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    Measuring chip device using magnets for installation/removal
    7.
    发明授权
    Measuring chip device using magnets for installation/removal 有权
    使用磁铁测量芯片装置进行安装/拆卸

    公开(公告)号：US08531658B2

    公开(公告)日：2013-09-10

    申请号：US13125279

    申请日：2009-10-28

    申请人： Tsutomu Horiuchi ,  Toru Miura ,  Yuzuru Iwasaki ,  Michiko Seyama ,  Tsuyoshi Hayashi ,  Jun-ichi Takahashi ,  Tsuneyuki Haga

    发明人： Tsutomu Horiuchi ,  Toru Miura ,  Yuzuru Iwasaki ,  Michiko Seyama ,  Tsuyoshi Hayashi ,  Jun-ichi Takahashi ,  Tsuneyuki Haga

    IPC分类号： G01N21/01

    CPC分类号： G01N21/13 ,  B01L9/527 ,  B01L2200/025 ,  B01L2300/0819 ,  B01L2400/043 ,  G01N21/553 ,  G01N2035/00158

    摘要： A measuring chip installation/removal device of the present invention secures and removes a measuring chip to and from the top surface of an SPR measurement device that measures a specimen in the measuring chip by surface plasmon resonance. The measuring chip installation/removal device includes: a chip carrier on which the measuring chip is mounted; a chip carrier guide that guides the chip carrier on the top surface; and a first magnet provided in the chip carrier, and a second magnet is provided in the chip carrier guide. Orientation of a magnetic force received by the first magnet from the second magnet is reversed by displacing the chip carrier guide, so that the chip carrier is secured to or removed from the top surface.

    摘要翻译： 本发明的测量芯片安装/拆卸装置将测量芯片固定并去除测量芯片上的表面等离子体共振测量芯片的SPR测量装置的顶表面。 测量芯片安装/拆卸装置包括：安装有测量芯片的芯片载体; 将芯片载体引导到顶表面上的芯片载体引导件; 以及设置在所述芯片载体中的第一磁体，并且在所述芯片载体引导件中设置第二磁体。 由第一磁体从第二磁体接收的磁力的方向通过移位芯片载体引导件来反转，使得芯片载体固定到顶表面或从顶表面移除。

    FLOW RATE MEASUREMENT APPARATUS, ANTIGEN CONCENTRATION MEASUREMENT APPARATUS, FLOW CELL, FLOW RATE MEASUREMENT METHOD, AND ANTIGEN CONCENTRATION MEASURING METHOD
    9.
    发明申请
    FLOW RATE MEASUREMENT APPARATUS, ANTIGEN CONCENTRATION MEASUREMENT APPARATUS, FLOW CELL, FLOW RATE MEASUREMENT METHOD, AND ANTIGEN CONCENTRATION MEASURING METHOD 审中-公开
    流量测量装置，抗原浓度测量装置，流量池，流量测量方法和抗原浓度测量方法

    公开(公告)号：US20100285612A1

    公开(公告)日：2010-11-11

    申请号：US12811400

    申请日：2009-01-15

    申请人： Yuzuru Iwasaki ,  Tsutomu Horiuchi ,  Michiko Seyama ,  Toru Miura ,  Tsuneyuki Haga ,  Jun-ichi Takahashi ,  Tsuyoshi Hayashi

    发明人： Yuzuru Iwasaki ,  Tsutomu Horiuchi ,  Michiko Seyama ,  Toru Miura ,  Tsuneyuki Haga ,  Jun-ichi Takahashi ,  Tsuyoshi Hayashi

    IPC分类号： G01N33/543 ,  G01N30/96

    CPC分类号： G01N21/75 ,  G01F1/704 ,  G01F1/712 ,  G01F1/8468 ,  G01N21/553 ,  G01P5/18

    摘要： A flow rate measurement apparatus includes a light oscillator; a thin metallic film which causes surface plasmon resonance by light output from the light oscillator; a focusing unit which fixes the thin metallic film and converts the output light of the light oscillator into incident light having a plurality of incident angles to focus the incident light at a location of a focal line in a straight line shape on the thin metallic film; a measurement part having antibody fixed areas to which an antibody is fixed and reference areas to which an antibody is not fixed, the antibody fixed areas and the reference areas being alternately arranged at a location along the focal line location on the thin metallic film; a light receiver which receives reflected light, at the focal line location, of the output light by surface plasmon resonance occurring at the focal line location, at each of the plurality of incident light angles; an SPR angle calculator which obtains a temporal change of an SPR angle in each of the antibody fixed areas and the reference areas in the measurement part; and a flow rate operation unit which calculates the flow rate of the sample flowing in the flow cell based on the temporal change of the SPR angle obtained by the SPR angle calculator.

