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    Collagen product containing collagen of marine origin with a low odor and preferably with improved mechanical properties, and its use in the form of cosmetic or pharmaceutical compositions or products
    3.
    发明授权
    Collagen product containing collagen of marine origin with a low odor and preferably with improved mechanical properties, and its use in the form of cosmetic or pharmaceutical compositions or products 有权
    含有海洋来源的胶原蛋白，具有低气味，优选具有改善的机械性能的胶原蛋白产品，其以化妆品或药物组合物或产品的形式使用

    公开(公告)号：US06660280B1

    公开(公告)日：2003-12-09

    申请号：US09435934

    申请日：1999-11-09

    申请人： Roland Allard ,  Nabil Abdul Malak ,  Alain Huc

    发明人： Roland Allard ,  Nabil Abdul Malak ,  Alain Huc

    IPC分类号： A61K600

    CPC分类号： A61K8/0208 ,  A61K8/0212 ,  A61K8/65 ,  A61K38/00 ,  A61Q19/00 ,  C07K14/78 ,  C08L89/06 ,  Y10S530/856

    摘要： The invention relates to a collagen product containing collagen of marine origin with a low odor. The collagen product includes one or more collagens or derivatives thereof, including hydrolyzates, with a low odor, at least part of the collagen or the derivatives being of marine origin and having been subjected to a deodorization treatment, particularly with an oxidizing substance such as a sulfite, hydrogen peroxide or ozone, at any stage of the manufacture of the collagen product. The invention also makes it possible to improve the mechanical properties and to use this low-odor collagen product in cosmetic or pharmaceutical products.

    摘要翻译： 本发明涉及含有低气味的海洋来源的胶原蛋白的胶原蛋白产品。 胶原蛋白产品包括一种或多种胶原蛋白或其衍生物，包括具有低气味的水解产物，至少部分胶原蛋白或衍生物为海洋来源并经过除臭处理，特别是与氧化物质如 亚硫酸盐，过氧化氢或臭氧，在制造胶原产品的任何阶段。 本发明还可以改善机械性能并且在化妆品或药物产品中使用这种低气味的胶原蛋白产品。

    Processes for the preparation of novel collagen-based supports for tissue engineering, and biomaterials obtained
    6.
    发明授权
    Processes for the preparation of novel collagen-based supports for tissue engineering, and biomaterials obtained 有权
    制备用于组织工程的新型胶原基载体和获得的生物材料的方法

    公开(公告)号：US06790454B1

    公开(公告)日：2004-09-14

    申请号：US09616526

    申请日：2000-07-14

    申请人： Nabil Abdul Malak ,  Valérie Andre ,  Alain Huc

    发明人： Nabil Abdul Malak ,  Valérie Andre ,  Alain Huc

    IPC分类号： A61F1300

    CPC分类号： A61L27/3891 ,  A61L27/3804 ,  A61L27/48 ,  A61L27/56 ,  A61L27/60 ,  C12N5/0068 ,  C12N2533/54

    摘要： A composite product is disclosed as a collagen support comprising at least one porous collagen layer covered on at least one side with an essentially compact collagen membrane consisting either of a collagen film prepared by drying a collagen gel, preferably in air or a gaseous fluid, or of a very highly compressed collagen sponge. At least one of the two layers, i.e. the porous layer and the essentially compact membrane, may comprise normal, genetically modified or malignant living cells originating particularly from young or elderly subjects. This composite product is used as a collagen support for the manufacture of artificial skin intended especially for performing in vitro tests on the efficacy of potentially active substances or for reconstructing damaged areas of skin in vivo.

    摘要翻译： 公开了复合产品作为胶原支持体，其包含至少一个多孔胶原层，该至少一个多孔胶原层被覆盖在至少一侧上，所述多孔胶原层具有基本上紧密的胶原膜，所述胶原膜由通过干燥胶原凝胶制备的胶原膜，优选在空气或气态流体中， 的非常高度压缩的胶原海绵。 两层中的至少一层，即多孔层和基本致密的膜，可以包括特别来自年轻或老年人的正常的，遗传修饰的或恶性的活细胞。 该复合产品用作制造人造皮肤的胶原支持物，其特别用于对潜在活性物质的功效进行体外测试或在体内重建损伤的皮肤区域。

    Biodegradable microcapsules having walls composed of crosslinked atelocollagen and polyholoside
    9.
    发明授权
    Biodegradable microcapsules having walls composed of crosslinked atelocollagen and polyholoside 失效
    可生物降解的微胶囊，其具有由交联的胶原和聚氧化物组成的壁

