公开(公告)号：US4875614A

公开(公告)日：1989-10-24

申请号：US264713

申请日：1988-10-31

申请人： Thomas M. Cipolla ,  Raymond R. Horton ,  Philip Murphy ,  Michael J. Palmer

发明人： Thomas M. Cipolla ,  Raymond R. Horton ,  Philip Murphy ,  Michael J. Palmer

IPC分类号： H01L21/60 ,  B23K20/02 ,  F16C19/50 ,  H01L21/00

CPC分类号： F16C19/50 ,  B23K20/02 ,  H01L21/67144 ,  H01L24/78 ,  H01L2224/75745 ,  H01L2224/75823 ,  H01L2224/78 ,  H01L2924/00014 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01039 ,  H01L2924/01082 ,  Y10S269/903

摘要： Apparatus for automatically adjusting the orientation of a first surface of a first body to be against a second surface of a second body when said first surface is pressed against said second surface. The apparatus includes a means for movably mounting the first body to a support which permits rotation of the first surface so that when the first surface is pressed against the second surface, the first surface rotates with respect to the support resulting in the first surface being against the second surface.

公开(公告)号：US5113565A

公开(公告)日：1992-05-19

申请号：US549577

申请日：1990-07-06

申请人： Thomas M. Cipolla ,  Paul W. Coteus ,  Glen W. Johnson ,  Philip Murphy ,  Christopher W. Oden

发明人： Thomas M. Cipolla ,  Paul W. Coteus ,  Glen W. Johnson ,  Philip Murphy ,  Christopher W. Oden

IPC分类号： H01L21/60 ,  H01L21/00 ,  H01L21/66 ,  H01L21/68

CPC分类号： H01L21/67144 ,  H01L22/12 ,  H01L2924/0002 ,  Y10T29/41 ,  Y10T29/49121 ,  Y10T29/49131 ,  Y10T29/49133 ,  Y10T29/53178

摘要： A method is described for aligning a contact pattern on an electronic device held by a first movable support, with a bond site pattern on a lead frame held by a second movable support. The method includes the steps of: (a) creating and storing models of a chip's contact pattern and a lead frame's bond site pattern; (b) imaging the electronic device and lead frame; (c) determining the position of contacts on said electronic device and reorienting the contact pattern model to a best fit with the imaged contact position; (d) determining the position of each bond site on the imaged lead frame and reorienting the bond site model to a best fit with the imaged bond site position; (e) determining positional differences between the reoriented lead frame and contact pattern models; and (f) generating signals to reorient the first and second movable supports to minimize the positional differences when they are moved into a bonding positon. A machine is described for performing the above method wherein each of three main movable elements of the machine is assigned a dimensional axis in which its travel is non-adjustable, so that other movable elements can be calibrated thereagainst.

公开(公告)号：US6104291A

公开(公告)日：2000-08-15

申请号：US167026

申请日：1998-10-06

申请人： Luc Beauvillier ,  Michael John Brady ,  Dah-Weih Duan ,  Daniel J. Friedman ,  Paul Andrew Moskowitz ,  Philip Murphy

发明人： Luc Beauvillier ,  Michael John Brady ,  Dah-Weih Duan ,  Daniel J. Friedman ,  Paul Andrew Moskowitz ,  Philip Murphy

IPC分类号： G06K17/00 ,  G06K19/07 ,  G06K19/077 ,  G08B13/24 ,  G08B21/00

CPC分类号： G08B13/2408 ,  G06K19/0723 ,  G06K19/07749 ,  G06K7/0095 ,  G06K7/10079 ,  G08B13/2417 ,  G08B13/244 ,  G01R31/2822 ,  G06K2017/0041

摘要： The present invention provides a method and apparatus for testing RFID tags using wireless radio frequency (RF) communication. The method and apparatus allow RFID tags to be tested individually or in groups while they are in close proximity to each other (e.g., within the read range of the tag).

