公开(公告)号：US20140185042A1

公开(公告)日：2014-07-03

申请号：US14143805

申请日：2013-12-30

Applicant: IMEC ,  UNIVERSITEIT GENT

Inventor： Roeland BAETS ,  Ananth SUBRAMANIAN ,  Nicolas LE THOMAS

IPC: G01N21/65

CPC classification number: G01N21/658 ,  G01N21/554 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2201/08

Abstract: In the present invention, a molecular analysis device comprises a substrate, and a waveguide with a planar integrating element and filter or reflector element adjacent thereto is disposed on the substrate. The waveguide comprises a coupling means configured for coupling a predetermined frequency range of laser radiation into the waveguide. At least one metallic nanostructure is disposed on or adjacent to the planar integrating element, at least one metallic nanostructure is configured such that the field intensity and the gradient of the laser radiation, that is coupled into the waveguide, are enhanced over a sufficiently large volume around the nanostructure to simultaneously cause plasmonic based optical trapping of analyte(s) in a medium, and plasmonic based excitation of the particles to produce Raman scattered radiation. A Raman scattered radiation collection means is disposed on the substrate for collecting said Raman scattered radiation produced by the particles.

Abstract translation: 在本发明中，分子分析装置包括衬底，并且具有平面积分元件的波导和与其相邻的过滤器或反射器元件设置在衬底上。 波导包括被配置为将激光辐射的预定频率范围耦合到波导中的耦合装置。 至少一个金属纳米结构设置在平面积分元件上或附近，至少一个金属纳米结构被配置为使得耦合到波导中的激光辐射的场强和梯度在足够大的体积上被增强 围绕纳米结构同时引起介质中分析物的等离子体光学捕获，以及等离子体激发的颗粒以产生拉曼散射辐射。 拉曼散射辐射收集装置设置在基板上用于收集由颗粒产生的所述拉曼散射辐射。

公开(公告)号：US20210063638A1

公开(公告)日：2021-03-04

申请号：US16958476

申请日：2018-12-31

Applicant: UNIVERSITEIT GENT ,  IMEC VZW

Inventor： Roeland BAETS ,  Eva RYCKEBOER ,  Abdul RAHIM ,  Anton VASILIEV ,  Xiaomin NIE

IPC: G02B6/12 ,  G02B6/124 ,  G02B6/293 ,  G01J3/18 ,  G01J3/22 ,  G01J3/36

Abstract: An integrated wavelength-selective filter device comprises a first optical element, for directing received radiation into a direction defined by a first angle, and a second optical element being a diffractive element configured for diffracting the directed radiation under a second angle. The second angle is such that for a single reference wavelength the diffracted radiation is directed into a propagation medium for advancing therein towards a predetermined position on the first optical element or on a further optical element for filtering radiation having a wavelength substantially matching the reference wavelength from radiation having a substantially different wavelength. The propagation medium is formed from a material that is different from any material of the substrate of the first and the second optical element.

公开(公告)号：US20170003454A1

公开(公告)日：2017-01-05

申请号：US15106428

申请日：2014-12-21

Applicant: UNIVERSITEIT GENT ,  IMEC vzw

Inventor： Roeland BAETS ,  Stijn VANDEWIELE ,  Danaë DELBEKE ,  Dries VANTHOURHOUT

IPC: G02B6/35

CPC classification number: G02B6/3538 ,  G02B6/3536 ,  G02B6/3568 ,  G02B6/3596 ,  G02B2006/12145

Abstract: A system for selectively adiabatically coupling electromagnetic waves from one waveguide to another waveguide is described. It comprises a first waveguide portion and a second waveguide portion having substantially different surface normal cross-sections. Portions thereof are positioned with respect to each other in a coupling region so that under first predetermined environmental conditions coupling of electromagnetic waves between the first waveguide portion and the second waveguide portion can occur and under second predetermined environmental conditions substantially no coupling of electromagnetic waves between the first waveguide portion and the second waveguide portion can occur. The system also comprises a fluid positioning means for selectively positioning at least a first fluid simultaneously overlaying both said first waveguide portion and said second waveguide portion in the coupling region thus selectively inducing first predetermined environmental conditions or second predetermined environmental conditions.

