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1.发明授权公开(公告)号：US07604776B2
公开(公告)日：2009-10-20
申请号：US12113643
申请日：2008-05-01
CPC分类号： G01N35/00069 , G01N35/08 , G01N2035/00544 , Y10T436/111666 , Y10T436/25 , Y10T436/25375
摘要： A reaction of a sample mixture liquid is detected accurately, by allowing a solid reagent to be dissolved and reacted in a liquid sample quickly and accurately. A disc main body, and at least one sample mixing unit provided at the disc main body are provided, and the sample mixing unit is provided with: a liquid sample reserve unit; a reagent chamber capable of disposing a plurality of the solid reagents; and a measurement chamber to which a sample mixture liquid containing a liquid sample and a solid reagent mixed in the reagent chamber is supplied. The reagent chamber has a form which allows a plurality of the solid reagents to be disposed in the direction substantially parallel to the radial direction of the disc in which centrifugal force is generated, or in the direction substantially perpendicular to the radial direction of the disc.
摘要翻译： 通过使固体试剂在液体样品中溶解和反应迅速而准确地准确地检测样品混合液体的反应。 设置盘主体和设置在盘主体上的至少一个样品混合单元，样品混合单元设置有：液体样品储备单元; 能够配置多个固体试剂的试剂室; 以及测量室，供给包含液体试样和混合在试剂室中的固体试剂的样品混合液。 试剂室具有允许多个固体试剂在基本上平行于产生离心力的盘的径向方向或者基本上垂直于盘的径向方向的方向上设置的形式。
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2.发明授权Substrate having channel portion including chambers, and method of transferring liquid by using the substrate 有权具有包括腔室的通道部分的基板，以及通过使用基板传送液体的方法公开(公告)号：US08168444B2
公开(公告)日：2012-05-01
申请号：US12595077
申请日：2008-04-04
申请人： Nobuhiko Ozaki , Tomohiro Yamamoto
发明人： Nobuhiko Ozaki , Tomohiro Yamamoto
IPC分类号： B01L3/00
CPC分类号： G01N35/10 , G01N2035/0449 , G01N2035/1034 , Y10T436/25 , Y10T436/2575
摘要： A substrate having a channel portion in which a liquid transfers, wherein, even if the channel portion has no micro-channel interconnecting chambers, a liquid can transfer stepwise from one region to the next region according to the speed of rotation of the substrate. The substrate can be rotated about a rotation axis as the center, and has the channel portion including the chambers formed therein. The inner wall of each chamber has a first area including an area intersecting with a centrifugal direction from the center; and also has a second area placed at a position farther from the center than the first area, and including a surface intersecting with the centrifugal direction from the center. Further, the first area has a region for holding a droplet of a liquid provided; and also has a region where a contact with the droplet expands when the substrate is rotated, and that communicate with the second area.
摘要翻译： 具有液体转移的通道部分的基板，其中即使通道部分没有微通道互连室，液体也可以根据基板的旋转速度从一个区域逐步转移到下一个区域。 基板可以围绕作为中心的旋转轴线旋转，并且具有包括形成在其中的室的通道部分。 每个室的内壁具有第一区域，其包括从中心与离心方向相交的区域; 并且还具有放置在比第一区域更远离中心的位置的第二区域，并且包括从中心与离心方向相交的表面。 此外，第一区域具有用于保持设置的液体的液滴的区域; 并且还具有当基板旋转时与液滴的接触膨胀并且与第二区域连通的区域。
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公开(公告)号：US08329116B2
公开(公告)日：2012-12-11
申请号：US12741435
申请日：2008-11-21
CPC分类号： G01N33/54366 , B01L3/502761 , B01L2200/0668 , B01L2300/0645 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , Y10T436/11
摘要： Provided is a measuring chip, which can spot a specimen liquid of a minute quantity for an immune agglutination easily and precisely to the measuring chip and which can prevent the flow of the specimen liquid and the contamination of the specimen. The measuring chip comprises at least two substrates, a spacer arranged between the substrates, at least one passage made of the substrates and the spacer into a hollow shape and having two open ends, counter electrodes for applying an electric field, and a specimen-spotted portion to be spotted with the specimen. The specimen-spotted portion has a structure made of a square, circular, elliptical or sector shape by that spacer. Moreover, the specimen-spotted portion has two open ends, one of which is connected to one open end of that passage.