摘要翻译： 本发明提供一种使用无线射频（RF）通信来测试RFID标签的方法和装置。 该方法和装置允许RFID标签在它们彼此靠近的地方（例如，在标签的读取范围内）被单独或分组地测试。

公开(公告)号：US20070087990A1

公开(公告)日：2007-04-19

申请号：US11594375

申请日：2006-11-07

申请人： Christophe Combadiere ,  Yu Feng ,  Ghalib Alkhatib ,  Edward Berger ,  Philip Murphy ,  Christopher Broder ,  Paul Kennedy

发明人： Christophe Combadiere ,  Yu Feng ,  Ghalib Alkhatib ,  Edward Berger ,  Philip Murphy ,  Christopher Broder ,  Paul Kennedy

IPC分类号： A61K31/70 ,  C12P21/06 ,  A01N43/04

CPC分类号： C07K14/7158 ,  A01K2217/05 ,  A61K38/00

摘要： The susceptibility of human macrophages to human immunodeficiency virus (HIV) infection depends on cell surface expression of the human CD4 molecule and CC cytokine receptor 5. CCR5 is a member of the 7-transmembrane segment superfamily of G-protein-coupled cell surface molecules. CCR5 plays an essential role in the membrane fusion step of infection by some HIV isolates. The establishment of stable, nonhuman cell lines and transgenic mammals having cells that coexpress human CD4 and CCR5 provides valuable tools for the continuing research of HIV infection. In addition, antibodies which bind to CCR5, CCR5 variants, and CCR5-binding agents, capable of blocking membrane fusion between HIV and target cells represent potential anti-HIV therapeutics for macrophage-tropic strains of HIV.

摘要翻译： 人类巨噬细胞对人类免疫缺陷病毒（HIV）感染的易感性取决于人CD4分子和CC细胞因子受体5的细胞表面表达。CCR5是G蛋白偶联细胞表面分子的7-跨膜段超家族的成员。 CCR5在一些HIV分离物感染的膜融合步骤中起着重要作用。 建立稳定的非人细胞系和具有共表达人CD4和CCR5的细胞的转基因哺乳动物为继续研究艾滋病毒感染提供了宝贵的工具。 此外，结合CCR5，CCR5变体和CCR5结合剂的能够阻断HIV和靶细胞之间的膜融合的抗体代表了HIV巨噬细胞趋化株的潜在的抗HIV治疗剂。

公开(公告)号：US5786626A

公开(公告)日：1998-07-28

申请号：US621784

申请日：1996-03-25

申请人： Michael J. Brady ,  Normand Gilles Favreau ,  Francois Guindon ,  Paul Andrew Moskowitz ,  Philip Murphy

发明人： Michael J. Brady ,  Normand Gilles Favreau ,  Francois Guindon ,  Paul Andrew Moskowitz ,  Philip Murphy

IPC分类号： H01Q1/40 ,  G06K19/077 ,  H01L23/29 ,  H01L23/31 ,  H01L23/495 ,  H01Q1/24 ,  H04B1/59 ,  H01L23/48 ,  H01L23/52 ,  H01L29/40

CPC分类号： G06K19/0775 ,  G06K19/07749 ,  H01L23/293 ,  H01L23/3135 ,  H01L23/495 ,  H01L2224/16 ,  H01L2224/16225 ,  H01L2224/16227 ,  H01L2224/48091 ,  H01L2224/4813 ,  H01L2224/48465 ,  H01L2224/48472 ,  H01L2224/73204 ,  H01L24/48 ,  H01L2924/00014 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/12042 ,  H01L2924/181 ,  H01L2924/19041 ,  Y10S439/916

摘要： A novel radio frequency transponder (tag) with a minimum of components and connects is thin and flexible because these components and connects can be unsupported by a substrate layer. This is accomplished by using a conducting leadframe structure not only as a connection medium but also as a circuit element, i.e., the transponder antenna. In various preferred embodiments, the leadframe is mechanically positioned and fixably attached to a circuit chip so that the leadframe (antenna) is self supporting. A protective coating can be added where the leadframe is attached to the circuit chip. Further a protective surrounding can envelops the entire leadframe antenna, circuit chip, and, if provided, the protective coating.

