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公开(公告)号：US20080113426A1
公开(公告)日：2008-05-15
申请号：US11597550
申请日：2005-05-26
申请人： Timothy J.N. Smith , Sydney M. Pugh , Lowell Misener , Guy Oram , Rupert Hagg , Roberto Tommasini , Yves Larcher
发明人： Timothy J.N. Smith , Sydney M. Pugh , Lowell Misener , Guy Oram , Rupert Hagg , Roberto Tommasini , Yves Larcher
IPC分类号： C12M3/00
CPC分类号： C12M21/08 , C12M23/24 , C12M23/34 , C12M23/44 , C12M25/14 , C12M27/16 , C12M41/12 , C12M45/09 , C12M47/04
摘要： The invention is an automated advanced tissue engineering system that comprises a housing in which one or more tissue engineering modules are accomodated together with a central microprocessor that controls functioning of the tissue engineering modules. In one embodiment, the tissue engineering module comprises a housing supporting one or more bioreactor chamber assemblies and a fluid reservoir operationally engageable with the housing. The bioreactor chamber assemblies may be selected depending on the end product option desired and may include, for example, a cell therapy bioreactor chamber, a single implant bioreactor chamber and a multiple (mosaic) implant bioreactor chamber.
摘要翻译： 本发明是一种自动化的高级组织工程系统，其包括壳体，其中一个或多个组织工程模块与控制组织工程模块功能的中央微处理器一起容纳。 在一个实施例中，组织工程模块包括支撑一个或多个生物反应器室组件的壳体和可操作地与壳体接合的流体储存器。 可以根据期望的最终产品选择来选择生物反应器室组件，并且可以包括例如细胞治疗生物反应器室，单个植入物生物反应器室和多个（镶嵌）植入物生物反应器室。
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公开(公告)号：US20140186937A1
公开(公告)日：2014-07-03
申请号：US13906719
申请日：2013-05-31
申请人： Timothy J.N. Smith , Sydney M. Pugh , Martin R. Pacaric , Rupert Hagg , Roberto Tommasini , Yves Larcher , Lowell D. Misener
发明人： Timothy J.N. Smith , Sydney M. Pugh , Martin R. Pacaric , Rupert Hagg , Roberto Tommasini , Yves Larcher , Lowell D. Misener
IPC分类号： C12M3/00
CPC分类号： C12M21/08 , C12M23/28 , C12M23/42 , C12M23/52 , C12M25/14 , C12M29/04 , C12M41/46 , C12M41/48 , C12M45/09 , C12M47/06 , C12M47/12 , C12N5/0068 , C12N5/0618 , C12N5/0654 , C12N5/0655 , C12N2509/00
摘要： The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.
摘要翻译： 本发明提供用于组织工程产品的自动化培养，增殖，分化，生产和维护的系统，模块，生物反应器和方法。 一方面是一种自动化组织工程系统，其包括壳体，由壳体支撑的至少一个生物反应器，促进生理细胞功能的生物反应器和/或从细胞和/或组织来源产生一种或多种组织构建体。 流体容纳系统由壳体支撑并且与生物反应器流体连通。 一个或多个传感器与壳体，生物反应器或流体容纳系统中的一个或多个相关联，用于监测与生理细胞功能相关的参数和/或组织构建体的产生; 以及连接到一个或多个传感器的微处理器。 本发明的系统，方法和产品可用于各种临床和实验室设置。
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公开(公告)号：US20120156276A1
公开(公告)日：2012-06-21
申请号：US12378591
申请日：2009-02-17
CPC分类号： C07K7/06 , A61K38/00 , A61K38/08 , A61K45/06 , A61L27/12 , A61L27/54 , A61L27/58 , A61L2300/25 , A61L2300/412 , A61L2430/02 , A61L2430/06 , C07K5/1008 , C07K5/101 , C07K5/1024 , C07K7/08 , C07K14/78 , C07K2319/00
摘要： Novel peptides are described which comprise an amino acid motif selected from the group consisting of “PG”, “GP”, “PI” and “IG” and having up to 10 amino acids upstream and/or downstream of the amino acid motif, wherein “P” in the motif is proline or hydroxyproline and the peptide stimulates the development, maintenance and repair of bone, cartilage and associated connective tissue. The invention further relates to pharmaceutical compositions of these peptides, as well as therapeutic and prophylactic uses of such peptides.
摘要翻译： 描述了包含选自“PG”，“GP”，“PI”和“IG”并且在氨基酸基序的上游和/或下游具有多达10个氨基酸的氨基酸基序的新型肽，其中 图案中的“P”是脯氨酸或羟脯氨酸，肽刺激骨，软骨和相关结缔组织的发育，维持和修复。 本发明还涉及这些肽的药物组合物，以及这些肽的治疗和预防用途。
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公开(公告)号：US20160237117A1
公开(公告)日：2016-08-18
申请号：US14854238
申请日：2015-09-15
CPC分类号： C07K7/06 , A61K38/00 , A61K38/08 , A61K45/06 , A61L27/12 , A61L27/54 , A61L27/58 , A61L2300/25 , A61L2300/412 , A61L2430/02 , A61L2430/06 , C07K5/1008 , C07K5/101 , C07K5/1024 , C07K7/08 , C07K14/78 , C07K2319/00
摘要： Novel peptides are described which comprise an amino acid motif selected from the group consisting of “PG”, “GP”, “PI” and “IG” and having up to 10 amino acids upstream and/or downstream of the amino acid motif, wherein “P” in the motif is proline or hydroxyproline and the peptide stimulates the development, maintenance and repair of bone, cartilage and associated connective tissue. The invention further relates to pharmaceutical compositions of these peptides, as well as therapeutic and prophylactic uses of such peptides.
