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33 条记录 (耗时 0.032 秒)

    METHOD FOR IMPROVING RECOVERY YIELD IN PROTEIN PURIFICATION WITH GEL FILTRATION CHROMATOGRAPHY
    3.
    发明申请
    METHOD FOR IMPROVING RECOVERY YIELD IN PROTEIN PURIFICATION WITH GEL FILTRATION CHROMATOGRAPHY 有权
    改进凝胶过滤色谱法提纯蛋白质回收率的方法

    公开(公告)号：US20060199948A1

    公开(公告)日：2006-09-07

    申请号：US11276509

    申请日：2006-03-03

    申请人： Daisuke Ejima ,  Ryosuke Yumioka ,  Tsutomu Arakawa

    发明人： Daisuke Ejima ,  Ryosuke Yumioka ,  Tsutomu Arakawa

    IPC分类号： C07K16/00 ,  C07K1/10

    CPC分类号： C07K1/20 ,  C07K1/14 ,  C07K14/50 ,  C07K14/5412 ,  C07K14/55 ,  C07K14/575 ,  C07K14/755 ,  C07K16/36

    摘要： A method to more quantitatively recover a peak of a protein and associated aggregates, hydrophobic proteins, or hydrophobic peptides which are typically difficult to recover and detect as a peak, using a commercially available gel filtration chromatography column and a mobile phase is described. More specifically, a compound, such as arginine, which may be added to the mobile phase, thereby eliminating the unnecessary interaction that occurs between the proteins, peptides, or aggregates and the column stationary phase is described.

    摘要翻译： 描述了使用市售的凝胶过滤色谱柱和流动相来更定量地回收通常难以回收和检测作为峰的相关聚集体，疏水性蛋白质或疏水性肽的峰值的方法。 更具体地，描述了可以添加到流动相中的化合物，例如精氨酸，从而消除了在蛋白质，肽或聚集体和柱固定相之间发生的不必要的相互作用。

    Apparatus and method of three-dimensional modeling
    5.
    发明授权
    Apparatus and method of three-dimensional modeling 失效
    三维建模的装置和方法

    公开(公告)号：US06363169B1

    公开(公告)日：2002-03-26

    申请号：US09120468

    申请日：1998-07-23

    申请人： Dieter Ritter ,  Yukinori Matsumoto ,  Kazuhide Sugimoto ,  Tsutomu Arakawa

    发明人： Dieter Ritter ,  Yukinori Matsumoto ,  Kazuhide Sugimoto ,  Tsutomu Arakawa

    IPC分类号： G06K928

    CPC分类号： G06T17/20 ,  G06T7/80 ,  G06T17/10

    摘要： A reference sheet is employed on which reference points are arranged irregularly and asymmetrically. An object of interest is placed on the reference sheet. The object of interest is shot together with the reference points by a camera. A shooting position of the camera is calculated according to the Hough transform method on the basis of the position of a reference point in the obtained object image. A three-dimensional model is generated according to the obtained object image and shooting position. Therefore, a simple and economic three-dimensional modeling apparatus that does not require a turntable can be provided.

    摘要翻译： 使用参考纸，其中参考点被布置不规则和不对称。 感兴趣的对象放在参考表上。 感兴趣的对象是通过相机与参考点一起拍摄的。 基于获取的对象图像中的参考点的位置，根据霍夫变换方法计算摄像机的拍摄位置。 根据获得的物体图像和拍摄位置生成三维模型。 因此，可以提供不需要转台的简单且经济的三维建模装置。

    Method of producing a curable composition containing 4,4'-bis(methacryloylthio)diphenylsulfide
    6.
    发明授权
    Method of producing a curable composition containing 4,4'-bis(methacryloylthio)diphenylsulfide 失效
    制备含有4,4'-双（甲基丙烯酰硫基）二苯硫醚的可固化组合物的方法

    公开(公告)号：US5270439A

    公开(公告)日：1993-12-14

    申请号：US952655

    申请日：1992-09-28

    申请人： Satoshi Maruyama ,  Naoki Minorikawa ,  Tsutomu Arakawa ,  Haruo Yoshida ,  Hirotaka Tagoshi ,  Kazuto Abe

    发明人： Satoshi Maruyama ,  Naoki Minorikawa ,  Tsutomu Arakawa ,  Haruo Yoshida ,  Hirotaka Tagoshi ,  Kazuto Abe

    IPC分类号： C07C327/22 ,  C08F28/02 ,  C08G75/00

    CPC分类号： C08F28/02 ,  C07C327/22

    摘要： A method of producing a curable composition containing a prepolymer having a polythioether skeleton, characterized by comprising addition reacting (A) 4,4'-bis(methacryloylthio)-diphenylsulfide having the formula (I): ##STR1## wherein R is a polyvalent organic group composed of an aliphatic or aromatic hydrocarbon and n represents an integer of 2 or more, with the functional group equivalent ratio of the mercapto groups of the component (B) (ii) to the methacryloyl groups of the component (A) being from 0.02 to 1.01, in another vinyl monomer copolymerizable with 4,4'-bis(methacryloylthio)diphenylsulfide having the above formula (I) in the presence of a base catalyst.

