公开(公告)号：US20130011845A1

公开(公告)日：2013-01-10

申请号：US13513425

申请日：2009-12-02

申请人： Vic Narry Kim ,  Jung Hyun Lee ,  Seogang Hyun ,  Hua Jin

发明人： Vic Narry Kim ,  Jung Hyun Lee ,  Seogang Hyun ,  Hua Jin

IPC分类号： G01N33/566 ,  C12Q1/02 ,  G01N21/64 ,  C12Q1/68

CPC分类号： G01N33/5023 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2320/10 ,  G01N33/5041 ,  G01N33/6893 ,  G01N2333/62 ,  G01N2500/00 ,  G01N2800/042

摘要： The present invention relates to a miRNA regulating the insulin signaling pathway, and to a method for screening a material for controlling the action of a target gene thereof, and particularly, to a method for screening a material for controlling the action of USH or FOG2, a target gene of miR-8 or miR-200 miRNA for promoting cell growth. The present inventors discovered miR-8, a conserved miRNA for regulating the body of a fruit fly by targeting u-shaped material (USH) in the fat cells of Drosophila. It was also confirmed that a target gene of miR-200, a human homologous gene of Drosophila miR-8 miRNA, is FOG2. It was found that Drosophila miR-8 and USH are also conserved in mammals, and FOG2, a human homologous gene of USH, directly binds to a regulating subunit of PI3K and functions. It was confirmed that when the expression of miR-200 is inhibited or FOG2 is expressed in a human cancer cell line, the activity of PI3K, which promotes cell growth, is decreased. Therefore, miR-200 and FOG2 may be useful in screening regulators of insulin signaling pathways.

摘要翻译： 本发明涉及调节胰岛素信号通路的miRNA，以及筛选用于控制其靶基因的作用的材料的方法，特别涉及筛选用于控制USH或FOG2的作用的材料的方法， 用于促进细胞生长的miR-8或miR-200 miRNA的靶基因。 本发明人发现miR-8是通过在果蝇的脂肪细胞中靶向u形材料（USH）来调节果蝇体的保守miRNA。 还证实了miR-200（果蝇miR-8 miRNA的人同源基因）的靶基因是FOG2。 发现果蝇miR-8和USH在哺乳动物中也保守，FOG2是USH的人同源基因，直接结合PI3K的调节亚基和功能。 证实当miR-200的表达被抑制或FOG2在人癌细胞系中表达时，促进细胞生长的PI3K的活性降低。 因此，miR-200和FOG2可用于筛选胰岛素信号通路的调节物。

公开(公告)号：US08673855B2

公开(公告)日：2014-03-18

申请号：US13703006

申请日：2010-06-08

申请人： Vic Narry Kim ,  Jung Hyun Lee

发明人： Vic Narry Kim ,  Jung Hyun Lee

IPC分类号： C07K14/47

CPC分类号： C07K14/4703 ,  A61K38/17 ,  C07K14/4702

摘要： The present invention relates to a phosphatidylinositol 3-kinases activity regulator which include the fifth zinc finger domain of FOG2 and which, more specifically, can induce cancer cells to die due to the inclusion of the fifth zinc finger domain of FOG2. Since the death of cancer cells is induced by suppressing the transfer of PI3K signals, the fifth zinc finger domain of FOG2 according to the present invention can be suitably use as a composition for the prevention and treatment of PI3K-related diseases.

摘要翻译： 本发明涉及磷脂酰肌醇3-激酶活性调节剂，其包括FOG2的第五锌指结构域，并且更具体地，可以由于包含FOG2的第五锌指结构域而导致癌细胞死亡。 由于通过抑制PI3K信号的转移来诱导癌细胞的死亡，根据本发明的FOG2的第五锌指结构域可以适当地用作预防和治疗PI3K相关疾病的组合物。

公开(公告)号：US20130116185A1

公开(公告)日：2013-05-09

申请号：US13703006

申请日：2010-06-08

申请人： Vic Narry Kim ,  Jung Hyun Lee

发明人： Vic Narry Kim ,  Jung Hyun Lee

IPC分类号： C07K14/47

CPC分类号： C07K14/4703 ,  A61K38/17 ,  C07K14/4702

摘要： The present invention relates to a phosphatidylinositol 3-kinases activity regulator which include the fifth zinc finger domain of FOG2 and which, more specifically, can induce cancer cells to die due to the inclusion of the fifth zinc finger domain of FOG2. Since the death of cancer cells is induced by suppressing the transfer of PI3K signals, the fifth zinc finger domain of FOG2 according to the present invention can be suitably use as a composition for the prevention and treatment of PI3K-related diseases.