摘要翻译： 描述了包含选自“PG”，“GP”，“PI”和“IG”并且在氨基酸基序的上游和/或下游具有多达10个氨基酸的氨基酸基序的新型肽，其中 图案中的“P”是脯氨酸或羟脯氨酸，肽刺激骨，软骨和相关结缔组织的发育，维持和修复。 本发明还涉及这些肽的药物组合物，以及这些肽的治疗和预防用途。
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公开(公告)号：US20110022180A1
公开(公告)日：2011-01-27
申请号：US12508856
申请日：2009-07-24
CPC分类号： A61L31/121 , A61F2/30724 , A61F2/4455 , A61F2002/30029 , A61F2002/30034 , A61F2002/30062 , A61F2002/30187 , A61F2002/30957 , A61F2002/30973 , A61F2002/4475 , A61L27/425 , A61L27/46 , A61L27/56 , A61L27/58 , A61L2400/08 , A61L2400/18 , A61L2420/02 , A61L2420/04 , B05D1/18 , B05D3/0272 , B29C45/0055 , B29C45/14795 , B29C2045/0058 , B29K2071/00 , B29L2031/7532 , C04B38/0051 , C04B41/4586 , C04B41/81 , C04B2235/606 , C08L71/12
摘要： Implantable medical devices are provided. In one embodiment, a device includes a body having an external surface defining an outer profile of the device. The body includes a porous matrix including a series of interconnected macropores defined by a plurality of interconnected struts each including a hollow interior. A filler material substantially fills at least a portion of the series of interconnected macropores. The external surface of the body includes a plurality of openings communicating with the hollow interior of at least a portion of the plurality of interconnected struts. In a further aspect of this embodiment, the external surface includes exposed areas of the filler material and porous matrix in addition to the exposed openings. In another aspect, the porous matrix is formed from a bioresorbable ceramic and the filler material is a biologically stable polymeric material. Still, other aspects related to this and other embodiments are also disclosed.
摘要翻译： 提供可植入的医疗设备。 在一个实施例中，装置包括具有限定装置的外部轮廓的外表面的主体。 主体包括多孔基体，其包括由多个相互连接的支柱限定的一系列相互连接的大孔，每个支柱包括中空的内部。 填充材料基本上填充了一系列互连的大孔的至少一部分。 主体的外表面包括与多个相互连接的支柱的至少一部分的中空内部连通的多个开口。 在该实施例的另一方面，除了暴露的开口之外，外表面还包括填充材料和多孔基体的暴露区域。 在另一方面，多孔基质由生物可吸收的陶瓷形成，填料是生物稳定的聚合材料。 仍然，还公开了与该实施例和其他实施例相关的其它方面。
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公开(公告)号：US20110021427A1
公开(公告)日：2011-01-27
申请号：US12843357
申请日：2010-07-26
CPC分类号： A61L24/0063 , A61L24/0015 , A61L24/0042 , A61L24/046 , A61L24/08 , A61L27/18 , A61L27/20 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/402 , A61L2300/404 , A61L2300/414 , A61L2300/602 , C08L71/02 , C08L5/02
摘要： This invention relates to biomineral-based cements incorporating biopolymer carriers for the site specific introduction of natural or synthetic compounds that influence bone repair and/or patient recovery. The invention further relates to methods for producing such biphasic calcium phosphate cements for drug delivery.
摘要翻译： 本发明涉及结合生物聚合物载体的生物矿物基水泥，用于特异性引入影响骨修复和/或患者恢复的天然或合成化合物。 本发明还涉及用于制备用于药物递送的这种双相磷酸钙粘结剂的方法。
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公开(公告)号：US20090030089A1
公开(公告)日：2009-01-29
申请号：US12245554
申请日：2008-10-03
申请人： Michael Sayer , Joel Reid , Timothy J.N. Smith , Jason Hendry
发明人： Michael Sayer , Joel Reid , Timothy J.N. Smith , Jason Hendry
CPC分类号： A61L27/425 , A61L27/12 , A61L27/32 , A61L27/46 , A61L27/54 , A61L2300/412 , A61L2300/43 , A61L2430/02 , C01B25/32
摘要： The invention is a silicon substituted oxyapatite compound (Si—OAp) for use as a synthetic bone biomaterial either used alone or in biomaterial compositions. The silicon substituted oxyapatite compound has the formula Ca5(PO4)3-x(SiO4)xO(1-x)/2, where 0
摘要翻译： 本发明是单独使用或用于生物材料组合物中的用作合成骨生物材料的硅取代的氧磷灰石化合物（Si-OAp）。 硅取代的氧磷灰石化合物具有式Ca 5（PO 4）3-x（SiO 4）x O（1-x）/ 2，其中0
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