公开(公告)号：US07271147B2

公开(公告)日：2007-09-18

申请号：US10239324

申请日：2001-03-28

申请人： Tomio Takeuchi ,  Hideki Hashizume ,  Masayuki Igarashi ,  Hiroshi Naganawa ,  Masa Hamada

发明人： Tomio Takeuchi ,  Hideki Hashizume ,  Masayuki Igarashi ,  Hiroshi Naganawa ,  Masa Hamada

IPC分类号： A01K31/16 ,  C12P21/06 ,  C12N1/20

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K11/02

摘要： By culturing Lysobacter sp. BMK333-48F3 (deposit number of FERM BP-7477), an antibiotic, tripropeptin Z, tripropeptin A, tripropeptin B, tripropeptin C or tripropeptin D represented by the general formula (I): wherein R is 7-methyl-octyl group, 8-methyl-nonyl group, 9-methyl-dodecyl group, 10-methyl-undecyl group or 11-methyl-dodecyl group, is obtained as antibiotics having excellent antibacterial activities against bacteria and having a novel molecular structure. These tripropeptins each have an excellent antibacterial activity against various bacteria and drug-resistant strains thereof, such as methicillin-resistant strains and vancomycin-resistant strains.

摘要翻译： 通过培养溶菌杆菌 BMK333-48F3（FERM BP-7477的保藏号），抗生素，三聚胰蛋白酶Z，三聚肽A，三聚蛋白B，三抗抑素C或由通式（I）表示的三聚蛋白D：其中R为7-甲基 - 辛基，8 甲基 - 壬基，9-甲基 - 十二烷基，10-甲基 - 十一烷基或11-甲基 - 十二烷基作为对细菌具有优异抗菌活性并具有新的分子结构的抗生素。 这些三柔比星各自对各种细菌和耐药菌株具有优异的抗菌活性，如耐甲氧西林株和万古霉素抗性菌株。

公开(公告)号：US06780616B1

公开(公告)日：2004-08-24

申请号：US10049970

申请日：2002-05-09

申请人： Tomio Takeuchi ,  Masayuki Igarashi ,  Hiroshi Naganawa ,  Masa Hamada

发明人： Tomio Takeuchi ,  Masayuki Igarashi ,  Hiroshi Naganawa ,  Masa Hamada

IPC分类号： A61K3170

CPC分类号： C07H19/06 ,  C12P17/16 ,  Y10S435/886

摘要： There have been obtained, by cultivation of Streptomyces sp. MK730-62F2 (deposit number of FERM BP-7218), antibiotic caprazamycins A to F having by the following general formula (I) wherein R is tridecyl group, 11-methyl-dodecyl group, and others. These caprazamycins have excellent antibacterial activities against various acid-fast bacteria and various bacteria as well as their drug-resistant strains.

摘要翻译： 已经通过培养链霉菌获得了。 MK730-62F2（FERM BP-7218的保藏号），具有以下通式（I）的抗生素caprazamycins A至F，其中R为十三烷基，11-甲基 - 十二烷基等。 这些caprazamycins对各种耐酸菌和各种细菌以及耐药菌株具有优异的抗菌活性。

公开(公告)号：US5096924A

公开(公告)日：1992-03-17

申请号：US531109

申请日：1990-05-31

申请人： Masaaki Ishizuka ,  Hiroyuki Kumagai ,  Tsutomu Sawa ,  Hiroshi Naganawa ,  Hironobu Iinuma ,  Kunio Isshiki ,  Masa Hamada ,  Kenji Maeda ,  Tomio Takeuchi

发明人： Masaaki Ishizuka ,  Hiroyuki Kumagai ,  Tsutomu Sawa ,  Hiroshi Naganawa ,  Hironobu Iinuma ,  Kunio Isshiki ,  Masa Hamada ,  Kenji Maeda ,  Tomio Takeuchi

IPC分类号： A61K31/35 ,  A61K31/352 ,  A61P35/00 ,  C07D311/76 ,  C12N1/20 ,  C12P17/06 ,  C12R1/625

CPC分类号： C12P17/06 ,  C07D311/76

摘要： As a new antibiotic is provided a compound, now nominated as MI43-37F11 substance, which has formula ##STR1## This MI43-37F11 substance has an antitumor activity, an activity to enhance the production of interleukin-1 in vivo in a mammalian, and an activity to activate a macrophage in vivo in a mammalian. MI43-37F11 substance may be produced by cultivation of Streptoverticillium eurocidicum MI43-37F11 strain identified as FERM BP-2783.