摘要翻译： 提供了一种测量芯片，其可以容易且准确地将测量芯片上的微量的微量样品液体点样，并且可以防止样品液体的流动和样品的污染。 测量芯片包括至少两个基板，布置在基板之间的间隔件，由基板和间隔件形成中空形状的至少一个通道，并具有两个开口端，用于施加电场的对电极和被检测点 用样品点样的部分。 样品点状部分具有由该间隔物形成的正方形，圆形，椭圆形或扇形的结构。 此外，样本点状部分具有两个开口端，其中一个连接到该通道的一个开口端。
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公开(公告)号：US20100266452A1
公开(公告)日：2010-10-21
申请号：US12741435
申请日：2008-11-21
IPC分类号： G01N33/544
CPC分类号： G01N33/54366 , B01L3/502761 , B01L2200/0668 , B01L2300/0645 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , Y10T436/11
摘要： Provided is a measuring chip, which can spot a specimen liquid of a minute quantity for an immune agglutination easily and precisely to the measuring chip and which can prevent the flow of the specimen liquid and the contamination of the specimen. The measuring chip comprises at least two substrates, a spacer arranged between the substrates, at least one passage made of the substrates and the spacer into a hollow shape and having two open ends, counter electrodes for applying an electric field, and a specimen-spotted portion to be spotted with the specimen. The specimen-spotted portion has a structure made of a square, circular, elliptical or sector shape by that spacer. Moreover, the specimen-spotted portion has two open ends, one of which is connected to one open end of that passage.
摘要翻译： 提供了一种测量芯片，其可以容易且准确地将测量芯片上的微量的微量样品液体点样，并且可以防止样品液体的流动和样品的污染。 测量芯片包括至少两个基板，布置在基板之间的间隔件，由基板和间隔件形成中空形状的至少一个通道，并具有两个开口端，用于施加电场的对电极和被检测点 用样品点样的部分。 样品点状部分具有由该间隔物形成的正方形，圆形，椭圆形或扇形的结构。 此外，样本点状部分具有两个开口端，其中一个连接到该通道的一个开口端。
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5.发明申请SUBSTRATE HAVING CHANNEL PORTION INCLUDING CHAMBERS, AND METHOD OF TRANSFERRING LIQUID BY USING THE SUBSTRATE 有权具有包括泡沫的通道部分的基板以及使用基板传送液体的方法公开(公告)号：US20100120166A1
公开(公告)日：2010-05-13
申请号：US12595077
申请日：2008-04-04
申请人： Nobuhiko Ozaki , Tomohiro Yamamoto
发明人： Nobuhiko Ozaki , Tomohiro Yamamoto
CPC分类号： G01N35/10 , G01N2035/0449 , G01N2035/1034 , Y10T436/25 , Y10T436/2575
摘要： A substrate having a channel portion in which a liquid transfers, wherein, even if the channel portion has no micro-channel interconnecting chambers, a liquid can transfer stepwise from one region to the next region according to the speed of rotation of the substrate. The substrate can be rotated about a rotation axis as the center, and has the channel portion including the chambers formed therein. The inner wall of each chamber has a first area including an area intersecting with a centrifugal direction from the center; and also has a second area placed at a position farther from the center than the first area, and including a surface intersecting with the centrifugal direction from the center. Further, the first area has a region for holding a droplet of a liquid provided; and also has a region where a contact with the droplet expands when the substrate is rotated, and that communicate with the second area.
摘要翻译： 具有液体转移的通道部分的基板，其中即使通道部分没有微通道互连室，液体也可以根据基板的旋转速度从一个区域逐步转移到下一个区域。 基板可以围绕作为中心的旋转轴线旋转，并且具有包括形成在其中的室的通道部分。 每个室的内壁具有第一区域，其包括从中心与离心方向相交的区域; 并且还具有放置在比第一区域更远离中心的位置的第二区域，并且包括从中心与离心方向相交的表面。 此外，第一区域具有用于保持设置的液体的液滴的区域; 并且还具有当基板旋转时与液滴的接触膨胀并且与第二区域连通的区域。
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公开(公告)号：US20100062414A1
公开(公告)日：2010-03-11
申请号：US12593986
申请日：2008-04-04
CPC分类号： G01N33/558 , B01L3/502707 , B01L3/502715 , B01L3/502738 , B01L2200/027 , B01L2200/0621 , B01L2300/043 , B01L2300/0645 , B01L2300/0825 , B01L2300/087 , B01L2400/0406 , B01L2400/0633 , B01L2400/0688 , Y10T29/49117
摘要： A sample liquid analytical chip that whilst being of simple structure, has a reaction region and a detection region isolated from each other and further has liquid feed control means for a sample liquid, thereby realizing speedy reliable analysis. The sample liquid analytical chip comprises a tubular sample liquid transfer channel with its both ends open, a reaction reagent layer disposed on the internal wall surface of the sample liquid transfer channel and a detection region for detecting any physical or chemical change of the sample liquid. In the sample liquid analytical chip, the sample liquid transfer channel at an area of its wall surface is provided an opening and a lid fitted to the opening. Portion of the lid forms a hinge in cooperation with the wall surface.