    摘要翻译： 一种制备含有具有聚硫醚骨架的预聚物的可固化组合物的方法，其特征在于包括使（A）具有式（I）的（A）4,4'-双（甲基丙烯酰硫基） - 二苯硫醚：（I）和（B ）（ii）具有式（II）的多硫醇：R（SH）n（II）其中R是由脂族或芳族烃构成的多价有机基团，n表示2以上的整数，官能团当量 组分（B）（ii）的巯基与组分（A）的甲基丙烯酰基的比例为0.02至1.01，可与可与具有上式的4,4'-双（甲基丙烯酰硫基）二苯硫醚共聚的乙烯基单体 （I）在碱催化剂存在下反应。

    Antibody-induced apoptosis
    8.
    发明授权
    Antibody-induced apoptosis 失效
    抗体诱导凋亡

    公开(公告)号：US06458356B1

    公开(公告)日：2002-10-01

    申请号：US09046785

    申请日：1998-03-23

    申请人： Tsutomu Arakawa ,  Yoshiko Kita

    发明人： Tsutomu Arakawa ,  Yoshiko Kita

    IPC分类号： A61K39395

    CPC分类号： C07K16/32 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/82 ,  C07K2319/00

    摘要： Anti-Her2 antibodies which induce apoptosis in Her2 expressing cells are disclosed. The antibodies are used to “tag” Her2 overexpressing tumors for elimination by the host immune system. Also disclosed are hybridoma cell lines producing the antibodies, methods for treating cancer using the antibodies, and pharmaceutical compositions.

    摘要翻译： 公开了在Her2表达细胞中诱导凋亡的抗Her2抗体。 该抗体用于“标记”Her2过表达的肿瘤以通过宿主免疫系统消除。 还公开了产生抗体的杂交瘤细胞系，使用该抗体治疗癌症的方法和药物组合物。

    Method for inactivating viruses with slightly acidic arginine
    10.
    发明授权
    Method for inactivating viruses with slightly acidic arginine 有权
    用微酸性精氨酸灭活病毒的方法

    公开(公告)号：US08669045B2

    公开(公告)日：2014-03-11

    申请号：US12030321

    申请日：2008-02-13

    申请人： Hajime Koyama ,  Tsutomu Arakawa ,  Daisuke Ejima

    发明人： Hajime Koyama ,  Tsutomu Arakawa ,  Daisuke Ejima

    IPC分类号： C12Q1/70

    CPC分类号： A01N47/44 ,  A23L3/3508 ,  A23V2002/00 ,  A61K31/198 ,  A61K2039/5252 ,  C12N7/00 ,  C12N7/04 ,  C12N7/06 ,  C12N2710/16663 ,  C12N2760/16163 ,  C12N2760/18863 ,  A23V2200/10 ,  A23V2250/0606

    摘要： The present invention provides a method for conveniently producing a protein formulation in which viruses are inactivated, without impairing the quality of the obtained protein formulation, characterized by including the step of exposing the protein formulation contaminated with the viruses to a 0.1-2M aqueous solution of arginine, an arginine derivative, or a mixture thereof, the aqueous solution being adjusted to pH 3.5 to 5. The present invention also provides a virus inactivation method characterized by including the step of contacting a virus-containing object with a 0.1-2M aqueous solution of arginine, an arginine derivative, or a mixture thereof, the aqueous solution being adjusted to pH 3.5 to 5.

    摘要翻译： 本发明提供了一种方便地制备其中病毒灭活而不损害所获得的蛋白质制剂的质量的蛋白质制剂的方法，其特征在于包括将被病毒污染的蛋白质制剂暴露于0.1-2M的 精氨酸，精氨酸衍生物或其混合物，将该水溶液调节至pH 3.5至5.本发明还提供了一种病毒灭活方法，其特征在于包括使病毒含有物体与0.1-2M水溶液接触的步骤 的精氨酸，精氨酸衍生物或其混合物，将该水溶液调节至pH 3.5至5。