公开(公告)号：US4049497A

公开(公告)日：1977-09-20

申请号：US747470

申请日：1976-12-06

申请人： Hamao Umezawa ,  Tomio Takeuchi ,  Masa Hamada ,  Shinichi Kondo ,  Masaaki Ishizuka ,  Hiroshi Naganawa

发明人： Hamao Umezawa ,  Tomio Takeuchi ,  Masa Hamada ,  Shinichi Kondo ,  Masaaki Ishizuka ,  Hiroshi Naganawa

IPC分类号： C07G11/00

CPC分类号： A61K36/06 ,  C07G11/00 ,  Y10S435/886

摘要： There are disclosed two new antibiotics formerly denominated MC916-A and MC916-B and now called neothramycin A and neothramycin B which are potent inhibitors of the growth of leukemia cells, e.g. Leukema L-1210 cells in mice. They are produced by controlled fermentation of Streptomyces FERM-P 2452 (A.T.C.C. 31123).

摘要翻译： 已经公开了两种以前称为MC916-A和MC916-B的新抗生素，现在称为新西霉素A和新霉素B，其是白血病细胞生长的有效抑制剂，例如。 白血病L-1210细胞在小鼠中。 它们通过Frep-P 2452链霉菌（A.T.C.C. 31123）的对照发酵生产。

公开(公告)号：US5215981A

公开(公告)日：1993-06-01

申请号：US720758

申请日：1991-07-01

申请人： Tomio Takeuchi ,  Yoshikazu Takahashi ,  Masa Hamada ,  Hiroshi Naganawa ,  Kiyoshi Sato

发明人： Tomio Takeuchi ,  Yoshikazu Takahashi ,  Masa Hamada ,  Hiroshi Naganawa ,  Kiyoshi Sato

IPC分类号： C07D493/10 ,  C12P17/18

CPC分类号： C07D493/10 ,  C12P17/181

摘要： In this invention, a new microbial strain which is a strain of Actinomycetes and belongs to the genus Actinomadura, namely Actinomadura sp. MI215-NF3 strain is cultured, and MI215-NF3 substance, a novel antibiotic classifiable as a polyether antibiotic, is recovered from the resultant culture. MI215-NF3 substance and its salts obtained according to this invention are useful for therapeutic treatment of chicken coccidiosis and also have useful antibacterial activities against certain species of bacteria.

公开(公告)号：US4565861A

公开(公告)日：1986-01-21

申请号：US567792

申请日：1984-01-03

申请人： Hamao Umezawa ,  Tomio Takeuchi ,  Masa Hamada ,  Hiroshi Naganawa ,  Tsutomu Sawa ,  Takeshi Uchida ,  Masaya Imoto

发明人： Hamao Umezawa ,  Tomio Takeuchi ,  Masa Hamada ,  Hiroshi Naganawa ,  Tsutomu Sawa ,  Takeshi Uchida ,  Masaya Imoto

IPC分类号： A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P31/04 ,  A61P35/00 ,  C07H15/252 ,  C12P19/56 ,  C12R1/465 ,  C07H15/24

CPC分类号： C07H15/252 ,  C12P19/56 ,  C12R1/465

摘要： An anthracycline, serirubicin, of the formula: ##STR1## wherein R represents the substituent: ##STR2## is produced by a process which comprises cultivating a strain of Streptomyces in a suitable culture medium under aerobic conditions, said strain having the ability to produce the anthracycline compound, serirubicin, and then recovering the anthracycline compound, serirubicin, from the cultured medium. This serirubicin, or an acid addition salt of the serirubicin, can be contained as the active ingredient in anti-tumor agents and in pharmaceutical compositions for treatment of infections induced by gram-positive microorganisms, whereby good results are attainable.

摘要翻译： 蒽环霉素，维拉霉素，其结构式如下：其中R表示取代基：IMAMA是通过包括在需氧条件下在合适的培养基中培养链霉菌属菌株的方法产生的，所述菌株具有产生 蒽环霉素化合物，苏维菌素，然后从培养基中回收蒽环霉素化合物，丝衣霉素。 作为抗肿瘤剂和用于治疗由革兰氏阳性微生物诱导的感染的药物组合物，可以含有这种苏维菌素或者苏维菌素的酸加成盐作为活性成分，从而获得了良好的效果。

公开(公告)号：US4198480A

公开(公告)日：1980-04-15

申请号：US886987

申请日：1978-03-15

申请人： Hamao Umezawa ,  Tomio Takeuchi ,  Masa Hamada ,  Masaaki Ishizuka ,  Hiroshi Naganawa ,  Toshikazu Oki ,  Taiji Inui

发明人： Hamao Umezawa ,  Tomio Takeuchi ,  Masa Hamada ,  Masaaki Ishizuka ,  Hiroshi Naganawa ,  Toshikazu Oki ,  Taiji Inui

IPC分类号： C12P1/06 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61K31/7048 ,  A61P31/04 ,  A61P35/00 ,  C07H15/252 ,  C12P19/56 ,  C12R1/465

CPC分类号： C12R1/465 ,  C07H15/252 ,  C12P19/56 ,  Y10S435/886

摘要： A novel anthracycline antibiotic complex designated herein as baumycin complex is produced by fermentation of a baumycin-producing strain of Streptomyces, e.g. Streptomyces coeruleorubidus ME 130-A4 (FERM-P3540, ATCC 31276). The complex and four bioactive components thereof designated baumycin A.sub.1, A.sub.2, B.sub.1 and B.sub.2 are useful as antibacterial and antitumor agents.

