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    Hematopoietin receptors HPR1 and HPR2
    1.
    发明申请
    Hematopoietin receptors HPR1 and HPR2 审中-公开
    血细胞生成素受体HPR1和HPR2

    公开(公告)号：US20080026402A1

    公开(公告)日：2008-01-31

    申请号：US11701331

    申请日：2007-01-31

    申请人： David Cosman ,  Bruce Mosley ,  Timothy Bird ,  Robert DuBose ,  Steven Wiley

    发明人： David Cosman ,  Bruce Mosley ,  Timothy Bird ,  Robert DuBose ,  Steven Wiley

    IPC分类号： C12P21/04 ,  C07K14/00 ,  C12N15/00 ,  G01N33/53 ,  C12N15/11 ,  C12N5/06

    CPC分类号： G01N33/6863 ,  C07K14/715 ,  C07K2319/00 ,  G01N33/74

    摘要： This invention relates to human and murine HPR1 and human and murine HPR2 polypeptides, new members of the hematopoietin receptor polypeptide family; to methods of making such HPR1 and HPR2 polypeptides; to non-human mammals in which the endogenous genomic sequences encoding HPR1 and/or HPR2 polypeptides have been partially or completely inactivated; to methods of using HPR1 or HPR2 polypeptides to identify compounds that alter HPR1 or HPR2 polypeptide activities; and to methods of preparing medicaments for and/or treating conditions associated with hematopoietin receptor function.

    摘要翻译： 本发明涉及人和鼠HPR1和人和鼠HPR2多肽，造血细胞因子受体多肽家族的新成员; 涉及制备此类HPR1和HPR2多肽的方法; 涉及编码HPR1和/或HPR2多肽的内源基因组序列部分或完全失活的非人哺乳动物; 涉及使用HPR1或HPR2多肽鉴定改变HPR1或HPR2多肽活性的化合物的方法; 以及制备用于和/或治疗与造血细胞受体功能相关的药物的方法。

    ULBP antibodies
    6.
    发明申请
    ULBP antibodies 失效

    公开(公告)号：US20080008715A1

    公开(公告)日：2008-01-10

    申请号：US11638966

    申请日：2006-12-13

    申请人： David Cosman ,  Jurgen Mullberg ,  William Fanslow ,  Marek Kubin ,  Richard Armitage

    发明人： David Cosman ,  Jurgen Mullberg ,  William Fanslow ,  Marek Kubin ,  Richard Armitage

    IPC分类号： A61K39/395 ,  C07K16/30

    CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00 ,  C07K2319/30

    摘要： The invention is directed to purified and isolated novel ULBP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above. ULBP polypeptide can be found on the surface of human B cell lymphomas. Mammalian forms of ULBP polypeptide in isolated or purified forms are provided. In addition, isolated nucleic acids encoding ULBP polypeptides and expression vectors comprising a cDNA encoding ULBP polypeptides are provided. The ULBP polypeptides can be isolated or synthesized and used to prepare antibodies, and in particular monoclonal antibodies, against the polypeptides. The antibodies, in turn, are useful for detecting the presence of ULBP polypeptides in human cell samples, which can be correlated with the existence of a malignant condition in a patient. ULBP polypeptides stimulate IFN-γ production, NK cell proliferation, and CTL activity.

    Family of immunoregulators designated leukocyte immunoglobulin-like receptors (LIR)
    7.
    发明申请
    Family of immunoregulators designated leukocyte immunoglobulin-like receptors (LIR) 审中-公开

    公开(公告)号：US20060078564A1

    公开(公告)日：2006-04-13

    申请号：US11299182

    申请日：2005-12-09

    申请人： David Cosman

    发明人： David Cosman

    IPC分类号： C07K14/715 ,  C07H21/04 ,  C12P21/06 ,  A61K39/00

    CPC分类号： C07K14/70503

    摘要： A new family of immunoreceptor molecules of the immunoglobulin superfamily, (LIR) polypeptides is described. Disclosed are sequences encoding LIR family members and their deduced amino acid sequences, polypeptides encoded by DNA that hybridize to oligonucleotide probes having defined sequences, processes for producing polypeptides of the LIR family, and antagonistic antibodies to LIR family members. LIR family members can be used to treat autoimmune diseases and disease states associated with suppressed immune function.