摘要翻译： 具有最少组件和连接的新颖的射频应答器（标签）是薄而灵活的，因为这些组件和连接可能不被衬底层支撑。 这通过使用不仅作为连接介质而且作为电路元件，即应答器天线的导电引线框架结构来实现。 在各种优选实施例中，引线框机械地定位并可固定地连接到电路芯片，使得引线框架（天线）是自支撑的。 在引线框架连接到电路芯片的地方，可以添加保护涂层。 此外，保护性环绕可以包围整个引线框天线，电路芯片，并且如果提供保护涂层。

公开(公告)号：US07844715B2

公开(公告)日：2010-11-30

申请号：US12199098

申请日：2008-08-27

申请人： Todd Matters ,  Philip Murphy ,  Todd Rimmer ,  Vladimir Tamarkin ,  Duane McCrory

发明人： Todd Matters ,  Philip Murphy ,  Todd Rimmer ,  Vladimir Tamarkin ,  Duane McCrory

IPC分类号： G06F15/16 ,  G06F3/00

CPC分类号： G06F11/2002 ,  G06F11/1616 ,  G06F11/2015 ,  H04L29/06 ,  H04L45/742 ,  H04L49/3009 ,  H04L49/358 ,  H04L49/602 ,  H04L49/90 ,  H04L67/1097 ,  H04L67/327 ,  H04L69/14 ,  H04L69/18 ,  H04L69/22 ,  H04L69/329

摘要： A computer system that includes a plurality of servers, and a shared I/O subsystem coupled to each of the servers and to one or more I/O interfaces. The shared I/O subsystem services I/O requests made by two or more of the servers. Each I/O interface may couple to a network, appliance, or other device. The I/O requests serviced by the shared I/O subsystem may alternatively include software initiated or hardware initiated I/O requests. Different servers coupled to the shared I/O subsystem may use different operating systems, and each I/O interface may be used by two or more servers.

摘要翻译： 包括多个服务器的计算机系统以及耦合到每个服务器和一个或多个I / O接口的共享I / O子系统。 共享的I / O子系统服务由两个或多个服务器进行的I / O请求。 每个I / O接口可以耦合到网络，设备或其他设备。 由共享I / O子系统服务的I / O请求可以替代地包括软件发起或硬件发起的I / O请求。 耦合到共享I / O子系统的不同服务器可以使用不同的操作系统，并且每个I / O接口可以由两个或更多个服务器使用。

公开(公告)号：US20050130890A1

公开(公告)日：2005-06-16

申请号：US10831524

申请日：2004-04-23

申请人： Ji Wang ,  Yingying Le ,  WangHua Gong ,  Hiroshi Yazawa ,  Zu-Xi Yu ,  Joost Oppenheim ,  Philip Murphy

发明人： Ji Wang ,  Yingying Le ,  WangHua Gong ,  Hiroshi Yazawa ,  Zu-Xi Yu ,  Joost Oppenheim ,  Philip Murphy

IPC分类号： C07K14/47 ,  C07K14/705 ,  G01N33/68 ,  G01N33/53 ,  A61K38/17 ,  G01N33/567

CPC分类号： C07K14/4711 ,  C07K14/705 ,  C07K2319/00 ,  G01N33/6896 ,  G01N2500/04 ,  G01N2800/2821

摘要： The invention relates to the discovery that amyloid β is a ligand for FPR class receptors, which mediate the inflammation associated with Alzheimer's disease.

摘要翻译： 本发明涉及淀粉样蛋白β是FPR类受体的配体的发现，其介导与阿尔茨海默氏病相关的炎症。

公开(公告)号：US20050118677A1

公开(公告)日：2005-06-02

申请号：US10846185

申请日：2004-05-14

申请人： Christophe Combadiere ,  Philip Murphy

发明人： Christophe Combadiere ,  Philip Murphy

IPC分类号： A61K38/00 ,  C07K14/715 ,  C12N15/12 ,  A61K38/17 ,  C07H21/04 ,  C07K14/74

CPC分类号： C07K14/7158 ,  A01K2217/05 ,  A61K38/00

摘要： The susceptibility of human macrophages to human immunodeficiency virus (HIV) infection depends on cell surface expression of the human CD4 molecule and CC cytokine receptor 5. CCR5 is a member of the 7-transmembrane segment superfamily of G-protein-coupled cell surface molecules. CCRS plays an essential role in the membrane fusion step of infection by some HIV isolates. The establishment of stable, nonhuman cell lines and transgenic mammals having cells that coexpress human CD4 and CCR5 provides valuable tools for the continuing research of HIV infection. In addition, antibodies which bind to CCR5, CCR5 variants, and CCR5-binding agents, capable of blocking membrane fusion between HIV and target cells represent potential anti-HIV therapeutics for macrophage-tropic strains of HIV.