    公开(公告)号：US5395620A

    公开(公告)日：1995-03-07

    申请号：US74701

    申请日：1993-06-08

    申请人： Alain Huc ,  Marie-Christine Levy ,  Chantal Buffevant ,  Marie-Christine Andry

    发明人： Alain Huc ,  Marie-Christine Levy ,  Chantal Buffevant ,  Marie-Christine Andry

    IPC分类号： A61K8/11 ,  A61K8/65 ,  A61K8/67 ,  A61K8/73 ,  A61K9/16 ,  A61K9/50 ,  A61Q19/00 ,  B01J13/02 ,  B01J13/04 ,  B01J13/10

    CPC分类号： A61K8/11 ,  A61K8/65 ,  A61K8/676 ,  A61K8/735 ,  A61K9/1652 ,  A61K9/1658 ,  A61K9/5036 ,  A61K9/5052 ,  A61Q19/00 ,  B01J13/02 ,  B01J13/04 ,  B01J13/10 ,  A61K2800/412 ,  Y10S514/963 ,  Y10T428/2989

    摘要： The invention relates to microcapsules with a mixed wall of crosslinked atelocollagen and polyholosides, for example glycosaminoglycans, and to processes for the manufacture of the said microcapsules. According to the invention, the microcapsules comprise a mixed wall of crosslinked atelocollagen and polyholosides, for example glycosaminoglycans, the proportion of polyholosides, for example glycosaminoglycans, relative to the atelocollagen preferably being between 18 and 50% by weight. These microcapsules can be manufactured either by a process involving interfacial crosslinking or by the extrusion of a laminar flow which is broken up by vibrations into individual droplets, which fall into a crosslinking bath. These microcapsules are biocompatible by virtue of the presence of atelocollagen, which has most of the advantageous properties of collagen, namely a very low antigenicity and a perfect biodegradability. They are therefore particularly suitable for the manufacture of cosmetic, pharmaceutical or food compositions.

    摘要翻译： 本发明涉及具有交联的阿胶原和多聚半乳糖苷的混合壁（例如葡糖胺聚糖）的微胶囊以及用于制备所述微胶囊的方法。 根据本发明，微胶囊包含交联的胶原蛋白和多聚半乳糖苷的混合壁，例如糖胺聚糖，多羟基化合物例如糖胺聚糖相对于胶原凝胶的比例优选在18-50重量％之间。 这些微胶囊可以通过涉及界面交联的过程或通过振动分解成分散到交联浴中的各个液滴的层流的挤出来制造。 这些微胶囊由于存在胶原蛋白而具有生物相容性，其具有胶原蛋白的大部分有利性质，即非常低的抗原性和完美的生物降解性。 因此，它们特别适用于制造化妆品，药​​物或食品组合物。

    Process and apparatus for freeze-drying comprising means forming an active thermal shield between the freeze-drying shelves
    10.
    发明授权
    Process and apparatus for freeze-drying comprising means forming an active thermal shield between the freeze-drying shelves 失效
    用于冷冻干燥的方法和装置包括在冷冻干燥架之间形成活性热屏蔽的装置

    公开(公告)号：US4953299A

    公开(公告)日：1990-09-04

    申请号：US272483

    申请日：1988-11-16

    申请人： Rene Gimeno ,  Alain Huc ,  Pierre DeVictor

    发明人： Rene Gimeno ,  Alain Huc ,  Pierre DeVictor

    IPC分类号： F26B5/06

    CPC分类号： F26B5/06

    摘要： This invention relates to a process and apparatus for freeze-drying, said apparatus comprising freeze-drying shelves disposed inside a freeze-drying enclosure, on which may be placed products or solutions to be freeze-dried, which may be contained in open recipients, as well as cooling and/or heating means associated with and preferably incorporated in said shelves, wherein means forming a thermal shield are disposed between said freeze-drying shelves, thus making it possible to slow down the heat exchanges between the surface of the product to be freeze-dried and the heating and/or cooling elements associated with the shelves. More homogeneous freeze-dried products are obtained in this way.

    摘要翻译： 本发明涉及一种用于冷冻干燥的方法和装置，所述装置包括设置在冷冻干燥机壳内部的冷冻干燥架，其上可放置可以包含在敞开式接收器中的要冷冻干燥的产品或溶液， 以及与所述搁架相关联并优选地结合在所述搁架中的冷却和/或加热装置，其中形成热屏蔽的装置设置在所述冷冻干燥架之间，从而可以减缓产品表面之间的热交换， 冷冻干燥和与搁架相关联的加热和/或冷却元件。 以这种方式获得更均匀的冻干产品。