摘要翻译： 本发明涉及磷脂酰肌醇3-激酶活性调节剂，其包括FOG2的第五锌指结构域，并且更具体地，可以由于包含FOG2的第五锌指结构域而导致癌细胞死亡。 由于通过抑制PI3K信号的转移来诱导癌细胞的死亡，根据本发明的FOG2的第五锌指结构域可以适当地用作预防和治疗PI3K相关疾病的组合物。

公开(公告)号：US09090805B2

公开(公告)日：2015-07-28

申请号：US13638407

申请日：2010-09-01

申请人： Hyo Young Lee ,  In Kyu Moon ,  Jung Hyun Lee

发明人： Hyo Young Lee ,  In Kyu Moon ,  Jung Hyun Lee

IPC分类号： C09K3/00 ,  B01D69/08 ,  B01D71/02 ,  B82Y30/00 ,  B82Y40/00 ,  C01B31/04 ,  H01G9/042 ,  H01M4/48

CPC分类号： C09K3/00 ,  B01D69/08 ,  B01D71/021 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/192 ,  H01G9/042 ,  H01M4/48 ,  Y10S977/847

摘要： The present invention relates to a novel graphene oxide reducing agent and a method for manufacturing a reduced graphene oxide from graphene oxide using same. More particularly, in the present invention, the reduced graphene oxide is manufactured by reducing a graphene oxide using a reducing agent containing a halogen element, and is applicable as an electric conductor, a semiconductor, and an insulator in various fields.

摘要翻译： 本发明涉及一种新颖的氧化石墨烯氧化物还原剂及其使用氧化石墨烯氧化物的方法。 更具体地，在本发明中，通过使用含有卤素元素的还原剂还原石墨烯氧化物来制造还原型石墨烯氧化物，并且可用作各种领域的导电体，半导体和绝缘体。

公开(公告)号：US20150191385A1

公开(公告)日：2015-07-09

申请号：US14412636

申请日：2012-08-14

申请人： Jung Hyun Lee ,  Jin Hyeok Choi ,  Joon Woo Gil

发明人： Jung Hyun Lee ,  Jin Hyeok Choi ,  Joon Woo Gil

IPC分类号： C02F9/00 ,  C02F1/52 ,  C02F1/70 ,  C02F1/20

CPC分类号： C02F9/00 ,  B01D53/62 ,  B01D2251/402 ,  B01D2252/1035 ,  B01D2257/504 ,  C02F1/20 ,  C02F1/5236 ,  C02F1/70 ,  C02F2101/10 ,  C02F2103/02 ,  C02F2103/08 ,  C02F2103/12 ,  C02F2103/16 ,  Y02C10/04

摘要： A method for sequestrating carbon dioxide in the ocean of the present invention coverts carbon dioxide into a high concentration of bicarbonate ions by using a neutralization method using calcium oxide commonly contained in alkaline industrial waste, prepares elution water for stably containing bicarbonate ions even when making contact with the atmosphere through aeration, and discharges the elution water into an area of the ocean of a relatively shallow depth to sequestrate carbon dioxide. According to the present invention, the present invention is a carbon dioxide storage method which uses alkaline industrial waste to carry out carbon dioxide ocean sequestration at relatively low cost, and can sequestrate carbon dioxide for a long time while minimizing bad environmental influences such as ocean acidification and the like, and is thus environmentally friendly. Therefore, it is possible to actively respond to carbon dioxide emission restrictions and simultaneously achieve economical efficiency by securing certified emission reductions henceforth.

摘要翻译： 本发明的海洋中的二氧化碳隔离方法通过使用通常包含在碱性工业废物中的氧化钙的中和方法将二氧化碳覆盖成高浓度的碳酸氢根离子，即使在接触时也制备用于稳定地含有碳酸氢根离子的洗脱水 通气通气，并将洗脱水排放到相对较浅深度的海洋区域以封存二氧化碳。 根据本发明，本发明是一种二氧化碳储存方法，其使用碱性工业废物以较低的成本进行二氧化碳海洋螯合，并可长时间地螯合二氧化碳，同时最小化诸如海洋酸化的不良环境影响 因此是环境友好的。 因此，有可能积极应对二氧化碳排放限制，同时通过确保今后的核证排放量同时实现经济效益。

