公开(公告)号：US10527626B2

公开(公告)日：2020-01-07

申请号：US14903012

申请日：2014-07-01

Applicant: University of Washington through its Center for Commercialization

Inventor： Daniel T. Chiu ,  Mengxia Zhao ,  Wyatt Nelson ,  Perry G. Schiro

IPC: G01N33/536 ,  G01N33/574 ,  B01L3/00 ,  G01N33/53

Abstract: Provided herein, among other aspects, are methods and apparatuses for analyzing particles in a sample. In some aspects, the particles can be analytes, cells, nucleic acids, or proteins and contacted with a tag, partitioned into aliquots, detected by a ranking device, and isolated. The methods and apparatuses provided herein may include a microfluidic chip. In some aspects, the methods and apparatuses may be used to quantify rare particles in a sample, such as cancer cells and other rare cells for disease diagnosis, prognosis, or treatment.

公开(公告)号：US11480575B2

公开(公告)日：2022-10-25

申请号：US16702176

申请日：2019-12-03

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Daniel T. Chiu ,  Mengxia Zhao ,  Wyatt Nelson ,  Perry G. Schiro

IPC: G01N33/574 ,  B01L3/00 ,  G01N15/06 ,  G01N15/14 ,  G01N33/49 ,  G01N21/64 ,  G01N33/53 ,  G01N35/10 ,  G01N35/00 ,  G01N15/10

Abstract: Provided herein, among other aspects, are methods and apparatuses for analyzing particles in a sample. In some aspects, the particles can be analytes, cells, nucleic acids, or proteins and contacted with a tag, partitioned into aliquots, detected by a ranking device, and isolated. The methods and apparatuses provided herein may include a microfluidic chip. In some aspects, the methods and apparatuses may be used to quantify rare particles in a sample, such as cancer cells and other rare cells for disease diagnosis, prognosis, or treatment.

公开(公告)号：US11808767B2

公开(公告)日：2023-11-07

申请号：US17932687

申请日：2022-09-16

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Daniel T. Chiu ,  Mengxia Zhao ,  Wyatt Nelson ,  Perry G. Schiro

IPC: G01N33/574 ,  B01L3/00 ,  G01N15/06 ,  G01N15/14 ,  G01N33/49 ,  G01N21/64 ,  G01N33/53 ,  G01N35/10 ,  G01N35/00 ,  G01N15/10

CPC classification number: G01N33/57492 ,  B01L3/502761 ,  B01L3/561 ,  B01L3/567 ,  G01N15/0612 ,  G01N15/0656 ,  G01N15/1456 ,  G01N15/1484 ,  G01N21/6428 ,  G01N21/6456 ,  G01N33/49 ,  G01N33/5304 ,  B01L3/502738 ,  B01L3/502776 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2300/0636 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0832 ,  B01L2300/0864 ,  B01L2300/0883 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0487 ,  B01L2400/06 ,  B01L2400/0633 ,  B01L2400/086 ,  G01N15/0618 ,  G01N35/0098 ,  G01N2015/0681 ,  G01N2015/0693 ,  G01N2015/1006 ,  G01N2015/149 ,  G01N2035/00237 ,  G01N2035/00356 ,  G01N2035/1034

Abstract: Provided herein, among other aspects, are methods and apparatuses for analyzing particles in a sample. In some aspects, the particles can be analytes, cells, nucleic acids, or proteins and contacted with a tag, partitioned into aliquots, detected by a ranking device, and isolated. The methods and apparatuses provided herein may include a microfluidic chip. In some aspects, the methods and apparatuses may be used to quantify rare particles in a sample, such as cancer cells and other rare cells for disease diagnosis, prognosis, or treatment.