摘要翻译： 一种样品液体分析芯片，其结构简单，具有彼此隔离的反应区域和检测区域，并且还具有用于样品液体的液体进料控制装置，从而实现了快速可靠的分析。 样品液体分析芯片包括其两端打开的管状样品液体传输通道，设置在样品液体传送通道的内壁表面上的反应试剂层和用于检测样品液体的任何物理或化学变化的检测区域。 在样品液体分析芯片中，在其壁表面的区域处的样品液体输送通道设置有开口和装配到开口的盖子。 盖的一部分与壁表面配合形成铰链。
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公开(公告)号：US20090238724A1
公开(公告)日：2009-09-24
申请号：US12092242
申请日：2006-10-31
申请人： Tomohiro Yamamoto , Nobuhiko Ozaki
发明人： Tomohiro Yamamoto , Nobuhiko Ozaki
CPC分类号： G01N35/00069 , G01N35/08
摘要： It is an object of the present invention to provide a disc for analyzing a fluid sample, which can analyze the fluid sample with accuracy by having the fluid sample react quickly and uniformly with the solid reagent held in the chamber. The disc has a chamber is defined by a gap formed with at least two opening, and defined by a spacer intervening between an upper substrate and a lower substrate, the upper substrate having a convex section, the lower substrate having a concave section, the reagent being attached to the concave section of the lower substrate.
摘要翻译： 本发明的目的是提供一种用于分析流体样品的盘，其可以通过使流体样品与保持在室中的固体试剂快速且均匀地反应而精确地分析流体样品。 所述盘具有由形成有至少两个开口的间隙限定的间隔，所述间隙由介于上基板和下基板之间的隔离物限定，所述上基板具有凸部，所述下基板具有凹部，所述试剂 附着在下基板的凹部。
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公开(公告)号：US06471839B1
公开(公告)日：2002-10-29
申请号：US09572797
申请日：2000-05-17
IPC分类号： G01N27327
摘要： The present invention provides a biosensor which enables quick measurement and is excellent in storage characteristic. This biosensor comprises an electrically insulating base plate on which an electrode system having at least a measuring electrode and a counter electrode is formed, a cover member which is integrated to the base plate so as to form a sample solution supply path for supplying a sample solution to the electrode system between the cover member and the base plate, and a carrier composed of fiber supporting a reagent containing at least an oxidoreductase, and the carrier is placed in the sample solution supply path. Preferably, the carrier is constituted at least of two carrier pieces and each carrier piece supports a different reagent.
