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    MULTICOMPONENT ANALYSIS SENSOR AND METHOD OF MEASURING MULTIPLE COMPONENTS
    2.
    发明申请
    MULTICOMPONENT ANALYSIS SENSOR AND METHOD OF MEASURING MULTIPLE COMPONENTS 审中-公开
    多功能分析传感器和测量多个组件的方法

    公开(公告)号：US20100096276A1

    公开(公告)日：2010-04-22

    申请号：US12444077

    申请日：2007-10-01

    申请人： Shinki Kojima ,  Tomohiro Yamamoto ,  Fumihisa Kitawaki ,  Tetsuo Yukimasa

    发明人： Shinki Kojima ,  Tomohiro Yamamoto ,  Fumihisa Kitawaki ,  Tetsuo Yukimasa

    IPC分类号： G01N27/26

    CPC分类号： G01N27/3272 ,  C12Q1/005 ,  C12Q1/006

    摘要： A multicomponent analysis sensor for measuring two or more kinds of the subjects to be measured by using redox reactions, which is a multicomponent analysis sensor comprising a liquid sample inlet from which a liquid sample containing two or more kinds of the subjects to be measured is introduced, a first measurement chamber, a second measurement chamber, a first channel connecting the above-described liquid sample inlet to the above-described first measurement chamber and a second channel connecting the above-described first measurement chamber to the second measurement chamber, wherein the above-described first measurement chamber and the above-described second measurement chamber respectively have a working electrode and a counter electrode. A first reagent layer containing an enzyme and an electron transfer substance is provided in the first channel or the first chamber, while another reagent layer containing an enzyme is provided in the second channel or the second chamber.

    摘要翻译： 一种多组分分析传感器，用于通过使用氧化还原反应来测量要测量的两种或更多种待测对象，所述氧化还原反应是包含液体样品入口的多组分分析传感器，其中引入含有两种或更多种待测对象的液体样品 第一测量室，第二测量室，将上述液体样品入口连接到上述第一测量室的第一通道和将上述第一测量室连接到第二测量室的第二通道，其中， 上述第一测量室和上述第二测量室分别具有工作电极和对电极。 在第一通道或第一室中设置含有酶和电子转移物质的第一试剂层，而在第二通道或第二室中设置含有酶的试剂层。

    Method of amplifying nucleic acid by electromagnetic induction heating and reaction container and reaction device to be used therein
    3.
    发明申请
    Method of amplifying nucleic acid by electromagnetic induction heating and reaction container and reaction device to be used therein 审中-公开
    通过电磁感应加热和反应容器放大核酸的方法及其中使用的反应装置

    公开(公告)号：US20050158725A1

    公开(公告)日：2005-07-21

    申请号：US10510819

    申请日：2003-09-24

    申请人： Tetsuo Yukimasa ,  Nobuhiko Ozaki ,  Masaya Nakatani ,  Hidenobu Yaku ,  Hiroaki Oka ,  Kimi Fukahi

    发明人： Tetsuo Yukimasa ,  Nobuhiko Ozaki ,  Masaya Nakatani ,  Hidenobu Yaku ,  Hiroaki Oka ,  Kimi Fukahi

    IPC分类号： C07H21/00 ,  C12Q1/68 ,  C12M1/34

    CPC分类号： C07H21/00 ,  C12Q1/6844

    摘要： The present invention provides a reaction container, a reaction device, and a method of amplifying a nucleic acid, which are suitable for locally heating a sample which contains a nucleic acid, enable rapid control of temperature changes in the sample, provide easy fabrication, and are low cost. The invention provides a reaction container used for a nucleic acid amplification reaction, which includes a sample holding portion formed from a cavity in the reaction container; and a heating element for heating a sample which contains a nucleic acid and which is held in the sample holding portion, wherein the heating element is made of a conductive material and arranged at a location where the sample or the sample and the periphery of the cavity is (are) to be locally heated, the conductive material generating heat by electromagnetic induction.

