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    Nucleic acid encoding a polypeptide with the biological activity of a serine hydroxymethyltransferase
    6.
    发明授权
    Nucleic acid encoding a polypeptide with the biological activity of a serine hydroxymethyltransferase 失效
    编码具有丝氨酸羟甲基转移酶生物活性的多肽的核酸

    公开(公告)号：US07662603B2

    公开(公告)日：2010-02-16

    申请号：US11949874

    申请日：2007-12-04

    申请人： Uwe Sonnewald ,  Frederik Boernke ,  Kirsten Deist ,  Marc Stitt Nigel ,  Wolfgang Lein ,  Thomas Ehrhardt ,  Andreas Reindl ,  Ralf-Michael Schmidt ,  Annette Freund

    发明人： Uwe Sonnewald ,  Frederik Boernke ,  Kirsten Deist ,  Marc Stitt Nigel ,  Wolfgang Lein ,  Thomas Ehrhardt ,  Andreas Reindl ,  Ralf-Michael Schmidt ,  Annette Freund

    IPC分类号： C12N9/00 ,  C12N9/10 ,  C12N1/20 ,  C12N15/00 ,  C07H21/04

    CPC分类号： C12N9/1014 ,  C12N15/8274

    摘要： The present invention relates to serine hydroxymethyltransferase (E.C. 2.1.2.1) as novel target for herbicides, and to nucleic acid sequences encoding a polypeptide with the biological activity of a serine hydroxymethyltransferase, which, when not present, bring about growth retardation symptoms and chlorotic leaves, comprising the nucleic acid sequence SEQ ID No:3, and functional equivalents of the abovementioned nucleic acid sequence or the nucleic acid sequence SEQ ID NO:7 and functional equivalents of the abovementioned nucleic acid sequence. Moreover, the present invention relates to the use of the abovementioned nucleic acid sequences, of functional analogs of the SEQ ID NO:3 or SEQ ID NO:7 or of polypeptides encoded by one of the abovementioned nucleic acid sequences in a method for identifying herbicidally active compounds which inhibit serine hydroxymethyltransferases, and to the use of these compounds which have been identified by the method as herbicides.

    摘要翻译： 本发明涉及丝氨酸羟甲基转移酶（EC 2.1.2.1）作为除草剂的新靶标，以及编码具有丝氨酸羟甲基转移酶生物活性的多肽的核酸序列，当不存在时，其产生生长迟缓症状和褪绿叶 包括核酸序列SEQ ID No：3和上述核酸序列或核酸序列SEQ ID NO：7的功能等同物和上述核酸序列的功能等同物。 此外，本发明涉及上述核酸序列，SEQ ID NO：3或SEQ ID NO：7的功能类似物或由上述核酸序列之一编码的多肽在除草方法中的用途 抑制丝氨酸羟甲基转移酶的活性化合物，以及通过该方法鉴定的这些化合物作为除草剂的用途。

    Serine hydroxymethyltransferase as a target for herbicides
    7.
    发明授权
    Serine hydroxymethyltransferase as a target for herbicides 失效
    丝氨酸羟甲基转移酶作为除草剂的靶标

    公开(公告)号：US07319013B2

    公开(公告)日：2008-01-15

    申请号：US10507989

    申请日：2003-03-13

    申请人： Uwe Sonnewald ,  Frederik Börnke ,  Kirsten Deist ,  Marc Stitt Nigel ,  Wolfgang Lein ,  Thomas Ehrhardt ,  Andreas Reindl ,  Ralf-Michael Schmidt ,  Annette Freund

    发明人： Uwe Sonnewald ,  Frederik Börnke ,  Kirsten Deist ,  Marc Stitt Nigel ,  Wolfgang Lein ,  Thomas Ehrhardt ,  Andreas Reindl ,  Ralf-Michael Schmidt ,  Annette Freund

    IPC分类号： C12Q1/48 ,  C12N9/10 ,  C12N5/04 ,  C12N5/14 ,  C07H21/04

    CPC分类号： C12N9/1014 ,  C12N15/8274

    摘要： The present invention relates to serine hydroxymethyltransferase (E.C. 2.1.2.1) as novel target for herbicides, and to nucleic acid sequences encoding a polypeptide with the biological activity of a serine hydroxymethyltransferase, which, when not present, bring about growth retardation symptoms and chlorotic leaves, comprising the nucleic acid sequence SEQ ID No:3, and functional equivalents of the abovementioned nucleic acid sequence or the nucleic acid sequence SEQ ID NO:7 and functional equivalents of the abovementioned nucleic acid sequence. Moreover, the present invention relates to the use of the abovementioned nucleic acid sequences, of functional analogs of the SEQ ID NO:3 or SEQ ID NO:7 or of polypeptides encoded by one of the abovementioned nucleic acid sequences in a method for identifying herbicidally active compounds which inhibit serine hydroxymethyltransferases, and to the use of these compounds which have been identified by the method as herbicides.

    摘要翻译： 本发明涉及丝氨酸羟甲基转移酶（EC 2.1.2.1）作为除草剂的新靶标，以及编码具有丝氨酸羟甲基转移酶生物活性的多肽的核酸序列，当不存在时，其产生生长迟缓症状和褪绿叶 包括核酸序列SEQ ID No：3和上述核酸序列或核酸序列SEQ ID NO：7的功能等同物和上述核酸序列的功能等同物。 此外，本发明涉及上述核酸序列，SEQ ID NO：3或SEQ ID NO：7的功能类似物或由上述核酸序列之一编码的多肽在除草方法中的用途 抑制丝氨酸羟甲基转移酶的活性化合物，以及通过该方法鉴定的这些化合物作为除草剂的用途。