摘要翻译： 本发明提供一种生物传感器，其能够快速测量并且具有优异的储存特性。 该生物传感器包括电绝缘基板，其上形成有至少具有测量电极和对电极的电极系统，盖构件，其与基板一体地形成用于提供样品溶液的样品溶液供应路径 涉及覆盖构件和基板之间的电极系统，以及由支撑含有至少一种氧化还原酶的试剂的纤维构成的载体，载体被放置在样品溶液供给路径中。 优选地，载体至少由两个载体片构成，并且每个载体片支撑不同的试剂。
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9.再颁专利Lipid-dispersed solution, production thereof and use in determining lipid levels 失效脂质分散溶液，其生产和用于确定脂质水平
公开(公告)号：USRE37002E
公开(公告)日：2000-12-26
申请号：US327019
申请日：1999-06-07
CPC分类号： G01N33/96 , G01N33/92 , G01N2800/044 , Y10S516/928 , Y10T436/104165
摘要： .[.There is disclosed an aqueous dispersed solution as a standard solution for determining lipid levels, having a dispersion form and a particle size, which are similar to those of serum lipids. A lipid-dispersed solution is obtained by evaporating an organic solvent from a mixture prepared by adding cholesterol, a phospholipid, a bile acid or bile acid salt, and a neutral lipid and/or a cholesterol ester in the organic solvent, swelling the resultant thin-film like mixture with water or buffer heated at a temperature higher than a phase transition temperature of the lecithin, and then dispersing the solution by a physical shear force. There can be easily obtained a solution having a cholesterol concentration of about less than 1,000 mg/dl, which is extremely stable and can be stored for a long period of time..]. .Iadd.There is disclosed an aqueous dispersed solution as a standard solution for determining lipid levels, having a dispersion form and a particle size, which are similar to those of serum lipids. A lipid-dispersed solution is obtained by evaporating an organic solvent from a mixture prepared by adding cholesterol, a phospholipid, a bile acid or bile acid salt, and a neutral lipid and/or a cholesterol ester in the organic solvent, swelling the resultant thin-film like mixture with water or buffer heated at a temperature higher than a phase transition temperature of the lecithin, and then dispersing the solution by a physical shear force. These can be easily obtained a solution having a cholesterol concentration of about less than 1,000 mg/dl, which is extremely stable and can be stored for a long period of time. The lipid dispersed solution is used as a standard solution in calibrating a device for performing enzymatic lipid level determination, and the calibrated device is used to determine the lipid level (e.g. cholesterol) in a solution.
摘要翻译： 公开了水分散溶液作为用于测定脂质水平的标准溶液，具有与血清脂质相似的分散体形式和粒径。 通过将有机溶剂从通过在有机溶剂中加入胆固醇，磷脂，胆汁酸或胆汁酸盐和中性脂质和/或胆固醇酯制备的混合物蒸发而获得脂质分散溶液，将所得薄片 在与高于卵磷脂相变温度的温度下加热的水或缓冲液混合，然后通过物理剪切力分散溶液。 可以容易地获得胆固醇浓度大约小于1,000mg / dl的溶液，其非常稳定并且可以长期储存。]公开了作为确定脂质的标准溶液的水性分散溶液 水平，具有与血清脂质相似的分散体形式和粒径。 通过将有机溶剂从通过在有机溶剂中加入胆固醇，磷脂，胆汁酸或胆汁酸盐和中性脂质和/或胆固醇酯制备的混合物蒸发而获得脂质分散溶液，将所得薄片 在与高于卵磷脂相变温度的温度下加热的水或缓冲液混合，然后通过物理剪切力分散溶液。 这些可以容易地获得胆固醇浓度大约小于1,000mg / dl的溶液，其非常稳定并且可以长期储存。 脂质分散溶液用作校准用于进行酶脂质水平测定的装置的标准溶液，并且校准的装置用于测定溶液中的脂质水平（例如胆固醇）。
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公开(公告)号：US5759445A
公开(公告)日：1998-06-02
申请号：US641765
申请日：1996-05-02
CPC分类号： G01N33/96 , G01N33/92 , G01N2800/044 , Y10S516/928 , Y10T436/104165
摘要： There is disclosed an aqueous dispersed solution as a standard solution for determining lipid levels, having a dispersion form and a particle size, which are similar to those of serum lipids. A lipid-dispersed solution is obtained by evaporating an organic solvent from a mixture prepared by adding cholesterol, a phospholipid, a bile acid or bile acid salt, and a neutral lipid and/or a cholesterol ester in the organic solvent, swelling the resultant thin-film like mixture with water or buffer heated at a temperature higher than a phase transition temperature of the lecithin, and then dispersing the solution by a physical shear force. There can be easily obtained a solution having a cholesterol concentration of about less than 1,000 mg/dl, which is extremely stable and can be stored for a long period of time.
摘要翻译： 公开了水分散溶液作为用于测定脂质水平的标准溶液，具有与血清脂质相似的分散体形式和粒径。 通过将有机溶剂从通过在有机溶剂中加入胆固醇，磷脂，胆汁酸或胆汁酸盐和中性脂质和/或胆固醇酯制备的混合物蒸发而获得脂质分散溶液，将所得薄片 在与高于卵磷脂相变温度的温度下加热的水或缓冲液混合，然后通过物理剪切力分散溶液。 可以容易地获得胆固醇浓度大约小于1,000mg / dl的溶液，其极为稳定并且可以长期储存。
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