摘要:
The invention features methods and devices for the delivery of a fluid medium containing analytes, e.g., particles, solutes, or solvents, to an analytical device. The systems are designed to minimize contact with potentially hazardous, fragile, or valuable samples. The systems allow for the dilution, mixing, and introduction of the fluid medium to an analytical device, followed by possible further analysis or sample manipulation.
摘要:
The invention relates to a method for diagnosing an animal for a condition by obtaining a fluid sample from the animal, enriching a first analyte having a concentration of less than 1×10−3 analytes/μL from said sample by a factor of at least 10,000 fold; and analyzing one or more enriched first analytes to determine a condition in said animal. Enrichment is preferably performed using one or more size-based separation modules.
摘要:
The invention features devices and methods for the enrichment of cells and other desired analytes by employing a magnetic field, alone or in conjunction with size-based separation. The devices and methods may be advantageously employed to enrich for rare cells, e.g., fetal cells or epithelial cells, present in a sample, e.g., maternal blood.
摘要:
The present invention features a new and useful magnetic device and methods of its use for isolation, enrichment, and purification of cells, proteins, DNA, and other molecules. In general the device includes magnetic regions or obstacles to which magnetic particles can bind. The chemical groups, i.e., capture moieties, on the surface of the magnetic particles may then be used to bind particles, e.g., cells, or molecules of interest from complex samples, and the bound species may then be selectively released for downstream collection or further analysis.
摘要:
The invention relates to one or more size-based separation modules adapted to increase a concentration of a first analyte in a sample by at least 10,000 fold, wherein said first analyte has an initial concentration in said sample of less than 1×10−3 analytes/μL, and an analyzer for analyzing said first analytes in an enriched medium.
摘要:
The present invention relates to methods for diagnosing a condition in a fetus by enriching and enumerating circulating red blood cells with the possible combination of results from maternal serum marker screens.
摘要:
The present invention provides a leak testing method and system therefore for any type of filtering device employing hollow fibers, such as filtration of aqueous or gaseous fluids, ultrafiltration of particulate materials and dialysis of blood. In an embodiment, the leak test is employed in testing a bundle of fibers placed in a dialyzer. The dialyzer includes a blood inlet and a blood outlet, wherein blood flows through the inside of a plurality of hollow fibers. Dialysate flows into the dialyzer through an inlet port, around the outside of the hollow fibers and out of the dialyzer through an outlet port. The test employs a dry aerosol that is injected into the blood inlet, outlet or both, wherein a particle counter counts particles that pass through the fiber walls and exit one or both the dialysate ports. If the counter detects more than an acceptable amount of particles, the dialyzer has a leak.