    摘要翻译： 本发明提供一种反应容器，反应装置和扩增核酸的方法，其适用于局部加热含有核酸的样品，能够快速控制样品中的温度变化，提供容易的制造，以及 是低成本的。 本发明提供了用于核酸扩增反应的反应容器，其包括由反应容器中的空腔形成的样品保持部分; 以及加热元件，用于加热含有核酸并被保持在样品保持部分中的样品，其中所述加热元件由导电材料制成并且布置在样品或样品和空腔周边的位置 被局部加热，导电材料通过电磁感应产生热量。

    APPARATUS AND METHOD FOR DETECTING PRESENCE OR DETERMINING BIOLOGICALLY SPECIFICALLY REACTIVE SUBSTANCE
    4.
    发明申请
    APPARATUS AND METHOD FOR DETECTING PRESENCE OR DETERMINING BIOLOGICALLY SPECIFICALLY REACTIVE SUBSTANCE 审中-公开
    检测存在或确定生物特异性反应物质的装置和方法

    公开(公告)号：US20100213081A1

    公开(公告)日：2010-08-26

    申请号：US12679339

    申请日：2008-10-10

    申请人： Nobuhiko Ozaki ,  Shinki Kojima ,  Tetsuo Yukimasa

    发明人： Nobuhiko Ozaki ,  Shinki Kojima ,  Tetsuo Yukimasa

    IPC分类号： G01N27/26 ,  G01N33/487

    CPC分类号： G01N33/5438

    摘要： This invention provides an apparatus for determining a biologically specifically reactive substance using the acceleration of a biologically specific reaction by pearl chaining of carrier particles. The apparatus can suppress the generation of heat caused by the pearl chaining to suppress the vaporization of a sample solution. The apparatus comprises a substrate comprising a pair of electrodes and a reaction field disposed between the pair of electrodes, voltage applying means for applying an alternating voltage to the pair of electrodes, and carrier particles which are disposed in the reaction field and undergo pearl chaining upon exposure of an alternating electric field applied to the reaction field by the alternating voltage. The apparatus is characterized in that the voltage applying means applies two or more alternating voltages different from each other in amplitude.

    摘要翻译： 本发明提供一种用于通过载体颗粒的珍珠链连接加速生物特异性反应来确定生物特异性反应物质的装置。 该装置可以抑制由珍珠链引起的热量的产生，以抑制样品溶液的蒸发。 该装置包括：基板，包括一对电极和设置在该对电极之间的反应场;施加电压到一对电极的电压施加装置;以及布置在反应场中并承载珍珠链的载体颗粒 通过交流电压施加到反应场的交变电场的暴露。 该装置的特征在于，电压施加装置在振幅上施加彼此不同的两个或更多个交流电压。

    Blood processing apparatus and blood introducing method
    6.
    发明申请
    Blood processing apparatus and blood introducing method 有权
    血液处理装置及血液导入方法

    公开(公告)号：US20060263247A1

    公开(公告)日：2006-11-23

    申请号：US11494749

    申请日：2006-07-28

    申请人： Nobuhiko Ozaki ,  Hiroaki Oka ,  Tetsuo Yukimasa ,  Hidenobu Yaku ,  Maki Yotsuhashi ,  Yukari Hataoka

    发明人： Nobuhiko Ozaki ,  Hiroaki Oka ,  Tetsuo Yukimasa ,  Hidenobu Yaku ,  Maki Yotsuhashi ,  Yukari Hataoka

    IPC分类号： G01N33/00

    CPC分类号： G01N35/00069 ,  Y10T436/111666 ,  Y10T436/2575

    摘要： The present invention provides a blood processing apparatus that can introduce a metered quantity of a blood sample into a chamber and does not require an opening linked to the chamber to be closed after the introduction of the blood sample. An introducing chamber, an injection port, and an air port are formed in a rotatable platform of a blood processing apparatus. The injection port links the introducing chamber with the outside of the rotatable platform. A blood sample is introduced from the injection port into the introducing chamber. A blood coagulant is held on the port wall surface of the air port and/or around a portion of the surface of the rotatable platform where the air port is open.

    摘要翻译： 本发明提供一种血液处理装置，其能够将计量量的血液样品引入腔室中，并且在引入血液样本之后不需要连接到待关闭的腔室的开口。 在血液处理装置的可旋转平台中形成有引入室，注射口和空气口。 注入口将引入室与可旋转平台的外部连接。 血液样品从注射口引入引入室。 血液凝结剂被保持在空气端口的端口壁表面上和/或在空气端口打开的可旋转平台的表面的一部分周围。

    Blood processing apparatus and blood introducing method
    7.
    发明授权
    Blood processing apparatus and blood introducing method 有权
    血液处理装置及血液导入方法

    公开(公告)号：US07368083B2

    公开(公告)日：2008-05-06

    申请号：US11494749

    申请日：2006-07-28

    申请人： Nobuhiko Ozaki ,  Hiroaki Oka ,  Tetsuo Yukimasa ,  Hidenobu Yaku ,  Maki Yotsuhashi ,  Yukari Hataoka