摘要翻译： 本文称为鲍曼霉素复合物的新型蒽环类抗生素复合物是通过发酵生产巴霉素的链霉菌菌株，例如， Streptomyces coeruleorubidus ME 130-A4（FERM-P3540，ATCC 31276）。 其中称为baumycin A1，A2，B1和B2的复合物和四种生物活性成分可用作抗细菌剂和抗肿瘤剂。

公开(公告)号：US06245734B1

公开(公告)日：2001-06-12

申请号：US09445581

申请日：1999-12-13

申请人： Tomio Takeuchi ,  Kazuo Umezawa ,  Shinichi Kondo ,  Yoko Ikeda ,  Hiroshi Naganawa ,  Masa Hamada

发明人： Tomio Takeuchi ,  Kazuo Umezawa ,  Shinichi Kondo ,  Yoko Ikeda ,  Hiroshi Naganawa ,  Masa Hamada

IPC分类号： A01N6100

CPC分类号： C12R1/465 ,  A61K38/00 ,  C07K7/06

摘要： As novel substances having an activity of inducing an apoptosis even on the apoptosis-resistant cancer cells, there are obtained polyoxypeptin and deoxypolyoxypeptin represented by the following general formula (I) wherein R denotes a hydroxyl group for polyoxypeptin, or R denotes a hydrogen atom for deoxypolyoxypeptin, by cultivation of Streptomyces sp. MK498-98F14 strain. Polyoxypeptin and deoxypolyoxypeptin are physiologically active substances which have an activity of inducing apoptosis on a human pancreatic adenocarcinoma cell, AsPC-1 cell.

摘要翻译： 作为具有诱导细胞凋亡抗性的癌细胞的细胞凋亡的活性的新物质，可以举出以下通式（I）表示的多羟脯氨酸和脱氧多肽，其中R表示多羟脯氨酸的羟基，或R表示氢原子， 脱氧脱氧蛋白，通过培养链霉菌 MK498-98F14菌株。 多核苷酸和脱氧多肽抗氧化素是具有诱导人胰腺癌细胞AsPC-1细胞凋亡活性的生理活性物质。

公开(公告)号：US06214340B1

公开(公告)日：2001-04-10

申请号：US09554362

申请日：2000-05-12

申请人： Tomio Takeuchi ,  Masa Hamada ,  Yasuhiko Muraoka ,  Tetsuo Akiyama ,  Masatoshi Abe ,  Hiroshi Naganawa ,  Yoshikazu Takahashi

发明人： Tomio Takeuchi ,  Masa Hamada ,  Yasuhiko Muraoka ,  Tetsuo Akiyama ,  Masatoshi Abe ,  Hiroshi Naganawa ,  Yoshikazu Takahashi

IPC分类号： C12N120

CPC分类号： C12N9/99 ,  A61K38/00 ,  C07K14/36 ,  C12P1/06 ,  C12R1/465

摘要： This invention provides a physiologically active substance having a strong dipeptidyl peptidase IV inhibitory activity. The physiologically active substance sulphostin is obtained by culturing a microorganism belonging to the genus Streptomyces and having an ability to produce the physiologically active substance sulphostin, producing and accumulating this substance in the cultures, and harvesting it from the cultures.

摘要翻译： 本发明提供具有强二肽基肽酶IV抑制活性的生理活性物质。 通过培养属于链霉菌属的微生物并且具有生产生理活性物质硫酸钙的能力，在培养物中产生和积累该物质，并从培养物中收获生物活性物质硫酸钙得到。

公开(公告)号：US5162500A

公开(公告)日：1992-11-10

申请号：US613759

申请日：1990-12-07

申请人： Tomio Takeuchi ,  Takaaki Aoyagi ,  Masa Hamada ,  Hiroshi Naganawa ,  Keiji Ogawa ,  Machiko Nagai ,  Yasuhiko Muraoka ,  Makoto Tsuda

发明人： Tomio Takeuchi ,  Takaaki Aoyagi ,  Masa Hamada ,  Hiroshi Naganawa ,  Keiji Ogawa ,  Machiko Nagai ,  Yasuhiko Muraoka ,  Makoto Tsuda

IPC分类号： A61K38/00 ,  C07C229/22 ,  C07C271/22 ,  C07K5/02 ,  C07K7/02

CPC分类号： C07C229/22 ,  C07C271/22 ,  C07K5/0202 ,  C07K7/02 ,  A61K38/00

摘要： A novel, biologically active substance, poststatin, has been isolated from a culture medium of microorganism belonging to Streptomyces. The novel substance is a peptide compound having a novel structure, wherein the peptide chains have ketone radicals. Thus substance has a high endopeptidase inhibition activity. It is possible to chemically synthesize poststatin related compound having ketone radicals in the peptide chains. These compounds also have an endopeptidase inhibition activity.