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15 条记录 (耗时 0.071 秒)

    Antibodies directed to the testis-specific tubulin tyrosine-ligase-like protein, BGS42
    2.
    发明授权
    Antibodies directed to the testis-specific tubulin tyrosine-ligase-like protein, BGS42 有权
    针对睾丸特异性微管蛋白酪氨酸连接酶样蛋白BGS42的抗体

    公开(公告)号：US07309779B2

    公开(公告)日：2007-12-18

    申请号：US11445988

    申请日：2006-06-02

    申请人： John N. Feder ,  Shujian Wu ,  Thomas C. Nelson ,  Liana M. Lee

    发明人： John N. Feder ,  Shujian Wu ,  Thomas C. Nelson ,  Liana M. Lee

    IPC分类号： C07K16/40 ,  C12N5/12

    CPC分类号： C12N9/93 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  C07K2319/00 ,  G01N33/57423 ,  G01N2333/9015 ,  Y10S435/81

    摘要： The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码BGS-42多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型BGS-42多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding novel cysteine proteases of the calpain superfamily, CAN-12v1 and CAN-12v2.
    5.
    发明授权
    Polynucleotides encoding novel cysteine proteases of the calpain superfamily, CAN-12v1 and CAN-12v2. 有权
    编码钙蛋白酶超家族，CAN-12v1和CAN-12v2的新型半胱氨酸蛋白酶的多核苷酸。

    公开(公告)号：US07186564B2

    公开(公告)日：2007-03-06

    申请号：US10116519

    申请日：2002-04-03

    申请人： Jian Chen ,  Thomas C. Nelson ,  Roy J. Vaz ,  Franck Duclos

    发明人： Jian Chen ,  Thomas C. Nelson ,  Roy J. Vaz ,  Franck Duclos

    IPC分类号： C12N15/57 ,  C12N9/64 ,  C12N15/74 ,  C12N15/79

    CPC分类号： C12N9/6472 ,  A61K38/00 ,  C07K2299/00 ,  Y02A90/26

    摘要： The present invention provides novel polynucleotides encoding CAN-12 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants of CAN-12 polypeptides, CAN-12v1 and CAN-12v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel CAN-12, CAN-12v1, and CAN-12v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly neuro- and musculo-degenerative conditions. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供编码CAN-12多肽的新型多核苷酸，其片段和同系物。 本发明还提供编码CAN-12多肽，CAN-12v1和CAN-12v2变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型CAN-12，CAN-12v1和CAN-12v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法，特别是神经 - 和肌肉退行性疾病。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Method of diagnosing lung cancer using BGS42
    7.
    发明授权
    Method of diagnosing lung cancer using BGS42 有权
    使用BGS42诊断肺癌的方法

    公开(公告)号：US07741025B2

    公开(公告)日：2010-06-22

    申请号：US11900344

    申请日：2007-09-10

    申请人： John N. Feder ,  Shujian Wu ,  Thomas C. Nelson ,  Liana M. Lee

    发明人： John N. Feder ,  Shujian Wu ,  Thomas C. Nelson ,  Liana M. Lee

    IPC分类号： C12Q1/70 ,  C12Q1/68

    CPC分类号： C12N9/93 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  C07K2319/00 ,  G01N33/57423 ,  G01N2333/9015 ,  Y10S435/81

    摘要： The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码BGS-42多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型BGS-42多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding a novel metalloprotease, MP-1
    9.
    发明授权
    Polynucleotides encoding a novel metalloprotease, MP-1 有权
    编码新型金属蛋白酶MP-1的多核苷酸

    公开(公告)号：US06642041B2

    公开(公告)日：2003-11-04

    申请号：US10067443

    申请日：2002-02-05

    申请人： Jian Chen ,  John N. Feder ,  Thomas C. Nelson ,  Stanley R. Krystek ,  Franck Duclos

    发明人： Jian Chen ,  John N. Feder ,  Thomas C. Nelson ,  Stanley R. Krystek ,  Franck Duclos

    IPC分类号： C12N948

    CPC分类号： C12N9/6489 ,  C07K2299/00

    摘要： The present invention provides novel polynucleotides encoding MP-1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MP-1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码MP-1多肽，其片段和同系物的新型多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型MP-1多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Printer switchable between duplex and simplex mode on a page by page basis
    10.
    发明授权
    Printer switchable between duplex and simplex mode on a page by page basis 失效
    打印机可以在双面和单面模式之间逐页切换

    公开(公告)号：US4924275A

    公开(公告)日：1990-05-08

    申请号：US351429

    申请日：1989-05-12

    申请人： Thomas C. Nelson

    发明人： Thomas C. Nelson

    IPC分类号： B41J3/60 ,  G03G15/23

    CPC分类号： B41J3/60 ,  G03G15/234

    摘要： The printer switchable between simplex and duplex mode of operation on a page by page basis makes use of a single simplex print engine. Duplex printing is accomplished by the reinsertion of a simplex printed page into the input of the print engine in a flipped mode so the other side of the printed page can be printed by the print engine. This printer also includes apparatus that dynamically switches the operation of the printer from duplex to simplex mode of operation when the printing commands input from the associated processor indicates that the other side of a simplex printed page is a blank page. This enables the print engine to eject the simplex printed page directly to the output paper bin without having to cycle this simplex printed page back through the print engine even though there are no characters to be printed thereon. This blank page suppression or simplex/duplex mode switching thereby increases the throughput of this printer system by avoiding the unnecessary delays occasioned by cycling a page of paper through the print engine when nothing is to printed thereon.

    摘要翻译： 可以在单页和双工操作模式之间逐页切换的打印机使用单个单面打印引擎。 双面打印是通过将单面打印页面以翻转模式重新插入打印引擎的输入来实现的，因此打印页面的另一面可以由打印引擎打印。 该打印机还包括当从相关联的处理器输入的打印命令指示单面打印页面的另一侧是空白页时，将打印机的操作从双工模式动态地切换到单工模式的装置。 这使得打印机能够将单面打印页面直接排出到输出纸盒，而不必将该单面打印页面循环通过打印引擎，即使没有要打印的字符。 这种空白页面抑制或单面/双面模式切换从而通过避免当没有打印在其上时通过打印引擎循环打印一页纸而引起的不必要的延迟来增加该打印机系统的吞吐量。