    发明人： Nobuhiko Ozaki ,  Hiroaki Oka ,  Tetsuo Yukimasa ,  Hidenobu Yaku ,  Maki Yotsuhashi ,  Yukari Hataoka

    IPC分类号： G01N33/00

    CPC分类号： G01N35/00069 ,  Y10T436/111666 ,  Y10T436/2575

    摘要： The present invention provides a blood processing apparatus that can introduce a metered quantity of a blood sample into a chamber and does not require an opening linked to the chamber to be closed after the introduction of the blood sample. An introducing chamber, an injection port, and an air port are formed in a rotatable platform of a blood processing apparatus. The injection port links the introducing chamber with the outside of the rotatable platform. A blood sample is introduced from the injection port into the introducing chamber. A blood coagulant is held on the port wall surface of the air port and/or around a portion of the surface of the rotatable platform where the air port is open.

    摘要翻译： 本发明提供一种血液处理装置，其能够将计量量的血液样品引入腔室中，并且在引入血液样本之后不需要连接到待关闭的腔室的开口。 在血液处理装置的可旋转平台中形成有引入室，注射口和空气口。 注入口将引入室与可旋转平台的外部连接。 血液样品从注射口引入引入室。 血液凝结剂被保持在空气端口的端口壁表面上和/或在空气端口打开的可旋转平台的表面的一部分周围。

    Polymerase chain reaction kit and method of manufacturing the same
    9.
    发明授权
    Polymerase chain reaction kit and method of manufacturing the same 有权
    聚合酶链反应试剂盒及其制备方法

    公开(公告)号：US07790441B2

    公开(公告)日：2010-09-07

    申请号：US12149147

    申请日：2008-04-28

    申请人： Masaya Nakatani ,  Tetsuo Yukimasa

    发明人： Masaya Nakatani ,  Tetsuo Yukimasa

    IPC分类号： C12M1/00

    CPC分类号： C07H21/00 ,  B01L3/502707 ,  B01L7/52 ,  B01L2300/0816 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2300/185

    摘要： The present invention provides a kit employed for polymerase chain reaction. The kit has a cavity and a flow channel on a substrate. The flow channel is separated from the cavity by at least a barrier formed along the cavity. Such a structure allows the cavity to be filled with a sample solution even in minute quantities. At the same time, the structure can provide a sample solution with a rapid temperature-control. The structure can therefore contribute to accelerated polymerase chain reaction.

    摘要翻译： 本发明提供了用于聚合酶链反应的试剂盒。 该套件在衬底上具有空腔和流动通道。 流动通道至少沿着空腔形成的屏障与空腔分离。 这种结构允许空腔即使以微量数量填充样品溶液。 同时，该结构可以提供具有快速温度控制的样品溶液。 因此，该结构可能有助于加速聚合酶链反应。

    Discrimination method of target base in DNA, and allele specific primer used in the method of the same
    10.
    发明授权
    Discrimination method of target base in DNA, and allele specific primer used in the method of the same 有权
    DNA中靶基因的鉴别方法及其方法中使用的等位基因特异性引物

    公开(公告)号：US07297499B2

    公开(公告)日：2007-11-20

    申请号：US11489582

    申请日：2006-07-20

    申请人： Hidenobu Yaku ,  Hiroaki Oka ,  Tetsuo Yukimasa

    发明人： Hidenobu Yaku ,  Hiroaki Oka ,  Tetsuo Yukimasa

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6858 ,  C12Q2535/125 ,  C12Q2525/185

    摘要： An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is C, while a base adjacent with one base spaced apart is T.According to the present invention, the 3′ end base is designed to be the base corresponding to SNP; the second base from the 3′ end to be T; the third base from the 3′ end to be any one of T, G or C; and the base sequence of from the fourth from the 3′ end to the 5′ end base to be completely complementary to the sequence of from a base three bases away from the target SNP base on the 3′ side to a desired base.

    摘要翻译： 本发明的目的是提供一种等位基因特异性引物，当与目标SNP碱基的3'侧紧邻的碱基是C时，伴随着假阳性的可能性较小，并且能够进行确定的鉴别，而邻近的碱基 其中一个基座间隔开。根据本发明，3'端基被设计为对应于SNP的基座; 从3'端的第二个基地是T; 3'末端的第3个碱基为T，G或C任一个; 并且从3'末端到5'末端碱基的第四个碱基序列与从3'侧的目标SNP碱基到碱基的碱基三碱基的序列完全互补。