Abstract translation: 描述了一种用于选择性地将电磁波从一个波导耦合到另一个波导的系统。 它包括具有基本不同的表面法线横截面的第一波导部分和第二波导部分。 其部分在耦合区域中相对于彼此定位，使得在第一预定环境条件下，可以发生第一波导部分和第二波导部分之间的电磁波耦合，并且在第二预定环境条件下，基本上不会在 可以发生第一波导部分和第二波导部分。 该系统还包括流体定位装置，用于选择性地定位至少第一流体，同时在耦合区域中覆盖所述第一波导部分和所述第二波导部分两者，从而选择性地诱导第一预定环境条件或第二预定环境条件。

公开(公告)号：US20180239089A1

公开(公告)日：2018-08-23

申请号：US15753700

申请日：2016-08-22

Applicant: UNIVERSITEIT GENT ,  IMEC VZW

Inventor： Roeland BAETS ,  Günther ROELKENS ,  Andreas DE GROOTE ,  Paolo CARDILE ,  Ananth SUBRAMANIAN

IPC: G02B6/122 ,  H01L33/00 ,  H01L33/30 ,  H01L33/58 ,  G02B6/13

CPC classification number: G02B6/1228 ,  G02B6/131 ,  G02B2006/12061 ,  G02B2006/12097 ,  G02B2006/12121 ,  G02B2006/12123 ,  H01L33/0045 ,  H01L33/0079 ,  H01L33/30 ,  H01L33/58 ,  H01S5/026

Abstract: An on-chip broadband radiation source, and methods for its manufacture such that a photonics IC comprises an optical waveguide such as a semiconductor waveguide, a thin III-V material membrane with absorption capability for absorbing an optical pump signal induced in the waveguide. The III-V membrane comprises a LED implemented therein. The photonics IC also comprises a coupling means between the waveguide and the membrane. The device provides a broadband radiation source at a wavelength longer than the wavelength of the transferred radiation. The broadband signal can then be coupled out through the waveguide and used in the chip.

公开(公告)号：US20170082421A1

公开(公告)日：2017-03-23

申请号：US15305713

申请日：2015-04-23

Applicant: UNIVERSITEIT GENT ,  IMEC VZW

Inventor： Roeland BAETS ,  Danaë DELBEKE ,  Günther ROELKENS ,  Wim BOGAERTS

IPC: G01B9/02 ,  G02B6/12 ,  G01J3/433 ,  G01N21/35

CPC classification number: G01B9/02051 ,  G01B9/02044 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/0259 ,  G01J3/18 ,  G01J3/1895 ,  G01J3/32 ,  G01J3/433 ,  G01N21/35 ,  G02B6/12019

Abstract: An integrated waveguide based spectrometer is described. The spectrometer comprises a sensing region for receiving multi-wavelength radiation for irradiating a sample in the sensing region, a wavelength demultiplexing element arranged for capturing said multi-wavelength radiation after interaction with the sample and for providing a number of wavelength demultiplexed radiation outputs or a number of different groups of wavelength demultiplexed radiation outputs, an integrated modulator for differently modulating the different demultiplexed radiation outputs or different groups of demultiplexed radiation outputs, and a multiplexer element for multiplexing the differently modulated demultiplexed radiation outputs or the differently grouped demultiplexed radiation outputs.

公开(公告)号：US20150148627A1

公开(公告)日：2015-05-28

申请号：US14091645

申请日：2013-11-27

Applicant: UNIVERSITEIT GENT

Inventor： Roeland BAETS ,  Eva RYCKEBOER

IPC: A61B5/145 ,  B01L3/00 ,  A61B5/1459

CPC classification number: A61B5/14532 ,  A61B5/14503 ,  A61B5/1459 ,  A61B5/150022 ,  A61B5/157 ,  A61B2562/04 ,  B01L3/5027 ,  G01N21/03 ,  G01N21/274 ,  G01N2201/0662

Abstract: A sensing system and method for sensing a component in a liquid is disclosed. The system comprises a microfluidic channel, the microfluidic channel comprising a first end and a second end, wherein the microfluidic channel is open at the first end and closed at the second end. The system also comprises at least one measurement sensor positioned adjacent the first end, the measurement sensor being arranged for detecting a measurement signal and a reference sensor positioned in the microfluidic channel adjacent the second end, the reference sensor being arranged for detecting a reference signal of the liquid. The system further is configured for combining the measurement signal and the reference signal so as to filter out background influences.