    摘要翻译： 流量测量装置包括光振荡器; 薄的金属膜，其通过来自光振荡器的光输出而引起表面等离子体共振; 聚焦单元，其固定所述薄金属膜并将所述光振荡器的输出光转换成具有多个入射角的入射光，以将所述入射光聚焦在所述薄金属膜上的直线形状焦点线的位置; 测定部，其具有抗体固定区域，抗体固定于该区域，抗体未固定的参照区域，抗体固定区域和参考区域交替配置在沿着薄金属膜上焦点位置的位置; 在所述多个入射光角度的每一个处，通过在焦点位置处发生的表面等离子体共振，在焦点位置处接收反射光的光接收器; SPR角度计算器，其获得测定部中的每个抗体固定区域和参考区域中的SPR角度的时间变化; 以及流量运算单元，其基于由SPR角计算器获得的SPR角度的时间变化来计算在流动池中流动的样本的流量。

    SENSOR ELEMENT FOR SPR MEASUREMENT
    10.
    发明申请
    SENSOR ELEMENT FOR SPR MEASUREMENT 有权
    传感器元件用于SPR测量

    公开(公告)号：US20100233028A1

    公开(公告)日：2010-09-16

    申请号：US12303693

    申请日：2007-06-26

    申请人： Yuzuru Iwasaki ,  Michiko Seyama ,  Toru Miura ,  Tsutomu Horiuchi ,  Tsuneyuki Haga ,  Serge Camou

    发明人： Yuzuru Iwasaki ,  Michiko Seyama ,  Toru Miura ,  Tsutomu Horiuchi ,  Tsuneyuki Haga ,  Serge Camou

    IPC分类号： G01N30/00

    CPC分类号： G01N21/553 ,  G01N33/53 ,  G01N33/543 ,  G01N33/54373 ,  G01N33/553 ,  Y10T436/2575

    摘要： An object of the present invention is to provide an element for SPR measurement without the need of a mechanical solution-sending mechanism. The scope of the present invention is defined by a sensor element for surface plasmon resonance (SPR) measurement utilizing an SPR effect, wherein the sensor element comprises a transparent substrate, a gold thin film formed on at least a part of the transparent substrate, and a thin film with affinity for a sample provided on the transparent substrate having the gold thin film formed on at least a part thereof, and the thin film with affinity for a sample has a measurement region (region A), a sample introduction section (region B) and a sample absorption section (region C) provided with the region A therebetween, the region A is provided with a sample measurement section containing a molecule-recognizing film, an introduction port is formed on the film with affinity for a sample in the region B, an absorption pad is provided on the film with affinity for a sample in the region C so that the whole region C should be covered, and a point in the region B, a point in the region A, and a point in the region C exist in one straight line on the thin film with affinity for a sample.

    摘要翻译： 本发明的目的是提供一种用于SPR测量的元件，而不需要机械解决方案发送机构。 本发明的范围由用于利用SPR效应的表面等离子体共振（SPR）测量的传感器元件限定，其中传感器元件包括透明基板，形成在透明基板的至少一部分上的金薄膜，以及 对在其至少部分形成有金薄膜的透明基板上提供的样品具有亲和性的薄膜，对样品具有亲和性的薄膜具有测量区域（区域A），样品导入部（区域 B）和在其间设置有区域A的样品吸收部（区域C），区域A设置有包含分子识别膜的样品测定部，在膜上形成有对样品的亲和性的引入口 区域B中，在膜C上提供吸收垫，对区域C中的样品具有亲和性，使得应该覆盖整个区域C，并且区域B中的点，区域A中的点和 区域C中的点在样品的亲和性上存在于薄膜上的一条直线上。