comprising an artificial cofactor, and the host cell is capable of uptaking the artificial cofactor by comprising a heterologous heme transport transmembrane protein, or homologue thereof.

公开(公告)号：US20230272202A1

公开(公告)日：2023-08-31

申请号：US17921520

申请日：2021-04-29

Applicant: The Regents Of The University Of California

Inventor： John F. Hartwig ,  Liye Chen

IPC: C08L23/30 ,  C08L23/06 ,  C08F4/80 ,  C08F2/06 ,  C08F110/02 ,  C08K5/3432 ,  C08F8/06

CPC classification number: C08L23/30 ,  C08F2/06 ,  C08F4/80 ,  C08F8/06 ,  C08F110/02 ,  C08K5/3432 ,  C08L23/06 ,  C08L2207/066

Abstract: Disclosed herein, inter alia, are oxidized polyethylene compounds and compositions and methods of making the same.

公开(公告)号：US09938204B2

公开(公告)日：2018-04-10

申请号：US14916787

申请日：2014-09-08

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： John F. Hartwig ,  Chen Cheng ,  Tyler Wilson

IPC: C07F7/00 ,  C07B47/00 ,  C07F7/08 ,  C07F7/18

CPC classification number: C07B47/00 ,  C07F7/0807 ,  C07F7/0829 ,  C07F7/0838 ,  C07F7/0878 ,  C07F7/1804 ,  C07F7/1876 ,  C07F7/188

Abstract: Reaction mixtures for silvlating arene substrates and methods of using such reaction mixtures to silyiate the arene substrates are provided. Exemplary reaction mixtures include the arene substrate, a liganded metal catalyst, a hydrogen acceptor and an organic solvent. The reaction conditions allow for diverse substituents on the arene substrate.