公开(公告)号：US20130073569A1

公开(公告)日：2013-03-21

申请号：US13577149

申请日：2011-01-31

申请人： Sang Keun Lee ,  Jong Woo Ha ,  Jung Hyun Lee

发明人： Sang Keun Lee ,  Jong Woo Ha ,  Jung Hyun Lee

IPC分类号： G06F17/30

CPC分类号： G06F17/30864 ,  G06F17/30595 ,  G06F17/30707 ,  G06K9/6282 ,  G06Q30/02

摘要： A portable communication device for extracting a user interest comprises a term vector generation unit for generating, based on types of text data stored in the portable communication device, a term vector representing each text data, a subject classification tree storage unit for storing a subject classification tree, which is a tree structure in which multiple nodes, each including at least one training data and representing a subject, are connected to one another, and a similarity calculation unit for calculating a similarity between the term vector and the training data for each node in the subject classification tree. The similarity calculation unit extracts a node name representing the user interest from the subject classification tree based on the similarity.

摘要翻译： 一种用于提取用户感兴趣的便携式通信设备包括：术语矢量生成单元，用于基于存储在便携式通信设备中的文本数据的类型生成表示每个文本数据的术语矢量;主题分类树存储单元，用于存储主题分类 树，其中每个包括至少一个训练数据并表示对象的多个节点彼此连接的树结构，以及用于计算每个节点的项向量和训练数据之间的相似度的相似度计算单元 在主题分类树中。 相似度计算单元基于相似度从对象分类树中提取表示用户兴趣的节点名称。

公开(公告)号：US07911899B2

公开(公告)日：2011-03-22

申请号：US11713668

申请日：2007-03-05

申请人： Jung Hyun Lee ,  Eun Jin Ryu ,  Eing Seob Cho ,  Jun Jin Kong

发明人： Jung Hyun Lee ,  Eun Jin Ryu ,  Eing Seob Cho ,  Jun Jin Kong

IPC分类号： G11B15/52

CPC分类号： G11B20/10009 ,  G11B20/10037 ,  G11B20/10046 ,  G11B20/10333 ,  G11B20/10425 ,  G11B2220/2562

摘要： An optical disc reproducing apparatus includes an analog-to-digital (A/D) converter which converts an analog signal obtained from an optical disc to a digital signal; an asymmetry compensator which detects and corrects an offset of the digital signal; a phase locked loop (PLL) which estimates a clock of the digital signal and compensates for a frequency error; a binary module which converts the digital signal to binary data; an equalizer which equalizes a particular frequency of the digital signal; and a channel identifier which detects a reference level of the binary module, based on an input signal of the equalizer.

摘要翻译： 一种光盘再现装置，包括将从光盘获得的模拟信号转换为数字信号的模数（A / D）转换器; 不对称补偿器，其检测和校正数字信号的偏移; 锁相环（PLL），其估计数字信号的时钟并补偿频率误差; 将数字信号转换为二进制数据的二进制模块; 均衡器，其均衡数字信号的特定频率; 以及基于均衡器的输入信号来检测二进制模块的参考电平的信道标识符。

公开(公告)号：US20100297706A1

公开(公告)日：2010-11-25

申请号：US12525347

申请日：2007-10-02

申请人： Jung Hyun Lee ,  Sung Gyun Kang ,  Sang Jin Kim ,  Kae Kyoung Kwon ,  Hyun Sook Lee ,  Yun Jae Kim ,  Yong Gu Ryu ,  Seung Seob Bae ,  Jae Kyu Lim ,  Jung Ho Jeon ,  Yo Na Cho

发明人： Jung Hyun Lee ,  Sung Gyun Kang ,  Sang Jin Kim ,  Kae Kyoung Kwon ,  Hyun Sook Lee ,  Yun Jae Kim ,  Yong Gu Ryu ,  Seung Seob Bae ,  Jae Kyu Lim ,  Jung Ho Jeon ,  Yo Na Cho

IPC分类号： C12P19/34 ,  C12N9/10 ,  C07H21/04 ,  C12N15/63 ,  C12N1/21

CPC分类号： C12N9/1252

摘要： The present invention relates to mutant DNA polymerases and their genes isolated from Thermococcus sp. More specifically, the present invention relates to mutant DNA polymerases which are originally isolated from Thermococcus sp NA1. strain and produced by site-specific mutagenesis, their amino acid sequences, genes encoding said mutant DNA polymerases, their nucleic acids sequences, recombinant vectors containing said nucleic acids sequences, host cells transformed with thereof and methods for producing mutant DNA polymerase protein by using thereof. As mutant DNA polymerases according to the present invention have increased processivity by site-specific mutagenesis on exonuclease active site compared to wild type DNA polymerase, the present invention is broadly applicable for PCR in various molecular genetic technologies.