Abstract translation: 公开了用于感测液体中的组分的感测系统和方法。 所述系统包括微流体通道，所述微流体通道包括第一端和第二端，其中所述微流体通道在所述第一端开放并且在所述第二端封闭。 所述系统还包括邻近所述第一端定位的至少一个测量传感器，所述测量传感器被布置用于检测位于所述微流体通道中的测量信号和参考传感器，所述参考传感器邻近所述第二端，所述参考传感器被布置用于检测参考信号 液体。 该系统还被配置为组合测量信号和参考信号，以便滤除背景影响。

公开(公告)号：US20250020585A1

公开(公告)日：2025-01-16

申请号：US18766951

申请日：2024-07-09

Applicant: IMEC VZW ,  Universiteit Gent

Inventor： YanLu LI ,  Roeland BAETS

IPC: G01N21/45 ,  G01F1/661 ,  G01M3/04 ,  G01N21/17 ,  G01N21/85

Abstract: A system for open-path sensing of a property of a fluid in an environment comprises: a sensing light source; a pumping light source for outputting a pumping beam into the environment for inducing a change of light propagation characteristics of the fluid; wherein the system outputs a probing beam and a reference beam into the environment, such that the probing beam has a larger intersection with the pumping beam than the reference beam; wherein a first interferometer detects a phase shift and/or an intensity change of a received probing beam; and wherein a second interferometer detects a phase shift and/or an intensity change of a received reference beam.

公开(公告)号：US20230152233A1

公开(公告)日：2023-05-18

申请号：US17919320

申请日：2021-04-19

Applicant: UNIVERSITEIT GENT ,  IMEC VZW

Inventor： Haolan ZHAO ,  Pieter WUYTENS ,  Roeland BAETS

IPC: G01N21/65 ,  G01N33/487

CPC classification number: G01N21/65 ,  G01N33/487

Abstract: A method and device for detecting the presence of an unbound portion of therapeutic agents in a bodily fluid sample provided in which the bodily fluid includes an endogenous component of geometrical size larger than the therapeutic agent. A photonic integrated circuit has a porous material enrichment layer, a waveguide formed in the enrichment layer, and a blocking means provided on an outer surface of the enrichment layer. The enrichment layer with blocking means is permeable to the unbound therapeutic agent and prevents penetration of the endogenous component into pores of enrichment layer. The blocking means is configured to cooperate with the enrichment layer to maintain therapeutic agent access to the pores of the enrichment layer and prevent light-matter interaction between the at least one endogenous component and light guided in the waveguide, when contacting the liquid sample with the photonic integrated circuit.

公开(公告)号：US20220390280A1

公开(公告)日：2022-12-08

申请号：US17776032

申请日：2020-11-18

Applicant: UNIVERSITEIT GENT ,  IMEC VZW

Inventor： Fabio PAVANELLO ,  Dries VAN THOURHOUT ,  Roeland BAETS

IPC: G01J3/02 ,  G01J3/28 ,  G01J3/12

Abstract: A temperature compensation method for wavelength monitoring using spectrometers on photonic integrated chips and a related temperature-compensated wavelength monitoring device include an optical filter of the chip filters a source signal to provide at least one spectral reference line to a first spectrometer to detect thermal wavelength drifts thereof. At least one spectral line to be monitored is received by the same or another spectrometer of the chip to detect wavelength shifts thereof. The detected thermal drift of the reference line is compared to calibrated thermal drifts for the reference line which is associated with a calibrated thermal drift for the spectral response curve of the spectrometer receiving the spectral line to be monitored. A thermal drift rate for the response curve of the optical filter differs from a thermal drift rate for the response curve of the first spectrometer at least by an amount.

公开(公告)号：US20210026069A1

公开(公告)日：2021-01-28

申请号：US16498764

申请日：2018-03-30

Applicant: UNIVERSITEIT GENT ,  IMEC VZW ,  ZHEJIANG UNIVERSITY

Inventor： Roeland BAETS ,  Zhechao WANG ,  Qing YANG ,  Xu LIU ,  Haifeng LI

IPC: G02B6/12 ,  G02B27/01 ,  G02F1/1347

Abstract: The display system for 3D light field generation comprises a photonic circuit comprising a plurality of light emitting units, wherein each light emitting unit comprises a light intensity modulator, and the display system comprises a phased liquid crystal array adapted to control the exiting optical angle of light for emission angle steering. The operations of light intensity modulators and the phased liquid crystal array are synchronized when reconstructing a light field of a virtual 3D object viewed by a user's eye.