摘要翻译： 人类巨噬细胞对人类免疫缺陷病毒（HIV）感染的易感性取决于人CD4分子和CC细胞因子受体5的细胞表面表达。CCR5是G蛋白偶联细胞表面分子的7-跨膜段超家族的成员。 CCRS在一些HIV分离株的感染膜融合步骤中发挥重要作用。 建立稳定的非人细胞系和具有共表达人CD4和CCR5的细胞的转基因哺乳动物为继续研究艾滋病毒感染提供了宝贵的工具。 此外，结合CCR5，CCR5变体和CCR5结合剂的能够阻断HIV和靶细胞之间的膜融合的抗体代表了HIV巨噬细胞趋化株的潜在的抗HIV治疗剂。

公开(公告)号：US20050085629A1

公开(公告)日：2005-04-21

申请号：US10987664

申请日：2004-11-12

申请人： Ji Wang ,  Joost Oppenheim ,  Shao-Bo Su ,  Wang Gong ,  Ji-Liang Gao ,  Philip Murphy

发明人： Ji Wang ,  Joost Oppenheim ,  Shao-Bo Su ,  Wang Gong ,  Ji-Liang Gao ,  Philip Murphy

IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/72 ,  G01N33/566 ,  G01N33/53 ,  C07H21/04

CPC分类号： G01N33/566 ,  A61K38/00 ,  C07K14/4711 ,  C07K14/723

摘要： The present invention relates to the discovery that serum amyloid A (SAA) is a ligand for the FPRL1 receptor. Disclosed herein, are novel biological tools for the study of SAA/FPRL1 complex assembly and prophylactics, therapeutics, and methods of use of the foregoing, which modulate the association of SAA with FPRL1 and thereby effect responses including, but not limited to, signal transduction, chemotaxis, leukocyte migration, immune system response, amyloidosis, inflammatory response, infection, organ rejection, arthritis, atherosclerosis, and neoplasia.

摘要翻译： 本发明涉及血清淀粉样蛋白A（SAA）是FPRL1受体的配体的发现。 本文公开了用于研究SAA / FPRL1复合物装配和预防，治疗和上述使用方法的新型生物工具，其调节SAA与FPRL1的缔合，从而影响响应，包括但不限于信号转导 ，趋化性，白细胞迁移，免疫系统反应，淀粉样变性，炎症反应，感染，器官排斥，关节炎，动脉粥样硬化和瘤形成。

公开(公告)号：US06808877B2

公开(公告)日：2004-10-26

申请号：US10199228

申请日：2002-07-17

申请人： Ji-Ming Wang ,  Yingying Le ,  WangHua Gong ,  Bao Qun Li ,  Thomas Rogers ,  Philip Murphy ,  Joost J. Oppenheim

发明人： Ji-Ming Wang ,  Yingying Le ,  WangHua Gong ,  Bao Qun Li ,  Thomas Rogers ,  Philip Murphy ,  Joost J. Oppenheim

IPC分类号： C12Q170

CPC分类号： C07K7/06 ,  A61K35/12 ,  A61K38/00 ,  A61K38/1709 ,  C07K14/005 ,  C07K14/715 ,  C07K14/7158 ,  C12N2710/24143 ,  C12N2740/16122 ,  G01N33/566 ,  G01N2500/04

摘要： The present invention relates to the discovery of molecules that inhibit viral infection and promote a host immune response to a pathogen. More specifically, the invention disclosed herein concerns molecules that interact with a FPR class receptor, inhibit HIV infection, and stimulate an inflammatory response in a subject. Embodiments of the invention include biotechnological tools, prophylactics, therapeutics, and methods of use of the foregoing, for the study, treatment, and prevention of HIV infection and the induction of an inflammatory response in a subject.

摘要翻译： 本发明涉及抑制病毒感染并促进对病原体的宿主免疫应答的分子的发现。 更具体地，本文公开的发明涉及与FPR类受体相互作用，抑制HIV感染并刺激受试者的炎症反应的分子。 本发明的实施方案包括生物技术工具，预防药物，治疗剂和上述用途的方法，用于研究，治疗和预防HIV感染和诱导受试者的炎症反应。