摘要翻译： 本发明涉及从Thermococcus sp。分离的突变型DNA聚合酶及其基因。 更具体地，本发明涉及最初从Thermococcus sp NA1分离的突变型DNA聚合酶。 菌株并通过位点特异性诱变产生，其氨基酸序列，编码所述突变型DNA聚合酶的基因，其核酸序列，含有所述核酸序列的重组载体，用其转化的宿主细胞和通过使用其产生突变型DNA聚合酶蛋白的方法 。 由于本发明的突变型DNA聚合酶与野生型DNA聚合酶相比，通过对外切核酸酶活性位点的位点特异性诱变具有增加的进行性，因此本发明广泛适用于各种分子遗传技术中的PCR。

公开(公告)号：US07745249B2

公开(公告)日：2010-06-29

申请号：US12245940

申请日：2008-10-06

申请人： Jung Hyun Lee ,  Pyung Soo Lee ,  Kun Hong Lee ,  Nayoung Shin

发明人： Jung Hyun Lee ,  Pyung Soo Lee ,  Kun Hong Lee ,  Nayoung Shin

IPC分类号： H01L31/00

CPC分类号： B81C1/0015 ,  G01N29/036 ,  G01N2291/0256

摘要： Provided are a multi-scale cantilever structure having nano-sized holes prepared by anodic oxidation and a method of preparing the same. The multi-scale cantilever structure is prepared using anodic oxidation and electro-polishing so that a manufacturing process is simple and a manufacturing cost is inexpensive. In addition, the multi-scale cantilever structure has a porous structure having a plurality of nano-sized holes inside thereof, and thus a surface area of the cantilever structure can be maximized. Therefore, when the cantilever structure is used in a sensor, the sensor can have improved sensitivity and selectivity.

摘要翻译： 提供了具有通过阳极氧化制备的纳米尺寸的孔的多尺度悬臂结构及其制备方法。 使用阳极氧化和电抛光制备多尺度悬臂结构，使得制造工艺简单并且制造成本便宜。 此外，多尺度悬臂结构具有在其内部具有多个纳米尺寸的孔的多孔结构，因此可以使悬臂结构的表面积最大化。 因此，当传感器中使用悬臂结构时，传感器可以提高灵敏度和选择性。

公开(公告)号：US07419764B2

公开(公告)日：2008-09-02

申请号：US11505395

申请日：2006-08-17

申请人： Jong Hyurk Park ,  Hyo Young Lee ,  Nak Jin Choi ,  Jung Hyun Lee ,  Gyeong Sook Bang

发明人： Jong Hyurk Park ,  Hyo Young Lee ,  Nak Jin Choi ,  Jung Hyun Lee ,  Gyeong Sook Bang

IPC分类号： G03C5/00

CPC分类号： G03F7/0002 ,  B82Y10/00 ,  B82Y40/00 ,  G03F7/0035 ,  G03F9/00 ,  Y10S430/143

摘要： Provided is a method of fabricating a nanoimprint mold which can form sub-100 nm fine pattern structures. The method includes forming patterns on a first substrate using an E-beam lithography (EBL) process, and transferring the patterns formed on the first substrate to a second substrate using a nanoimprint lithography (NIL) process to complete an NIL mold. Accordingly, the method can easily fabricate the nanoimprint mold at low costs on a quartz or glass substrate, which is not suitable for an EBL process to produce sub-100 nm patterns, by utilizing the advantages of the EBL process with a resolution of tens of nanometers.

摘要翻译： 提供一种制造能够形成亚100nm精细图案结构的纳米压印模具的方法。 该方法包括使用电子束光刻（EBL）工艺在第一衬底上形成图案，并使用纳米压印光刻（NIL）工艺将形成在第一衬底上的图案转移到第二衬底以完成NIL模具。 因此，该方法可以容易地在石英或玻璃基板上以低成本制造纳米压印模具，其不适用于生产亚100nm图案的EBL工艺，通过利用具有数十个分辨率的EBL工艺的优点 纳米。